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1. 发明申请

US20120087927A1 ANTIBODY CONTAINING IGG2 HAVING AMINO ACID MUTATION INTRODUCED THEREIN 有权
标题翻译：含有氨基酸的IGG2抗体含有氨基酸
公开(公告)号：US20120087927A1
公开(公告)日：2012-04-12
申请号：US13265075
申请日：2010-04-20
申请人： Aki Matsushima , Hiroshi Namisaki , Shigenori Yagi
发明人： Aki Matsushima , Hiroshi Namisaki , Shigenori Yagi
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , A61P35/00 , C12P21/00 , C12N1/19 , C12N5/10 , C07K16/18 , C12N1/21
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/72 , C07K2317/73 , C07K2317/75 , C07K2317/94 , C12R1/91 , Y02A50/412
摘要： The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein valine at position 234, glutamine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively (numbering is based on the EU index of Kabat et al); has an agonist activity; and binds to human CD40.
摘要翻译：本发明可以提供一种单克隆抗体，其包含重链恒定区，其为IgG2，其中234位的缬氨酸，237位的谷氨酰胺和331位的脯氨酸至少分别被丙氨酸，丙氨酸和丝氨酸取代（编号基于欧盟指数Kabat等人）; 具有激动剂活性; 并结合人CD40。

2. 发明授权

US5257277A Semiconductor-laser-pumped, solid-state laser 失效
标题翻译：半导体激光泵浦固体激光器
公开(公告)号：US5257277A
公开(公告)日：1993-10-26
申请号：US914750
申请日：1992-07-15
申请人： Shigenori Yagi , Takashi Yamamoto , Mayumi Fujimura , Toyohiro Uchiumi , Akira Ishimori
发明人： Shigenori Yagi , Takashi Yamamoto , Mayumi Fujimura , Toyohiro Uchiumi , Akira Ishimori
IPC分类号： H01S3/0941 , H01S5/022 , H01S3/094
CPC分类号： H01S3/0941 , H01S3/025 , H01S3/0604 , H01S3/061 , H01S3/0621 , H01S3/0625 , H01S3/08081 , H01S3/08095 , H01S3/094084 , H01S5/02248
摘要： A semiconductor-laser-pumped, solid-state laser includes a semiconductor pumping laser emitting pumping light, a solid-state laser medium arranged to be excited by the pumping light, and a laser resonator structure for emitting laser light from the solid-state laser medium. The solid-state laser medium is plate shaped having a thickness less than the broadening width of he pumping light in the solid-state laser medium. The semiconductor laser is arranged close to the face of the solid-state laser medium, and the laser resonator structure has an optical axis thereof coinciding with that of the pumping light.
摘要翻译：半导体激光泵浦固体激光器包括发射泵浦光的半导体激光激光器，布置成被泵浦光激发的固体激光介质，以及用于从固态激光器发射激光的激光谐振器结构中。固体激光介质是板状的，其厚度小于固体激光介质中的泵浦光的加宽宽度。半导体激光器靠近固态激光介质的表面布置，并且激光谐振器结构的光轴与泵浦光的光轴重合。

3. 发明授权

US4937424A Laser machining apparatus 失效
标题翻译：激光加工设备
公开(公告)号：US4937424A
公开(公告)日：1990-06-26
申请号：US221801
申请日：1988-07-20
申请人： Koji Yasui , Masaaki Tanaka , Shigenori Yagi , Masaki Kuzumoto
发明人： Koji Yasui , Masaaki Tanaka , Shigenori Yagi , Masaki Kuzumoto
IPC分类号： B23K26/073 , H01S3/08
CPC分类号： H01S3/08081 , B23K26/073
摘要： A laser machining apparatus includes a laser resonator capable of producing a laser beam having a filled-in intensity distribution pattern and a condensing device for converting the beam into a suitable beam to perform an intended machining. A device is provided for regulating phase of the laser beam to improve the condensed laser beam. The apparatus may also include a device for pulsating the beam and a device for changing a focal depth of the beam.

4. 发明授权

US07108836B2 Ozonizer 有权
标题翻译：臭氧发生器
公开(公告)号：US07108836B2
公开(公告)日：2006-09-19
申请号：US10156031
申请日：2002-05-29
申请人： Yujiro Okihara , Youichiro Tabata , Akaru Usui , Hiromichi Komiya , Yuji Ganryu , Masaki Kuzumoto , Noboru Wada , Koji Ohta , Shigenori Yagi , Hirozoh Kanegae
发明人： Yujiro Okihara , Youichiro Tabata , Akaru Usui , Hiromichi Komiya , Yuji Ganryu , Masaki Kuzumoto , Noboru Wada , Koji Ohta , Shigenori Yagi , Hirozoh Kanegae
IPC分类号： B01J19/08
CPC分类号： C01B13/11 , C01B2201/12 , C01B2201/22 , C01B2201/32 , C01B2201/76
摘要： An ozonizer has a flat plate-shaped low voltage electrode, flat plate-shaped first and second high voltage electrodes facing the low voltage electrode, a first dielectric, and a first spacer, located between the low voltage electrode and the first high voltage electrode, a second dielectric, and a second spacer between the electrode and the second high voltage electrode. The ozonizer also has a first electrode cooling sheet facing the first high voltage electrode at a side opposite a first discharge gap, a second electrode cooling sheet facing the second high voltage electrode, a first thermally conducting and electrically insulating sheet sandwiched between the first high voltage electrode and the first electrode cooling sheet, and a second thermally conducting and electrically insulating sheet sandwiched between the second high voltage electrode and the second electrode cooling sheet.
摘要翻译：臭氧发生器具有位于低电压电极和第一高压电极之间的平板状低电压电极，面对低电压电极的平板状的第一和第二高压电极，第一电介质和第一间隔件，第二电介质，以及在所述电极和所述第二高压电极之间的第二间隔物。臭氧发生器还具有与第一放电间隙相对的一侧面对第一高压电极的第一电极冷却片，与第二高压电极相对的第二电极冷却片，夹在第一高压电极之间的第一导热电绝缘片电极和第一电极冷却片，以及夹在第二高压电极和第二电极冷却片之间的第二导热和电绝缘片。

5. 发明授权

US5759497A Ozone generating apparatus 失效
公开(公告)号：US5759497A
公开(公告)日：1998-06-02
申请号：US422900
申请日：1995-04-17
申请人： Masaki Kuzumoto , Youichiro Tabata , Shigenori Yagi , Kenji Yoshizawa , Masahiro Mukai , Junji Ochi , Tateki Ozawa
发明人： Masaki Kuzumoto , Youichiro Tabata , Shigenori Yagi , Kenji Yoshizawa , Masahiro Mukai , Junji Ochi , Tateki Ozawa
IPC分类号： C01B13/11 , H01T23/00 , B01J19/08
CPC分类号： C01B13/11 , C01B2201/12 , C01B2201/22 , C01B2201/32 , C01B2201/60 , C01B2201/66 , C01B2201/74 , C01B2201/90
摘要： There is provided a highly efficient and compact ozone generating apparatus in which a very short air gap of about 0.2 mm is formed at high accuracy. Non-discharge portions are dispersed and disposed to cover an entire discharge space, or a spacer is provided to form the non-discharge portion. Further, an elastic body is mounted on a back face of an electrode, thereby enhancing an air gap accuracy of the discharge space.

6. 发明授权

US5378436A Method and apparatus for producing hydrogen peroxide 失效
标题翻译：用于生产过氧化氢的方法和装置
公开(公告)号：US5378436A
公开(公告)日：1995-01-03
申请号：US658030
申请日：1991-02-22
申请人： Shinji Endoh , Keisuke Namba , Shigenori Yagi , Kazuhiko Maeda
发明人： Shinji Endoh , Keisuke Namba , Shigenori Yagi , Kazuhiko Maeda
IPC分类号： C01B15/029 , B01J19/08 , B01D5/00 , C01B15/01
CPC分类号： C01B15/0295
摘要： A method for producing hydrogen peroxide by electrical discharge in a material gas in which oxygen concentration is not less than 0.5% and less than 13% is disclosed in the first aspect. In the second aspect, an apparatus for producing hydrogen peroxide having a plurality of electrical discharge chambers connected in series is disclosed. In the third aspect, an apparatus in which a material gas is recycled is disclosed. In the forth aspect, an apparatus having its electrodes covered with dielectric and an electrical discharge chamber which is cooled by a cooling member. In the fifth aspect, a method for producing hydrogen peroxide having a step of inactivating radical species produced by electrical discharges is disclosed. In the sixth aspect, an apparatus having a condensation tube coated with resin with low reactivity with hydrogen peroxide is disclosed. In the seventh aspect, an apparatus for, after producing hydrogen peroxide, mixing the exhaust gas and the air in order to remove danger of explosion is disclosed. A method and an apparatus for producing hydrogen peroxide in accordance with the present invention produces hydrogen peroxide safely and efficiently.
摘要翻译：在第一方面中公开了在氧浓度不小于0.5％且小于13％的原料气体中通过放电生产过氧化氢的方法。在第二方面中，公开了一种串联连接多个放电室的生产过氧化氢的设备。在第三方面，公开了一种其中回收材料气体的装置。在第四方面中，一种其电极被电介质覆盖的设备和由冷却构件冷却的放电室。在第五方面中，公开了一种生产过氧化氢的方法，其具有使通过放电产生的自由基物质失活的步骤。在第六方面中，公开了一种具有涂覆有与过氧化氢反应性低的树脂的冷凝管的装置。在第七方面中，公开了一种用于在产生过氧化氢之后混合废气和空气以消除爆炸危险的装置。根据本发明的用于生产过氧化氢的方法和设备可以安全有效地产生过氧化氢。

7. 发明授权

US06905659B2 Ozonizer 有权
标题翻译：臭氧发生器
公开(公告)号：US06905659B2
公开(公告)日：2005-06-14
申请号：US10155069
申请日：2002-05-28
申请人： Akaru Usui , Youichiro Tabata , Yujiro Okihara , Hiromichi Komiya , Yuji Ganryu , Masaki Kuzumoto , Noboru Wada , Koji Ohta , Shigenori Yagi , Hirozoh Kanegae
发明人： Akaru Usui , Youichiro Tabata , Yujiro Okihara , Hiromichi Komiya , Yuji Ganryu , Masaki Kuzumoto , Noboru Wada , Koji Ohta , Shigenori Yagi , Hirozoh Kanegae
IPC分类号： C01B13/11 , B01J19/08
CPC分类号： C01B13/11 , C01B2201/12 , C01B2201/22 , C01B2201/32 , C01B2201/64 , C01B2201/76
摘要： An ozonizer has a flat plate-shaped low voltage electrode and a flat plate-shaped high voltage electrode facing a main surface of the low voltage electrode. The ozomzer also has a flat plate-shaped dielectric and a spacer forming a discharge gap in a laminating direction, located between the low voltage electrode and the high voltage electrode, a high voltage electrode cooling unit forming a cooling water passage insulated from the high voltage electrode inside the high voltage electrode. An alternating voltage is applied between the low voltage electrode and the high voltage electrode and a discharge is produced in the discharge gap, into which oxygen is injected, to produce ozone gas.
摘要翻译：臭氧发生器具有平板状的低压电极和面对低压电极的主面的平板状的高电压电极。臭氧还具有平板状电介质和在层叠方向上形成位于低电压电极和高压电极之间的间隔物的间隔件，形成与高电压绝缘的冷却水通道的高压电极冷却单元电极内部高压电极。在低电压电极和高压电极之间施加交流电压，并且在注入氧气的放电间隙中产生放电以产生臭氧气体。

8. 发明授权

US06869575B2 Ozonizer 有权
标题翻译：臭氧发生器
公开(公告)号：US06869575B2
公开(公告)日：2005-03-22
申请号：US10190566
申请日：2002-07-09
申请人： Youichiro Tabata , Yujiro Okihara , Akaru Usui , Hiromichi Komiya , Yuji Ganryu , Masaki Kuzumoto , Noboru Wada , Koji Ohta , Shigenori Yagi , Hirozoh Kanegae
发明人： Youichiro Tabata , Yujiro Okihara , Akaru Usui , Hiromichi Komiya , Yuji Ganryu , Masaki Kuzumoto , Noboru Wada , Koji Ohta , Shigenori Yagi , Hirozoh Kanegae
IPC分类号： C01B13/11 , B01J19/08
CPC分类号： C01B13/11 , C01B2201/12 , C01B2201/22 , C01B2201/32 , C01B2201/76
摘要： The ozonizer of this present invention is small in size, and capable of generating highly concentrated ozone with a high (generating) efficiency. A low voltage electrode includes a disc-shaped low voltage electrode main body facing a high voltage electrode and an extension at one side of the low voltage electrode main body, and the extensions are laminated in layers on a base via blocks, and a coolant inlet portion for supplying coolant to a coolant passage, a coolant outlet portion for exhausting coolant from the coolant passage, and an ozone gas outlet portion for exhausting ozone gas from the ozone gas passage pass through the extensions and the blocks, respectively, in a laminating direction of the discharge cells.
摘要翻译：本发明的臭氧发生器的尺寸小，能够以高（产生）效率产生高浓度的臭氧。低电压电极包括面向高压电极的盘状低电压电极主体和低压电极主体一侧的延伸部，并且延伸部通过块体层叠在基部上，并且冷却剂入口用于向冷却剂通道供应冷却剂的部分，用于从冷却剂通道排出冷却剂的冷却剂出口部分和用于从臭氧气体通道排出臭氧气体的臭氧气体出口部分别沿层叠方向穿过延伸部分和块体的放电单元。

9. 发明授权

US5948374A Ozone generating apparatus 失效
标题翻译：臭氧发生装置
公开(公告)号：US5948374A
公开(公告)日：1999-09-07
申请号：US939989
申请日：1997-09-29
申请人： Masaki Kuzumoto , Youichiro Tabata , Shigenori Yagi , Kenji Yoshizawa , Masahiro Mukai , Junji Ochi , Tateki Ozawa
发明人： Masaki Kuzumoto , Youichiro Tabata , Shigenori Yagi , Kenji Yoshizawa , Masahiro Mukai , Junji Ochi , Tateki Ozawa
IPC分类号： C01B13/11 , H01T23/00 , B01J19/12
CPC分类号： C01B13/11 , C01B2201/12 , C01B2201/22 , C01B2201/32 , C01B2201/60 , C01B2201/66 , C01B2201/74 , C01B2201/90
摘要： There is provided a highly efficient and compact ozone generating apparatus in which a very short air gap of about 0.2 mm is formed at high accuracy. Non-discharge portions are dispersed and disposed to cover an entire discharge space, or a spacer is provided to form the non-discharge portion. Further, an elastic body is mounted on a back face of an electrode, thereby enhancing an air gap accuracy of the discharge space.
摘要翻译：提供了一种高效紧凑的臭氧发生装置，其中以高精度形成约0.2mm的非常短的气隙。不排出部分被分散和设置以覆盖整个放电空间，或者设置间隔件以形成不排出部分。此外，弹性体安装在电极的背面，从而提高放电空间的气隙精度。

10. 发明授权

US5159605A Semiconductor-laser-pumped, solid-state laser 失效
标题翻译：半导体激光泵，固体激光器
公开(公告)号：US5159605A
公开(公告)日：1992-10-27
申请号：US641279
申请日：1991-01-15
申请人： Shigenori Yagi , Takashi Yamamoto , Mayumi Fujimura
发明人： Shigenori Yagi , Takashi Yamamoto , Mayumi Fujimura
IPC分类号： H01S3/0941 , H01S5/022
CPC分类号： H01S3/09415 , H01S3/025 , H01S3/0401 , H01S3/042 , H01S3/0604 , H01S3/061 , H01S3/0621 , H01S3/0625 , H01S3/08081 , H01S3/08095 , H01S3/094084 , H01S5/02248
摘要： A semiconductor-laser-pumped, solid-state laser includes a semiconductor pumping laser emitting pumping light, a solid-state laser medium arranged to be excited by the pumping light, and a laser resonator structure for emitting laser light from the solid-state laser medium. The solid-state laser medium is plate shaped having a thickness less than the broadening width of the pumping light in the solid-state laser medium. The semiconductor laser is arranged close to the face of the solid-state laser medium, and the laser resonator structure has optical axis coinciding with that of the pumping light.
摘要翻译：半导体激光泵浦固体激光器包括发射泵浦光的半导体激光激光器，布置成被泵浦光激发的固体激光介质，以及用于从固态激光器发射激光的激光谐振器结构中。固态激光介质是板状的，其厚度小于固体激光介质中的泵浦光的加宽宽度。半导体激光器靠近固态激光介质的表面设置，激光谐振器结构的光轴与泵浦光的轴线重合。

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