专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4609736A Rhodanines useful as a therapeutic agent for diabetic complications 失效
标题翻译：用作糖尿病并发症治疗剂的红豆杉素
公开(公告)号：US4609736A
公开(公告)日：1986-09-02
申请号：US675579
申请日：1984-11-28
申请人： Yoshitaka Ohishi , Michiko Nagahara , Yoshitaka Takehisa , Motoyuki Yajima , Shigeki Kurokawa , Norio Kajikawa , Akira Itoh
发明人： Yoshitaka Ohishi , Michiko Nagahara , Yoshitaka Takehisa , Motoyuki Yajima , Shigeki Kurokawa , Norio Kajikawa , Akira Itoh
IPC分类号： A61K31/425 , A61K31/426 , A61P3/08 , A61P3/10 , A61P7/02 , A61P9/10 , A61P43/00 , C07D277/20 , C07D277/36 , C07D417/06 , C12N9/99
CPC分类号： C07D277/20 , C07D417/06
摘要： A rhodanine derivative having the following general formula (I): ##STR1## wherein R is an acyclic alkyl group having 2 to 10 carbon atoms which may be substituted by a halogen atom or an acyclic alkenyl group having 2 to 19 carbon atoms which may be substituted by a halogen atom; or a nontoxic salt thereof. The rhodanine derivative has potent platelet aggregation inhibiting activity and aldose reductase inhibiting activity and therefore is useful as a therapeutic agent for diabetic complications.
摘要翻译：具有以下通式（I）的绕丹宁衍生物：其中R是可被卤素原子取代的具有2至10个碳原子的无环烷基或具有2至19个碳原子的无环烯基其可以被卤素原子取代; 或其无毒盐。罗丹明衍生物具有有效的血小板聚集抑制活性和醛糖还原酶抑制活性，因此可用作糖尿病并发症的治疗剂。

2. 发明授权

US4606860A Rhodanines useful as a therapeutic agent for diabetic complications 失效
标题翻译：用作糖尿病并发症治疗剂的红豆杉素
公开(公告)号：US4606860A
公开(公告)日：1986-08-19
申请号：US675580
申请日：1984-11-28
申请人： Michiko Nagahara , Yoshitaka Ohishi , Motoyuki Yajima , Katsumi Nogimori , Shigeki Kurokawa , Norio Kajikawa
发明人： Michiko Nagahara , Yoshitaka Ohishi , Motoyuki Yajima , Katsumi Nogimori , Shigeki Kurokawa , Norio Kajikawa
IPC分类号： A61K31/425 , A61K31/426 , A61K31/495 , A61K31/535 , A61K31/55 , A61P3/08 , A61P3/10 , A61P7/02 , A61P13/02 , A61P15/00 , A61P25/02 , A61P27/02 , C07D243/00 , C07D277/20 , C07D277/36 , C07D417/06 , C07D421/04 , A61K31/33
CPC分类号： C07D277/20 , C07D417/06
摘要： A rhodanine derivative having the following general formula (I): ##STR1## wherein R is a mono- or di-alkylamino group having 1 to 6 carbon atoms which may be substituted by a hydroxyl group; an alkenylamino group having 3 to 6 carbon atoms; a phenylamino group, the benzene ring of which may be substituted by a lower alkyl group, a lower alkoxyl group, phenyl group or a halogen atom; or a cyclic amino group which may contain in the ring an oxygen atom or a nitrogen atom to which a lower alkyl group is attached; or a nontoxic salt thereof. The rhodanine derivative has potent platelet aggregation inhibiting activity and aldose reductase inhibiting activity and therefore is useful as a therapeutic agent for diabetic complications.
摘要翻译：具有以下通式（I）的绕丹宁衍生物：其中R是可以被羟基取代的具有1至6个碳原子的单或二烷基氨基; 具有3至6个碳原子的链烯基氨基; 苯基氨基，其苯环可以被低级烷基，低级烷氧基，苯基或卤素原子取代; 或在环中可以含有低级烷基的氧原子或氮原子的环状氨基; 或其无毒盐。罗丹明衍生物具有有效的血小板聚集抑制活性和醛糖还原酶抑制活性，因此可用作糖尿病并发症的治疗剂。

3. 发明授权

US4234570A Proteinic active substances 失效
标题翻译：蛋白质活性物质
公开(公告)号：US4234570A
公开(公告)日：1980-11-18
申请号：US911665
申请日：1978-06-01
申请人： Yoshinori Kanbayashi , Michio Ui , Koichi Hosoda , Akira Ito , Shigeki Kurokawa , Akio Terashima , Isamu Takahashi , Motoyuki Yajima , Chikanori Tomioka , Tsutomu Nakamura , Katsumi Nogimori , Taira Okamoto
发明人： Yoshinori Kanbayashi , Michio Ui , Koichi Hosoda , Akira Ito , Shigeki Kurokawa , Akio Terashima , Isamu Takahashi , Motoyuki Yajima , Chikanori Tomioka , Tsutomu Nakamura , Katsumi Nogimori , Taira Okamoto
IPC分类号： C07K14/195 , A61K35/74 , A61K38/00 , A61K38/04 , A61P3/08 , A61P3/10 , A61P37/04 , C07K14/00 , C07K14/005 , C07K14/235 , C07K14/41 , C12P1/04 , C12P21/00 , C12R1/01 , A61K37/00 , C07C103/52
CPC分类号： C07K14/235 , Y10S530/806 , Y10S530/825
摘要： Novel biologically active substances prepared by dissociating the protein obtained from the cultivation of the microorganism Bordetella and having insulin secretion promoting action as well as glucose tolerance improving action for mammals.
摘要翻译：通过解离从培养微生物博德特氏菌获得的蛋白质并具有胰岛素分泌促进作用以及哺乳动物的葡萄糖耐量改善作用制备的新型生物活性物质。

4. 发明授权

US4666931A Benzofuran derivatives useful in treating diabetic complications 失效
标题翻译：可用于治疗糖尿病并发症的苯并呋喃衍生物
公开(公告)号：US4666931A
公开(公告)日：1987-05-19
申请号：US814135
申请日：1985-12-27
申请人： Yoshitaka Ohishi , Michiko Nagahara , Norio Kajikawa , Motoyuki Yajima , Katsumi Nogimori , Shigeki Kurokawa
发明人： Yoshitaka Ohishi , Michiko Nagahara , Norio Kajikawa , Motoyuki Yajima , Katsumi Nogimori , Shigeki Kurokawa
IPC分类号： C07D337/00 , A61K31/34 , A61K31/343 , A61K31/36 , A61K31/415 , A61P3/08 , A61P3/10 , A61P7/02 , C07D307/79 , C07D307/80 , C07D307/82 , C07D307/85 , C07D307/86 , C07D405/04 , C07D493/04
CPC分类号： C07D307/82 , C07D307/80 , C07D307/85 , C07D307/86 , C07D405/04 , C07D493/04
摘要： A benzofuran derivative having the general formula (I): ##STR1## wherein R.sup.1 is hydrogen atom, a benzyl group, unsubstituted or substituted with a halogen atom or an alkyloxy group, or an alkyl group having 1 to 3 carbon atoms, R.sup.2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R.sup.3 is acetyl group, ethyl group, carboxyl group or 4-methyl-2,5-dioxoimidazolidine-4-yl group, R.sup.4 is hydrogen atom, hydroxyl group, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 9 carbon atoms, carboxymethoxy group, nitro group, acetoamino group, a benzylozy group unsubstituted or substituted with a halogen atom, nitro group or an alkyloxy group or a group having the formula: --OR.sup.6, wherein R.sup.6 is an alkenyl group having 2 to 4 carbon atoms or an alkyl group having 2 to 3 carbon atoms having a halogen atom, cyano group or oxo group, R.sup.5 is hydrogen atom or methylenedioxy group together with R.sup.4 group, n is 1 or 2, and the unsubstituted or substituted N-carboxymethylsulfamoyl group, R.sup.4 and R.sup.5 are attached at 3-position, 4-position, 5-position, 6-position or 7-position of the benzofuran ring, or a nontoxic salt thereof, process for preparing the same and a pharmaceutical composition containing the same.The compounds of the present invention have powerful aldose reductase inhibiting activity, platelet aggregation inhibiting activity and arachidonic acid metabolism inhibiting activity and are useful for a remedy for treatment of diabetic complications.
摘要翻译：具有通式（I）的苯并呋喃衍生物：其中R1是氢原子，未被取代或被卤素原子或烷氧基取代的苄基或具有1至3个碳原子的烷基的苄基， R2是氢原子或碳原子数1〜3的烷基，R3是乙酰基，乙基，羧基或4-甲基-2,5-二氧代咪唑烷-4-基，R4是氢原子，羟基，具有1至6个碳原子的烷基，具有1至9个碳原子的烷氧基，羧甲氧基，硝基，乙酰氨基，未被取代或被卤素原子取代的苄氧基，硝基或烷氧基或具有式：-OR6，其中R6是具有2至4个碳原子的烯基或具有2至3个碳原子的具有卤素原子的烷基，氰基或氧代基，R5是氢原子或亚甲二氧基以及R4基团， n为1或2，未取代或取代的N-羧甲基氨磺酰基基团，R4和R5连接在苯并呋喃环的3-位，4-位，5-位，6-位或7-位上，或其无毒盐，其制备方法和含有它们的药物组合物。本发明化合物具有强大的醛糖还原酶抑制活性，血小板聚集抑制活性和花生四烯酸代谢抑制活性，可用于治疗糖尿病并发症的治疗方法。

5. 发明授权

US4609549A Biologically active substance from Islets-Activating Protein 失效
标题翻译：来自胰岛素活化蛋白的生物活性物质
公开(公告)号：US4609549A
公开(公告)日：1986-09-02
申请号：US606479
申请日：1984-05-03
申请人： Katsumi Nogimori , Makoto Tamura , Shigeki Kurokawa , Motoyuki Yajima
发明人： Katsumi Nogimori , Makoto Tamura , Shigeki Kurokawa , Motoyuki Yajima
IPC分类号： A61K38/04 , A61K35/74 , A61K39/00 , A61P3/08 , A61P3/10 , C07K14/235 , C07K15/04 , A61K37/02 , A61K37/43 , A61K39/10
CPC分类号： C07K14/235 , A61K39/00 , Y10S530/825
摘要： The present invention relates to biologically active substances obtained by reacting Islets-Activating Protein having an insulin secretion promoting action with a carbonyl compound in the presence of a reducing agent; to anti-diabetic composition in dosage unit form comprising the substance of the present invention; to pertussis vaccine in dosage unit form comprising the substance of the present invention; and to a process for the preparation of the same. The substances of the present invention are suppressed in leukocytosis-promoting effect.
摘要翻译：本发明涉及通过在还原剂存在下将胰岛素分泌促进作用的胰岛激活蛋白与羰基化合物反应而获得的生物活性物质; 涉及包含本发明物质的剂量单位形式的抗糖尿病组合物; 以包含本发明物质的剂量单位形式的百日咳疫苗; 以及制备该方法的过程。抑制白细胞增多作用的本发明物质。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式