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1. 发明申请

WO2022011544A1 POLYOL COMPOUNDS AND ADHESIVE COMPOSITIONS PREPARED WITH SAME 审中-公开
公开(公告)号：WO2022011544A1
公开(公告)日：2022-01-20
申请号：PCT/CN2020/101838
申请日：2020-07-14
申请人： DOW GLOBAL TECHNOLOGIES LLC , ROHM AND HAAS COMPANY , SHI, Ke , BAI, Chenyan , QU, Zhaohui , WANG, Tao , SHEN, Cheng
发明人： SHI, Ke , BAI, Chenyan , QU, Zhaohui , WANG, Tao , SHEN, Cheng
IPC分类号： C08G18/28 , C09J175/04
摘要： A unique polyol compound formed by a reaction between a carbonate compound represented by Formula (I) and a polyamine compound is provided. A polyurethane-based adhesive composition comprising the polyol compound can produce an adhesive layer exhibiting superior bond strength and heat seal strength which will not be substantially deteriorated by the change in the weight ratio between isocyanate component and polyol component. Methods for preparing the polyol compound and for preparing the adhesive composition, as well as a laminate article prepared with said adhesive composition are also provided.

2. 发明申请

WO2021253381A1 POLYOL COMPOUNDS AND ADHESIVE COMPOSITIONS PREPARED WITH THE SAME 审中-公开
公开(公告)号：WO2021253381A1
公开(公告)日：2021-12-23
申请号：PCT/CN2020/097040
申请日：2020-06-19
申请人： DOW GLOBAL TECHNOLOGIES LLC , ROHM AND HAAS COMPANY , BAI, Chenyan , SHI, Ke , QU, Zhaohui , CHEN, Gaobing , WANG, Tao
发明人： BAI, Chenyan , SHI, Ke , QU, Zhaohui , CHEN, Gaobing , WANG, Tao
IPC分类号： C08G18/10 , C08G18/12
摘要： A novel polyol compound represented by Formula (I) is provided. A polyurethane-based adhesive composition comprising the polyol compound can produce an adhesive layer exhibiting superior bond strength and heat seal strength which will not be substantially deteriorated by the change in the weight ratio between isocyanate component and polyol component. Methods for preparing the polyol compound and for preparing the adhesive composition, as well as a laminate article prepared with said adhesive composition are also provided.

3. 发明申请

WO2021092881A1 CURABLE COMPOSITION AND METHOD FOR ADHERING SUBSTRATES THEREOF 审中-公开
公开(公告)号：WO2021092881A1
公开(公告)日：2021-05-20
申请号：PCT/CN2019/118724
申请日：2019-11-15
申请人： DOW GLOBAL TECHNOLOGIES LLC , TANG, Zhengming , CHEN, Yongchun , XU, Xiuqing , CHEN, Hongyu , SHI, Ke , WANG, Nan , MENG, Qingwei
发明人： TANG, Zhengming , CHEN, Yongchun , XU, Xiuqing , CHEN, Hongyu , SHI, Ke , WANG, Nan , MENG, Qingwei
IPC分类号： C08L83/12 , C08L63/00 , C04B26/14 , C04B26/32
摘要： Described is a curable composition, and particularly a two-component composition comprising a silane modified polymer; an epoxy resin terminated with epoxy terminal group; wherein the composition further comprises a hardening-compatibilizing agent which has at least one silane group and at least two amine groups. The curable composition exhibits enhanced adhesion strength and good elongation at break. A method for applying the curable composition on the surface of a substrate is also provided.

4. 发明申请

WO2021092879A1 CURABLE COMPOSITION AND METHOD FOR ADHERING SUBSTRATES THEREOF 审中-公开
公开(公告)号：WO2021092879A1
公开(公告)日：2021-05-20
申请号：PCT/CN2019/118720
申请日：2019-11-15
申请人： DOW GLOBAL TECHNOLOGIES LLC , TANG, Zhengming , CHEN, Yongchun , XU, Xiuqing , CHEN, Hongyu , ZHAI, Xuemei , SHI, Ke , WANG, Nan , MENG, Qingwei
发明人： TANG, Zhengming , CHEN, Yongchun , XU, Xiuqing , CHEN, Hongyu , ZHAI, Xuemei , SHI, Ke , WANG, Nan , MENG, Qingwei
IPC分类号： C08L83/12 , C08L63/00 , C09J171/00 , C09J163/00
摘要： Described is a curable composition, and particularly a two-component composition comprising a silane modified polymer; an epoxy resin terminated with epoxy terminal group; wherein the composition further comprises a hardening agent and a compatibilizer which has at least one silane group and at least one epoxy terminal group. The curable composition exhibits enhanced adhesion strength and good elongation at break. A method for applying the curable composition on the surface of a substrate is also provided.

5. 发明授权

US07371364B2 Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy 失效
标题翻译：循环肽和成像化合物组合物和用于靶向成像和治疗的用途
公开(公告)号：US07371364B2
公开(公告)日：2008-05-13
申请号：US10918009
申请日：2004-08-13
申请人： Chun Li , Wei Wang , Shi Ke
发明人： Chun Li , Wei Wang , Shi Ke
IPC分类号： A61K51/00 , A61K38/00 , A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： A61K49/0032 , A61K49/0034 , A61K49/0056 , A61K51/08 , A61K51/082 , A61K51/088 , C07K7/56 , C07K14/8146
摘要： The present invention relates to novel cyclic peptides that may be conjugated with imaging agents, including novel imaging agents. Specifically, it includes c(KRGDf; SEQ ID NO. 3) NIR imaging compositions and novel cyclic HWGFTL (SEQ ID NO. 5) polypeptides which may be used inter alia in NIR, MRI and nuclear imaging as well as therapy. Additionally, the invention includes novel imaging agents, such as TS-ICG derivatives. The invention also relates to methods of making and using such compounds. Such uses include both pre-operative and intraoperative detection of tumor cells and treatment monitoring.
摘要翻译：本发明涉及可与成像剂缀合的新型环肽，包括新型成像剂。具体地说，它包括可以特别用于NIR，MRI和核成像以及治疗的c（KRGDf; SEQ ID NO.3）NIR成像组合物和新的循环HWGFTL（SEQ ID NO.5）多肽。此外，本发明包括新型成像剂，例如TS-ICG衍生物。本发明还涉及制备和使用这些化合物的方法。这些用途包括手术前和术中检测肿瘤细胞和治疗监测。

6. 外观设计

USD928925S1 Quick hose connector assembly 有权
公开(公告)号：USD928925S1
公开(公告)日：2021-08-24
申请号：US29675105
申请日：2018-12-28
申请人： Shi Ke Lei
设计人： Shi Ke Lei

7. 发明申请

US20120244079A1 TRACEABLE RETINOID ACID FOR IMAGING, DISEASE PREVENTION AND THERAPY 审中-公开
标题翻译：用于成像，疾病预防和治疗的可追踪的抗感染药
公开(公告)号：US20120244079A1
公开(公告)日：2012-09-27
申请号：US13319012
申请日：2010-05-06
申请人： Shi Ke , Michel Mawad , Wei Wang
发明人： Shi Ke , Michel Mawad , Wei Wang
IPC分类号： C07D403/08 , A61K49/04 , A61K49/00
CPC分类号： A61K49/0052 , A61K49/0032 , G01N33/5008 , G01N33/5014 , G01N33/5088 , G01N33/574 , G01N33/582 , G01N2800/56
摘要： The present invention provides nonradioactive NIR optical imaging agents based up on the structure of retinoid acid derivatives. The nonradioactive NIR optical imaging agent has been evaluated at the cellular level by confocal microscopy, and in vivo in a whole animal using a various xenograft models. The specific uptake of this agent in human cancer cells and multiple xenograft models demonstrate that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for early stage cancer studies and diagnoses. Also, the present invention provides that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for visualization of drug redistribution within the body which is useful in determining the optimal biological dose. Ultimately, the visualization data can be used as an analytical tool to reduce any systemic toxicity.
摘要翻译：本发明提供了基于类视黄酸衍生物结构的非放射性近红外光学成像剂。已经通过共聚焦显微镜在细胞水平上评估了非放射性近红外光学成像剂，并且在使用各种异种移植模型的整个动物体内进行了评估。该药物在人类癌细胞和多种异种移植物模型中的特异性摄取表明，非放射性近红外染料标记的类视黄醇代谢物和/或类似物可用于早期癌症研究和诊断。此外，本发明提供非放射性近红外染料标记的类视黄醇代谢物和/或类似物可用于体内药物再分布的可视化，其可用于确定最佳生物剂量。最终，可视化数据可用作分析工具，以减少任何全身毒性。

8. 发明申请

US20050069494A1 Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy 失效
标题翻译：循环肽和成像化合物组合物和用于靶向成像和治疗的用途
公开(公告)号：US20050069494A1
公开(公告)日：2005-03-31
申请号：US10918009
申请日：2004-08-13
申请人： Chun Li , Wei Wang , Shi Ke
发明人： Chun Li , Wei Wang , Shi Ke
IPC分类号： A61K49/00 , A61K51/08 , C07K7/56 , C07K14/81 , A61K51/00 , A61K38/12 , C07K7/64
CPC分类号： A61K49/0032 , A61K49/0034 , A61K49/0056 , A61K51/08 , A61K51/082 , A61K51/088 , C07K7/56 , C07K14/8146
摘要： The present invention relates to novel cyclic peptides that may be conjugated with imaging agents, including novel imaging agents. Specifically, it includes c(KRGDf) NIR imaging compositions and novel cyclic HWGFTL polypeptides which may be used inter alia in NIR, MRI and nuclear imaging as well as therapy. Additionally, the invention includes novel imaging agents, such as TS-ICG derivatives. The invention also relates to methods of making and using such compounds. Such uses include both pre-operative and intraoperative detection of tumor cells and treatment monitoring.
摘要翻译：本发明涉及可与成像剂缀合的新型环肽，包括新型成像剂。具体地说，它包括c（KRGDf）NIR成像组合物和可以特别用于NIR，MRI和核成像以及治疗的新型循环HWGFTL多肽。此外，本发明包括新型成像剂，例如TS-ICG衍生物。本发明还涉及制备和使用这些化合物的方法。这些用途包括手术前和术中检测肿瘤细胞和治疗监测。

9. 发明申请

US20130224115A1 NON-RADIOACTIVE AGENTS FOR NEUROBLASTOMA IMAGING 审中-公开
标题翻译：非放射性药物用于神经细胞成像
公开(公告)号：US20130224115A1
公开(公告)日：2013-08-29
申请号：US13638060
申请日：2011-04-01
申请人： Wei Wang , Jason Shohet , Michel Mawad , Shi Ke
发明人： Wei Wang , Jason Shohet , Michel Mawad , Shi Ke
IPC分类号： C07D209/26
CPC分类号： C07D209/26 , A61K49/0032 , A61K49/0052 , C09B23/0025 , C09B23/0066 , C09B23/086
摘要： Multi-modal tumor imaging of neuroblastoma is essential for tumor staging, response evaluation and detection of relapsed diseased. The present invention provides a norepinephine analogue with a near-infrared (near-IR) dye, W765-BG, that efficiently and stably detects neuroblastoma in vivo using near-IR optical imaging. Confocal microscopy and optical imaging of neuroblastoma xenografts shows cell specific uptake and reveals exceptional tumor retention with a high tumor-to-tissue ratio up to 7 days after injection of W765-BG.
摘要翻译：神经母细胞瘤的多形态肿瘤成像对肿瘤分期，应答评估和复发性疾病的检测至关重要。本发明提供了具有近红外（近红外）染料W765-BG的去甲肾上腺素类似物，其使用近红外光学成像在体内有效且稳定地检测神经母细胞瘤。神经母细胞瘤异种移植物的共聚焦显微镜和光学成像显示细胞特异性摄取，并在注射W765-BG后7天内显示具有高肿瘤组织比的特殊肿瘤保留。

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