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1. 发明申请

US20120138485A1 ORGANELLE BIOELECTRODES AND METHODS OF MAKING AND USING THE SAME 有权
标题翻译：有机生物电池及其制造和使用方法
公开(公告)号：US20120138485A1
公开(公告)日：2012-06-07
申请号：US13301773
申请日：2011-11-21
申请人： Shelley Minteer , Abdul Waheed
发明人： Shelley Minteer , Abdul Waheed
IPC分类号： G01N27/327 , B05D5/12 , G01N33/50
CPC分类号： G01N33/5076
摘要： A method for monitoring the metabolic state of an organelle in the presence of a potential organelle modulating agent is disclosed. A first organelle-modified bioelectrode is provided that is electrically coupled to a second electrode of opposite polarity in a circuit. The first bioelectrode is contacted with an aqueous carrier containing a biologically acceptable electrolyte and an effective amount of a potential organelle modulating agent and an effective amount of an organelle substrate. The substrate is reacted at the bioelectrode to form an ionic product that is released into the aqueous carrier-containing electrolyte to thereby provide a current at the second electrode when the circuit is closed. A metabolic flux data set is obtained during the reaction and is compared to a control metabolic flux data set obtained under the same conditions in the absence of the organelle modulating agent, thereby determining the metabolic state of the organelle.
摘要翻译：公开了在潜在的细胞器调节剂存在下监测细胞器的代谢状态的方法。提供了在电路中电耦合到具有相反极性的第二电极的第一细胞器改性的生物电极。将第一生物电极与含有生物可接受的电解质和有效量的潜在的细胞器调节剂和有效量的细胞器底物的含水载体接触。衬底在生物电极处反应形成离子产物，其释放到含水载体的电解质中，从而当电路闭合时在第二电极处提供电流。在反应期间获得代谢通量数据集，并与在不存在细胞器调节剂的相同条件下获得的对照代谢通量数据集进行比较，从而确定细胞器的代谢状态。

2. 发明申请

US20070077461A1 Drug delivery from electroactive molecularly imprinted polymer 有权
标题翻译：从电活性分子印迹聚合物的药物递送
公开(公告)号：US20070077461A1
公开(公告)日：2007-04-05
申请号：US11372653
申请日：2006-03-10
申请人： Shelley Minteer , Jenny Ulyanova
发明人： Shelley Minteer , Jenny Ulyanova
IPC分类号： H01M8/00
CPC分类号： A61K9/0097 , A61K9/0009 , H01M8/16 , Y02E60/527
摘要： A device delivers a chemical or biological agent, the device comprises an imprint molecule (IM) to be delivered by the device; an electroactive molecularly imprinted polymer (EMIP) imprinted with the imprint molecule, the EMIP having a plurality of binding sites capable of binding the imprint; and an electric potential producing member (EPM), the EPM being capable of producing an electric potential between the EPM and the EMIP; whereby when the EMIP has a predetermined density of imprint molecule bound at the binding sites, and whereby when a sufficient potential is produced between the EPM and the EMIP, the imprint molecule is released from the binding site and thereby delivered by the device.
摘要翻译：装置递送化学或生物制剂，该装置包括由装置输送的压印分子（IM）; 印记有印记分子的电活性分子印迹聚合物（EMIP），EMIP具有能够结合印记的多个结合位点; 和电位产生部件（EPM），EPM能够在EPM和EMIP之间产生电位; 由此当EMIP具有在结合位点处结合的预定密度的印迹分子，并且由此当在EPM和EMIP之间产生足够的电势时，印记分子从结合位点释放，从而由装置递送。

3. 发明申请

US20050095466A1 Immobilized enzymes in biocathodes 有权
标题翻译：生物阴极中的固定化酶
公开(公告)号：US20050095466A1
公开(公告)日：2005-05-05
申请号：US10931147
申请日：2004-08-31
申请人： Shelley Minteer , Sabina Topcagic , Becky Treu
发明人： Shelley Minteer , Sabina Topcagic , Becky Treu
IPC分类号： H01M4/86 , H01M8/16 , H01M8/00
CPC分类号： B82Y30/00 , H01M4/8605 , H01M8/16 , Y02E60/527
摘要： Disclosed is an improved biofuel cell having a cathode comprising a dual function membrane, which contains an oxygen oxidoreductase enzyme immobilized within a buffered compartment of the membrane and an electron transport mediator which transfers electrons from an electron conducting electrode to the redox reaction catalyzed by the oxygen oxidoreductase enzyme. The improved biofuel cell also has an anode that contains an oxidoreductase enzyme that uses an organic fuel, such as alcohol, as a substrate. An electric current can flow between the anode and the cathode.
摘要翻译：公开了一种改进的生物燃料电池，其具有包括双功能膜的阴极，其包含固定在膜的缓冲隔室内的氧化还原酶，以及将电子从电子传导电极转移到由氧气催化的氧化还原反应的电子传输介质氧化还原酶。改进的生物燃料电池还具有包含使用有机燃料（例如醇）作为底物的氧化还原酶的阳极。电流可以在阳极和阴极之间流动。

4. 发明授权

US08252045B2 Drug delivery from electroactive molecularly imprinted polymer 有权
公开(公告)号：US08252045B2
公开(公告)日：2012-08-28
申请号：US11372653
申请日：2006-03-10
申请人： Shelley Minteer , Jenny Ulyanova
发明人： Shelley Minteer , Jenny Ulyanova
IPC分类号： A61F2/06 , C09K11/06 , A61K31/785
CPC分类号： A61K9/0097 , A61K9/0009 , H01M8/16 , Y02E60/527
摘要： A device delivers a chemical or biological agent, the device comprises an imprint molecule (IM) to be delivered by the device; an electroactive molecularly imprinted polymer (EMIP) imprinted with the imprint molecule, the EMIP having a plurality of binding sites capable of binding the imprint; and an electric potential producing member (EPM), the EPM being capable of producing an electric potential between the EPM and the EMIP; whereby when the EMIP has a predetermined density of imprint molecule bound at the binding sites, and whereby when a sufficient potential is produced between the EPM and the EMIP, the imprint molecule is released from the binding site and thereby delivered by the device.

5. 发明授权

US08845879B2 Organelle bioelectrodes and methods of making and using the same 有权
标题翻译：细胞器生物电极及其使用方法
公开(公告)号：US08845879B2
公开(公告)日：2014-09-30
申请号：US13301773
申请日：2011-11-21
申请人： Shelley Minteer , Abdul Waheed
发明人： Shelley Minteer , Abdul Waheed
IPC分类号： G01N27/327 , B05D5/12 , G01N33/50
CPC分类号： G01N33/5076
摘要： A method for monitoring the metabolic state of an organelle in the presence of a potential organelle modulating agent is disclosed. A first organelle-modified bioelectrode is provided that is electrically coupled to a second electrode of opposite polarity in a circuit. The first bioelectrode is contacted with an aqueous carrier containing a biologically acceptable electrolyte and an effective amount of a potential organelle modulating agent and an effective amount of an organelle substrate. The substrate is reacted at the bioelectrode to form an ionic product that is released into the aqueous carrier-containing electrolyte to thereby provide a current at the second electrode when the circuit is closed. A metabolic flux data set is obtained during the reaction and is compared to a control metabolic flux data set obtained under the same conditions in the absence of the organelle modulating agent, thereby determining the metabolic state of the organelle.
摘要翻译：公开了在潜在的细胞器调节剂存在下监测细胞器的代谢状态的方法。提供了在电路中电耦合到具有相反极性的第二电极的第一细胞器改性的生物电极。将第一生物电极与含有生物可接受的电解质和有效量的潜在的细胞器调节剂和有效量的细胞器底物的含水载体接触。衬底在生物电极处反应形成离子产物，其释放到含水载体的电解质中，从而当电路闭合时在第二电极处提供电流。在反应期间获得代谢通量数据集，并与在不存在细胞器调节剂的相同条件下获得的对照代谢通量数据集进行比较，从而确定细胞器的代谢状态。

6. 发明申请

US20070287034A1 Microfluidic Biofuel Cell 失效
标题翻译：微流体生物燃料电池
公开(公告)号：US20070287034A1
公开(公告)日：2007-12-13
申请号：US10598951
申请日：2005-01-19
申请人： Shelley Minteer , Robert Martin , Christine Moore
发明人： Shelley Minteer , Robert Martin , Christine Moore
IPC分类号： H01M8/16 , C25B3/00
CPC分类号： H01M4/8857 , H01M4/8605 , H01M8/1007 , H01M8/16 , Y02E50/343 , Y02E60/527
摘要： Microfluidic biofuel cells comprising a bioanode and/or a biocathode are formed using microfluidic principles and soft lithography. The enzymes utilized in the redox reactions at the bioanode and/or the biocathode are stabilized in a micellar or inverted micellar structure. The biofuel cell is used to produce high power densities.
摘要翻译：使用微流体原理和软光刻法形成包含生物阳极和/或生物阴极的微流体生物燃料电池。用于生物阳极和/或生物阴极的氧化还原反应中的酶在胶束或倒置的胶束结构中稳定。生物燃料电池用于产生高功率密度。

7. 发明申请

US20050213187A1 Methods for forming magnetically modified electrodes and articles produced thereby 审中-公开
标题翻译：用于形成磁改性电极的方法和由此制备的制品
公开(公告)号：US20050213187A1
公开(公告)日：2005-09-29
申请号：US11130231
申请日：2005-05-17
申请人： Johna Leddy , Shelley Minteer
发明人： Johna Leddy , Shelley Minteer
IPC分类号： G01N27/26 , G02F1/15 , G02F1/155
CPC分类号： G02F1/155
摘要： The present invention is directed to methods for making magnetically modified electrodes and electrodes made according to the method. Such electrode are useful as electrodes in batteries, such as Ni-MH batteries, Ni—Cd batteries, Ni—Zn batteries and Ni—Fe batteries.
摘要翻译：本发明涉及根据该方法制造磁修饰电极和电极的方法。这种电极可用作电池中的电极，例如Ni-MH电池，Ni-Cd电池，Ni-Zn电池和Ni-Fe电池。

8. 发明授权

US06355166B1 Magnetically enhanced composite materials and methods for making and using the same 失效
标题翻译：磁性增强复合材料及其制造和使用方法
公开(公告)号：US06355166B1
公开(公告)日：2002-03-12
申请号：US09429931
申请日：1999-10-29
申请人： Sudath Amarasinghe , Shelley Minteer , Lois Anne Zook , Drew C. Dunwoody , Catherine Spolar , Hachull Chung , Johna Leddy
发明人： Sudath Amarasinghe , Shelley Minteer , Lois Anne Zook , Drew C. Dunwoody , Catherine Spolar , Hachull Chung , Johna Leddy
IPC分类号： H01M490
CPC分类号： H01M10/42 , B01D49/00 , B03C1/00 , B03C1/01 , B03C1/023 , B03C1/025 , B03C1/035 , B82Y25/00 , B82Y40/00 , C23C6/00 , C23C24/08 , C23C30/00 , C25B11/00 , C25B13/00 , C25D3/54 , G21F9/12 , H01F1/0027 , H01F1/0054 , H01F1/009 , H01F10/007 , H01F41/24 , H01F41/26 , H01F41/301 , H01M4/02 , H01M4/36 , H01M4/86 , H01M4/8605 , H01M4/8892 , H01M4/90 , H01M4/9083 , H01M4/926 , H01M8/00 , H01M8/04223 , H01M8/04225 , H01M8/1004 , H01M8/1007 , H01M8/1009 , H01M8/241 , H01M8/249 , H01M2300/0082
摘要： Materials and methods for making and using magnetically enhanced composite materials are provided. Surfaces coated with such composites can be used to improve fuel cells, material separators, and other applications. A variety of devices can incorporate such composites, including fuel cells, separators, batteries, and electrodes that effect electrolysis of magnetic species.
摘要翻译：提供了制造和使用磁性增强复合材料的材料和方法。用这种复合材料涂覆的表面可用于改进燃料电池，材料分离器和其他应用。各种装置可以并入这样的复合材料，包括燃料电池，分离器，电池和影响磁性物质电解的电极。

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