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1. 发明授权

US09201078B2 TSH immunoassays and processes for performing TSH immunoassays in the presence of endogenous contaminants in restricted wash formats 有权
标题翻译： TSH免疫测定和在限制性洗涤形式的内源性污染物存在下进行TSH免疫测定的方法
公开(公告)号：US09201078B2
公开(公告)日：2015-12-01
申请号：US13306536
申请日：2011-11-29
申请人： Dan Wang , Gordon Bruce Collier , Joseph P. Skinner , Qiaoqiao Ruan , Sergey Y. Tetin
发明人： Dan Wang , Gordon Bruce Collier , Joseph P. Skinner , Qiaoqiao Ruan , Sergey Y. Tetin
IPC分类号： G01N33/543 , G01N33/74 , G01N33/76 , C07K16/26 , C12M3/00 , B01L3/00 , G01N33/53
CPC分类号： G01N33/76 , B01L3/50273 , B01L3/502738 , C07K16/26 , C07K2317/33 , G01N33/5302 , G01N33/543 , G01N33/74 , G01N2333/59
摘要： The invention relates to low wash Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay having limited or no wash step between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
摘要翻译：本发明涉及使用ELISA夹心测定法的低洗涤甲状腺刺激激素（TSH）免疫测定法，其在抗原捕获，检测抗体添加和底物引入步骤之间具有有限或不洗涤步骤。本发明与生物相似的干扰交叉反应物质如卵泡刺激激素（FSH），促黄体激素（LH）和绒毛膜促性腺激素（CG）表现出低交叉反应性。

2. 发明申请

US20090124022A1 ANTIBODIES THAT BIND TO MAMMALIAN NGAL AND USES THEREOF 审中-公开
公开(公告)号：US20090124022A1
公开(公告)日：2009-05-14
申请号：US12104413
申请日：2008-04-16
申请人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner
发明人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner
IPC分类号： G01N33/566 , C07K16/18 , C12N5/06
CPC分类号： C07K16/18 , C07K2317/34 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.

3. 发明申请

US20160109466A1 TSH ANTIBODIES FOR POINT-OF-CARE IMMUNOASSAY FORMATS 有权
标题翻译：点状免疫球蛋白TSH抗体
公开(公告)号：US20160109466A1
公开(公告)日：2016-04-21
申请号：US14927505
申请日：2015-10-30
申请人： Dan WANG , Gordon Bruce Collier , Joseph P. Skinner , Qiaoqiao Ruan , Sergey Y. Tetin
发明人： Dan WANG , Gordon Bruce Collier , Joseph P. Skinner , Qiaoqiao Ruan , Sergey Y. Tetin
IPC分类号： G01N33/76
CPC分类号： G01N33/76 , B01L3/50273 , B01L3/502738 , B01L2200/04 , B01L2200/0605 , B01L2200/0647 , B01L2200/0689 , B01L2200/141 , B01L2200/16 , B01L2300/0636 , B01L2300/0672 , B01L2300/0681 , B01L2300/0867 , B01L2300/161 , B01L2300/163 , B01L2400/043 , B01L2400/0481 , B01L2400/0688 , C07K16/26 , G01N33/5302 , G01N33/543 , G01N33/74 , G01N2333/59
摘要： The invention relates to antibody characteristics used to design a whole blood Point of Care Thyroid Stimulating Hormone (TSH) immunoassay using an ELISA sandwich assay lacking one or more wash steps between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
摘要翻译：本发明涉及使用在抗原捕获，检测抗体添加和底物引入步骤之间缺少一个或多个洗涤步骤的ELISA夹心测定来设计全血点护甲甲状腺刺激激素（TSH）免疫测定的抗体特征。本发明与生物相似的干扰交叉反应物质如卵泡刺激激素（FSH），促黄体激素（LH）和绒毛膜促性腺激素（CG）表现出低交叉反应性。

4. 发明申请

US20120301905A1 TSH IMMUNOASSAYS AND PROCESSES FOR PERFORMING TSH IMMUNOASSAYS IN THE PRESENCE OF ENDOGENOUS CONTAMINANTS IN RESTRICTED WASH FORMATS 有权
标题翻译： TSH免疫和在限制性洗涤格式中内源性污染物存在下进行TSH免疫的方法
公开(公告)号：US20120301905A1
公开(公告)日：2012-11-29
申请号：US13306536
申请日：2011-11-29
申请人： Dan Wang , Gordan Bruce Collier , Joseph P. Skinner , Qiaoqiao Ruan , Sergey Y. Tetin
发明人： Dan Wang , Gordan Bruce Collier , Joseph P. Skinner , Qiaoqiao Ruan , Sergey Y. Tetin
IPC分类号： G01N33/74
CPC分类号： G01N33/76 , B01L3/50273 , B01L3/502738 , C07K16/26 , C07K2317/33 , G01N33/5302 , G01N33/543 , G01N33/74 , G01N2333/59
摘要： The invention relates to low wash Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay having limited or no wash step between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
摘要翻译：本发明涉及使用ELISA夹心测定法的低洗涤甲状腺刺激激素（TSH）免疫测定法，其在抗原捕获，检测抗体添加和底物引入步骤之间具有有限或不洗涤步骤。本发明与生物相似的干扰交叉反应物质如卵泡刺激激素（FSH），促黄体激素（LH）和绒毛膜促性腺激素（CG）表现出低交叉反应性。

5. 发明授权

US08846036B2 Antibodies that bind to mammalian NGAL and uses thereof 有权
标题翻译：结合哺乳动物NGAL的抗体及其用途
公开(公告)号：US08846036B2
公开(公告)日：2014-09-30
申请号：US12329357
申请日：2008-12-05
申请人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Robert N. Ziemann , Frank C. Grenier , Ryan F. Workman , Lowell Tyner
发明人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann , Frank C. Grenier , Ryan F. Workman
IPC分类号： A61K38/00 , C07K16/18
CPC分类号： C07K16/18 , C07K2317/34 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
摘要翻译：本发明涉及对糖基化哺乳动物NGAL特异的抗体，以及制备和使用这些抗体的方法。

6. 发明申请

US20090269777A1 IMMUNOASSAYS AND KITS FOR THE DETECTION OF NGAL 审中-公开
公开(公告)号：US20090269777A1
公开(公告)日：2009-10-29
申请号：US12104410
申请日：2008-04-16
申请人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Ryan F. Workman , Robert N. Ziemann
发明人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Ryan F. Workman , Robert N. Ziemann
IPC分类号： G01N33/53
CPC分类号： G01N33/566
摘要： The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.

7. 发明授权

US10190986B2 Spatially resolved ligand-receptor binding assays 有权
公开(公告)号：US10190986B2
公开(公告)日：2019-01-29
申请号：US13153934
申请日：2011-06-06
申请人： Qiaoqiao Ruan , Sylvia C. Saldana , Joseph P. Skinner , Sergey Y. Tetin
发明人： Qiaoqiao Ruan , Sylvia C. Saldana , Joseph P. Skinner , Sergey Y. Tetin
IPC分类号： G01N21/00 , G01N21/64
摘要： A method for analyzing the results of a ligand-receptor binding assay comprising the steps of: (a) providing the results of a ligand-receptor binding assay; and (b) qualifying the results of a ligand-receptor binding assay. More particularly, the ligand-receptor binding assay involves the steps of combining appropriate reagents in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is directly proportional to the amount of ligand present in the sample. Alternatively, the ligand-receptor binding assay involves the steps of combining appropriate reagents to perform a ligand-receptor binding assay in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is inversely proportional to the amount of analyte present in the sample.

8. 发明申请

US20120308997A1 SPATIALLY RESOLVED LIGAND-RECEPTOR BINDING ASSAYS 审中-公开
标题翻译：空间分辨的配体 - 受体结合测定
公开(公告)号：US20120308997A1
公开(公告)日：2012-12-06
申请号：US13153934
申请日：2011-06-06
申请人： Qiaoqiao Ruan , Sylvia C. Saldana , Joseph P. Skinner , Sergey Y. Tetin
发明人： Qiaoqiao Ruan , Sylvia C. Saldana , Joseph P. Skinner , Sergey Y. Tetin
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： G01N21/6456
摘要： A method for analyzing the results of a ligand-receptor binding assay comprising the steps of: (a) providing the results of a ligand-receptor binding assay; and (b) qualifying the results of a ligand-receptor binding assay. More particularly, the ligand-receptor binding assay involves the steps of combining appropriate reagents in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is directly proportional to the amount of ligand present in the sample. Alternatively, the ligand-receptor binding assay involves the steps of combining appropriate reagents to perform a ligand-receptor binding assay in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is inversely proportional to the amount of analyte present in the sample.
摘要翻译：用于分析配体 - 受体结合测定结果的方法，包括以下步骤：（a）提供配体 - 受体结合测定的结果; 和（b）限定配体 - 受体结合测定的结果。更具体地，配体 - 受体结合测定包括合并适当的试剂的步骤，其中连接到固体支持物的受体，怀疑含有配体的样品和包含标记的缀合物形成复合物，其中标记物存在于浓度与样品中存在的配体的量成正比。或者，配体 - 受体结合测定包括合并试剂以进行配体 - 受体结合测定的步骤，其中连接到固体支持物的受体，怀疑含有配体的样品和包含标记的缀合物形成复合物其标签以与样品中存在的分析物的量成反比的浓度存在。

9. 发明申请

US20110008766A1 Dual Variable Domain Immunoglobulins and Uses Thereof 审中-公开
标题翻译：双变量域免疫球蛋白及其用途
公开(公告)号：US20110008766A1
公开(公告)日：2011-01-13
申请号：US12771874
申请日：2010-04-30
申请人： Tariq Ghayur , Junjian Liu , Susan E. Brophy , Sushil G. Devare , Frank C. Grenier , Jeffrey A. Moore , Qiaoqiao Ruan , Sergey Y. Tetin , Jennifer M. Steinhaus , Salman Ali , Hina N. Syed
发明人： Tariq Ghayur , Junjian Liu , Susan E. Brophy , Sushil G. Devare , Frank C. Grenier , Jeffrey A. Moore , Qiaoqiao Ruan , Sergey Y. Tetin , Jennifer M. Steinhaus , Salman Ali , Hina N. Syed
IPC分类号： G01N33/53 , C07K16/46 , C12Q1/70
CPC分类号： C07K16/18 , C07K16/1045 , C07K16/244 , C07K16/26 , C07K2317/31 , C07K2317/56 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2319/00
摘要： Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译：工程化的多价和多特异性结合蛋白，制备方法，特别是其在预防，诊断和/或治疗疾病中的用途。

10. 发明申请

US20090263894A1 ANTIBODIES THAT BIND TO MAMMALIAN NGAL AND USES THEREOF 有权
标题翻译：与马马里亚NGAL相关的抗体和其用途
公开(公告)号：US20090263894A1
公开(公告)日：2009-10-22
申请号：US12329357
申请日：2008-12-05
申请人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann
发明人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann
IPC分类号： C12N5/06 , C07K16/18
CPC分类号： C07K16/18 , C07K2317/34 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
摘要翻译：本发明涉及对糖基化哺乳动物NGAL特异的抗体，以及制备和使用这些抗体的方法。

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