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1. 发明授权

US06190637B1 Method for preparing [F-18-]fluoride ion 有权
标题翻译： [F-18-]氟离子的制备方法
公开(公告)号：US06190637B1
公开(公告)日：2001-02-20
申请号：US09266603
申请日：1999-03-11
申请人： Sento Ino , Masahiko Tamura , Osamu Itoh
发明人： Sento Ino , Masahiko Tamura , Osamu Itoh
IPC分类号： A61K5100
CPC分类号： G21G1/10 , C07B59/00 , G21G2001/0015
摘要： The present invention provides a method for preparing [F-18]-fluoride ion which comprises the step of bringing [O-18]-enriched water containing [F-18]-fluoride ion formed by proton irradiation of [O-18]-enriched water into contact with a strongly acidic cation exchange resin to remove impurity cations, the step of then bringing the [O-18]-enriched water containing [F-18]-fluoride ion treated above into contact with a weakly basic anion exchange resin to make [F-18]-fluoride ion adsorbed to the resin and, along therewith, to recover the [O-18]-enriched water which has passed through the resin, and the step of eluting and collecting the [F-18]-fluoride ion adsorbed to the weakly basic anion exchange resin. According to the method for preparing [F-18]-fluoride ion of the present invention, [F-18]-fluoride ion can be collected at a high collection efficiency even from a larger amount (about 2 ml or more) of [O-18]-enriched water containing [F-18]-fluoride ion than the amount in prior method, and moreover expensive [O-18]-enriched water can be recovered and reused in the preparation of [F-18]-fluoride ion.
摘要翻译：本发明提供了制备[F-18] - 氟化物离子的方法，该方法包括使含有[O-18] - 氟化物离子的[O-18] - 含氟[ 富含水与强酸性阳离子交换树脂接触以除去杂质阳离子，然后将含有上述[F-18] - 氟化物离子的[O-18]富含水的水溶液与弱碱性阴离子交换树脂接触的步骤使[F-18] - 氟化物离子吸附到树脂上，并与其一起回收已经通过树脂的[O-18]富含水，以及洗脱和收集[F-18] 氟离子吸附到弱碱性阴离子交换树脂上。根据本发明的[F-18] - 氟化物离子的制备方法，即使从大量（约2ml以上）的[O -18]富含[F-18] - 氟离子的富含水的水，而且[F-18] - 氟化物离子的制备中可以回收并重复使用富含[O-18]的富含水的[F-18] 。

2. 发明申请

US20110003981A1 PROCESS FOR PRODUCING RADIOACTIVE FLUORINE LABELED ORGANIC COMPOUND, AND RELEVANT SYNTHETIC APPARATUS AND PROGRAM 审中-公开
标题翻译：生产放射性荧光标记有机化合物的方法及相关合成装置及方案
公开(公告)号：US20110003981A1
公开(公告)日：2011-01-06
申请号：US12439892
申请日：2007-08-31
申请人： Keiichi Hirano , Taku Ito , Sento Ino
发明人： Keiichi Hirano , Taku Ito , Sento Ino
IPC分类号： C07H15/04 , C09K3/00 , B01J19/00 , G05D23/00
CPC分类号： C07B59/00 , C07B59/005 , C07H5/02
摘要： A method of producing a radioactive-fluorine-labeled compound has a step of heating in a reaction vessel a mixture containing [18F] fluoride ions, a phase transfer catalyst, potassium ions, and water to evaporate water from the mixture (S10), and in the above step has a step of measuring a temperature of an outlet tube for discharging evaporated water during the heating of the reaction vessel (S12), and the evaporation process is finished at a timing determined based on the result of temperature measurement in the step (S12) of measuring the temperature (S16). Consequently, the amount of water present in the mixture can be controlled to an appropriate range and a stable yield can be achieved in the method of producing a radioactive-fluorine-labeled organic compound.
摘要翻译：放射性氟标记化合物的制造方法具有在反应容器内加热含有[18 F]氟化物离子，相转移催化剂，钾离子和水的混合物以从混合物蒸发水的步骤（S10），以及在上述步骤中，具有测定在反应容器加热期间排出蒸发水的出口管的温度的步骤（S12），并且蒸发处理在基于步骤中的温度测量结果确定的时刻完成（S12）（S16）。因此，在制造放射性氟标记的有机化合物的方法中，可以将混合物中存在的水的量控制到适当的范围，并且可以获得稳定的产率。

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