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1. 发明公开

KR20180066042A 광학 측정 장치 审中-公开
公开(公告)号：KR20180066042A
公开(公告)日：2018-06-18
申请号：KR20187007778
申请日：2016-10-05
申请人： HAMAMATSU PHOTONICS KK , SEKISUI MEDICAL CO LTD
发明人： HONDA NAOYUKI , SADAMORI KENGO , SUSUKI DAICHI , KOHNO KEIGO , MORITA MOTOKI
IPC分类号： G01N21/78 , G01N33/543
CPC分类号： G01N21/78 , G01N33/543
摘要： 광학측정장치(1)는면역크로마토시험편(K)의검출부(16)에대해서측정광을조사하여, 측정광의조사에의해서검출부(16)로부터얻어지는광을측정하는측정부(광학헤드(2) 및제어부(3))와, 측정부로얻어진측정값과미리설정된임계값의비교에의한판정에기초하여, 면역크로마토시험편(K)에관한판단을행하는판단부(4)를구비하며, 측정부는검출부(16)로부터얻어지는광의측정을복수회 행하고, 판단부(4)는 n회째의측정에있어서의측정값이임계값이상이라고판정하고, 또한 n+1회째의측정에있어서의측정값이임계값이상이라고판정했을경우에, 면역크로마토시험편(K)에관한판단을행한다.

2. 发明公开

KR20180016721A 혈청 또는 혈장 분리용 조성물, 혈액 검사용 용기, 그리고 혈청 또는 혈장 분리용 조성물의 안정화 방법 审中-公开
标题翻译：血清或血浆分离用组合物，血液检查用容器，血清或血浆分离用组合物稳定化方法
公开(公告)号：KR20180016721A
公开(公告)日：2018-02-19
申请号：KR20177024276
申请日：2016-06-09
申请人： SEKISUI MEDICAL CO LTD
发明人： ANRAKU HIDEO , OKAMOTO RYUSUKE
IPC分类号： G01N33/50 , G01N1/28
CPC分类号： G01N33/48
摘要： 액상유기화합물과요변성부여성분이분리되기어려워, 균일한배합상태를장기간에걸쳐유지가능한혈청또는혈장분리용조성물을제공한다. 액상유기화합물과, 요변성부여성분과, 열가소성엘라스토머를포함하는, 혈청또는혈장분리용조성물.
摘要翻译：用于分离血清或血浆的组合物，其难以从液体有机化合物和缓泻剂部分雌性中分离，并且能够长时间保持均匀的混合状态。用于血清或血浆分离的组合物，其包含液体有机化合物，触变部分的阴性可变区和热塑性弹性体。

3. 发明公开

KR20180038414A 면역학적 검출 방법 및 이것에 사용하는 테스트 스트립 审中-公开
公开(公告)号：KR20180038414A
公开(公告)日：2018-04-16
申请号：KR20177034654
申请日：2016-08-03
申请人： SEKISUI MEDICAL CO LTD
发明人： OCHIAI YASUSHI , NISHITANI KIMIYOSHI
IPC分类号： G01N33/558 , C07K16/42 , G01N33/543 , G01N33/569
CPC分类号： G01N33/54393 , C07K16/42 , G01N33/531 , G01N33/543 , G01N33/56983 , G01N2333/08
摘要： 분변유래의샘플을불용성멤브레인중에서전개시킴으로써샘플중의피검출물질을검출하는면역크로마토그래피를이용한검출방법에있어서, 분변에특유한비특이반응을억제하는방법및 이것에사용하는면역크로마토그래피용테스트스트립을제공하는것을과제로한다. 항IgA 항체의존재하에서, 면역크로마토그래피반응을행함으로써분변유래샘플중의피검출물질을, 비특이반응의영향을받지않고검출하는방법및 이것에사용하는면역크로마토그래피용테스트스트립을제공한다.

4. 发明公开

KR20180055823A PIVKA-II의 측정 방법, 및 PIVKA-II 면역측정 시약 또는 키트의 제조 방법 审中-公开
公开(公告)号：KR20180055823A
公开(公告)日：2018-05-25
申请号：KR20187007870
申请日：2016-10-06
申请人： FUJIREBIO KK , SEKISUI MEDICAL CO LTD
发明人： KITAMURA YOSHIYUKI , AOYAGI KATSUMI
IPC分类号： G01N33/53 , C07K16/36 , C07K16/40 , C12N15/02 , G01N33/86
CPC分类号： C07K16/36 , C07K16/40 , C12N15/02 , G01N33/53
摘要： 인간프로트롬빈에대한모노클로날항체를사용한, 보다정밀도가높은 PIVKA-II의면역학적측정계의구축을가능하게하는수단이개시되어있다. 본발명에의한 PIVKA-II의측정방법은, 친수성의 PIVKA-II 분자를인식하는제1의항프로트롬빈항체또는그 항원결합성단편과, 소수성의 PIVKA-II 분자를인식하는제2의항프로트롬빈항체또는그 항원결합성단편의혼합물, 및 PIVKA-II에특이적으로결합하는항PIVKA-II 항체또는그 항원결합성단편을사용한면역측정에의해검체중의 PIVKA-II를측정하는것을포함한다.

5. 发明申请

WO2010064435A8 METHOD FOR MEASURING CYSTATIN C IN HUMAN BODY FLUID 审中-公开
标题翻译：测定人体液中胱氨酸C的方法
公开(公告)号：WO2010064435A8
公开(公告)日：2010-09-16
申请号：PCT/JP2009006590
申请日：2009-12-03
申请人： SEKISUI MEDICAL CO LTD , NAKAYAMA SHINYA , TAKAHASHI HIROSHI , NAKAMURA YASUSHI , SHIMIZU TOMO
发明人： NAKAYAMA SHINYA , TAKAHASHI HIROSHI , NAKAMURA YASUSHI , SHIMIZU TOMO
IPC分类号： G01N33/53 , G01N33/543 , G01N33/577
CPC分类号： G01N33/543 , G01N33/6893 , G01N2333/8139
摘要： Disclosed is a particle-enhanced immunoassay method for cystatin C in a human body fluid, which has higher specificity, is more inexpensive, and can be automated more readily compared with conventional assay methods in which polyclonal antibodies having low specificity or monoclonal antibodies having high specificity but having poor aggregability have been used in large quantities. The particle-enhanced immunoassay method utilizes a combination of an antibody-sensitized particle comprising an insoluble carrier particle and an anti-human cystatin C monoclonal antibody having higher affinity and bound to the particle and an antibody-sensitized particle comprising the insoluble carrier particle and an anti-human cystatin C monoclonal antibody having a different recognition site from that of the aforementioned monoclonal antibody and having a relatively lower affinity, wherein the quantity of each of the human cystatin C monoclonal antibodies bound to the insoluble carrier particle is less than 5 wt% relative to the weight of the antibody-sensitized particle.
摘要翻译：公开了一种人体液中半胱氨酸蛋白酶抑制剂C的颗粒增强免疫测定方法，与特异性低的多克隆抗体或特异性高的单克隆抗体的常规测定方法相比，该方法具有更高的特异性，更便宜，并且可以更容易自动化但具有较差的可聚合性已被大量使用。颗粒增强免疫测定方法利用包含不溶性载体颗粒的抗体敏化颗粒和具有较高亲和力且结合于颗粒的抗人半胱氨酸蛋白酶抑制剂C单克隆抗体的组合以及包含不溶性载体颗粒和抗体敏化颗粒与上述单克隆抗体具有不同识别位点并具有相对较低亲和力的抗人半胱氨酸蛋白酶抑制剂C单克隆抗体，其中与不溶性载体颗粒结合的每种人半胱氨酸蛋白酶抑制剂C单克隆抗体的量小于5重量％相对于抗体致敏颗粒的重量。

6. 发明公开

US20240302366A1 IMMUNOLOGICAL ASSAY METHOD 审中-公开
公开(公告)号：US20240302366A1
公开(公告)日：2024-09-12
申请号：US18273153
申请日：2022-01-25
申请人： SEKISUI MEDICAL CO., LTD.
发明人： Kengo FUJIMURA , Daigo NOMOTO , Tomo SHIMIZU , Yuki KORA
IPC分类号： G01N33/564 , G01N33/543
CPC分类号： G01N33/564 , G01N33/54313 , G01N2333/4716
摘要： An object of the invention is to suppress non-specific reaction in an immunoreaction measurement method. An immunoassay method characterized by conducting immunoreaction in the presence of an anti-C3 antibody in a method for measuring an analyte in a sample immunologically is provided. Moreover, a method for suppressing non-specific reaction in a method for immunologically measuring an analyte in a sample which is characterized by conducting immunoreaction in the presence of an anti-C3 antibody is provided.

7. 发明公开

US20240019451A1 TEMPERATURE ADJUSTMENT SYSTEM FOR AUTOMATIC ANALYZER DEVICE 审中-公开
公开(公告)号：US20240019451A1
公开(公告)日：2024-01-18
申请号：US18476326
申请日：2023-09-28
申请人： SEKISUI MEDICAL CO., LTD.
发明人： Yoshihiro YANO
IPC分类号： G01N35/00
CPC分类号： G01N35/00584 , G01N2035/00346
摘要： A temperature adjustment system includes: a temperature adjustment unit for adjusting a temperature of a liquid required for measurement to a desired temperature; a measurement unit for obtaining measurement information of a measurement object-containing liquid; a connection flow path connecting the temperature adjustment unit and the measurement unit; temperature detection units and to detect temperatures of the liquids in the temperature adjustment unit and the measurement unit; and a control unit to perform liquid temperature control to control a temperature of the temperature adjustment unit such that the temperature of the liquid in the measurement unit becomes a target temperature while considering a temperature change associated with a flow of the liquids from the temperature adjustment unit to the measurement unit through the connection flow path, based on the temperature of the liquid in the measurement unit and the temperature of the liquid in the temperature adjustment unit.

8. 发明公开

US20240011013A1 NUCLEIC ACID PURIFICATION METHOD, NUCLEIC ACID EXTRACTION LIQUID, AND NUCLEIC ACID PURIFICATION KIT 审中-公开
公开(公告)号：US20240011013A1
公开(公告)日：2024-01-11
申请号：US18024322
申请日：2021-09-03
申请人： SEKISUI MEDICAL CO., LTD. , SEKISUI CHEMICAL CO., LTD.
发明人： Sou YAMAGUCHI , Katsura UCHIDA , Tatsunori TAKAMATSU , Takamasa KOUNO , Takuya KINOSHITA
IPC分类号： C12N15/10
CPC分类号： C12N15/1006
摘要： Provided is a nucleic acid purification method capable of efficiently purifying a nucleic acid. The nucleic acid purification method including the steps of: mixing a nucleic acid with an antifoaming agent and a coprecipitation agent; and purifying the nucleic acid, in which the antifoaming agent is at least one of a nonionic surfactant and a silicone antifoaming agent.

9. 发明公开

US20230393156A1 METHOD FOR DETECTING BLOOD COAGULATION REACTION 审中-公开
公开(公告)号：US20230393156A1
公开(公告)日：2023-12-07
申请号：US18250783
申请日：2021-10-29
申请人： SEKISUI MEDICAL CO., LTD.
发明人： Toshiki KAWABE , Kengo ONISHI
IPC分类号： G01N33/86
CPC分类号： G01N33/86
摘要： A method for detecting a blood coagulation reaction, comprising: 1) measuring a blood coagulation reaction of a subject blood specimen and acquiring a first derivative V(i) of a coagulation reaction up to a latest measurement point; 2) calculating areas under the curve (AUCs) before the peak and after the peak, wherein a top of the peak of V(i) is cVmax(k) which is a maximum value of V(i); and 3) detecting cVmax(k) as Vmax which is a true maximum value of V(i) when the pre-peak AUC and the post-peak AUC are both equal to or higher than a first threshold AUCth1 and a period L during which the pre-peak AUC and the post-peak AUC have continued to be a constant value reaches a predetermined length.

10. 发明公开

US20230341423A1 BLOOD COAGULATION TIME MEASUREMENT METHOD 审中-公开
公开(公告)号：US20230341423A1
公开(公告)日：2023-10-26
申请号：US17788869
申请日：2020-12-25
申请人： SEKISUI MEDICAL CO., LTD.
发明人： Toshiki KAWABE
IPC分类号： G01N33/86 , G01N21/77
CPC分类号： G01N33/86 , G01N21/77
摘要： Provided is a blood coagulation time measurement method. In the method, reaction X(i) is acquired through smoothing and zero-point adjustment of a measured value P(i) for coagulation reaction of a blood specimen, and then an integration ratio Z(i) of the reaction X(i) is acquired. These values are used to calculate an index for coagulation time Tc calculation, and it is determined whether or not the index satisfies the criteria. The procedure is sequentially repeated until an index that satisfies the criteria is obtained.

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