专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130156776A1 COMPOSITIONS AND METHODS FOR TREATING CANCER AND MODULATING STRESS GRANULE FORMATION 有权
标题翻译：用于治疗癌症和调节应力颗粒形成的组合物和方法
公开(公告)号：US20130156776A1
公开(公告)日：2013-06-20
申请号：US13435932
申请日：2012-03-30
申请人： Paul Chang , Sejal . Vyas , Anthony Leung , Phillip A. Sharp
发明人： Paul Chang , Sejal . Vyas , Anthony Leung , Phillip A. Sharp
IPC分类号： A61K38/47 , A61K31/713 , A61K39/395 , C12Q1/68 , C07H21/02 , C12N15/113 , G01N33/68 , A61K38/45 , C07K16/40
CPC分类号： C12N15/1137 , A61K31/713 , A61K38/45 , A61K38/47 , A61K39/395 , A61K39/3955 , C07H21/02 , C07K16/40 , C12N15/113 , C12N2310/14 , C12N2320/12 , C12Q1/6886 , G01N33/6893 , G01N2333/91142 , G01N2500/02
摘要： The invention provides methods for treating or decreasing the likelihood of developing a stress-granule related disorder and/or cancer by administering one or more poly-ADP-ribose polymerase (PARP) inhibitors, one or more PARP activators, one or more poly-ADP-ribose glycosylase (PARG) activators, and/or one or more poly-ADP-ribose glycohydrolase ARH3 activators. The invention also provides corresponding methods of decreasing stress granule formation and/or proliferation in a cell or a population of cells. The invention further provides methods of increasing the number of stress granules and proliferation in a cell or a population of cells by administering one or more PARP activators, one or more PARP inhibitors, one or more PARG inhibitors, and/or one or more ARH3 inhibitors. The invention also provides methods for screening for agents for treating or decreasing the likelihood of developing a stress granule-related disorder or cancer, and methods for determining the propensity for developing a stress granule-related disorder or cancer, as well as compositions and kits containing one or more PARP inhibitors, one or more PARP activators, one or more PARG activators, and one or more ARH3 activators.
摘要翻译：本发明提供了通过施用一种或多种聚ADP-核糖聚合酶（PARP）抑制剂，一种或多种PARP激活剂，一种或多种聚ADP来治疗或降低发展应激颗粒相关病症和/或癌症的可能性的方法核糖糖酵解酶（PARG）激活剂和/或一种或多种聚ADP-核糖糖水解酶ARH3激活剂。本发明还提供减少细胞或细胞群体中应激颗粒形成和/或增殖的相应方法。本发明还提供了通过施用一种或多种PARP激活剂，一种或多种PARP抑制剂，一种或多种PARG抑制剂和/或一种或多种ARH3抑制剂来增加细胞或细胞群体中的应激颗粒数量和增殖的方法。本发明还提供筛选用于治疗或降低发展应激颗粒相关病症或癌症的可能性的药剂的方法，以及用于确定发展应激颗粒相关病症或癌症倾向的方法，以及含有一种或多种PARP抑制剂，一种或多种PARP活化剂，一种或多种PARG活化剂和一种或多种ARH3活化剂。

2. 发明申请

US20110097329A1 COMPOSITIONS AND METHODS FOR TREATING CANCER AND MODULATING STRESS GRANULE FORMATION 审中-公开
标题翻译：用于治疗癌症和调节应力颗粒形成的组合物和方法
公开(公告)号：US20110097329A1
公开(公告)日：2011-04-28
申请号：US12822995
申请日：2010-06-24
申请人： Paul Chang , Sejal Vyas , Anthony Leung , Phillip A. Sharp
发明人： Paul Chang , Sejal Vyas , Anthony Leung , Phillip A. Sharp
IPC分类号： A61K39/395 , C12N5/02 , A61P35/00 , C12Q1/48 , C12Q1/68
CPC分类号： C12N15/1137 , A61K31/713 , A61K38/45 , A61K38/47 , A61K39/395 , A61K39/3955 , C07H21/02 , C07K16/40 , C12N15/113 , C12N2310/14 , C12N2320/12 , C12Q1/6886 , G01N33/6893 , G01N2333/91142 , G01N2500/02
摘要： The invention provides methods for treating or decreasing the likelihood of developing a stress-granule related disorder and/or cancer by administering one or more poly-ADP-ribose polymerase (PARP) inhibitors, one or more PARP activators, one or more poly-ADP-ribose glycosylase (PARG) activators, and/or one or more poly-ADP-ribose glycohydrolase ARH3 activators. The invention also provides corresponding methods of decreasing stress granule formation and/or proliferation in a cell or a population of cells. The invention further provides methods of increasing the number of stress granules and proliferation in a cell or a population of cells by administering one or more PARP activators, one or more PARP inhibitors, one or more PARG inhibitors, and/or one or more ARH3 inhibitors. The invention also provides methods for screening for agents for treating or decreasing the likelihood of developing a stress granule-related disorder or cancer, and methods for determining the propensity for developing a stress granule-related disorder or cancer, as well as compositions and kits containing one or more PARP inhibitors, one or more PARP activators, one or more PARG activators, and one or more ARH3 activators.
摘要翻译：本发明提供了通过施用一种或多种聚ADP-核糖聚合酶（PARP）抑制剂，一种或多种PARP激活剂，一种或多种聚ADP来治疗或降低发展应激颗粒相关病症和/或癌症的可能性的方法核糖糖酵解酶（PARG）激活剂和/或一种或多种聚ADP-核糖糖水解酶ARH3激活剂。本发明还提供减少细胞或细胞群体中应激颗粒形成和/或增殖的相应方法。本发明还提供了通过施用一种或多种PARP激活剂，一种或多种PARP抑制剂，一种或多种PARG抑制剂和/或一种或多种ARH3抑制剂来增加细胞或细胞群体中的应激颗粒数量和增殖的方法。本发明还提供筛选用于治疗或降低发展应激颗粒相关病症或癌症的可能性的药剂的方法，以及用于确定发展应激颗粒相关病症或癌症倾向的方法，以及含有一种或多种PARP抑制剂，一种或多种PARP活化剂，一种或多种PARG活化剂和一种或多种ARH3活化剂。

3. 发明申请

US20100330583A1 Compositions and methods for identification of PARP function, inhibitors, and activators 有权
标题翻译：用于鉴定PARP功能，抑制剂和活化剂的组合物和方法
公开(公告)号：US20100330583A1
公开(公告)日：2010-12-30
申请号：US12459212
申请日：2009-06-26
申请人： Paul Chang , Sejal Vyas
发明人： Paul Chang , Sejal Vyas
IPC分类号： G01N33/53 , C12N15/11 , C12N9/96 , C07K16/18
CPC分类号： C12Q1/48 , C07K16/40 , C12N9/1077 , C12N9/2402 , C12N15/1137 , C12N15/62 , C12N2310/14 , C12Y204/0203 , C12Y302/01143 , G01N2333/91142 , G01N2500/02 , G01N2500/04
摘要： The invention provides nucleic acids encoding PARP fusion proteins, PARP fusion proteins, antibodies that bind to one or more of these PARP fusion proteins, and transgenic cells expressing one or more PARP fusion proteins. The invention also provides methods for identifying an agent as a specific PARP inhibitor or activator requiring contacting one or more PARP fusion proteins with a labeled nicotinamide adenine dinucleotide substrate and the agent and measuring the amount of labeled of ADP-ribose covalently attached to the one or more PARP fusion proteins. The invention also provides methods for identifying an agent that specifically binds to one or more PARP fusion proteins and methods for quantitating the level of one or more PARP proteins in a sample.
摘要翻译：本发明提供编码PARP融合蛋白，PARP融合蛋白，结合这些PARP融合蛋白中的一种或多种的抗体以及表达一种或多种PARP融合蛋白的转基因细胞的核酸。本发明还提供用于鉴定作为特异性PARP抑制剂或活化剂的试剂的方法，其需要使一种或多种PARP融合蛋白与标记的烟酰胺腺嘌呤二核苷酸底物和所述试剂接触，并测量共价连接到所述一种或多种PARP融合蛋白的ADP-核糖的标记量更多PARP融合蛋白。本发明还提供用于鉴定特异性结合一种或多种PARP融合蛋白的试剂的方法和用于定量样品中一种或多种PARP蛋白的水平的方法。

4. 发明授权

US08268550B2 Compositions and methods for identification of PARP function, inhibitors, and activators 有权
标题翻译：用于鉴定PARP功能，抑制剂和活化剂的组合物和方法
公开(公告)号：US08268550B2
公开(公告)日：2012-09-18
申请号：US12459212
申请日：2009-06-26
申请人： Paul Chang , Sejal Vyas
发明人： Paul Chang , Sejal Vyas
IPC分类号： G01N33/53
CPC分类号： C12Q1/48 , C07K16/40 , C12N9/1077 , C12N9/2402 , C12N15/1137 , C12N15/62 , C12N2310/14 , C12Y204/0203 , C12Y302/01143 , G01N2333/91142 , G01N2500/02 , G01N2500/04
摘要： The invention provides nucleic acids encoding PARP fusion proteins, PARP fusion proteins, antibodies that bind to one or more of these PARP fusion proteins, and transgenic cells expressing one or more PARP fusion proteins. The invention also provides methods for identifying an agent as a specific PARP inhibitor or activator requiring contacting one or more PARP fusion proteins with a labeled nicotinamide adenine dinucleotide substrate and the agent and measuring the amount of labeled of ADP-ribose covalently attached to the one or more PARP fusion proteins. The invention also provides methods for identifying an agent that specifically binds to one or more PARP fusion proteins and methods for quantitating the level of one or more PARP proteins in a sample.
摘要翻译：本发明提供了编码PARP融合蛋白，PARP融合蛋白，结合这些PARP融合蛋白中的一种或多种的抗体以及表达一种或多种PARP融合蛋白的转基因细胞的核酸。本发明还提供用于鉴定作为特异性PARP抑制剂或活化剂的试剂的方法，其需要使一种或多种PARP融合蛋白与标记的烟酰胺腺嘌呤二核苷酸底物和所述试剂接触，并测量共价连接到所述一种或多种PARP融合蛋白的ADP-核糖的标记量更多PARP融合蛋白。本发明还提供用于鉴定特异性结合一种或多种PARP融合蛋白的试剂的方法和用于定量样品中一种或多种PARP蛋白的水平的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式