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1. 发明授权

US08710417B2 Stable light source device 有权
标题翻译：稳定光源装置
公开(公告)号：US08710417B2
公开(公告)日：2014-04-29
申请号：US13410962
申请日：2012-03-02
申请人： Seishi Ikami
发明人： Seishi Ikami
IPC分类号： G01J1/32 , G01J1/58 , G01N21/64 , G01T1/00
CPC分类号： H05B37/0218 , H01L31/02019 , H01L31/147 , H05B33/0854 , Y02B20/46
摘要： A stable light source device is provided with a light source, a pinhole constricting optical flux emitted from the light source, a first integrating element inside which optical flux from the pinhole is multiply reflected, a light detection sensor monitoring a light amount, a control section controlling the light source on the basis of the light amount monitored by the light detection sensor and making the light amount consistent, an aperture formed in the first integrating element and emitting light outside the first integrating element, a diffusion-transmission member disposed at a light emission side of the aperture, a branching section disposed at a light emission side of the diffusion-transmission member and branching incident light towards plural light emission portions, and neutral density filters provided at the light emission portions, transmitted light amounts thereof respectively differing such that light amounts at the light emission portions are respectively different.
摘要翻译：稳定的光源装置设置有光源，限制从光源发射的光束的针孔，其中来自针孔的光通量被多次反射的第一积分元件，监测光量的光检测传感器，控制部分基于由光检测传感器监测的光量并使光量一致地控制光源;形成在第一积分元件中的孔，并且发射第一积分元件外部的光;布置在光的扩散透射元件所述分支部分设置在所述扩散透射部件的发光侧，并且分支入射光朝向多个发光部分，以及设置在所述发光部分的中性浓度滤光器，其透射光量分别不同，使得发光部分的光量分别不同。

2. 发明授权

US06937282B1 Method and apparatus for correcting distortion aberration in position and density in digital image by using distortion aberration characteristic 失效
标题翻译：通过使用失真像差特性来校正数字图像中的位置和密度的失真像差的方法和装置
公开(公告)号：US06937282B1
公开(公告)日：2005-08-30
申请号：US09415201
申请日：1999-10-12
申请人： Masato Some , Seishi Ikami
发明人： Masato Some , Seishi Ikami
IPC分类号： H04N5/228 , G06T5/00 , H04N1/40 , H04N5/225
CPC分类号： G06T5/006 , H04N5/217
摘要： A method and an apparatus for correcting influences of a distortion aberration of a lens in an image formed on an image surface by the lens. Distortions of respective portions of the image are corrected according to a distortion aberration characteristic of the lens. The distortion aberration characteristic indicates distortions at respective distances from an optical axis of the lens on the image surface. Then, a value of at least one kind of information belonging to each point of the image in which the distortions are corrected is determined based on values of the at least one kind of information belonging to points around a corresponding point in the image before the correction. Further, the density or brightness values of the predetermined pixels after the correction of the positions may be further corrected in consideration of the change of areas due to the distortion of the image.
摘要翻译：一种用于校正由透镜在图像表面上形成的图像中的透镜的畸变像差的影响的方法和装置。根据透镜的畸变像差特性校正图像的各部分的变形。畸变像差特性表示在与图像表面上的透镜的光轴相距的距离处的失真。然后，基于校正前的图像中的对应点周围的点的至少一种信息的值来确定属于图像的每个点的至少一种类型的信息，其中纠正失真的值。此外，考虑到由于图像的失真引起的区域的变化，可以进一步校正校正位置之后的预定像素的浓度或亮度值。

3. 发明授权

US06504167B2 Image reading apparatus 失效
标题翻译：图像读取装置
公开(公告)号：US06504167B2
公开(公告)日：2003-01-07
申请号：US09832791
申请日：2001-04-12
申请人： Seishi Ikami
发明人： Seishi Ikami
IPC分类号： G03B4202
CPC分类号： G03B42/02
摘要： An image reading apparatus includes a laser stimulating ray source for emitting a laser beam, a stage on which an image carrier can be placed, a scanning mechanism for scanning the image carrier with the laser beam emitted from the laser stimulating ray source, thereby stimulating the image carrier with the laser beam, a light detector for photoelectrically detecting light emitted from the image carrier, and an optical head for leading the laser beam emitted from the laser stimulating ray source to the image carrier, irradiating the image carrier with the laser beam and leading light emitted from the image carrier to the light detector, the optical head being constituted so as to lead light emitted from a point of the image carrier located upstream of a point of the image carrier onto which the laser beam impinges with respect to a direction of scanning with the laser beam. The thus constituted image reading apparatus can efficiently read a fluorescent image at a high SIN ratio by detecting residual fluorescence released from a fluorescent substance after the completion of irradiation with a stimulating ray.
摘要翻译：图像读取装置包括用于发射激光的激光刺激射线源，可以放置图像载体的台，用于从激光刺激射线源发射的激光束扫描图像载体的扫描机构，从而刺激具有激光束的图像载体，用于光电检测从图像载体发射的光的光检测器，以及用于将从激光刺激射线源发射的激光束引导到图像载体的光学头，用激光束照射图像载体，引导从图像载体发射到光检测器的光，所述光学头被构造成引导从位于激光束照射的图像载体的点的上游的图像载体的点相对于方向用激光束进行扫描。这样构成的图像读取装置可以通过检测在用刺激光线照射完成后从荧光物质释放的残留荧光，以高的SIN比率有效地读取荧光图像。

4. 发明授权

US06458410B1 Sample tray to be used in an image information reader and fabrication method thereof 有权
标题翻译：用于图像信息阅读器的样品托盘及其制造方法
公开(公告)号：US06458410B1
公开(公告)日：2002-10-01
申请号：US09449904
申请日：1999-12-02
申请人： Seishi Ikami , Koji Yoshida
发明人： Seishi Ikami , Koji Yoshida
IPC分类号： G01N2164
CPC分类号： G01N21/6456 , B01L3/5085 , B01L9/52 , B01L2300/0627 , B01L2300/168
摘要： In an image information reader 100 that includes an excitation light source 45, a photoelectric reading mechanism, and an external light shield for reading a sample distributing specific organism-originated material labeled with a fluorescent dye, a sample tray 10 is provided having the qualities of easy rinsing and enduring of repeated use. The sample tray includes a base material, e.g. an aluminum plate 10d, that is coated with a fluororesin, e.g. an hybrid resin 10c of PTFE and PFA having a black color as a base. The tray can also include depressed or projected markings 10a on the surface on which the sample is placed which represent a readable range of the photoelectric reading mechanism. A method of making the sample tray for the reader is also described.
摘要翻译：在包括激发光源45，光电读取机构和用于读取分配由荧光染料标记的特定生物体的材料的样品的外部光屏蔽的图像信息读取器100中，提供具有质量的样品盘10 容易冲洗和持久的反复使用。样品托盘包括基材，例如涂有氟树脂的铝板10d，例如。 PTFE和具有黑色为基础的PFA的混合树脂10c。托盘还可以包括在其上放置样品的表面上的凹陷或凸起的标记10a，其表示光电读取机构的可读范围。还描述了制造读取器的样品盘的方法。

5. 发明申请

US20070026532A1 Method and system for detecting fluorescence from microarray disk 有权
标题翻译：用于从微阵列盘检测荧光的方法和系统
公开(公告)号：US20070026532A1
公开(公告)日：2007-02-01
申请号：US11492911
申请日：2006-07-26
申请人： Seishi Ikami
发明人： Seishi Ikami
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , B01L3/5085 , B01L3/5088 , B01L2300/0636 , B01L2300/0806 , G01N21/6456 , G01N35/00069
摘要： In a fluorescence detection method: each of one or more biological specimens is irradiated with excitation light while a substrate disk is rotated, where the one or more biological specimens are labeled with a fluorescent material and fixed on the substrate disk. Fluorescence which is emitted from each of the one or more biological specimens is detected when a predetermined time elapses since the biological specimen is irradiated with the excitation light.
摘要翻译：在荧光检测方法中，一个或多个生物样品中的每一个被激发光照射，同时旋转基板盘，其中一个或多个生物样品用荧光材料标记并固定在基板盘上。当从激发光照射生物样本起经过预定时间时，检测从一个或多个生物样本中的每一个发射的荧光。

6. 发明授权

US06822242B2 Image data producing method and apparatus 失效
标题翻译：图像数据生成方法和装置
公开(公告)号：US06822242B2
公开(公告)日：2004-11-23
申请号：US09988370
申请日：2001-11-19
申请人： Seishi Ikami
发明人： Seishi Ikami
IPC分类号： G01N2164
CPC分类号： G01N21/6456
摘要： An image data producing apparatus includes comprising at least one stimulating ray source for emitting a stimulating ray, a stage on which an image carrier including independently formed and two-dimensionally distributed specimen spots, at least some of which contain a fluorescent substance, is to be placed, a two-dimensional area sensor, and a controller for irradiating the image carrier placed on the stage with a stimulating ray emitted from the at least one stimulating ray source, thereby exciting a fluorescent substance contained in the specimens, stopping the irradiation with the stimulating ray and causing the two-dimensional area sensor to photoelectrically detect residual fluorescence emission released from the fluorescent substance contained in the specimens. According to the thus constituted image data producing apparatus, it is possible to produce low-noise image data rapidly with a simple operation by irradiating the image carrier including independently formed and two-dimensionally distributed specimen spots with a stimulating ray to excite the fluorescent substance and photoelectrically detecting fluorescence emission released from the fluorescent substance.
摘要翻译：一种图像数据产生装置，包括至少一个用于发射刺激光线的刺激射线源，包括独立形成的图像载体和其中至少一部分含有荧光物质的二维分布的样本斑点的阶段为放置，二维区域传感器和控制器，用于利用从至少一个刺激射线源发射的刺激射线照射放置在舞台上的图像载体，由此激发包含在样本中的荧光物质，停止照射刺激射线并使二维区域传感器光电检测从样本中包含的荧光物质释放的残余荧光发射。根据这样构成的图像数据产生装置，通过用刺激光线照射包括独立形成的二维分布的样本斑点的图像载体来激发荧光物质，可以通过简单的操作快速地产生低噪声图像数据，光电检测从荧光物质释放的荧光发射。

7. 发明授权

US08658989B2 Fluorometric assay apparatus and fluorometric assay method 有权
标题翻译：荧光测定装置和荧光测定法
公开(公告)号：US08658989B2
公开(公告)日：2014-02-25
申请号：US13478958
申请日：2012-05-23
申请人： Seishi Ikami , Kazuhiro Makino
发明人： Seishi Ikami , Kazuhiro Makino
IPC分类号： G01V8/00
CPC分类号： G01N21/6456 , G01N21/6428 , G01N2021/6419 , G01N2021/6441 , G01N2021/6471 , G01N2201/0627
摘要： A fluorometric assay apparatus comprising an LED light source configured with at least two types of excitation LED that have different principle wavelengths from each other and are disposed in a two dimensional array on a substrate; an imaging lens for imaging a subject; a single excitation filter provided between the LED light source and a subject, the single excitation filter transmitting each of principle wavelength components of the LED light source; and a single detection long pass filter provided between the imaging lens and the subject.
摘要翻译：一种荧光测定装置，包括配置有至少两种类型的激发LED的LED光源，所述至少两种激发LED具有彼此不同的原理波长并且以基板上的二维阵列设置; 用于成像对象的成像镜头; 设置在所述LED光源和被摄体之间的单个激发滤光器，所述单个激发滤光器传输所述LED光源的各个主要波长分量; 以及设置在成像透镜和被摄体之间的单个检测长通滤波器。

8. 发明申请

US20120248989A1 STABLE LIGHT SOURCE DEVICE 有权
标题翻译：稳定的光源设备
公开(公告)号：US20120248989A1
公开(公告)日：2012-10-04
申请号：US13410962
申请日：2012-03-02
申请人： Seishi IKAMI
发明人： Seishi IKAMI
IPC分类号： H05B37/02
CPC分类号： H05B37/0218 , H01L31/02019 , H01L31/147 , H05B33/0854 , Y02B20/46
摘要： A stable light source device is provided with a light source, a pinhole constricting optical flux emitted from the light source, a first integrating element inside which optical flux from the pinhole is multiply reflected, a light detection sensor monitoring a light amount, a control section controlling the light source on the basis of the light amount monitored by the light detection sensor and making the light amount consistent, an aperture formed in the first integrating element and emitting light outside the first integrating element, a diffusion-transmission member disposed at a light emission side of the aperture, a branching section disposed at a light emission side of the diffusion-transmission member and branching incident light towards plural light emission portions, and neutral density filters provided at the light emission portions, transmitted light amounts thereof respectively differing such that light amounts at the light emission portions are respectively different.
摘要翻译：稳定的光源装置设置有光源，限制从光源发射的光束的针孔，其中来自针孔的光通量被多次反射的第一积分元件，监测光量的光检测传感器，控制部分基于由光检测传感器监测的光量并使光量一致地控制光源;形成在第一积分元件中的孔，并且发射第一积分元件外部的光;布置在光的扩散透射元件所述分支部分设置在所述扩散透射部件的发光侧，并且分支入射光朝向多个发光部分，以及设置在所述发光部分的中性浓度滤光器，其透射光量分别不同，使得发光部分的光量分别不同。

9. 发明授权

US07773223B2 Image scanning apparatus and image scanning method 有权
标题翻译：图像扫描装置和图像扫描方法
公开(公告)号：US07773223B2
公开(公告)日：2010-08-10
申请号：US12049018
申请日：2008-03-14
申请人： Seishi Ikami
发明人： Seishi Ikami
IPC分类号： G01N21/64
CPC分类号： G01N21/6456 , G01N21/77
摘要： An image scanning apparatus has an organic CMOS image sensor mounted in a base, and a photoreceptive surface of the image sensor is exposed on a top side of the base. A subject is placed directly on the photoreceptive surface, and the subject and the photoreceptive surface are covered up with a cover light-tightly. Thus the image sensor detects only chemiluminescent light from the subject. As for a fluorochrome-labeled subject, the subject placed directly on the photoreceptive surface is irradiated with excitation light from a light source mounted in the cover. The image sensor is provided with a filter for blocking the excitation light from its photoelectric conversion layers, so the image sensor detects only fluorescent rays generated from the excited fluorochrome-labeled subject. The image scanning apparatus needs no redundant space in perpendicular direction to the photoreceptive surface.
摘要翻译：图像扫描装置具有安装在基座中的有机CMOS图像传感器，并且图像传感器的感光面暴露在基部的顶侧。将受试者直接放置在感光表面上，并将受试者和感光表面用盖子轻轻地覆盖。因此，图像传感器仅检测来自受试者的化学发光光。对于荧光染料标记的受试者，直接放置在感光表面上的被摄体被来自安装在盖中的光源的激发光照射。图像传感器设置有用于阻挡来自其光电转换层的激发光的滤光器，因此图像传感器仅检测由激发的荧光染料标记的物体产生的荧光。图像扫描装置在与感光面垂直的方向上不需要冗余的空间。

10. 发明申请

US20080240747A1 IMAGE SCANNING APPARATUS AND IMAGE SCANNING METHOD 有权
标题翻译：图像扫描装置和图像扫描方法
公开(公告)号：US20080240747A1
公开(公告)日：2008-10-02
申请号：US12049018
申请日：2008-03-14
申请人： Seishi Ikami
发明人： Seishi Ikami
IPC分类号： G03G15/16
CPC分类号： G01N21/6456 , G01N21/77
摘要： An image scanning apparatus has an organic CMOS image sensor mounted in a base, and a photoreceptive surface of the image sensor is exposed on a top side of the base. A subject is placed directly on the photoreceptive surface, and the subject and the photoreceptive surface are covered up with a cover light-tightly. Thus the image sensor detects only chemiluminescent light from the subject. As for a fluorochrome-labeled subject, the subject placed directly on the photoreceptive surface is irradiated with excitation light from a light source mounted in the cover. The image sensor is provided with a filter for blocking the excitation light from its photoelectric conversion layers, so the image sensor detects only fluorescent rays generated from the excited fluorochrome-labeled subject. The image scanning apparatus needs no redundant space in perpendicular direction to the photoreceptive surface.
摘要翻译：图像扫描装置具有安装在基座中的有机CMOS图像传感器，并且图像传感器的感光面暴露在基部的顶侧。将受试者直接放置在感光表面上，并将受试者和感光表面用盖子轻轻地覆盖。因此，图像传感器仅检测来自受试者的化学发光光。对于荧光染料标记的受试者，直接放置在感光表面上的被摄体被来自安装在盖中的光源的激发光照射。图像传感器设置有用于阻挡来自其光电转换层的激发光的滤光器，因此图像传感器仅检测由激发的荧光染料标记的物体产生的荧光。图像扫描装置在与感光面垂直的方向上不需要冗余的空间。

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