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1. 发明申请

US20110117567A1 Micro-RNA Associated With Rheumatoid Arthritis 审中-公开
标题翻译：与类风湿关节炎相关的微RNA
公开(公告)号：US20110117567A1
公开(公告)日：2011-05-19
申请号：US13001812
申请日：2009-02-23
申请人： Seiji Kawano , Yuji Nakamachi
发明人： Seiji Kawano , Yuji Nakamachi
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： C12N15/113 , C12N2310/141 , C12N2330/10 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： An object of the present invention is to provide a novel marker for rheumatoid arthritis (RA), and more specifically, to provide a marker whose expression may be specifically increased or decreased in RA. Another object of the present invention is to confirm whether or not miRNA serving as the marker is involved as the etiology of RA, and to provide an inspection method for RA and a therapeutic agent for RA each using the miRNA involved. The marker includes miRNA (for example, miR124a) whose expression is specifically increased or decreased in RA synovial cells based on a small RNA expression profile in the RA synovial cells. In addition, the therapeutic agent for RA includes miRNA (for example, miR124a) as an active ingredient.
摘要翻译：本发明的目的是提供类风湿性关节炎（RA）的新型标记物，更具体地，提供RA的表达可以特异性增加或降低的标记物。本发明的另一个目的是确认作为标志物的miRNA是否作为RA的病因参与，并且提供RA和RA治疗剂的检查方法，每个使用所涉及的miRNA。标记物包括miRNA（例如miR124a），其基于RA滑膜细胞中的小RNA表达谱，在RA滑膜细胞中其表达特异性增加或减少。此外，RA的治疗剂包括作为活性成分的miRNA（例如，miR124a）。

2. 发明申请

US20130039505A1 AUDIO SIGNAL PROCESSING CIRCUIT 有权
标题翻译：音频信号处理电路
公开(公告)号：US20130039505A1
公开(公告)日：2013-02-14
申请号：US13572171
申请日：2012-08-10
申请人： Seiji Kawano
发明人： Seiji Kawano
IPC分类号： G10K11/16
CPC分类号： H04B1/1036 , H03G5/005 , H03G5/165 , H04B1/0007
摘要： An audio-signal-processing circuit includes: a noise-detecting unit to detect presence or absence of noise in an audio signal generated based on an output from a tuner configured to receive a broadcast signal; a low-pass filter, having predetermined phase characteristics, to pass the audio signal having a band of frequencies lower than a predetermined frequency; a high-pass filter, having the predetermined phase characteristics, to pass the audio signal having a band of frequencies higher than the predetermined frequency; first- and second-output units to multiply the signals outputted from the low-pass and high-pass filters by first and second coefficients and output the multiplied signals, respectively; an adding unit to add the signals respectively outputted from the first and the second output units; and a coefficient control unit to, when the noise-detecting unit has detected the presence of noise, decrease the second coefficient below the first coefficient.
摘要翻译：音频信号处理电路包括：噪声检测单元，用于检测基于被配置为接收广播信号的调谐器的输出产生的音频信号中的噪声的存在或不存在; 具有预定相位特性的低通滤波器，以使具有低于预定频率的频带的音频信号通过; 具有预定相位特性的高通滤波器使具有高于预定频率的频带的音频信号通过; 第一和第二输出单元，用于将从低通滤波器和高通滤波器输出的信号乘以第一和第二系数，并分别输出相乘的信号; 添加单元，用于添加从第一和第二输出单元分别输出的信号; 以及系数控制单元，当所述噪声检测单元检测到噪声的存在时，将所述第二系数降低到低于所述第一系数。

3. 发明授权

US08324183B2 Micro-RNA associated with rheumatoid arthritis 有权
标题翻译：与类风湿关节炎相关的微RNA
公开(公告)号：US08324183B2
公开(公告)日：2012-12-04
申请号：US13304768
申请日：2011-11-28
申请人： Seiji Kawano , Yuji Nakamachi
发明人： Seiji Kawano , Yuji Nakamachi
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/113 , C12N2310/141 , C12N2330/10 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： An object of the present invention is to provide a novel marker for rheumatoid arthritis (RA), and more specifically, to provide a marker whose expression may be specifically increased or decreased in RA. Another object of the present invention is to confirm whether or not miRNA serving as the marker is involved as the etiology of RA, and to provide an inspection method for RA and a therapeutic agent for RA each using the miRNA involved. The marker includes miRNA (for example, miR124a) whose expression is specifically increased or decreased in RA synovial cells based on a small RNA expression profile in the RA synovial cells. In addition, the therapeutic agent for RA includes miRNA (for example, miR124a) as an active ingredient.
摘要翻译：本发明的目的是提供类风湿性关节炎（RA）的新型标记物，更具体地，提供RA的表达可以特异性增加或降低的标记物。本发明的另一个目的是确认作为标志物的miRNA是否作为RA的病因参与，并且提供RA和RA治疗剂的检查方法，每个使用所涉及的miRNA。标记物包括miRNA（例如miR124a），其基于RA滑膜细胞中的小RNA表达谱，在RA滑膜细胞中其表达特异性增加或减少。此外，RA的治疗剂包括作为活性成分的miRNA（例如，miR124a）。

4. 发明申请

US20050089174A1 Stereophonic Device for Headphones and Audio Signal Processing Program 有权
标题翻译：用于耳机和音频信号处理程序的立体声设备
公开(公告)号：US20050089174A1
公开(公告)日：2005-04-28
申请号：US10468898
申请日：2002-02-25
申请人： Seiji Kawano , Makoto Yamanaka
发明人： Seiji Kawano , Makoto Yamanaka
IPC分类号： H04R5/033 , H04S1/00 , H04S3/00 , H04S5/00 , H04S5/02 , H04R5/00
CPC分类号： H04S1/005 , H04S3/004 , H04S2420/01
摘要： A stereophonic device for headphones to which a monophonic signal or a stereophonic signal is inputted comprises an uncorrelating processing unit for reducing the correlation between two signals obtained by dividing the inputted monophonic signal into two channels or two signals constituting the inputted stereophonic signal, a reflected sound adding processing unit for adding a reflected sound, and a sound image localizing processing unit for controlling the position where a sound image is localized.
摘要翻译：用于单声道信号或立体声信号的耳机的立体声装置包括：不相关处理单元，用于减少通过将输入的单声道信号划分为构成输入的立体声信号的两个或两个信号而获得的两个信号之间的相关性，用于添加反射声音的添加处理单元，以及用于控制声像被定位的位置的声音图像定位处理单元。

5. 发明授权

US06492542B2 Method for producing carboxylic acid tertiary alkyl ester 有权
标题翻译：羧酸叔烷基酯的制备方法
公开(公告)号：US06492542B2
公开(公告)日：2002-12-10
申请号：US09934238
申请日：2001-08-21
申请人： Sachiko Miyagi , Masayuki Maeda , Seiji Kawano , Taiichi Shiomi
发明人： Sachiko Miyagi , Masayuki Maeda , Seiji Kawano , Taiichi Shiomi
IPC分类号： C07C6976
CPC分类号： C07C67/12 , C07C2601/14 , C07C2602/28 , C07C2602/42 , C07C2603/74 , C07C2603/86 , C07C69/753 , C07C69/78 , C07C69/24
摘要： A carboxylic acid tertiary alkyl ester (Chemical formula 1) of high purity is obtained at a high yield ratio, by continually adding an esterification agent possessing a monovalent acid group, which agent is ester-interchangeable with a tertiary alcohol, to a mixed fluid of a carboxylic acid and a tertiary alcohol: R1(COOR2)n. (1)
摘要翻译：通过连续添加具有一价酸基的酯化剂（该酯与叔醇酯可互换的酯），以高产率获得高纯度的羧酸叔烷基酯（化学式1）羧酸和叔醇：

6. 发明授权

US09106299B2 Audio signal processing circuit 有权
标题翻译：音频信号处理电路
公开(公告)号：US09106299B2
公开(公告)日：2015-08-11
申请号：US13572171
申请日：2012-08-10
申请人： Seiji Kawano
发明人： Seiji Kawano
IPC分类号： H04H40/72 , H04B15/00 , H04B1/10 , H03G5/00 , H03G5/16 , H04B1/00
CPC分类号： H04B1/1036 , H03G5/005 , H03G5/165 , H04B1/0007
摘要： An audio-signal-processing circuit includes: a noise-detecting unit to detect presence or absence of noise in an audio signal generated based on an output from a tuner configured to receive a broadcast signal; a low-pass filter, having predetermined phase characteristics, to pass the audio signal having a band of frequencies lower than a predetermined frequency; a high-pass filter, having the predetermined phase characteristics, to pass the audio signal having a band of frequencies higher than the predetermined frequency; first- and second-output units to multiply the signals outputted from the low-pass and high-pass filters by first and second coefficients and output the multiplied signals, respectively; an adding unit to add the signals respectively outputted from the first and the second output units; and a coefficient control unit to, when the noise-detecting unit has detected the presence of noise, decrease the second coefficient below the first coefficient.
摘要翻译：音频信号处理电路包括：噪声检测单元，用于检测基于被配置为接收广播信号的调谐器的输出产生的音频信号中的噪声的存在或不存在; 具有预定相位特性的低通滤波器，以使具有低于预定频率的频带的音频信号通过; 具有预定相位特性的高通滤波器使具有高于预定频率的频带的音频信号通过; 第一和第二输出单元，用于将从低通滤波器和高通滤波器输出的信号乘以第一和第二系数，并分别输出相乘的信号; 添加单元，用于添加从第一和第二输出单元分别输出的信号; 以及系数控制单元，当所述噪声检测单元检测到噪声的存在时，将所述第二系数降低到低于所述第一系数。

7. 发明申请

US20120071541A1 Micro-RNA Associated With Rheumatoid Arthritis 有权
标题翻译：与类风湿关节炎相关的微RNA
公开(公告)号：US20120071541A1
公开(公告)日：2012-03-22
申请号：US13304768
申请日：2011-11-28
申请人： Seiji Kawano , Yuji Nakamachi
发明人： Seiji Kawano , Yuji Nakamachi
IPC分类号： A61K31/7105 , A61P29/00
CPC分类号： C12N15/113 , C12N2310/141 , C12N2330/10 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： An object of the present invention is to provide a novel marker for rheumatoid arthritis (RA), and more specifically, to provide a marker whose expression may be specifically increased or decreased in RA. Another object of the present invention is to confirm whether or not miRNA serving as the marker is involved as the etiology of RA, and to provide an inspection method for RA and a therapeutic agent for RA each using the miRNA involved. The marker includes miRNA (for example, miR124a) whose expression is specifically increased or decreased in RA synovial cells based on a small RNA expression profile in the RA synovial cells. In addition, the therapeutic agent for RA includes miRNA (for example, miR124a) as an active ingredient.
摘要翻译：本发明的目的是提供类风湿性关节炎（RA）的新型标记物，更具体地，提供RA的表达可以特异性增加或降低的标记物。本发明的另一个目的是确认作为标志物的miRNA是否作为RA的病因参与，并且提供RA和RA治疗剂的检查方法，每个使用所涉及的miRNA。标记物包括miRNA（例如miR124a），其基于RA滑膜细胞中的小RNA表达谱，在RA滑膜细胞中其表达特异性增加或减少。此外，RA的治疗剂包括作为活性成分的miRNA（例如，miR124a）。

8. 发明授权

US07706555B2 Stereophonic device for headphones and audio signal processing program 有权
标题翻译：用于耳机和音频信号处理程序的立体声设备
公开(公告)号：US07706555B2
公开(公告)日：2010-04-27
申请号：US10468898
申请日：2002-02-25
申请人： Seiji Kawano , Makoto Yamanaka
发明人： Seiji Kawano , Makoto Yamanaka
IPC分类号： H04R5/02
CPC分类号： H04S1/005 , H04S3/004 , H04S2420/01
摘要： A stereophonic device for headphones to which a monophonic signal or a stereophonic signal is inputted comprises an uncorrelating processing unit for reducing the correlation between two signals obtained by dividing the inputted monophonic signal into two channels or two signals constituting the inputted stereophonic signal, a reflected sound adding processing unit for adding a reflected sound, and a sound image localizing processing unit for controlling the position where a sound image is localized.
摘要翻译：用于单声道信号或立体声信号的耳机的立体声装置包括：不相关处理单元，用于减少通过将输入的单声道信号划分为构成输入的立体声信号的两个或两个信号而获得的两个信号之间的相关性，用于添加反射声音的添加处理单元，以及用于控制声像被定位的位置的声音图像定位处理单元。

9. 发明授权

US06816597B1 Pseudo stereophonic device 失效
标题翻译：伪立体声装置
公开(公告)号：US06816597B1
公开(公告)日：2004-11-09
申请号：US09581532
申请日：2000-08-31
申请人： Seiji Kawano
发明人： Seiji Kawano
IPC分类号： H04R500
CPC分类号： H04R5/00 , H04S5/00
摘要： In a pseudo stereophonic device for producing a pseudo stereophonic signal from a monophonic signal, there are provided m delay units connected in series and gradually delaying an input signal S, m FIR digital filters for respectively subjecting output signals Sk (k=1, 2, . . . m) of the delay units to filter processing, and an operating circuit for executing a predetermined operation on the basis of outputs Yk (k=1, 2, . . . m) of the respective FIR digital filters, to produce pseudo stereophonic signals LOUT and ROUT.
摘要翻译：在用于从单声道信号产生伪立体声信号的伪立体声装置中，提供串联连接的m个延迟单元，并逐渐延迟输入信号S，m FIR数字滤波器，用于分别使输出信号Sk（k = 1,2， ... m）和用于根据各个FIR数字滤波器的输出Y k（k = 1,2，...，m）执行预定操作的操作电路，以产生伪立体声信号LOUT和ROUT。

10. 发明授权

US08563751B2 Method for manufacturing trimellitic anhydride aryl ester 有权
标题翻译：偏苯三酸酐芳基酯的制备方法
公开(公告)号：US08563751B2
公开(公告)日：2013-10-22
申请号：US13140564
申请日：2009-12-22
申请人： Tomoya Yamamoto , Seiji Kawano , Kouji Muragaki
发明人： Tomoya Yamamoto , Seiji Kawano , Kouji Muragaki
IPC分类号： C07D307/89 , C07D407/10
CPC分类号： C07D307/89
摘要： Disclosed is a method for manufacturing a trimellitic anhydride aryl ester in an efficient, high-yielding manner, wherein carboxylic acid lithium salt is used as a catalyst when a carboxylic acid aryl ester and trimellitic anhydride are caused to undergo an ester exchange reaction to manufacture a trimellitic anhydride aryl ester.
摘要翻译：公开了一种以有效的高收率方式制备偏苯三酸酐芳基酯的方法，其中当使羧酸芳酯和偏苯三酸酐进行酯交换反应制造时，使用羧酸锂盐作为催化剂偏苯三酸酐芳基酯。

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