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1. 发明申请

US20180256494A1 TOPICAL COMPOSITION FOR TREATING AN INFLAMMATORY SKIN DISEASE AND A METHOD FOR TREATING THE INFLAMMATORY SKIN DISEASE WITH THE SAME 审中-公开
公开(公告)号：US20180256494A1
公开(公告)日：2018-09-13
申请号：US15917496
申请日：2018-03-09
申请人： Beyong Deog PARK , Se Kyoo JEONG , Kyung Ho PARK , Kyong Oh SHIN , Hyun Jong KIM
发明人： Beyong Deog PARK , Se Kyoo JEONG , Kyung Ho PARK , Kyong Oh SHIN , Hyun Jong KIM
IPC分类号： A61K9/00 , A61P17/00 , A61P29/00 , A61K31/155 , A61K31/436 , A61K31/573 , A61K31/59
CPC分类号： A61K9/0014 , A61K31/155 , A61K31/436 , A61K31/573 , A61K31/59 , A61P17/00 , A61P29/00
摘要： A topical composition for treating an inflammatory skin disease in a subject includes a therapeutically effective amount of a biguanidine, and is in a dosage form for topical administration. A method for treating an inflammatory skin disease in a subject includes the following steps: identifying a subject in need thereof; providing a biguanidine; and administering the biguanidine in a therapeutically effective amount to a part of the subject to treat the inflammatory skin disease.

2. 发明申请

US20130165652A1 NOVEL HETEROCYCLIC COMPOUND, AND COMPOSITION FOR TREATING INFLAMMATORY DISEASES USING SAME 审中-公开
标题翻译：新颖的杂环化合物，以及使用其处理炎症疾病的组合物
公开(公告)号：US20130165652A1
公开(公告)日：2013-06-27
申请号：US13818420
申请日：2011-08-25
申请人： Hyung Sub Gwak , Yong Zu Kim , Uk Il Kim , Byeong Deog Park , Tae Kyo Park , Sung Ho Woo , Joung Yul Yun , Dae Yon Lee , Hyang Sook Lee , Jeong Eun Jeon , Se Kyoo Jeong , Hyung Mook Choi
发明人： Hyung Sub Gwak , Yong Zu Kim , Uk Il Kim , Byeong Deog Park , Tae Kyo Park , Sung Ho Woo , Joung Yul Yun , Dae Yon Lee , Hyang Sook Lee , Jeong Eun Jeon , Se Kyoo Jeong , Hyung Mook Choi
IPC分类号： C07D471/04
CPC分类号： C07D235/08 , A61K8/4946 , A61Q19/00 , A61Q19/007 , A61Q19/008 , C07D471/04
摘要： The heterocyclic compound according to the present invention may treat and prevent inflammatory diseases and heal skin wounds, and particularly, have effects of recovering damaged skin barrier, reducing inflammation and pruritus in inflammatory skin diseases. In addition, the composition containing the compound according to the present invention as an active ingredient may be used to alleviate various inflammatory diseases and diseases in which PAR-2 is excessively expressed, and particularly, the composition may inhibit activity of PAR-2 in skin, such that the composition may be used as a composition having anti-inflammatory function in inflammatory skin diseases including atopic dermatitis, or the like.
摘要翻译：根据本发明的杂环化合物可以治疗和预防炎性疾病并愈合皮肤伤口，特别是具有恢复受损的皮肤屏障，减少炎性皮肤疾病中的炎症和瘙痒的作用。此外，含有本发明化合物作为活性成分的组合物可以用于缓和各种炎性疾病和PAR-2过度表达的疾病，特别是该组合物可抑制PAR-2在皮肤中的活性，使得该组合物可以用作具有抗炎功能的组合物，所述炎性皮肤病包括特应性皮炎等。

3. 发明申请

US20130158047A1 NOVEL HETEROCYCLIC COMPOUND, AND COMPOSITION FOR TREATING INFLAMMATORY DISEASES USING SAME 有权
标题翻译：新颖的杂环化合物，以及使用其处理炎症疾病的组合物
公开(公告)号：US20130158047A1
公开(公告)日：2013-06-20
申请号：US13818355
申请日：2011-08-25
申请人： Hyung Sub Gwak , Yong Zu Kim , Uk Il Kim , Byeong Deog Park , Tae Kyo Park , Sung Ho Woo , Joung Yul Yun , Dae Yon Lee , Hyang Sook Lee , Jeong Eun Jeon , Se Kyoo Jeong , Hyung Mook Choi
发明人： Hyung Sub Gwak , Yong Zu Kim , Uk Il Kim , Byeong Deog Park , Tae Kyo Park , Sung Ho Woo , Joung Yul Yun , Dae Yon Lee , Hyang Sook Lee , Jeong Eun Jeon , Se Kyoo Jeong , Hyung Mook Choi
IPC分类号： C07D235/08
CPC分类号： C07D235/08 , A61K8/4946 , A61Q19/00 , A61Q19/007 , A61Q19/008 , C07D471/04
摘要： Provided are heterocyclic compounds, having effects of treating and preventing inflammatory diseases and treating skin wounds, and particularly, exhibiting effects of recovering disrupted skin barriers, mitigating inflammation, and pruritus. Also, a composition containing the compound as an effective component can be used to mitigate various inflammatory diseases and protease activated receptor-2 (PAR-2)-overexpressed diseases, and can be particularly used as a composition having an anti-inflammatory function in inflammatory skin diseases including atopic dermatitis and the like, by inhibiting PAR-2 activity.
摘要翻译：提供具有治疗和预防炎性疾病和治疗皮肤伤口的作用的杂环化合物，特别是显示恢复破坏的皮肤屏障，减轻炎症和瘙痒的作用。此外，含有该化合物作为有效成分的组合物可用于缓解各种炎性疾病和蛋白酶活化受体-2（PAR-2） - 去表达疾病，并且可特别用作具有炎性功能的组合物皮肤病，包括特应性皮炎等，通过抑制PAR-2活性。

4. 发明授权

US08809541B2 Heterocyclic compound, and composition for treating inflammatory diseases using same 有权
标题翻译：杂环化合物和使用其治疗炎性疾病的组合物
公开(公告)号：US08809541B2
公开(公告)日：2014-08-19
申请号：US13818355
申请日：2011-08-25
申请人： Hyung Sub Gwak , Yong Zu Kim , Uk Il Kim , Byeong Deog Park , Tae Kyo Park , Sung Ho Woo , Joung Yul Yun , Dae Yon Lee , Hyang Sook Lee , Jeong Eun Jeon , Se Kyoo Jeong , Hyung Mook Choi
发明人： Hyung Sub Gwak , Yong Zu Kim , Uk Il Kim , Byeong Deog Park , Tae Kyo Park , Sung Ho Woo , Joung Yul Yun , Dae Yon Lee , Hyang Sook Lee , Jeong Eun Jeon , Se Kyoo Jeong , Hyung Mook Choi
IPC分类号： A61K31/497 , C07D211/32 , A61Q19/00 , A61K8/49 , C07D471/04 , C07D235/08
CPC分类号： C07D235/08 , A61K8/4946 , A61Q19/00 , A61Q19/007 , A61Q19/008 , C07D471/04
摘要： Provided are heterocyclic compounds, having effects of treating and preventing inflammatory diseases and treating skin wounds, and particularly, exhibiting effects of recovering disrupted skin barriers, mitigating inflammation, and pruritus. Also, a composition containing the compound as an effective component can be used to mitigate various inflammatory diseases and protease activated receptor-2 (PAR-2)-overexpressed diseases, and can be particularly used as a composition having an anti-inflammatory function in inflammatory skin diseases including atopic dermatitis and the like, by inhibiting PAR-2 activity.
摘要翻译：提供具有治疗和预防炎性疾病和治疗皮肤伤口的作用的杂环化合物，特别是显示恢复破坏的皮肤屏障，减轻炎症和瘙痒的作用。此外，含有该化合物作为有效成分的组合物可用于缓解各种炎性疾病和蛋白酶活化受体-2（PAR-2） - 去表达疾病，并且可特别用作具有炎性功能的组合物皮肤病，包括特应性皮炎等，通过抑制PAR-2活性。

5. 发明申请

US20100173995A1 Use of PPAR-alpha activator as inflammatory skin disease-treating agent and method for treating skin diseases using the same 审中-公开
标题翻译：使用PPAR-α激活剂作为炎性皮肤病治疗剂及使用其治疗皮肤疾病的方法
公开(公告)号：US20100173995A1
公开(公告)日：2010-07-08
申请号：US12319324
申请日：2009-01-06
申请人： Byeong-Deog Park , Hyung-Sub Gwak , Se-Kyoo Jeong , Jong-Hwan Bae
发明人： Byeong-Deog Park , Hyung-Sub Gwak , Se-Kyoo Jeong , Jong-Hwan Bae
IPC分类号： A61K31/164 , C07C233/31 , A61P17/10
CPC分类号： A61K31/164
摘要： Disclosed herein is the use of a non-natural compound represented by the following formula 1 as an activator of the peroxisome proliferator activated receptor-α (PPAR-α) which shows an anti-inflammatory effect on inflammatory skin diseases. The PPAR-α activator increases the expression of PPAR-α in the skin to enhance various physiological effects of PPAR-α, that is, the anti-inflammatory effect caused by inhibiting the activity of transcription factors such as the nuclear factor κK (NF-κK) that induces inflammatory reactions, the effect of improving the epidermal permeability barrier function of the skin, and the effect of promoting the terminal differentiation of epidermal keratinocytes. Thus, the PPAR-α activator is useful for the treatment, alleviation or amelioration of skin diseases such as acne, seborrheic dermatitis, viral skin diseases, urticaria, pruritus, viral infectious diseases and contact dermatitis. wherein R1 and R2 are the same or different and each represents a linear or branched C1-22 alkyl group, a phenyl group or a benzene group.
摘要翻译：本文公开了使用由下式1表示的非天然化合物作为对炎性皮肤疾病具有抗炎作用的过氧化物酶体增殖物激活受体α（PPAR-α）的活化剂。 PPAR-α活化剂增加PPAR-α在皮肤中的表达，以增强PPAR-α的各种生理作用，即通过抑制转录因子如核因子和kgr（K）的活性而引起的抗炎作用 NF-和kgr; K），其诱导炎症反应，改善皮肤表皮渗透屏障功能的作用，以及促进表皮角化细胞末端分化的作用。因此，PPAR-α活化剂可用于治疗，缓解或改善皮肤疾病如痤疮，脂溢性皮炎，病毒性皮肤病，荨麻疹，瘙痒症，病毒感染性疾病和接触性皮炎。其中R1和R2相同或不同，并且各自表示直链或支链C 1-22烷基，苯基或苯基。

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