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1. 发明申请

US20130116203A1 ISOTHIOCYNATES AND GLUCOSINOLATE COMPOUNDS AND ANTI-TUMOR COMPOSITIONS CONTAINING SAME 审中-公开
标题翻译：异硫氰酸酯和葡糖苷酸酯化合物和含有其的抗肿瘤组合物
公开(公告)号：US20130116203A1
公开(公告)日：2013-05-09
申请号：US13290571
申请日：2011-11-07
申请人： Scott R. Rajski , Jared Rae Mays
发明人： Scott R. Rajski , Jared Rae Mays
IPC分类号： A61K31/7028 , A61K31/44 , A61K31/4152 , A61K31/357 , A61K31/341 , A61K31/13 , C07H15/00 , C07D213/53 , C07D231/48 , C07D317/46 , C07D307/02 , C07C331/20 , C07C331/28 , A61P35/00 , C12N5/02
CPC分类号： C07H13/00 , C07C331/20 , C07C331/24 , C07C331/26 , C07C331/28 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07D213/53 , C07D231/46 , C07D307/52 , C07D317/58
摘要： The present invention provides glucosinolate and isothiocyanate compounds and related methods for synthesizing these compounds and analogs. In certain embodiments, these glucosinolate and isothiocyanate compounds are useful and chemopreventive and or chemotherapeutic agents.
摘要翻译：本发明提供硫代葡萄糖苷和异硫氰酸酯化合物以及合成这些化合物和类似物的相关方法。在某些实施方案中，这些硫代葡萄糖苷和异硫氰酸酯化合物是有用的和化学预防的和/或化学治疗剂。

2. 发明授权

US07465544B2 Synthetic cofactor analogs of S-adenosylmethionine as ligatable probes of biological methylation and methods for their use 有权
标题翻译： S-腺苷甲硫氨酸的合成辅因子类似物作为生物甲基化的可连接探针及其使用方法
公开(公告)号：US07465544B2
公开(公告)日：2008-12-16
申请号：US11330370
申请日：2006-01-11
申请人： Scott R. Rajski , Lindsay R. Comstock , Rachel L. Weller
发明人： Scott R. Rajski , Lindsay R. Comstock , Rachel L. Weller
IPC分类号： C12Q1/68 , C07H21/00 , C07H19/16 , C07H19/20
CPC分类号： C07H19/16 , C07H19/20 , C07H21/04
摘要： The present invention discloses compounds and methods used to specifically target substrates of methylation by S-adenosyl-L-methionine (SAM)-dependent methyltransferases. The substrates can be peptides, single stranded nucleic acids or double stranded nucleic acids, including RNA, DNA and PNA or phospholipids. The compounds disclosed are SAM analogs that are ligated to a methylation site by the methyltransferase. Also disclosed, are reacting groups that are ligatable to the cofactor analogs and can also be used as detectable labels. The reacting group can be used to cleave the substrate providing a methylation footprint. The invention can be used clinically to determine methylation state of a gene or gene promoter such as those involved in imprinting and transcription. In some preferred embodiments, the invention includes a kit, which can include one or more suitable SAM analogs and may include one or more detectable labels. In other preferred embodiments, the invention includes a pharmaceutical composition.
摘要翻译：本发明公开了通过S-腺苷-L-甲硫氨酸（SAM）依赖性甲基转移酶特异性靶向甲基化底物的化合物和方法。底物可以是肽，单链核酸或双链核酸，包括RNA，DNA和PNA或磷脂。所公开的化合物是通过甲基转移酶连接到甲基化位点的SAM类似物。还公开的是可与辅因子类似物连接的反应基团，也可以用作可检测标记。反应基团可用于切割提供甲基化足迹的基材。本发明可用于临床确定基因或基因启动子的甲基化状态，例如涉及印记和转录的基因启动子。在一些优选实施方案中，本发明包括试剂盒，其可以包括一种或多种合适的SAM类似物，并且可以包括一种或多种可检测标记。在其它优选实施方案中，本发明包括药物组合物。

3. 发明申请

US20080312164A1 ISOTHIOCYANATES AND GLUCOSINOLATE COMPOUNDS AND ANTI-TUMOR COMPOSITIONS CONTAINING SAME 审中-公开
标题翻译：异硫氰酸酯和葡糖苷酸酯化合物和含有其的抗肿瘤组合物
公开(公告)号：US20080312164A1
公开(公告)日：2008-12-18
申请号：US11777620
申请日：2007-07-13
申请人： Scott R. Rajski , Jared Rae Mays
发明人： Scott R. Rajski , Jared Rae Mays
IPC分类号： C07C331/16 , C07C331/18 , C07C331/26 , A61K31/26 , A61K31/4152 , C07D231/44 , C07H15/00 , A61K31/7028 , A61P35/00
CPC分类号： C07C331/24 , C07C331/20 , C07C331/22 , C07C331/26 , C07C331/28 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07D213/36 , C07D231/26 , C07D307/52 , C07D317/58
摘要： The present invention provides glucosinolate and isothiocyante compounds and related methods for synthesizing these compounds and analogs. In certain embodiments, these glucosinolate and isothiocyanate compounds are useful and chemopreventive and or chemotherapeutic agents.
摘要翻译：本发明提供硫代葡萄糖苷和异硫氰酸酯化合物以及合成这些化合物和类似物的相关方法。在某些实施方案中，这些硫代葡萄糖苷和异硫氰酸酯化合物是有用的和化学预防的和/或化学治疗剂。

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