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1. 发明授权

US08609073B2 Compositions and methods for reducing photosensitivity associated with photodynamic therapy 有权
标题翻译：用于降低与光动力疗法相关的光敏性的组合物和方法
公开(公告)号：US08609073B2
公开(公告)日：2013-12-17
申请号：US11817455
申请日：2006-03-03
申请人： Scott Lundahl , Stuart Marcus
发明人： Scott Lundahl , Stuart Marcus
IPC分类号： A61K8/00 , A61Q17/04
CPC分类号： A61K33/26 , A61K31/409 , A61K41/0061 , A61K41/0071 , A61N5/062 , A61K2300/00 , A61K41/0057
摘要： The present invention provides compositions and methods for decreasing photosensitivity induced by photodynamic therapy (PDT). The compositions and methods of the present method employ porphyrin complexing molecules as agents for reducing photosensitivity.
摘要翻译：本发明提供了降低由光动力疗法（PDT）引起的光敏性的组合物和方法。本发明方法的组合物和方法使用卟啉络合分子作为降低光敏性的试剂。

2. 发明授权

US08216289B2 Illuminator for photodynamic therapy 有权
标题翻译：光动力疗法照明器
公开(公告)号：US08216289B2
公开(公告)日：2012-07-10
申请号：US12969999
申请日：2010-12-16
申请人： Scott Lundahl , Rebecca Kozodoy , Ronald Carroll , Elton Leppelmeier
发明人： Scott Lundahl , Rebecca Kozodoy , Ronald Carroll , Elton Leppelmeier
IPC分类号： A61N5/06 , A61B6/00
CPC分类号： A61B5/0071 , A61B2017/00057 , A61N5/0616 , A61N5/0617 , A61N5/062 , A61N2005/0642 , A61N2005/0655
摘要： An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. Adjustment of the ballast voltage controls the output power of the tubes. The tubes are supported by a sheet-metal or plastic housing and are covered by a polycarbonate shield which directs cooling airflow within the unit and prevents glass-patient contact in the vent of tube breakage. An aluminum reflector located behind the tubes increases both the output irradiance and the uniformity of the output distribution. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity. A light sensor monitors output from the U-shaped tubes to provide a signal for adjusting the output from the tubes.
摘要翻译：一种用于光动力学治疗或光动力学诊断的装置和方法，其使用照明器，所述照明器包括通常符合轮廓表面的多个光源，并且以基本均匀的强度可见光照射所述轮廓表面。光源可以包括由电子镇流器驱动的大致U形荧光管。镇流器电压的调节控制管的输出功率。管由金属板或塑料外壳支撑，并被聚碳酸酯防护罩覆盖，聚碳酸酯防护罩可引导设备内的冷却气流，并防止玻璃 - 患者接触管道破裂。位于管后面的铝反射器增加了输出辐照度和输出分布的均匀性。改变U形管的间距以增加照明器边缘处的输出，使得输出更均匀。而且，不同部分的管以不同的量被冷却，以提高均匀性。光传感器监测来自U形管的输出，以提供用于调节管的输出的信号。

3. 发明申请

US20050267213A1 Use of photodynamic therapy to enhance treatment with immuno-modulating agents 审中-公开
标题翻译：使用光动力疗法来增强免疫调节剂的治疗
公开(公告)号：US20050267213A1
公开(公告)日：2005-12-01
申请号：US11030311
申请日：2005-01-07
申请人： Michael Gold , Mitchel Goldman , Scott Lundahl , Paul Sowyrda
发明人： Michael Gold , Mitchel Goldman , Scott Lundahl , Paul Sowyrda
IPC分类号： A61K31/198 , A61N5/06
CPC分类号： A61N5/062
摘要： Methods of enhancing the efficacy and safety of treatment with immuno-modulating agents are provided. The inventive methods combine treatment with immuno-modulating agents with photodynamic therapy (PDT). PDT can be administered before, during or after administration of the immuno-modulating agent. Combination therapy achieves at least the same efficacy as immuno-modulatory therapy in less time, with less immuno-modulating agent and fewer side-effects.
摘要翻译：提供了增强免疫调节剂治疗功效和安全性的方法。本发明的方法将免疫调节剂与光动力疗法（PDT）联合起来。可以在给予免疫调节剂之前，期间或之后施用PDT。联合治疗在较少时间内达到与免疫调节治疗相同的功效，免疫调节剂少，副作用少。

4. 发明申请

US20140316491A1 COMPOSITIONS AND METHODS FOR REDUCING PHOTOSENSITIVITY ASSOCIATED WITH PHOTODYNAMIC THERAPY 审中-公开
标题翻译：用于降低与光动力治疗相关的光敏性的组合物和方法
公开(公告)号：US20140316491A1
公开(公告)日：2014-10-23
申请号：US14088711
申请日：2013-11-25
申请人： Scott Lundahl , Stuart Marcus
发明人： Scott Lundahl , Stuart Marcus
IPC分类号： A61K33/26 , A61N5/06 , A61K41/00
CPC分类号： A61K33/26 , A61K31/409 , A61K41/0061 , A61K41/0071 , A61N5/062 , A61K2300/00 , A61K41/0057
摘要： The present invention provides compositions and methods for decreasing photosensitivity induced by photodynamic therapy (PDT). The compositions and methods of the present method employ porphyrin complexing molecules as agents for reducing photosensitivity.
摘要翻译：本发明提供了降低由光动力疗法（PDT）引起的光敏性的组合物和方法。本发明方法的组合物和方法使用卟啉络合分子作为降低光敏性的试剂。

5. 发明授权

US08030836B2 Illuminator for photodynamic therapy 有权
标题翻译：光动力疗法照明器
公开(公告)号：US08030836B2
公开(公告)日：2011-10-04
申请号：US12621845
申请日：2009-11-19
申请人： Scott Lundahl , Rebecca Kozodoy , Ronald Carroll , Elton Leppelmeier
发明人： Scott Lundahl , Rebecca Kozodoy , Ronald Carroll , Elton Leppelmeier
IPC分类号： H01J61/44 , A61B5/00
CPC分类号： A61B5/0071 , A61B2017/00057 , A61N5/0616 , A61N5/0617 , A61N5/062 , A61N2005/0642 , A61N2005/0655
摘要： An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. Adjustment of the ballast voltage controls the output power of the tubes. The tubes are supported by a sheet-metal or plastic housing and are covered by a polycarbonate shield which directs cooling airflow within the unit and prevents glass-patient contact in the vent of tube breakage. An aluminum reflector located behind the tubes increases both the output irradiance and the uniformity of the output distribution. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity. A light sensor monitors output from the U-shaped tubes to provide a signal for adjusting the output from the tubes.
摘要翻译：一种用于光动力学治疗或光动力学诊断的装置和方法，其使用照明器，所述照明器包括通常符合轮廓表面的多个光源，并且以基本均匀的强度可见光照射所述轮廓表面。光源可以包括由电子镇流器驱动的大致U形荧光管。镇流器电压的调节控制管的输出功率。管由金属板或塑料外壳支撑，并被聚碳酸酯防护罩覆盖，聚碳酸酯防护罩可引导设备内的冷却气流，并防止玻璃 - 患者接触管道破裂。位于管后面的铝反射器增加了输出辐照度和输出分布的均匀性。改变U形管的间距以增加照明器边缘处的输出，使得输出更均匀。而且，不同部分的管以不同的量被冷却，以提高均匀性。光传感器监测来自U形管的输出，以提供用于调节管的输出的信号。

6. 发明申请

US20090192071A1 USE OF PHOTODYNAMIC THERAPY TO ENHANCE TREATMENT WITH IMMUNO-MODULATING AGENTS 审中-公开
标题翻译：使用光化疗治疗免疫调节剂加强治疗
公开(公告)号：US20090192071A1
公开(公告)日：2009-07-30
申请号：US12239645
申请日：2008-09-26
申请人： Michael GOLD , Mitchel Goldman , Scott Lundahl , Paul Sowyrda
发明人： Michael GOLD , Mitchel Goldman , Scott Lundahl , Paul Sowyrda
IPC分类号： A61K38/00 , A61P37/00 , A61K31/198 , A61M37/00
CPC分类号： A61N5/062
摘要： Methods of enhancing the efficacy and safety of treatment with immuno-modulating agents are provided. The inventive methods combine treatment with immuno-modulating agents with photodynamic therapy (PDT). PDT can be administered before, during or after administration of the immuno-modulating agent. Combination therapy achieves at least the same efficacy as immuno-modulatory therapy in less time, with less immuno-modulating agent and fewer side-effects.
摘要翻译：提供了增强免疫调节剂治疗功效和安全性的方法。本发明的方法将免疫调节剂与光动力疗法（PDT）联合起来。可以在给予免疫调节剂之前，期间或之后施用PDT。联合治疗在较少时间内达到与免疫调节治疗相同的功效，免疫调节剂少，副作用少。

7. 发明申请

US20090123400A1 COMPOSITIONS AND METHODS FOR REDUCING PHOTOSENSITIVITY ASSOCIATED WITH PHOTODYNAMIC THERAPY 有权
标题翻译：用于降低与光动力治疗相关的光敏性的组合物和方法
公开(公告)号：US20090123400A1
公开(公告)日：2009-05-14
申请号：US11817455
申请日：2006-03-03
申请人： Scott Lundahl , Stuart Marcus
发明人： Scott Lundahl , Stuart Marcus
IPC分类号： A61K8/00 , A61K31/195 , A61K33/24 , A61K31/555 , A61K33/38 , A61K33/06 , A61K33/34 , A61P17/18 , A61K33/30 , A61Q17/04
CPC分类号： A61K33/26 , A61K31/409 , A61K41/0061 , A61K41/0071 , A61N5/062 , A61K2300/00 , A61K41/0057
摘要： The present invention provides compositions and methods for decreasing photosensitivity induced by photodynamic therapy (PDT). The compositions and methods of the present method employ porphyrin complexing molecules as agents for reducing photosensitivity.
摘要翻译：本发明提供了降低由光动力疗法（PDT）引起的光敏性的组合物和方法。本发明方法的组合物和方法使用卟啉络合分子作为降低光敏性的试剂。

8. 发明授权

US06709446B2 Illuminator for photodynamic therapy and diagnosis which produces substantially uniform intensity visible light 有权
标题翻译：用于光动力学治疗和诊断的照明器，其产生基本均匀的强度可见光
公开(公告)号：US06709446B2
公开(公告)日：2004-03-23
申请号：US09774084
申请日：2001-01-31
申请人： Scott Lundahl , Rebecca Kozodoy , Ronald Carroll , Elton Leppelmeier
发明人： Scott Lundahl , Rebecca Kozodoy , Ronald Carroll , Elton Leppelmeier
IPC分类号： A61N506
CPC分类号： A61B5/0071 , A61B2017/00057 , A61N5/0616 , A61N5/0617 , A61N5/062 , A61N2005/0642 , A61N2005/0655
摘要： An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. Adjustment of the ballast voltage controls the output power of the tubes. The tubes are supported by a sheet-metal or plastic housing and are covered by a polycarbonate shield which directs cooling airflow within the unit and prevents glass-patient contact in the event of tube breakage. An aluminum reflector located behind the tubes increases both the output irradiance and the uniformity of the output distribution. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity. A light sensor monitors output from the U-shaped tubes to provide a signal for adjusting the output from the tubes.
摘要翻译：一种用于光动力学治疗或光动力学诊断的装置和方法，其使用照明器，所述照明器包括通常符合轮廓表面的多个光源，并且以基本均匀的强度可见光照射所述轮廓表面。光源可以包括由电子镇流器驱动的大致U形荧光管。镇流器电压的调节控制管的输出功率。管由金属板或塑料外壳支撑，并被聚碳酸酯护罩所覆盖，聚碳酸酯防护罩可引导单元内的冷却气流，并防止管子破裂时玻璃与患者接触。位于管后面的铝反射器增加了输出辐照度和输出分布的均匀性。改变U形管的间距以增加照明器边缘处的输出，使得输出更均匀。而且，不同部分的管以不同的量被冷却，以提高均匀性。光传感器监测来自U形管的输出，以提供用于调节管的输出的信号。

9. 发明授权

US5303324A Method and apparatus for providing controlled light distribution from a cylindrical fiberoptic diffuser 失效
标题翻译：用于从圆柱形光纤扩散器提供受控光分布的方法和装置
公开(公告)号：US5303324A
公开(公告)日：1994-04-12
申请号：US968140
申请日：1992-10-29
申请人： Scott Lundahl
发明人： Scott Lundahl
IPC分类号： A61B18/22 , A61N5/06 , F21V8/00 , G02B6/36 , G02B6/00
CPC分类号： G02B6/262 , A61B18/22 , A61N5/0601 , A61N5/062 , G02B6/0008 , A61B2018/2261 , A61B2018/2272 , A61N2005/063 , G02B6/3624 , Y10S385/901
摘要： The invention discloses a cylindrical optical radiating device for obtaining controlled light distribution in a cylindrical pattern from an optical fiber. The device is constructed of a solid cylindrical tip made from material containing an optical scattering material in which a tapered central lumen having a conical shape has been drilled, cast or bored. Light emerging from the end of the fiber is radiated out in a cylindrical pattern through the use of the tapered central lumen.
摘要翻译：本发明公开了一种用于从光纤获得圆柱形图案的受控光分布的圆柱形光辐射装置。该装置由由含有光学散射材料的材料制成的实心圆柱形尖端构成，其中已经钻出，铸造或钻孔具有圆锥形的锥形中心管腔。从纤维端部出射的光通过使用锥形中央管腔以圆柱形图案辐射出。

10. 发明申请

US20100191172A1 ILLUMINATOR FOR PHOTODYNAMIC THERAPY 有权
标题翻译：用于光化疗治疗的照明器
公开(公告)号：US20100191172A1
公开(公告)日：2010-07-29
申请号：US12621845
申请日：2009-11-19
申请人： Scott Lundahl , Rebecca Kozodoy , Ronald Carroll , Elton Leppelmeier
发明人： Scott Lundahl , Rebecca Kozodoy , Ronald Carroll , Elton Leppelmeier
IPC分类号： A61N5/00
CPC分类号： A61B5/0071 , A61B2017/00057 , A61N5/0616 , A61N5/0617 , A61N5/062 , A61N2005/0642 , A61N2005/0655
摘要： An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. Adjustment of the ballast voltage controls the output power of the tubes. The tubes are supported by a sheet-metal or plastic housing and are covered by a polycarbonate shield which directs cooling airflow within the unit and prevents glass-patient contact in the vent of tube breakage. An aluminum reflector located behind the tubes increases both the output irradiance and the uniformity of the output distribution. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity. A light sensor monitors output from the U-shaped tubes to provide a signal for adjusting the output from the tubes.
摘要翻译：一种用于光动力学治疗或光动力学诊断的装置和方法，其使用照明器，所述照明器包括通常符合轮廓表面的多个光源，并且以基本均匀的强度可见光照射所述轮廓表面。光源可以包括由电子镇流器驱动的大致U形荧光管。镇流器电压的调节控制管的输出功率。管由金属板或塑料外壳支撑，并被聚碳酸酯防护罩覆盖，聚碳酸酯防护罩可引导设备内的冷却气流，并防止玻璃 - 患者接触管道破裂。位于管后面的铝反射器增加了输出辐照度和输出分布的均匀性。改变U形管的间距以增加照明器边缘处的输出，使得输出更均匀。而且，不同部分的管以不同的量被冷却，以提高均匀性。光传感器监测来自U形管的输出，以提供用于调节管的输出的信号。

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