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1. 发明授权

US09162053B2 Directional lead assembly 有权
标题翻译：定向导线总成
公开(公告)号：US09162053B2
公开(公告)日：2015-10-20
申请号：US13076874
申请日：2011-03-31
申请人： Gregory T. Schulte , Scott Kokones
发明人： Gregory T. Schulte , Scott Kokones
IPC分类号： A61N1/05 , A61N1/04 , A61N1/375
CPC分类号： A61N1/0551 , A61N1/05 , A61N1/0534 , A61N1/375 , Y10T29/49172
摘要： Leads having directional electrodes thereon. Also provided are leads having directional electrodes as well as retention ledges to secure the electrodes to the leads. Also provided are leads with directional electrodes where all the electrodes have the same surface area. Methods of manufacturing leads and methods of treating conditions and selectively stimulating regions of the nervous system are also provided.
摘要翻译：在其上具有定向电极的引线。还提供了具有定向电极的引线以及用于将电极固定到引线的保持凸缘。还提供了具有定向电极的引线，其中所有电极具有相同的表面积。还提供了生产线索的方法和处理条件并选择性地刺激神经系统的区域的方法。

2. 发明申请

US20120330374A1 SYSTEM AND METHOD FOR DETERMINING TARGET STIMULATION VOLUMES 有权
标题翻译：用于确定目标刺激体积的系统和方法
公开(公告)号：US20120330374A1
公开(公告)日：2012-12-27
申请号：US13431258
申请日：2012-03-27
申请人： David Arthur BLUM , Scott KOKONES , Michael A. MOFFITT , Jordan BARNHORST , Keith CARLTON
发明人： David Arthur BLUM , Scott KOKONES , Michael A. MOFFITT , Jordan BARNHORST , Keith CARLTON
IPC分类号： A61N1/36
CPC分类号： G06T7/0038 , A61B34/25 , A61N1/08 , A61N1/36128 , A61N1/37247 , F04C2270/041 , G06F3/04815 , G06F3/04845 , G06F19/00 , G06F19/321 , G06F19/3481 , G06K9/4642 , G06K9/6215 , G06K2009/4666 , G06T3/40 , G06T3/4038 , G06T7/0012 , G06T7/30 , G06T7/33 , G06T7/38 , G06T11/003 , G06T11/60 , G06T15/005 , G06T15/08 , G06T19/00 , G06T19/003 , G06T2200/04 , G06T2200/24 , G06T2207/10064 , G06T2207/10072 , G06T2207/10081 , G06T2207/10088 , G06T2207/10092 , G06T2207/30016 , G06T2219/028
摘要： A system and method may include determining a target stimulation volume based on modifying a patient population image for which an efficacious volume had been determined. A system and method for suggesting stimulation devices may include determining which stimulation device is capable of producing an output volume of activation that most closely matches the target volume. A system and method for facilitating selection of stimulation parameters may include graphically identifying a maximum volume in which tissue is stimulatable by an implanted stimulation device. A system and method may pre-compute volumes of activation that result from a predetermined modification of programming settings. A system and method may transmit stimulation programming settings from a stimulation programming module to a stimulation generating device.
摘要翻译：系统和方法可以包括基于修改已经确定有效体积的患者群体图像来确定目标刺激体积。用于建议刺激装置的系统和方法可以包括确定哪个刺激装置能够产生与目标体积最接近匹配的激活的输出体积。用于促进选择刺激参数的系统和方法可以包括以图形方式识别组织由植入的刺激装置刺激的最大体积。系统和方法可以预先计算由编程设置的预定修改产生的激活量。系统和方法可以将刺激编程设置从刺激编程模块传送到刺激产生装置。

3. 发明申请

US20120265267A1 CLINICIAN PROGRAMMER SYSTEM AND METHOD FOR CALCULATING VOLUMES OF ACTIVATION 审中-公开
标题翻译：临床编程系统和计算激活体积的方法
公开(公告)号：US20120265267A1
公开(公告)日：2012-10-18
申请号：US13534650
申请日：2012-06-27
申请人： David Arthur BLUM , Keith CARLTON , Alan GRESZLER , Scott KOKONES , Troy SPARKS
发明人： David Arthur BLUM , Keith CARLTON , Alan GRESZLER , Scott KOKONES , Troy SPARKS
IPC分类号： A61N1/36
CPC分类号： A61N1/36128 , A61B5/055 , A61B34/10 , A61B2034/104 , A61B2034/105 , A61B2034/107 , A61B2090/103 , A61N1/36082 , A61N1/36185 , A61N1/37247 , G06F19/325 , G06K9/00885 , G16H40/63 , G16H50/50
摘要： A system and method for providing a volume of activation (VOA) of a stimulation electrode leadwire may include a processor that calculates a VOA for each of a plurality of sets of parameter settings of the leadwire, stores in a database each of the calculated VOAs in association with the respective set of parameter settings for which it was calculated, obtains a set of parameter settings of the leadwire for a stimulation, and determines a VOA for the obtained set of parameter settings based on the stored VOAs.
摘要翻译：用于提供刺激电极引线的激活量（VOA）的系统和方法可以包括处理器，其针对引线的多组参数设置中的每一个计算VOA，在数据库中存储每个计算的VOA在与其计算的相应参数设置的关联获得用于刺激的引线的一组参数设置，并且基于所存储的VOA来确定所获得的参数设置集合的VOA。

4. 发明授权

US08260425B2 Deep brain stimulation system with inputs 有权
标题翻译：深入脑刺激系统与输入
公开(公告)号：US08260425B2
公开(公告)日：2012-09-04
申请号：US11871468
申请日：2007-10-12
申请人： Scott Kokones , Keith Carlton , Alan Greszler
发明人： Scott Kokones , Keith Carlton , Alan Greszler
IPC分类号： A61N1/36
CPC分类号： A61N1/37252 , A61B5/0476 , A61B5/1116 , A61B5/1121 , A61B5/1127 , A61B5/16 , A61B5/224 , A61B5/4094 , A61B5/6885 , A61N1/36082 , A61N1/37247
摘要： A stimulation system can have a first sensor to generate a first reading and a second sensor to generate a second reading. An analysis module of a programmer such as a patient programmer, which programs a stimulation signal to be delivered to a patient, conducts an evaluation of the patient based on the first and second readings. Evaluations may include determinations such as range of motion determinations, posture determinations, physical task-specific brain activity determinations, cognitive task-specific brain activity determinations, and brain activity-specific movement determinations.
摘要翻译：刺激系统可以具有第一传感器以产生第一读数和第二传感器以产生第二读数。诸如病人编程器的程序员的分析模块，其对要传送给患者的刺激信号进行编程，基于第一和第二读数对患者进行评估。评估可以包括诸如运动测定范围，姿势确定，物理任务特定的脑活动测定，认知任务特定的脑活动测定和脑活动特异性运动测定的确定。

5. 发明申请

US20110313487A1 Clinician programmer system and method for steering volumes of activation 有权
标题翻译：临床医生程序员系统和方法，用于控制活动量
公开(公告)号：US20110313487A1
公开(公告)日：2011-12-22
申请号：US13137511
申请日：2011-08-23
申请人： Scott Kokones , David Arthur Blum , Keith Carlton , Troy Sparks
发明人： Scott Kokones , David Arthur Blum , Keith Carlton , Troy Sparks
IPC分类号： A61N1/08 , G06G7/60
CPC分类号： A61N1/36128 , A61B5/055 , A61B34/10 , A61B2034/104 , A61B2034/105 , A61B2034/107 , A61B2090/103 , A61N1/36082 , A61N1/36185 , A61N1/37247 , G06F19/00 , G06F19/325 , G06K9/00885 , G16H40/63 , G16H50/50
摘要： A system and method for selection of stimulation parameters for Deep Brain Stimulation (DBS) may include a processor that displays in a display device and in relation to a displayed model of a leadwire including model electrodes, a current field corresponding to a first stimulation parameter set, provides a user interface for receipt of user input representing a shift of the current field, in response to the user input, moves, in the display device, the current field with respect to the displayed model, determines a second stimulation parameter set that results in the moved current field, and outputs the second stimulation parameter set and/or sets a stimulation device with the second stimulation parameter set, where the stimulation device is configured for performing a stimulation using the leadwire in accordance with the second stimulation parameter set.
摘要翻译：用于选择用于深脑刺激（DBS）的刺激参数的系统和方法可以包括显示在显示装置中并且涉及包括模型电极的引线的显示模型的处理器，对应于第一刺激参数组的当前场提供用于接收表示当前场的移位的用户输入的用户界面，响应于用户输入，在显示设备中相对于所显示的模型移动当前场，确定结果的第二刺激参数集并且输出所述第二刺激参数组和/或设置具有所述第二刺激参数集的刺激装置，其中所述刺激装置被配置为根据所述第二刺激参数集执行使用所述引线的刺激。

6. 发明申请

US20110307031A1 LEAD EXTENSION WITH INPUT CAPABILITIES 有权
标题翻译：引领能力与输入能力
公开(公告)号：US20110307031A1
公开(公告)日：2011-12-15
申请号：US13213688
申请日：2011-08-19
申请人： Scott KOKONES , Keith CARLTON
发明人： Scott KOKONES , Keith CARLTON
IPC分类号： A61N1/36
CPC分类号： A61N1/0529 , A61B5/0031 , A61B5/0478 , A61B5/0484 , A61B5/4041 , A61B5/4064 , A61N1/0534 , A61N1/36025 , A61N1/36082
摘要： A lead extension useful in deep brain stimulation treatment includes a body portion having a distal end and a proximal end, wherein the proximal end receives a stimulation signal from a generator. A lead interface is disposed at the distal end to send the stimulation signal to a brain stimulation lead. The lead extension also includes a sensor interface disposed at the distal end to receive an input signal from a sensor that is detached from the stimulation lead and send the input signal to the generator.
摘要翻译：用于深部脑刺激治疗的引导延伸包括具有远端和近端的主体部分，其中近端接收来自发生器的刺激信号。引线接口设置在远端，以将刺激信号发送到脑刺激引线。引线延伸部还包括设置在远端处的传感器接口，以接收来自与刺激引线分离的传感器的输入信号，并将输入信号发送到发生器。

7. 发明授权

US08024045B2 Multi-functional burr hole assembly 有权
标题翻译：多功能毛刺孔组件
公开(公告)号：US08024045B2
公开(公告)日：2011-09-20
申请号：US12028085
申请日：2008-02-08
申请人： Keith Carlton , Alan Greszler , Scott Kokones
发明人： Keith Carlton , Alan Greszler , Scott Kokones
IPC分类号： A61N1/36
CPC分类号： A61N1/0529 , A61B5/01 , A61B5/031 , A61B5/0476 , A61B5/6864 , A61B2562/0219 , A61N1/0534 , A61N1/0539 , A61N1/086 , A61N1/36082 , A61N1/3718
摘要： A burr hole assembly for use in neurosurgery. In one aspect, the burr hole assembly comprises a burr hole portion and one or more sensors, such as EEG sensors, temperature sensors, intracranial pressure sensors, or motion sensors. In certain embodiments, an input/output unit, which may include a multiplexer, provides a coupling between the sensors and a brain stimulation system which operates in cooperation with the burr hole assembly. In another aspect, the burr hole assembly comprises a burr hole portion and a rotation mechanism which operates in cooperation with an electrode lead. In certain embodiments, the burr hole assembly includes a control system for controlling the rotation mechanism. Also disclosed are systems comprising a burr hole assembly and various components of a brain stimulation system, such as pulse generators, electrode leads, lead extension, or external control systems.
摘要翻译：用于神经外科的钻孔组件。一方面，毛刺孔组件包括毛刺孔部分和一个或多个传感器，例如EEG传感器，温度传感器，颅内压力传感器或运动传感器。在某些实施例中，可包括多路复用器的输入/输出单元提供传感器与与钻孔组件协作操作的脑刺激系统之间的耦合。另一方面，毛刺孔组件包括与电极引线配合操作的毛刺孔部分和旋转机构。在某些实施例中，钻孔组件包括用于控制旋转机构的控制系统。还公开了包括钻孔组件和脑刺激系统的各种部件的系统，例如脉冲发生器，电极引线，引线延伸或外部控制系统。

8. 发明申请

US20160022375A1 SYSTEM AND METHOD FOR CARDIAC ABLATION 审中-公开
标题翻译：用于心脏消融的系统和方法
公开(公告)号：US20160022375A1
公开(公告)日：2016-01-28
申请号：US14808353
申请日：2015-07-24
申请人： Robert BLAKE , Scott Kokones , Brock Tice
发明人： Robert BLAKE , Scott Kokones , Brock Tice
IPC分类号： A61B19/00 , A61B5/02 , A61B18/14 , A61B5/00
CPC分类号： A61B5/06 , A61B5/02 , A61B5/6844 , A61B5/742 , A61B5/7455 , A61B5/746 , A61B18/1492 , A61B34/10 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2034/104 , A61B2034/105 , A61B2034/2051 , A61B2090/363 , A61B2090/502 , A61B2576/023 , G06T7/0012 , G06T7/11 , G06T19/00 , G06T2207/20128 , G06T2207/30048 , G16H50/00
摘要： A system for determining cardiac targets is provided. The system may include at least one processing device configured to carry out instructions to receive cardiac imaging data, segment the cardiac imaging data to identify at least two types of cardiac tissue, generate a cardiac model based on the identified tissue, simulate cardiac activity based on the generated cardiac model, and identify at least one cardiac target based on the simulation. A cardiac therapy system may be utilized to provide feedback to a user in order to guide a cardiac treatment device to a cardiac target.
摘要翻译：提供了一种用于确定心脏靶标的系统。该系统可以包括至少一个处理装置，其被配置为执行接收心脏成像数据的指令，分割心脏成像数据以识别至少两种类型的心脏组织，基于所识别的组织产生心脏模型，基于生成的心脏模型，并且基于模拟识别至少一个心脏靶标。可以使用心脏治疗系统来向用户提供反馈，以便将心脏治疗装置引导到心脏靶。

9. 发明授权

US08958615B2 System and method for weighted atlas generation 有权
标题翻译：用于加权地图集生成的系统和方法
公开(公告)号：US08958615B2
公开(公告)日：2015-02-17
申请号：US13570748
申请日：2012-08-09
申请人： David Arthur Blum , Scott Kokones , Keith Carlton
发明人： David Arthur Blum , Scott Kokones , Keith Carlton
IPC分类号： G06T7/00
CPC分类号： G06T7/0014 , G06T7/30 , G06T2207/10088 , G06T2207/20128 , G06T2207/20216 , G06T2207/30016
摘要： A system and method for generating a patient-specific anatomical atlas, e.g., includes, for each patient of a patient population: obtaining a respective anatomical atlas, and registering, by a computer processor, the respective anatomical atlas to an anatomical image of a current patient to obtain a respective registered anatomical atlas, and further includes, determining, by the processor, an average of the registered anatomical atlases.
摘要翻译：用于生成患者特异性解剖图谱的系统和方法，例如，对于患者群体的每个患者包括：获得相应的解剖图谱，并且由计算机处理器将相应的解剖图谱登记到当前的解剖图像患者以获得相应的登记的解剖图谱，并且还包括由处理器确定登记的解剖图谱的平均值。

10. 发明授权

US08675945B2 System and method for image registration 有权
标题翻译：图像配准系统和方法
公开(公告)号：US08675945B2
公开(公告)日：2014-03-18
申请号：US13431221
申请日：2012-03-27
申请人： Jordan Barnhorst , Keith Carlton , Scott Kokones , Troy Sparks , Aaron Omar Shinn , Zhen Zeng
发明人： Jordan Barnhorst , Keith Carlton , Scott Kokones , Troy Sparks , Aaron Omar Shinn , Zhen Zeng
IPC分类号： G06K9/00 , A61N1/00
CPC分类号： G06T7/0038 , A61B34/25 , A61N1/08 , A61N1/36128 , A61N1/37247 , F04C2270/041 , G06F3/04815 , G06F3/04845 , G06F19/00 , G06F19/321 , G06F19/3481 , G06K9/4642 , G06K9/6215 , G06K2009/4666 , G06T3/40 , G06T3/4038 , G06T7/0012 , G06T7/30 , G06T7/33 , G06T7/38 , G06T11/003 , G06T11/60 , G06T15/005 , G06T15/08 , G06T19/00 , G06T19/003 , G06T2200/04 , G06T2200/24 , G06T2207/10064 , G06T2207/10072 , G06T2207/10081 , G06T2207/10088 , G06T2207/10092 , G06T2207/30016 , G06T2219/028
摘要： A system and method for providing processable data associated with anatomical images may provide a user interface including a pivot and stem tool via which to align multiple images, a flashlight bar for viewing portions of an overlaid image, and/or user-movable markers for establishing a location of one or more anatomical landmarks with regions of one or more images.
摘要翻译：用于提供与解剖图像相关联的可处理数据的系统和方法可以提供包括用于对准多个图像的枢轴和杆工具的用户界面，用于观看覆盖图像的部分的手电筒和/或用于建立具有一个或多个图像的区域的一个或多个解剖学界标的位置。

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