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1. 发明授权

US08462981B2 Spectral unmixing for visualization of samples 有权
标题翻译：用于可视化样品的光谱解混合
公开(公告)号：US08462981B2
公开(公告)日：2013-06-11
申请号：US12755831
申请日：2010-04-07
申请人： Scott Determan , Peter J. Miller
发明人： Scott Determan , Peter J. Miller
IPC分类号： G06K9/00 , G01J5/02 , G01J3/28
CPC分类号： G06K9/0014
摘要： Disclosed methods include: acquiring a first sequence of multiple images of a sample, with each image in the first sequence corresponding to a different spectral weighting function; unmixing the first sequence of images into data corresponding to a first set of unmixed images, where each unmixed image in the first set corresponds to a spatial distribution in the sample of a different one of multiple components at a first time; acquiring one or more additional images of the sample and combining the additional images with one or more of the images in the first sequence to form a second sequence of images; unmixing the second sequence of images into data corresponding to a second set of unmixed images; and displaying information about the sample as a function of time based on the data corresponding to the first and second sets of unmixed images.
摘要翻译：公开的方法包括：获取样本的多个图像的第一序列，其中第一序列中的每个图像对应于不同的频谱加权函数; 将第一序列图像混合成对应于第一组非混合图像的数据，其中第一组中的每个未混合图像在第一时间对应于多个分量中的不同组分的样本中的空间分布; 获取样本的一个或多个附加图像并将附加图像与第一序列中的一个或多个图像组合以形成第二图像序列; 将所述第二图像序列解混合成对应于第二组未混合图像的数据; 并且基于与第一组和第二组非混合图像相对应的数据，显示关于样本的信息作为时间的函数。

2. 发明授权

US07526114B2 Analysis, secure access to, and transmission of array images 有权
标题翻译：分析，安全访问和传输阵列图像
公开(公告)号：US07526114B2
公开(公告)日：2009-04-28
申请号：US10714203
申请日：2003-11-14
申请人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
发明人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
摘要翻译：系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中许多受体与微粒或微珠相关。编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

3. 发明申请

US20060222226A1 Analysis, secure access to, and transmission of array images 审中-公开
公开(公告)号：US20060222226A1
公开(公告)日：2006-10-05
申请号：US11439598
申请日：2006-05-23
申请人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
发明人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

4. 发明申请

US20080200818A1 Surface measurement apparatus and method using parallax views 审中-公开
标题翻译：表面测量装置和使用视差视图的方法
公开(公告)号：US20080200818A1
公开(公告)日：2008-08-21
申请号：US12005474
申请日：2007-12-27
申请人： Scott Determan , Peter Miller
发明人： Scott Determan , Peter Miller
IPC分类号： A61B6/04
CPC分类号： A61B5/1077 , A61B5/0064 , A61B90/20 , A61B90/36 , A61B2090/061 , A61B2090/373 , G01B11/24 , G06T7/593 , G06T2207/10012 , G06T2207/10064 , G06T2207/30004
摘要： The invention provides for surface mapping of in-vivo imaging subjects using a single camera having a lens which is not telecentric in object space, and a moveable stage on which a subject animal for in-vivo imaging is placed. Images are taken and the stage is moved by known amounts, and the height of individual features on the subject is determined through analysis of how much the feature shifts in the image, given the known stage displacement and lens placement. A mesh or other surface can be constructed from individual features, to provide a map of the subject. Alternatively, two cameras are used in a calibrated stereo viewing arrangement. Resolution of 0.5 mm or better can be attained for mice and similarly sized subjects.
摘要翻译：本发明提供使用具有在物体空间中不远心的透镜的单个照相机的体内成像对象的表面映射以及放置用于体内成像的被摄体动物的可移动台。拍摄图像并且阶段以已知的量移动，并且通过分析图像中的特征移动多少来确定被摄体上的各个特征的高度，给定已知的位移和透镜放置。网格或其他表面可以从各个特征构建，以提供主体的地图。或者，在校准的立体观看布置中使用两个相机。对于小鼠和类似大小的受试者，可以获得0.5mm或更好的分辨率。

5. 发明申请

US20110251093A1 ANALYSIS, SECURE ACCESS TO, AND TRANSMISSION OF ARRAY IMAGES 有权
标题翻译：分析，安全访问和传输阵列图像
公开(公告)号：US20110251093A1
公开(公告)日：2011-10-13
申请号：US13084869
申请日：2011-04-12
申请人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
发明人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
IPC分类号： C40B30/04
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
摘要翻译：系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中许多受体与微粒或微珠相关。编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

6. 发明申请

US20080204697A1 Surface measurement apparatus and method using depth of field 有权
标题翻译：表面测量装置和使用景深的方法
公开(公告)号：US20080204697A1
公开(公告)日：2008-08-28
申请号：US12005471
申请日：2007-12-27
申请人： Peter Domenicali , Clifford Hoyt , Scott Determan , Peter Miller
发明人： Peter Domenicali , Clifford Hoyt , Scott Determan , Peter Miller
IPC分类号： G01C11/12
CPC分类号： G01C11/12
摘要： The invention provides for surface mapping of in-vivo imaging subjects using a single camera and a moveable stage on which a subject animal for in-vivo imaging is placed. Images are taken and the stage is moved by known amounts along the optical axis, and the heights of individual features on the subject are determined through analysis of focus, given the known stage displacement. Alternatively, height of sub-regions of the subject are determined through analysis of focus. A mesh or other surface can be constructed from individual features, to provide a surface map of the subject. Accuracy of 0.5 mm or better can be attained for mice and similarly sized subjects.
摘要翻译：本发明提供了使用单个照相机和放置用于体内成像的受试动物的可移动阶段的体内成像对象的表面映射。拍摄图像并且沿着光轴移动已知量的阶段，并且考虑已知的阶段位移，通过对焦点的分析来确定对象上的个体特征的高度。或者，通过对焦点的分析确定受试者的子区域的高度。网格或其他表面可以从各个特征构造，以提供主体的表面图。对于小鼠和类似大小的受试者，可以获得0.5mm或更好的精度。

7. 发明授权

US08712123B2 Analysis, secure access to, and transmission of array images 有权
标题翻译：分析，安全访问和传输阵列图像
公开(公告)号：US08712123B2
公开(公告)日：2014-04-29
申请号：US13084869
申请日：2011-04-12
申请人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
发明人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
摘要翻译：系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中许多受体与微粒或微珠相关。编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

8. 发明申请

US20110249911A1 SPECTRAL UNMIXING FOR VISUALIZATION OF SAMPLES 有权
标题翻译：用于可视化样品的光谱
公开(公告)号：US20110249911A1
公开(公告)日：2011-10-13
申请号：US12755831
申请日：2010-04-07
申请人： Scott Determan , Peter J. Miller
发明人： Scott Determan , Peter J. Miller
IPC分类号： G06K9/36
CPC分类号： G06K9/0014
摘要： Disclosed methods include: acquiring a first sequence of multiple images of a sample, with each image in the first sequence corresponding to a different spectral weighting function; unmixing the first sequence of images into data corresponding to a first set of unmixed images, where each unmixed image in the first set corresponds to a spatial distribution in the sample of a different one of multiple components at a first time; acquiring one or more additional images of the sample and combining the additional images with one or more of the images in the first sequence to form a second sequence of images; unmixing the second sequence of images into data corresponding to a second set of unmixed images; and displaying information about the sample as a function of time based on the data corresponding to the first and second sets of unmixed images.
摘要翻译：公开的方法包括：获取样本的多个图像的第一序列，其中第一序列中的每个图像对应于不同的频谱加权函数; 将第一序列图像混合成对应于第一组非混合图像的数据，其中第一组中的每个未混合图像在第一时间对应于多个分量中的不同组分的样本中的空间分布; 获取样本的一个或多个附加图像并将附加图像与第一序列中的一个或多个图像组合以形成第二图像序列; 将所述第二图像序列解混合成对应于第二组未混合图像的数据; 并且基于与第一组和第二组非混合图像相对应的数据，显示关于样本的信息作为时间的函数。

9. 发明授权

US07782470B2 Surface measurement apparatus and method using depth of field 有权
标题翻译：表面测量装置和使用景深的方法
公开(公告)号：US07782470B2
公开(公告)日：2010-08-24
申请号：US12005471
申请日：2007-12-27
申请人： Peter Domenicali , Clifford Hoyt , Scott Determan , Peter Miller
发明人： Peter Domenicali , Clifford Hoyt , Scott Determan , Peter Miller
IPC分类号： G01B11/14
CPC分类号： G01C11/12
摘要： The invention provides for surface mapping of in-vivo imaging subjects using a single camera and a moveable stage on which a subject animal for in-vivo imaging is placed. Images are taken and the stage is moved by known amounts along the optical axis, and the heights of individual features on the subject are determined through analysis of focus, given the known stage displacement. Alternatively, height of sub-regions of the subject are determined through analysis of focus. A mesh or other surface can be constructed from individual features, to provide a surface map of the subject. Accuracy of 0.5 mm or better can be attained for mice and similarly sized subjects.
摘要翻译：本发明提供了使用单个照相机和放置用于体内成像的受试动物的可移动阶段的体内成像对象的表面映射。拍摄图像并且沿着光轴移动已知量的阶段，并且考虑已知的阶段位移，通过对焦点的分析来确定对象上的个体特征的高度。或者，通过对焦点的分析确定受试者的子区域的高度。网格或其他表面可以从各个特征构造，以提供主体的表面图。对于小鼠和类似大小的受试者，可以获得0.5mm或更好的精度。

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