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1. 发明授权

US06727083B2 Protein capable of catalyzing transamination stereoselectively, gene encoding said protein and use thereof 失效
标题翻译：能够立体选择性地催化转氨酶的蛋白质，编码所述蛋白质的基因及其用途
公开(公告)号：US06727083B2
公开(公告)日：2004-04-27
申请号：US10067291
申请日：2002-02-07
申请人： Yoshiki Takashima , Satoshi Mitsuda , Marco Wieser
发明人： Yoshiki Takashima , Satoshi Mitsuda , Marco Wieser
IPC分类号： C12N910
CPC分类号： C12N9/1096 , C12P41/009
摘要： DNA encoding a novel protein from Mycobacterium aurum SC-S423 capable of converting acetophenone to an optically active 1-phenylethlamine in the presence of a racemic mixture of sec-butylamine is provided, along with a vector and host cell comprising the same and a method of producing the same.
摘要翻译：提供了编码来自能够在仲丁胺的外消旋混合物存在下将苯乙酮转化为光学活性的1-苯乙基胺的分枝杆菌SC-S423的新型蛋白质的DNA，以及包含其的载体和宿主细胞以及生产相同。

2. 发明授权

US06413752B1 Protein capable of catalyzing transamination stereoselectively, gene encoding said protein and use thereof 失效
标题翻译：能够立体选择性地催化转氨酶的蛋白质，编码所述蛋白质的基因及其用途
公开(公告)号：US06413752B1
公开(公告)日：2002-07-02
申请号：US09527522
申请日：2000-03-16
申请人： Yoshiki Takashima , Satoshi Mitsuda , Marco Wieser
发明人： Yoshiki Takashima , Satoshi Mitsuda , Marco Wieser
IPC分类号： C12N910
CPC分类号： C12N9/1096 , C12P41/009
摘要： A novel protein from Mycobacterium aurum SC-D423 capable of converting acetophenone to an optically active 1-phenylethylamine in the presence of a racemic mixture of sec-butylamine is provided.
摘要翻译：提供了在仲丁胺的外消旋混合物存在下能够将苯乙酮转化为光学活性1-苯基乙胺的来自分枝杆菌aurum SC-D423的新型蛋白质。

3. 发明授权

US06306634B1 Esterase gene and its use 失效
标题翻译：酯酶基因及其用途
公开(公告)号：US06306634B1
公开(公告)日：2001-10-23
申请号：US08979170
申请日：1997-11-26
申请人： Takeshi Ishii , Satoshi Mitsuda
发明人： Takeshi Ishii , Satoshi Mitsuda
IPC分类号： C12N918
CPC分类号： C12P7/26 , C12N9/18 , C12P7/38 , C12P41/004
摘要： An isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I; wherein R1 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl or C1-C4 haloalkyl, to produce the cyclopentenolone of formula I in (S)-form, and hybridizing to the base sequence of SEQ ID NO:1, is useful for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals or other active products.
摘要翻译：编码能够引起式I的环戊烯醇酮的有机羧酸酯的不对称水解的酯酶的分离的酯酶基因;其中R1是C1-C10烷基，C2-C10链烯基，C2-C10炔基或C1-C4卤代烷基，产生（S） - 型的式I的环戊烯醇酮，并与SEQ ID NO：1的碱基序列杂交，可用于工业上有利地生产作为药物中间体的式I的光学活性的环戊烯醇酮，农药或其他活性产品。

4. 发明授权

US06184008B2 Production of optically active sphingoid compound 失效
标题翻译：光学活性鞘氨醇化合物的制备
公开(公告)号：US06184008B2
公开(公告)日：2001-02-06
申请号：US09336601
申请日：1999-06-21
申请人： Hiromichi Ohta , Takeshi Sugai , Takeshi Ishii , Satoshi Mitsuda
发明人： Hiromichi Ohta , Takeshi Sugai , Takeshi Ishii , Satoshi Mitsuda
IPC分类号： C12P1302
CPC分类号： C07C233/17 , C12N9/18 , C12P13/02 , C12P41/004
摘要： An industrially advantageous production method of an optically active alcohol useful for cosmetics and medical supplies or production intermediates thereof using an esterase having an ability to selectively hydrolyze an optically active sphingoid compound.
摘要翻译：可用于化妆品和医疗用途的光学活性醇的工业上有利的生产方法或其使用具有选择性水解旋光性类鞘氨醇化合物的能力的酯酶的生产中间体。

5. 发明授权

US6087145A Esterase gene and its use 失效
标题翻译：酯酶基因及其用途
公开(公告)号：US6087145A
公开(公告)日：2000-07-11
申请号：US978589
申请日：1997-11-26
申请人： Takeshi Ishii , Satoshi Mitsuda
发明人： Takeshi Ishii , Satoshi Mitsuda
IPC分类号： C12N15/09 , C07H21/04 , C12N1/21 , C12N9/16 , C12N9/18 , C12N15/00 , C12N15/55 , C12P7/38 , C12P41/00 , C12R1/01 , C12R1/19 , C12N1/00 , C12N5/10 , C12N15/63
CPC分类号： C12P7/38 , C12N9/18 , C12P41/004
摘要： An isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I: ##STR1## wherein R.sub.1 is hydrogen or methyl, and R.sub.2 is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.1 -C.sub.4 haloalkyl, a C.sub.5 -C.sub.9 aliphatic hydrocarbon moiety which may be optionally protected on the terminal hydroxyl group thereof, or a C.sub.5 -C.sub.9 fatty acid residue which may be optionally protected on the terminal carboxyl group thereof, to produce the cyclopentenolone of formula I in (R)-form, and hybridizing to the base sequence of SEQ ID NO:1, is useful for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals or other active products.
摘要翻译：编码能够导致式I的环戊烯醇酮的有机羧酸酯不对称水解的酯酶的分离的酯酶基因：其中R1是氢或甲基，R2是C1-C10烷基，C2-C10链烯基，C2-C10炔基，C 1 -C 4卤代烷基，可以在其末端羟基上任意保护的C 5 -C 9脂族烃部分或可以任选地保护在其末端羧基上的C5-C9脂肪酸残基，以制备环戊烯醇酮（R）形式的式I化合物和与SEQ ID NO：1的碱基序列杂交可用于工业上有利地生产作为药物，农药或其它活性产物的中间体的式I的光学活性环戊烯酮。

6. 发明授权

US4985365A Process for producing optically active benzyl alcohol compound 失效
标题翻译：光学活性苄醇化合物的制造方法
公开(公告)号：US4985365A
公开(公告)日：1991-01-15
申请号：US201927
申请日：1988-06-03
申请人： Satoshi Mitsuda , Noritada Matsuo , Hideo Hirohara
发明人： Satoshi Mitsuda , Noritada Matsuo , Hideo Hirohara
IPC分类号： A01N37/38 , C12P7/02 , C12P13/00 , C12P41/00
CPC分类号： C12P13/004 , A01N37/38 , C07C255/00 , C12P41/004 , Y10S435/822
摘要： A process for preparing resolved (S)-(-)-.alpha.-cyano-3-phenoxybenzyl alcohol or an (S)-isomer-rich optically active .alpha.-cyano-3-phenoxybenzyl alcohol compound.
摘要翻译：一种制备分解的（S） - （ - ） - α-氰基-3-苯氧基苄醇或（S） - 异构体的光学活性α-氰基-3-苯氧基苄醇化合物的方法。

7. 发明授权

US06514740B1 Esterase gene and its use 失效
标题翻译：酯酶基因及其用途
公开(公告)号：US06514740B1
公开(公告)日：2003-02-04
申请号：US09842898
申请日：2001-04-27
申请人： Takeshi Ishii , Satoshi Mitsuda
发明人： Takeshi Ishii , Satoshi Mitsuda
IPC分类号： C12N918
CPC分类号： C12P7/26 , C12N9/18 , C12P7/38 , C12P41/004
摘要： An isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I: wherein R1 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl or C1-C4 haloalky, to produce the cyclopentenolone of formula I in (S)-form, and hybridizing to the base sequence of SEQ ID NO:1, is useful for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals or other active products.
摘要翻译：编码能够使式I的环戊烯醇酮的有机羧酸酯不对称水解的酯酶的分离的酯酶基因：其中R1是C1-C10烷基，C2-C10链烯基，C2-C10炔基或C1-C4卤代烷基，产生（S） - 型的式I的环戊烯醇酮，并与SEQ ID NO：1的碱基序列杂交，可用于工业上有利地生产作为药物中间体的式I的光学活性的环戊烯醇酮，农药或其他活性产品。

8. 发明授权

US6127152A Process for producing nucleoside derivatives 失效
标题翻译：制备核苷衍生物的方法
公开(公告)号：US6127152A
公开(公告)日：2000-10-03
申请号：US127124
申请日：1998-07-30
申请人： Hiromichi Ohta , Takeshi Sugai , Takeshi Ishii , Satoshi Mitsuda
发明人： Hiromichi Ohta , Takeshi Sugai , Takeshi Ishii , Satoshi Mitsuda
IPC分类号： C12N9/16 , C07H19/06 , C07H19/16 , C12N9/18 , C12N15/09 , C12P19/38 , C12P19/40
CPC分类号： C12P19/385 , C12N9/18 , C12P19/40
摘要： There is disclosed a process for producing a nucleoside derivative of the formula [I]: ##STR1## characterized by contacting 2',3',5'-O-triacylribonucleoside derivative of the formula [II]: ##STR2## with an ester hydrolase: (i) capable of regio-selectively deacylating the acyl group at 5'-O-position in the formula [II] above, and(ii) having an amino acid sequence encoded by a gene which hybridizes to a nucleotide sequence encoding an amino acid sequence of SEQ ID NO:1.
摘要翻译：公开了具有式[I]的核苷衍生物的方法：其特征在于使式[II]的2'，3'，5'-O-三酰基核糖核苷衍生物与酯水解酶接触：（i）能够选择性地使上述式[II]中的5'-O-位的酰基取代酰基，和（ii）具有与编码SEQ ID NO的氨基酸序列的核苷酸序列杂交的基因编码的氨基酸序列：1。

9. 发明授权

US5395758A Process for production of amide compounds using agrobacterium radiobacter 失效
标题翻译：使用农杆菌的生产酰胺化合物的方法
公开(公告)号：US5395758A
公开(公告)日：1995-03-07
申请号：US54250
申请日：1993-04-30
申请人： Yoshiki Takashima , Kazuo Kumagai , Satoshi Mitsuda
发明人： Yoshiki Takashima , Kazuo Kumagai , Satoshi Mitsuda
IPC分类号： C12N1/20 , C12P13/02 , C12P17/12 , C12R1/01 , C12P13/00
CPC分类号： C12R1/01 , C12P13/02 , C12P17/12
摘要： There is disclosed a process for production of amide compounds which includes converting a nitrile compound into an amide compound using a cultured broth of bacterial cells, or bacterial cells or materials obtainable by treating bacterial cells, the bacterial cells being cells of a microorganism Agrobacterium radiobacter FERM BP-3843, having activity to convert nitrile compounds into corresponding amide compounds.
摘要翻译：公开了一种酰胺化合物的制造方法，其包括使用培养的细菌细胞培养液将腈化合物转化为酰胺化合物，或细菌细胞或通过处理细菌细胞获得的材料，所述细菌细胞为微生物农杆菌FERM BP-3843，具有将腈化合物转化为相应的酰胺化合物的活性。

10. 发明授权

US5180671A Method for producing optically active cyclopropane carboxylic acid 失效
标题翻译：光学活性环丙烷羧酸的制备方法
公开(公告)号：US5180671A
公开(公告)日：1993-01-19
申请号：US620385
申请日：1990-11-30
申请人： Kanji Nishizawa , Satoshi Mitsuda , Ryohei Komaki , Masako Sugimoto , Chiaki Sugiki , Yasutaka Ogami , Kazumi Sonoda , Fumitaka Kishimoto
发明人： Kanji Nishizawa , Satoshi Mitsuda , Ryohei Komaki , Masako Sugimoto , Chiaki Sugiki , Yasutaka Ogami , Kazumi Sonoda , Fumitaka Kishimoto
IPC分类号： C07C51/09 , C12P7/40 , C12P41/00
CPC分类号： C12P41/005 , C07C51/09 , C12P7/40
摘要： The present relates to a process for preparing optically active cyclopropane carboxylic acid derivatives of salts thereof represented by the formula (III) ##STR1## wherein X is chlorine atom, bromine atom, methyl group or trifluoromethyl group and R' is hydrogen atom or metal ion, by asymmetrically hydrolyzing cyclopropane carboxylic acid esters having the formula (II) ##STR2## wherein X is as defined above and R is C.sub.1-4 alkyl group or halogen-substituted C.sub.1-4 alkyl group with specific strains of microorganisms or esterase derived therefrom.
摘要翻译： PCT No.PCT / JP87 / 00244 Sec。 371日期1987年12月16日 102（e）1987年12月16日日期PCT提交1987年4月16日PCT公布。公开号WO87 / 06269 日本专利公开号为1987年10月22日。本发明涉及一种制备式（III）表示的其光学活性的环丙烷羧酸衍生物的方法，其中X为氯原子，溴原子，甲基或三氟甲基基团和R'是氢原子或金属离子，通过不对称地水解具有式（II）的环丙烷羧酸酯其中X如上所定义，R是C 1-4烷基或卤素取代的C1- 4个具有微生物菌株或由其衍生的酯酶的烷基。

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