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1. 发明授权

US09778260B2 Process for the detection and early serotyping of the dengue virus 有权
公开(公告)号：US09778260B2
公开(公告)日：2017-10-03
申请号：US14113631
申请日：2012-04-26
申请人： Frederic Bedin , Sandrine Busseret , Marine Steidel
发明人： Frederic Bedin , Sandrine Busseret , Marine Steidel
IPC分类号： C07K16/10 , C12Q1/70 , C07K14/005 , C12N7/00 , A61K39/00 , G01N33/569 , G01N33/68
CPC分类号： G01N33/56983 , G01N33/6851 , G01N2333/185 , G01N2800/56 , Y02A50/53
摘要： Disclosed is a process for in vitro detection of an infection by a dengue virus in an individual, including the following steps: contacting a blood sample from the individual with a ligand specific to the NS1 protein of said dengue virus, to capture NS1 protein if it is present in the blood sample, said ligand being immobilized on a solid support; detecting the presence of NS1 protein via a mass spectrometry reading; and if NS1 protein is detected, concluding that the individual has been infected by dengue virus.

2. 发明授权

US09062099B2 Prodefensin-A6 assay method for the in vitro diagnosis of colorectal cancer 有权
标题翻译： Prodefensin-A6测定方法用于体外诊断结肠直肠癌
公开(公告)号：US09062099B2
公开(公告)日：2015-06-23
申请号：US13260854
申请日：2010-04-01
申请人： Yasemin Ataman-Önal , Corinne Beaulieu , Sandrine Busseret , Jean-Philippe Charrier , Geneviève Choquet-Kastylevsky , Dominique Rolland
发明人： Yasemin Ataman-Önal , Corinne Beaulieu , Sandrine Busseret , Jean-Philippe Charrier , Geneviève Choquet-Kastylevsky , Dominique Rolland
IPC分类号： G01N33/53 , C07K16/18 , C07K16/30 , G01N33/574
CPC分类号： G01N33/74 , C07K16/18 , C07K16/30 , C07K16/3046 , C07K2317/34 , G01N33/57419 , G01N2333/4704 , G01N2333/4721
摘要： The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the Prodefensin-A6 tumour marker in a biological sample taken from a patient suspected of having colorectal cancer, it being possible for said method to be used both in early diagnosis, screening, therapeutic follow-up and prognosis, and in relapse diagnosis in relation to colorectal cancer.
摘要翻译：本发明涉及通过测定取自怀疑患有结肠直肠癌的患者的生物样品中Proproensin-A6肿瘤标志物的存在来确定结肠直肠癌体外诊断的方法，所述方法可用于两者在早期诊断，筛查，治疗后续和预后以及与结肠直肠癌相关的复发诊断中。

3. 发明申请

US20100136539A1 EZRIN ASSAY METHOD FOR THE IN VITRO DIAGNOSIS OF COLORECTAL CANCER 有权
标题翻译： EZRIN测定方法用于阴道癌的体外诊断
公开(公告)号：US20100136539A1
公开(公告)日：2010-06-03
申请号：US12452038
申请日：2008-07-10
申请人： Monique Arpin , Yasmin Ataman-Onal , Corinne Beaulieu , Sandrine Busseret , Jean-Philippe Charrier , Genevieve Choquet-Kastylevsky , Dominique Rolland
发明人： Monique Arpin , Yasmin Ataman-Onal , Corinne Beaulieu , Sandrine Busseret , Jean-Philippe Charrier , Genevieve Choquet-Kastylevsky , Dominique Rolland
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/573 , C07K7/06 , C07K7/08 , C07K16/00
CPC分类号： C07K7/08 , C07K7/06 , G01N33/57419 , G01N2333/705
摘要： A method for the in vitro diagnosis of colorectal cancer by determining the presence of the Ezrin tumor marker in a biological sample taken from a patient suspected of having colorectal cancer using at least one anti-Ezrin monoclonal antibody directed against an Ezrin epitope chosen from the epitopes of sequence SEQ ID No.1, SEQ ID No.2, SEQ ID No.3, SEQ ID No.4+SEQ ID No.5, SEQ ID No.6+SEQ ID No.7 and SEQ ID No.8. Said method can be used for early diagnosis, screening, therapeutic follow-up and prognosis, and also for relapse diagnosis in relation to colorectal cancer.
摘要翻译：通过使用至少一种针对选自表位的Ezrin表位的抗Ezrin单克隆抗体，通过确定从疑似患有结肠直肠癌的患者的生物样品中确定Ezrin肿瘤标志物的存在而进行体外诊断结肠直肠癌的方法序列SEQ ID No.1，SEQ ID No.2，SEQ ID No.3，SEQ ID No.4 + SEQ ID No.5，SEQ ID No.6 + SEQ ID No.7和SEQ ID No.8。所述方法可用于早期诊断，筛查，治疗后续和预后，以及与结肠直肠癌相关的复发诊断。

4. 发明申请

US20140017710A1 PROCESS AND KIT FOR IN VITRO DIAGNOSIS OF A PROSTATE CANCER 审中-公开
标题翻译：用于前列腺癌的体外诊断的方法和工具包
公开(公告)号：US20140017710A1
公开(公告)日：2014-01-16
申请号：US13990211
申请日：2011-12-07
申请人： Yasemin Ataman-Onal , Sandrine Busseret , Genevieve Choquet-Kastylevsky , Emanuelle Gallet-Gorius , Gaspard Gervasi , Michele Guillotte , Celine Hamelin
发明人： Yasemin Ataman-Onal , Sandrine Busseret , Genevieve Choquet-Kastylevsky , Emanuelle Gallet-Gorius , Gaspard Gervasi , Michele Guillotte , Celine Hamelin
IPC分类号： G01N33/68
摘要： The object of the present invention is a process for in vitro diagnosis of a prostate cancer, according to which a urine sample to be analysed is contacted with two antibodies, a capture antibody and a detection antibody, one of the two antibodies being directed against the first repeat domain of native human Annexin A3 identified as SEQ ID NO: 1, and the other of the two antibodies being directed against the fourth repeat domain of native human Annexin A3, identified as SEQ ID NO: 2, as well as a kit for implementing the process.
摘要翻译：本发明的目的是一种用于体外诊断前列腺癌的方法，根据该方法将要分析的尿液样品与两种抗体，捕获抗体和检测抗体接触，两种抗体中的一种针对识别为SEQ ID NO：1的天然人膜联蛋白A3的第一重复结构域，并且两种抗体中的另一种针对天然人膜联蛋白A3的第四重复结构域，鉴定为SEQ ID NO：2，以及用于实施过程。

5. 发明申请

US20070254317A1 Method for Detecting the Activatable Free Form of Psa and the Use Thereof for Diagnosing Benign Pathologies of the Prostate and Adenocarcinoma of the Prostate 审中-公开
标题翻译：检测Psa可活化自由形式的方法及其用途，用于诊断前列腺前列腺和腺癌的良性病理
公开(公告)号：US20070254317A1
公开(公告)日：2007-11-01
申请号：US10590272
申请日：2005-03-01
申请人： Sandrine Busseret-Michel , Colette Jolivet-Reynaud
发明人： Sandrine Busseret-Michel , Colette Jolivet-Reynaud
IPC分类号： G01N33/53
CPC分类号： G01N33/57434 , G01N2333/96455
摘要： The present invention relates to a method for the in vitro diagnosing of a benign pathology of the prostate or of an adenocarcinoma of the prostate, characterized in that it comprises the step consisting of detection, in a biological sample from a patient suspected of suffering from a benign pathology of the prostate or from an adenocarcinoma of the prostate, of the activatable free form of PSA. This method of diagnosis can be carried out by means of the steps consisting in: i) bringing a binding partner capable of binding specifically to activatable free PSA into contact with a biological sample from a patient suspected of suffering from a benign pathology of the prostate or of an adenocarcinoma of the prostate, ii) demonstrating the capture of the activatable free form of PSA by said binding partner, iii) calculating the ratio of the amount of activatable free form of PSA detected in step ii) to the amount of a form of PSA other than the activatable free form, present in a sample of the same nature taken from the same individual, and iv) determining whether the patients are suffering from an adenocarcinoma of the prostate or from a benign pathology of the prostate by comparing the value of the ratio determined in step iii) with a predetermined threshold value, chosen according to the type of ratio used and representative of the detection limit of each pathology.
摘要翻译：本发明涉及用于体外诊断前列腺或前列腺腺癌的良性病理学的方法，其特征在于它包括以下步骤：检测来自怀疑患有前列腺的良性病理学或来自前列腺的腺癌的可激活的游离形式的PSA。这种诊断方法可以通过以下步骤进行：i）使能够特异性结合可活化游离PSA的结合配偶体与怀疑患有前列腺良性病变的患者的生物样品接触，或的前列腺腺癌，ii）证明通过所述结合配偶体捕获可激活的游离形式的PSA，iii）计算在步骤ii）中检测到的PSA的可活化游离形式的量与所述结合配偶体形式的量的比例存在于从相同个体获得的相同性质的样品中的PSA以外的PSA，以及iv）通过比较前列腺的患者是否患有前列腺腺癌或从前列腺的良性病理确定根据所使用的比例类型选择具有预定阈值的步骤iii）中确定的比例，并代表每个病理学的检测限。

6. 发明申请

US20140051067A1 PROCESS FOR THE DETECTION AND EARLY SEROTYPING OF THE DENGUE VIRUS 有权
标题翻译：用于检测和早期登录登革热病毒的方法
公开(公告)号：US20140051067A1
公开(公告)日：2014-02-20
申请号：US14113631
申请日：2012-04-26
申请人： Frederic Bedin , Sandrine Busseret , Marine Steidel
发明人： Frederic Bedin , Sandrine Busseret , Marine Steidel
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , G01N33/6851 , G01N2333/185 , G01N2800/56 , Y02A50/53
摘要： Disclosed is a process for in vitro detection of an infection by a dengue virus in an individual, including the following steps: contacting a blood sample from the individual with a ligand specific to the NS1 protein of said dengue virus, to capture NS1 protein if it is present in the blood sample, said ligand being immobilized on a solid support; detecting the presence of NS1 protein via a mass spectrometry reading; and if NS1 protein is detected, concluding that the individual has been infected by dengue virus.
摘要翻译：公开了用于体外检测个体中登革热病毒感染的方法，包括以下步骤：将来自个体的血液样品与所述登革热病毒的NS1蛋白特异性配体接触，以捕获NS1蛋白，如果存在于血液样品中，所述配体被固定在固体支持物上; 通过质谱读数检测NS1蛋白的存在; 如果检测到NS1蛋白，则认定个体已被登革热病毒感染。

7. 发明授权

US08367806B2 Protein disulfide isomerase assay method for the in vitro diagnosis of colorectal cancer 有权
标题翻译：蛋白二硫键异构酶测定方法用于体外诊断结肠直肠癌
公开(公告)号：US08367806B2
公开(公告)日：2013-02-05
申请号：US12999242
申请日：2009-07-09
申请人： Yasemin Ataman-Onal , Corinne Beaulieu , Sandrine Busseret , Jean-Philippe Charrier , Genevieve Choquet-Kastylevsky , Dominique Rolland
发明人： Yasemin Ataman-Onal , Corinne Beaulieu , Sandrine Busseret , Jean-Philippe Charrier , Genevieve Choquet-Kastylevsky , Dominique Rolland
IPC分类号： C07K16/00 , A61K39/395 , A61K35/12
CPC分类号： C12N9/90 , G01N33/57419 , G01N2333/99
摘要： A method for the in vitro diagnosis of colorectal cancer by determining the presence of the protein disulfide isomerase tumor marker in a biological sample taken from a patient suspected of having colorectal cancer using at least one anti-PDI monoclonal antibody directed against a PDI epitope chosen from the epitopes of sequence SEQ ID NO: 1, SEQ ID NO: 2 with an aromatic amino acid having a three-dimensional structure similar to that of PDI, and SEQ ID NO: 3.
摘要翻译：一种用于通过使用至少一种针对选自以下的PDI表位的抗PDI单克隆抗体来测定从疑似患有结肠直肠癌的患者的生物样品中存在蛋白质二硫键异构酶肿瘤标志物来进行体外诊断结肠直肠癌的方法。具有与PDI类似的三维结构的芳香族氨基酸的序列SEQ ID NO：1，SEQ ID NO：2的表位和SEQ ID NO：3。

8. 发明授权

US08361731B2 Ezrin assay method for the in vitro diagnosis of colorectal cancer 有权
标题翻译： Ezrin测定方法用于体外诊断结肠直肠癌
公开(公告)号：US08361731B2
公开(公告)日：2013-01-29
申请号：US12452038
申请日：2008-07-10
申请人： Monique Arpin , Yasmin Ataman-Onal , Corinne Beaulieu , Sandrine Busseret , Jean-Philippe Charrier , Genevieve Choquet-Kastylevsky , Dominique Rolland
发明人： Monique Arpin , Yasmin Ataman-Onal , Corinne Beaulieu , Sandrine Busseret , Jean-Philippe Charrier , Genevieve Choquet-Kastylevsky , Dominique Rolland
IPC分类号： G01N33/53 , G01N33/574
CPC分类号： C07K7/08 , C07K7/06 , G01N33/57419 , G01N2333/705
摘要： A method for the in vitro diagnosis of colorectal cancer by determining the presence of the Ezrin tumor marker in a biological sample taken from a patient suspected of having colorectal cancer using at least one anti-Ezrin monoclonal antibody directed against an Ezrin epitope chosen from the epitopes of sequence SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, SEQ ID No. 4+SEQ ID No. 5, SEQ ID No. 6+SEQ ID No. 7 and SEQ ID No. 8. Said method can be used for early diagnosis, screening, therapeutic follow-up and prognosis, and also for relapse diagnosis in relation to colorectal cancer.
摘要翻译：通过使用至少一种针对选自表位的Ezrin表位的抗Ezrin单克隆抗体，通过确定从疑似患有结肠直肠癌的患者的生物样品中确定Ezrin肿瘤标志物的存在而进行体外诊断结肠直肠癌的方法的序列SEQ ID No.1，SEQ ID No.2，SEQ ID No.3，SEQ ID No.4 + SEQ ID No.5，SEQ ID No.6 + SEQ ID No.7和SEQ ID No.8。所述方法可用于早期诊断，筛查，治疗后续和预后，以及与结肠直肠癌相关的复发诊断。

9. 发明申请

US20120129200A1 PRODEFENSIN-A6 ASSAY METHOD FOR THE IN VITRO DIAGNOSIS OF COLORECTAL CANCER 有权
标题翻译： PRODEFENSIN-A6测定方法用于阴道癌的体外诊断
公开(公告)号：US20120129200A1
公开(公告)日：2012-05-24
申请号：US13260854
申请日：2010-04-01
申请人： Yasemin Ataman-Önal , Corinne Beaulieu , Sandrine Busseret , Jean-Philippe Charrier , Geneviève Choquet-Kastylevsky , Dominique Rolland
发明人： Yasemin Ataman-Önal , Corinne Beaulieu , Sandrine Busseret , Jean-Philippe Charrier , Geneviève Choquet-Kastylevsky , Dominique Rolland
IPC分类号： G01N33/577 , C07K16/18 , G01N33/566
CPC分类号： G01N33/74 , C07K16/18 , C07K16/30 , C07K16/3046 , C07K2317/34 , G01N33/57419 , G01N2333/4704 , G01N2333/4721
摘要： The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the Prodefensin-A6 tumour marker in a biological sample taken from a patient suspected of having colorectal cancer, it being possible for said method to be used both in early diagnosis, screening, therapeutic follow-up and prognosis, and in relapse diagnosis in relation to colorectal cancer.
摘要翻译：本发明涉及通过测定取自怀疑患有结肠直肠癌的患者的生物样品中Proproensin-A6肿瘤标志物的存在来确定结肠直肠癌体外诊断的方法，所述方法可用于两者在早期诊断，筛查，治疗后续和预后，以及与结肠直肠癌相关的复发诊断。

10. 发明申请

US20110104701A1 PROTEIN DISULFIDE ISOMERASE ASSAY METHOD FOR THE IN VITRO DIAGNOSIS OF COLORECTAL CANCER 有权
标题翻译：蛋白质差异异构体检测方法用于阴道癌的体外诊断
公开(公告)号：US20110104701A1
公开(公告)日：2011-05-05
申请号：US12999242
申请日：2009-07-09
申请人： Yasemin Ataman-Onal , Corinne Beaulieu , Sandrine Busseret , Jean-Philippe Charrier , Genevieve Choquet-Kastylevsky , Dominique Rolland
发明人： Yasemin Ataman-Onal , Corinne Beaulieu , Sandrine Busseret , Jean-Philippe Charrier , Genevieve Choquet-Kastylevsky , Dominique Rolland
IPC分类号： C12Q1/68 , G01N33/53 , C07K7/08 , C07K7/06 , C07K16/00
CPC分类号： C12N9/90 , G01N33/57419 , G01N2333/99
摘要： A method for the in vitro diagnosis of colorectal cancer by determining the presence of the protein disulfide isomerase tumor marker in a biological sample taken from a patient suspected of having colorectal cancer using at least one anti-PDI monoclonal antibody directed against a PDI epitope chosen from the epitopes of sequence SEQ ID NO: 1, SEQ ID NO: 2 with an aromatic amino acid having a three-dimensional structure similar to that of PDI, and SEQ ID NO: 3.
摘要翻译：一种用于通过使用至少一种针对选自以下的PDI表位的抗PDI单克隆抗体来测定从疑似患有结肠直肠癌的患者的生物样品中存在蛋白质二硫键异构酶肿瘤标志物来进行体外诊断结肠直肠癌的方法。具有与PDI类似的三维结构的芳香族氨基酸的序列SEQ ID NO：1，SEQ ID NO：2的表位和SEQ ID NO：3。

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