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1. 发明授权

US07442781B2 Diagnosis, prevention and treatment of cancer 有权
标题翻译：诊断，预防和治疗癌症
公开(公告)号：US07442781B2
公开(公告)日：2008-10-28
申请号：US10486101
申请日：2002-08-15
申请人： Uri Nir , Erez Pery , Sally Shpungin
发明人： Uri Nir , Erez Pery , Sally Shpungin
IPC分类号： C07H21/02 , C07H21/04 , A61K31/70 , A61K31/74
CPC分类号： C12N15/1137 , A61K38/00 , C07K16/18 , C07K2317/81 , C12N2310/14 , C12N2310/53 , C12Y207/10002 , G01N33/57496 , G01N33/6893 , G01N2333/4703
摘要： Methods and compositions for the diagnosis, prevention, and treatment of cancer are provided. More particularly, the present invention provides methods and compositions for the diagnosis, prevention, and treatment of cancer through detection and modulation of the expression of TMF/ARA160 and Fer.
摘要翻译：提供了诊断，预防和治疗癌症的方法和组合物。更具体地，本发明提供了通过检测和调节TMF / ARA160和Fer的表达来诊断，预防和治疗癌症的方法和组合物。

2. 发明申请

US20110028533A1 NOVEL FER -LIKE PROTEIN, PHARMACEUTICAL COMPOSITIONS CONTAINING IT AND METHOD FOR ITS USE 审中-公开
标题翻译：新型FER -LIKE蛋白，包含其的药物组合物及其使用方法
公开(公告)号：US20110028533A1
公开(公告)日：2011-02-03
申请号：US12866403
申请日：2009-02-05
申请人： Uri Nir , Adar Makovsky , Sally Shpungin
发明人： Uri Nir , Adar Makovsky , Sally Shpungin
IPC分类号： A61K31/711 , C07H21/04 , G01N33/53 , G01N33/574 , C07K14/00 , A61P35/00
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/14 , G01N33/57419 , G01N2333/9121
摘要： Provided is a novel Fer-like protein, referred to as “FerC” (Fer colorectal cancer). FerC is a 47kDa protein having a unique N-terminal sequence and was found to be present in six colon cancer cell-lines and in five hepatocarcinoma (liver cancer) cell-lines, but not in CCD33 normal colon epithelial cells or normal human and mouse fibroblasts. Depletion of FerC impairs cell-cycle progression and induces apoptotic death in treated colon cancer (CC) cells. Also provided are nucleotide sequences that are antisense to at least a portion of the N-terminal sequence, short interfering nucleotides including such an antisense sequence, as well as pharmaceutical compositions containing an antisense sequence. The present pharmaceutical composition may be used in the treatment of cancer, in particular, colorectal cancer and liver cancer.
摘要翻译：提供了一种新颖的Fer样蛋白，称为“FerC”（Fer结肠直肠癌）。 FerC是一种具有独特N末端序列的47kDa蛋白质，发现存在于六个结肠癌细胞系和五个肝癌（肝癌）细胞系中，但不存在于CCD33正常结肠上皮细胞或正常人和小鼠中成纤维细胞。 FerC的消耗会损害细胞周期进程，并在治疗结肠癌（CC）细胞中诱导凋亡死亡。还提供了与N末端序列的至少一部分，包括这种反义序列的短干扰核苷酸以及含有反义序列的药物组合物反义的核苷酸序列。本药物组合物可用于治疗癌症，特别是结肠直肠癌和肝癌。

3. 发明申请

US20050063973A1 Diagnosis, prevention and treatment of cancer 有权
标题翻译：诊断，预防和治疗癌症
公开(公告)号：US20050063973A1
公开(公告)日：2005-03-24
申请号：US10486101
申请日：2004-02-09
申请人： Uri Nir , Erez Pery , Sally Shpungin
发明人： Uri Nir , Erez Pery , Sally Shpungin
IPC分类号： A61K38/00 , C07K16/18 , C12N15/113 , G01N33/574 , G01N33/68 , A61K39/395 , C07K16/24
CPC分类号： C12N15/1137 , A61K38/00 , C07K16/18 , C07K2317/81 , C12N2310/14 , C12N2310/53 , C12Y207/10002 , G01N33/57496 , G01N33/6893 , G01N2333/4703
摘要： Methods and compositions for the diagnosis, prevention, and treatment of cancer are provided. More particularly, the present invention provides methods and compositions for the diagnosis, prevention, and treatment of cancer through detection and modulation of the expression of TMF/ARA160 and Fer.

4. 发明授权

US08653082B2 6-phenyl-2-[((piperidin-4-ylmethyl)-piperazin-1YL) or piperazin 1-ylmethyl)-piperidin-1-yl)]-imidazo[2,1-B][1,3,4]thiadiazole derivatives and their use 有权
标题翻译： 6-苯基-2 - [（（哌啶-4-基甲基） - 哌嗪-1-基）或哌嗪-1-基甲基） - 哌啶-1-基）] - 咪唑并[2,1-B] [1,3,4] 噻二唑衍生物及其用途
公开(公告)号：US08653082B2
公开(公告)日：2014-02-18
申请号：US13203172
申请日：2010-02-25
申请人： Uri Nir , Sally Shpungin , Etai Yaffe , Moshe Cohen
发明人： Uri Nir , Sally Shpungin , Etai Yaffe , Moshe Cohen
IPC分类号： A61K31/497 , C07D417/04
CPC分类号： C07D513/04
摘要： Heterocyclic compounds of formula (I), (II), (III) or a pharmaceutically acceptable salt thereof: wherein R1, R2 and R3 are each independently selected from hydrogen, halogen, C1-6alkyl, C2-6alkenyl, N—(C1-6alkyl)2, and N—(C2-6alkenyl)2, the C1-6alkyl and C2-6alkenyl being straight or branched; and Y1 and Y2 are selected from N and CH where one of Y1 and Y2 is N and the other is CH, are provided. Also provided are the synthesis of and pharmaceutical compositions including these compounds. These compounds and pharmaceutical compositions thereof can be used for the treatment of disorders, and in particular, cancer.
摘要翻译：式（I），（II），（III）的杂环化合物或其药学上可接受的盐：其中R 1，R 2和R 3各自独立地选自氢，卤素，C 1-6烷基，C 2-6烯基，N- 6烷基）2和N-（C 2-6烯基）2，C 1-6烷基和C 2-6烯基是直链或支链的; Y1和Y2选自其中Y1和Y2之一是N并且另一个是CH的N和CH。还提供了包括这些化合物的药物组合物的合成。这些化合物及其药物组合物可用于治疗疾病，特别是癌症。

5. 发明申请

US20100151452A1 Methods and Systems for Searching for Regulators of the Fer Protein and for Monitoring the Effects of the Fer Protein 审中-公开
标题翻译：搜索Fer蛋白调节因子和监测Fer蛋白影响的方法和系统
公开(公告)号：US20100151452A1
公开(公告)日：2010-06-17
申请号：US12225238
申请日：2007-03-20
申请人： Uri Nir , Orel Pasder , Sally Shpungin , Etai Yaffe
发明人： Uri Nir , Orel Pasder , Sally Shpungin , Etai Yaffe
IPC分类号： C12Q1/68
CPC分类号： C12Y207/10002 , C12N9/1205 , C12N15/1137 , C12N2310/14
摘要： A method for modulating a Fer mediated pathway in a cell, for monitoring the effect of a Fer protein in a cell, for altering and inhibiting one or more effects of a Fer protein in a cell is provided. The method includes modulating, monitoring, altering or inhibiting any one or more or of the association of the Fer protein to PP1; the phosphorylation of PP1, the phosphatase activity of PP1, and the tumor suppressive activity of the retinoblastoma protein (RB). In a preferred embodiment, modulating a Fer mediated pathway in a cell, monitoring the effect of a Fer protein in a cell, for altering and inhibiting one or more effects of a Fer protein in a cell involves administrating to a cell a compound having a molecular weight of up to 1000 Dalton capable of modulating, altering or inhibiting an effect of Fer. Further provided is a method for determining whether a substance is capable of altering or inhibiting an effect of a Fer protein in a cell. The method includes presenting the substance to a first cell expressing an exogenous Fer gene or Fer cDNA; and measuring a rate of proliferation of the cell. A significant difference between the growth rate of the first cell and the growth rate of a second cell not expressing an exogenous Fer gene or Fer cDNA indicates that the substance is capable of altering a fer mediated pathway.
摘要翻译：提供了调节细胞中Fer介导途径的方法，用于监测细胞中Fer蛋白的作用，用于改变和抑制细胞中Fer蛋白的一种或多种作用。该方法包括调节，监测，改变或抑制Fer蛋白与PP1的任何一种或多种或结合; PP1的磷酸化，PP1的磷酸酶活性以及视网膜母细胞瘤蛋白（RB）的肿瘤抑制活性。在优选的实施方案中，调节细胞中Fer介导的途径，监测Fer蛋白在细胞中的作用，用于改变和抑制细胞中Fer蛋白的一种或多种作用涉及向细胞施用具有分子重量高达1000道尔顿能够调节，改变或抑制Fer的作用。还提供了一种用于确定物质是否能够改变或抑制细胞中Fer蛋白的作用的方法。该方法包括将物质呈递给表达外源性Fer基因或Fer cDNA的第一个细胞; 并测量细胞增殖的速率。第一细胞的生长速率和不表达外源性Fer基因或Fer cDNA的第二细胞的生长速率之间的显着差异表明该物质能够改变fer介导的途径。

6. 发明授权

US08481572B2 Pharmaceutical compositions and methods for the treatment of cancer 有权
标题翻译：用于治疗癌症的药物组合物和方法
公开(公告)号：US08481572B2
公开(公告)日：2013-07-09
申请号：US12672157
申请日：2008-08-10
申请人： Uri Nir , Sally Shpungin , Etai Yaffe , Moshe Cohen
发明人： Uri Nir , Sally Shpungin , Etai Yaffe , Moshe Cohen
IPC分类号： A61K31/407 , A61K31/415 , A61K31/433 , A61K31/496 , A61K31/381 , A61K31/4162 , A61K31/429 , A61P35/00
CPC分类号： A61K31/407 , A61K31/415 , A61K31/433 , A61K31/4706 , A61K31/496 , C07D215/46 , C07D231/38 , C07D471/04 , C07D487/04 , C07D513/04
摘要： Provided is a pharmaceutical composition including as an active component a compound of formula (I): wherein X and (R1)n are as defined, and a physiological acceptable carrier. Also provided is a method for treating cancer including administering to an individual in need of such treatment an effective amount of the presently described pharmaceutical composition.
摘要翻译：本发明提供一种药物组合物，其包含作为活性成分的式（I）化合物：其中X和（R 1）n如上定义，和生理学上可接受的载体。还提供了治疗癌症的方法，包括向需要这种治疗的个体施用有效量的目前描述的药物组合物。

7. 发明申请

US20110306619A1 6-PHENYL-2-[((PIPERIDIN-4-YLMETHYL)-PIPERAZIN-1YL) OR PIPERAZIN 1-YLMETHYL)-PIPERIDIN-1-YL)]-IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES AND THEIR USE 有权
标题翻译： 6-苯基-2 - [（（哌啶-4-基 - 甲基） - 哌嗪-1-基）或哌嗪-1-基] - 哌啶-1-基]] - 咪唑并[2,1-B] [1,3,4] 噻唑衍生物及其用途
公开(公告)号：US20110306619A1
公开(公告)日：2011-12-15
申请号：US13203172
申请日：2010-02-25
申请人： Uri Nir , Sally Shpungin , Etai Yaffe , Moshe Cohen
发明人： Uri Nir , Sally Shpungin , Etai Yaffe , Moshe Cohen
IPC分类号： A61K31/496 , A61P35/00 , C07D513/04
CPC分类号： C07D513/04
摘要： Provided are heterocyclic compounds, their synthesis and pharmaceutical compositions including them for the treatment of disorders, in particular, cancer.
摘要翻译：提供杂环化合物，它们的合成和药物组合物，包括它们用于治疗疾病，特别是癌症。

8. 发明申请

US20110086861A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER 有权
标题翻译：药物组合物和治疗癌症的方法
公开(公告)号：US20110086861A1
公开(公告)日：2011-04-14
申请号：US12672157
申请日：2008-08-10
申请人： Uri Nir , Sally Shpungin , Etai Yaffe , Moshe Cohen
发明人： Uri Nir , Sally Shpungin , Etai Yaffe , Moshe Cohen
IPC分类号： A61K31/496 , A61K31/437 , A61K31/433 , A61K31/415 , A61K31/4706 , A61P35/00
CPC分类号： A61K31/407 , A61K31/415 , A61K31/433 , A61K31/4706 , A61K31/496 , C07D215/46 , C07D231/38 , C07D471/04 , C07D487/04 , C07D513/04
摘要： Provided is a pharmaceutical composition including as an active component a compound of formula (I): wherein X and (R1)n are as defined, and a physiological acceptable carrier. Also provided is a method for treating cancer including administering to an individual in need of such treatment an effective amount of the presently described pharmaceutical composition.
摘要翻译：本发明提供一种药物组合物，其包含作为活性成分的式（I）化合物：其中X和（R 1）n如上定义，和生理学上可接受的载体。还提供了治疗癌症的方法，包括向需要这种治疗的个体施用有效量的目前描述的药物组合物。

9. 发明申请

US20090082294A1 Diagnosis, prevention and treatment of cancer 审中-公开
标题翻译：诊断，预防和治疗癌症
公开(公告)号：US20090082294A1
公开(公告)日：2009-03-26
申请号：US12068345
申请日：2008-02-05
申请人： Uri Nir , Erez Pery , Sally Shpungin
发明人： Uri Nir , Erez Pery , Sally Shpungin
IPC分类号： A61K31/7105 , C07H21/02 , A61P35/00
CPC分类号： C12N15/1137 , A61K38/00 , C07K16/18 , C07K2317/81 , C12N2310/14 , C12N2310/53 , C12Y207/10002 , G01N33/57496 , G01N33/6893 , G01N2333/4703
摘要： Nucleic acid molecules useful in the treatment of cancer are provided. The nucleic acid molecules may include a short interfering ribonucleic acid molecule directed against fer mRNA. A kit for the treatment of cancer including a short interfering ribonucleic acid molecule of the presently described subject matter, as well as a pharmaceutical composition containing a short interfering ribonucleic acid molecule, is also provided. In addition, a method of treating cancer in an individual in which expression of fer in cells or tissues of an individual is inhibited using a short interfering ribonucleic acid molecule is provided.
摘要翻译：提供了可用于治疗癌症的核酸分子。核酸分子可以包括针对fer mRNA的短干扰核糖核酸分子。还提供了用于治疗癌症的试剂盒，包括目前描述的主题的短干扰核糖核酸分子，以及含有短干扰核糖核酸分子的药物组合物。此外，提供了使用短干扰性核糖核酸分子来抑制个体中细胞或组织中的fer的表达的个体中的癌症的治疗方法。

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