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1. 发明申请

US20050209477A1 Process for producing vinyl perfluoroalkanesulfonate derivative 审中-公开
标题翻译：生产乙烯基全氟烷基磺酸酯衍生物的方法
公开(公告)号：US20050209477A1
公开(公告)日：2005-09-22
申请号：US10518492
申请日：2003-06-20
申请人： Sachiko Kato , Iwao Chujo , Koji Suzuki
发明人： Sachiko Kato , Iwao Chujo , Koji Suzuki
IPC分类号： C07C303/26 , C07C309/65 , C07J31/00 , C07F9/02 , C07C33/02
CPC分类号： C07J31/00 , C07C303/26 , C07C309/65
摘要： (wherein R1, R2, R3, R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, or the like; R17 represents trifluoromethyl or the like; R18, R19, R20, R21 and R22 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like). An easy and simple process for producing a vinyl perfluoroalkanesulfonate derivative represented by general formula (IV) which is a useful intermediate in synthesis of medicines, natural products, or the like, at a low cost, is provided. The process is characterized by, for example, reacting a carbonyl compound represented by general formula (I) described above with a perfluoroalkanesulfonic anhydride represented by general formula (II) described above in the presence of a pyridine derivative represented by general formula (III) described above in an amount of 0.1 to 1.0 equivalent to the perfluoroalkanesulfonic anhydride.
摘要翻译：（其中R 1，R 2，R 3，R 4和R 5）可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的低级烷氧基等; R 17表示三氟甲基等; R 18 R 20，R 20，R 21和R 22可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等）。提供了一种制备以通常式（Ⅳ）表示的乙烯基全氟烷基磺酸酯衍生物的方法和方法，该衍生物是低成本合成药物，天然产物等中有用的中间体。该方法的特征在于使上述通式（I）表示的羰基化合物与上述通式（II）表示的全氟烷基磺酸酐在通式（III）表示的吡啶衍生物存在下反应，所述吡啶衍生物以上，相对于全氟烷基磺酸酐为0.1〜1.0当量。

2. 发明授权

US5756823A Glutathione monoester sulfonate 失效
标题翻译：谷胱甘肽单酯磺酸盐
公开(公告)号：US5756823A
公开(公告)日：1998-05-26
申请号：US852256
申请日：1997-05-06
申请人： Sachiko Kato , Iwao Chujo , Takehiro Ogasa , Masaji Kasai , Yukiteru Mimura
发明人： Sachiko Kato , Iwao Chujo , Takehiro Ogasa , Masaji Kasai , Yukiteru Mimura
IPC分类号： C07K5/02 , C07C323/41
CPC分类号： C07K5/0215
摘要： The present invention relates to glutathione monoester sulfonate represented by formula (I): ##STR1## (wherein R.sup.1 represent lower alkyl, and R.sup.2 represents lower alkyl, or substituted or unsubstituted aryl) which readily crystallizes and has high stability, and a simple process for producing the same. According to the process, the product having high purity can be obtained in high yields.
摘要翻译：本发明涉及由式（I）表示的谷胱甘肽单酯磺酸盐：其中R 1表示低级烷基，R 2表示低级烷基或取代或未取代的芳基，其易于结晶并具有高稳定性，简单的生产过程。根据该方法，可以高产率获得高纯度的产品。

3. 发明授权

US07485593B2 Titania-silica glass 失效
标题翻译：二氧化钛 - 二氧化硅玻璃
公开(公告)号：US07485593B2
公开(公告)日：2009-02-03
申请号：US11874373
申请日：2007-10-18
申请人： Masanobu Ezaki , Masashi Kobata , Sachiko Kato
发明人： Masanobu Ezaki , Masashi Kobata , Sachiko Kato
IPC分类号： C03C3/06 , C03C3/076 , C03B20/00 , C03B32/00
CPC分类号： B82Y40/00 , B82Y10/00 , C03C3/06 , C03C4/0085 , C03C2201/42 , G03F1/24 , G03F1/60
摘要： To provide titania-silica glass which is transparent glass of low thermal expansion, in particular, is of a low thermal expansion coefficient over a wide range of temperatures of 0 to 100° C. (an operating temperature range) when it is used as a photomask or a mirror material in extreme ultraviolet ray lithography, and which is excellent in homogeneity within the field and stability.Titania-silica glass is used which has 8 to 10% by weight of titania and 90 to 92% by weight of silica, where a Ti3+ concentration is 10 to 60 ppm by weight.
摘要翻译：为了提供作为低热膨胀的透明玻璃的二氧化钛 - 二氧化硅玻璃，特别是在0〜100℃的宽的温度范围（工作温度范围）中作为光掩模或极光紫外线光刻中的镜面材料，其在场内的均匀性和稳定性方面优异。使用二氧化钛 - 二氧化硅玻璃，其具有8至10重量％的二氧化钛和90至92重量％的二氧化硅，其中Ti 3+浓度为10至60重量ppm。

4. 发明申请

US20070105959A1 Cynnamyl alcohol derivative compounds and drugs containing the compounds as active ingredient 审中-公开
标题翻译：辛醇衍生物化合物和含有这些化合物的药物作为活性成分
公开(公告)号：US20070105959A1
公开(公告)日：2007-05-10
申请号：US10548474
申请日：2004-03-10
申请人： Shinya Kusuda , Yoshisuke Nakayama , Hisao Tajima , Sachiko Kato
发明人： Shinya Kusuda , Yoshisuke Nakayama , Hisao Tajima , Sachiko Kato
IPC分类号： A61K31/192 , C07C62/30
CPC分类号： C07D277/24 , A61K31/192 , A61K31/222 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4409 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07C51/00 , C07C69/734 , C07C235/34 , C07C255/37 , C07C311/51 , C07C323/19 , C07D211/18 , C07D213/30 , C07D213/55 , C07D257/04 , C07D263/32 , C07D271/07 , C07D277/30 , C07D277/42 , C07D277/64 , C07D285/08 , C07D291/04 , C07D317/54 , C07D333/24 , C07D413/04 , C07D413/10
摘要： A compound represented by formula (I) (wherein all the symbols are as defined in the specification) or a salt thereof Since the compound represented by formula (I) or a salt thereof has a regulatory activity for peroxisome proliferator activated receptor, the compound represented by formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or therapeutic agent for diseases associating metabolic disorders (e.g., diabetes, adiposity, metabolic syndrome, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipidemia, atherosclerosis, hypertension, circulatory diseases, overeating, ischemic heart diseases, etc., a HDL cholesterol-elevating agent, a LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or metabolic syndrome.
摘要翻译：由式（I）表示的化合物或其盐由式（I）表示的化合物（其中所有符号如说明书中所定义）或其盐由于由式（I）表示的化合物或其盐具有对过氧化物酶体增殖物激活受体的调节活性，式（I）可用作降血糖剂，降血脂剂，与代谢紊乱（例如糖尿病，肥胖，代谢综合征，高胆固醇血症，高脂蛋白血症等）相关疾病，预防和/或治疗剂，高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，缺血性心脏病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂以及用于缓解糖尿病或代谢综合征危险因素的药物。

5. 发明申请

US20080096756A1 TITANIA-SILICA GLASS 失效
标题翻译：钛硅玻璃
公开(公告)号：US20080096756A1
公开(公告)日：2008-04-24
申请号：US11874373
申请日：2007-10-18
申请人： Masanobu Ezaki , Masashi Kobata , Sachiko Kato
发明人： Masanobu Ezaki , Masashi Kobata , Sachiko Kato
IPC分类号： C04B35/14
CPC分类号： B82Y40/00 , B82Y10/00 , C03C3/06 , C03C4/0085 , C03C2201/42 , G03F1/24 , G03F1/60
摘要： To provide titania-silica glass which is transparent glass of low thermal expansion, in particular, is of a low thermal expansion coefficient over a wide range of temperatures of 0 to 100° C. (an operating temperature range) when it is used as a photomask or a mirror material in extreme ultraviolet ray lithography, and which is excellent in homogeneity within the field and stability. Titania-silica glass is used which has 8 to 10% by weight of titania and 90 to 92% by weight of silica, where a Ti3+ concentration is 10 to 60 ppm by weight.
摘要翻译：为了提供作为低热膨胀的透明玻璃的二氧化钛 - 二氧化硅玻璃，特别是在0〜100℃的宽的温度范围（工作温度范围）中作为光掩模或极光紫外线光刻中的镜面材料，其在场内的均匀性和稳定性方面优异。使用二氧化钛 - 二氧化硅玻璃，其具有8至10重量％的二氧化钛和90至92重量％的二氧化硅，其中Ti 3+浓度为10至60重量ppm。

6. 发明申请

US20100267778A1 Diphenyl ether compound, process for producing the same, and use 审中-公开
标题翻译：二苯醚化合物，其制备方法和用途
公开(公告)号：US20100267778A1
公开(公告)日：2010-10-21
申请号：US10567363
申请日：2004-08-03
申请人： Shinya Kusuda , Yoshisuke Nakayama , Masaki Ima , Hisao Tajima , Sachiko Kato
发明人： Shinya Kusuda , Yoshisuke Nakayama , Masaki Ima , Hisao Tajima , Sachiko Kato
IPC分类号： A61K31/455 , C07C65/28 , A61K31/192 , A61P3/06 , A61K31/235 , C07C69/94 , C07C59/68 , C07D263/32 , A61K31/421 , C07D277/30 , A61K31/426 , C07D213/55 , A61K31/435 , C07C217/90 , A61K31/196
CPC分类号： C07D263/32 , C07C65/24 , C07C217/90 , C07D213/30
摘要： The present invention relates to a compound represented by formula (I): wherein ring A, ring B and ring D each independently represents a cyclic group which may have a substituent(s); W is a spacer having 1 to 8 atom(s) in its main chain; X is a spacer having 1 to 2 atom(s) in its main chain; Y is a binding bond or a spacer having 1 to 8 atom(s) in its main chain; and Z is an acidic group, or a salt thereof, a solvate thereof or a prodrug thereof. The compound represented by formula (I) has a PPAR δ agonistic action and is useful as a preventive and/or treating agent for diseases where sugar and lipid metabolisms are abnormal (diabetes, hyperlipemia, arteriosclerosis, cardiovascular diseases, obesity and metabolic syndrome or the like), hypertension, circulatory diseases and skin inflammation diseases.
摘要翻译：本发明涉及由式（I）表示的化合物：其中环A，环B和环D各自独立地表示可以具有取代基的环状基团。 W是其主链中具有1至8个原子的间隔基; X是其主链中具有1至2个原子的间隔基; Y是其主链中具有1至8个原子的结合键或间隔基; 并且Z是酸性基团，或其盐，其溶剂合物或其前药。由式（I）表示的化合物具有PPARδ激动作用，并且可用作糖和脂质代谢异常（糖尿病，高脂血症，动脉硬化，心血管疾病，肥胖症和代谢综合征或疾病）的疾病的预防和/或治疗剂喜欢），高血压，循环系统疾病和皮肤炎症疾病。

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