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1. 发明申请

WO2009073118A1 TRYPTAMINE SULFONAMIDES AS 5-HT6 ANTAGONISTS 审中-公开
标题翻译：作为5-HT6拮抗剂的TRYPTAMINE SULFONAMIDES
公开(公告)号：WO2009073118A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/013104
申请日：2008-11-25
申请人： MERCK & CO., INC. , PASTERNAK, Alexander , SZYMONIFKA, Michael, J.
发明人： PASTERNAK, Alexander , SZYMONIFKA, Michael, J.
IPC分类号： A61K31/497
CPC分类号： C07D209/16
摘要： Novel compounds of the structural formula (I) are antagonists of the 5-HT 6 receptor and are useful in the treatment, prevention and suppression of diseases mediated by the 5-HT 6 receptor. The compounds of the present invention are useful in the treatment of obesity, diabetes, metabolic disorder, cognitive disorders, age related cognitive disorder, depression, mania, bipolar disorders, schizophrenia, anxiety, generalized anxiety disorder, panic disorder, and obsessive compulsive disorder, epilepsy, convulsions, migraine, substance withdrawal from substances including but not limited to opiates, nicotine, tobacco products, alcohol, benzodiazepines, sedatives, and the like, sleep disorders, attention deficit/hyperactivity disorder, and Alzheimer's disease.
摘要翻译：结构式（I）的新化合物是5-HT 6受体的拮抗剂，可用于治疗，预防和抑制由5-HT 6受体介导的疾病。本发明的化合物可用于治疗肥胖，糖尿病，代谢紊乱，认知障碍，与年龄相关的认知障碍，抑郁症，躁狂症，双相情感障碍，精神分裂症，焦虑症，广泛性焦虑症，恐慌症和强迫症，癫痫症，惊厥，偏头痛，物质从物质包括但不限于阿片剂，尼古丁，烟草产品，酒精，苯二氮卓类，镇静剂等，物质戒断，睡眠障碍，注意力缺陷/多动症和阿尔茨海默病。

2. 发明申请

WO2007027532A3 NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 审中-公开
公开(公告)号：WO2007027532A3
公开(公告)日：2007-03-08
申请号：PCT/US2006/033304
申请日：2006-08-25
申请人： MERCK & CO., INC. , COLLETTI, Steven, L. , SHEN, Hong , TATA, James, R. , SZYMONIFKA, Michael, J.
发明人： COLLETTI, Steven, L. , SHEN, Hong , TATA, James, R. , SZYMONIFKA, Michael, J.
IPC分类号： C07D209/54 , C07D209/96 , C07D491/107 , A61K31/403 , A61K31/407 , A61K31/438 , C07D241/44 , C07D417/04 , C07D413/04 , C07D243/08 , C07D407/12 , C07D239/74 , A61K31/4709 , A61K31/5513 , A61K31/499
摘要： Compounds of the formula (I): as well as pharmaceutically acceptable salts and solvates are disclosed. The compounds are useful for treating dyslipidemias, and in particular, reducing serum LDL, VLDL and triglycerides, and raising HDL levels. Pharmaceutical compositions and methods of treatment are also included.

3. 发明申请

WO2007027532A2 NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 审中-公开
标题翻译： NIACIN受体激素，包含这些化合物的组合物和治疗方法
公开(公告)号：WO2007027532A2
公开(公告)日：2007-03-08
申请号：PCT/US2006033304
申请日：2006-08-25
申请人： MERCK & CO INC , COLLETTI STEVEN L , SHEN HONG , TATA JAMES R , SZYMONIFKA MICHAEL J
发明人： COLLETTI STEVEN L , SHEN HONG , TATA JAMES R , SZYMONIFKA MICHAEL J
IPC分类号： A61K31/551
CPC分类号： C07D403/04 , C07D207/09 , C07D211/40 , C07D241/04 , C07D413/04 , C07D491/10
摘要： Compounds of the formula (I): as well as pharmaceutically acceptable salts and solvates are disclosed. The compounds are useful for treating dyslipidemias, and in particular, reducing serum LDL, VLDL and triglycerides, and raising HDL levels. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了式（I）的化合物以及药学上可接受的盐和溶剂合物。该化合物可用于治疗血脂异常，特别是降低血清LDL，VLDL和甘油三酸酯，并提高HDL水平。还包括药物组合物和治疗方法。

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