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1. 发明申请

WO2001096868A3 IMMUNOASSAY AND IMMUNOASSAY APPARATUS 审中-公开
公开(公告)号：WO2001096868A3
公开(公告)日：2001-12-20
申请号：PCT/JP2001/004917
申请日：2001-06-11
申请人： SYSMEX CORPORATION , NAKASHIMA, Kazuhiro , TORII, Tsuneyoshi , TSUCHIYA, Hiroshi , UCHIDA, Shinya , KONISHI, Aya , TANAKA, Kunio
发明人： NAKASHIMA, Kazuhiro , TORII, Tsuneyoshi , TSUCHIYA, Hiroshi , UCHIDA, Shinya , KONISHI, Aya , TANAKA, Kunio
IPC分类号： G01N33/53
摘要： An immunoassay comprises the steps of: (a) mixing a whole blood sample with sensitized insoluble carrier particles smaller than erythrocytes to cause an immune agglutination reaction; (b) introducing the resulting immune agglutination reaction mixture including agglutinated particles and unagglutinated particles to a flow cell, irradiating the particles passing through the flow cell with laser light, and detecting scattered lights generated thereby; (c) setting a threshold value for distinguishing unagglutinated particles from agglutinated particles and a threshold value for distinguishing the agglutinated particles from blood cells with regard to intensity of the scattered light; and (d) distinguishing and counting the unagglutinated particles, the agglutinated particles and the blood cells from the scattered lights detected in the step (b), in reference to the threshold values set in the step (c).

2. 发明申请

WO2014068407A3 EMULSION SYSTEMS AND EMULSION-BASED AMPLIFICATION OF NUCLEIC ACID 审中-公开
公开(公告)号：WO2014068407A3
公开(公告)日：2014-05-08
申请号：PCT/IB2013/003084
申请日：2013-10-28
申请人： SYSMEX CORPORATION
发明人： DIEHL, Frank , ANGENENDT, Philipp
IPC分类号： C12Q1/68
摘要： Methods for efficient and high throughput emulsion-based nucleic amplification are provided. In some aspects, emulsion mixtures are provided that require extremely low input energy (e.g., the energy generated by pipetting) to form emulsions that are effective for nucleic acid amplification. Efficient formulations for breaking emulsions are likewise provided.

3. 发明申请

WO2013035074A9 METHOD FOR ASSAYING PLASMINOGEN IN A LIQUID MEDIUM, ASSOCIATED COMPOSITIONS AND KIT 审中-公开
公开(公告)号：WO2013035074A9
公开(公告)日：2013-03-14
申请号：PCT/IB2012/054634
申请日：2012-09-07
申请人： SYSMEX CORPORATION , AMIRAL, Jean
发明人： AMIRAL, Jean
IPC分类号： C12Q1/56 , G01N33/86
摘要： The invention relates to a method for assaying plasminogen in a sample comprising a step consisting in particular of reacting a streptokinase (Rl), and a streptokinase activator, with a control solution or a diluted plasma sample, in which the streptokinase activator is selected from the group comprising a fibrin DD fragment and/or at least one DD fragment derivative. The invention also relates to a liquid composition, a plasminogen assay kit for implementing this method and the use of a streptokinase activator selected from the group comprising a fibrin DD fragment and/or at least one DD fragment derivative.

4. 发明申请

WO2005020794A2 TAXANE CHEMOSENSITIVITY PREDICTION TEST 审中-公开
标题翻译： TAXANE CHEMOSENSITIVITY预测测试
公开(公告)号：WO2005020794A2
公开(公告)日：2005-03-10
申请号：PCT/US2004/027661
申请日：2004-08-25
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , SYSMEX CORPORATION , UENO, Naoto, T. , ISHIHARA, Hideki , SUDO, Tamotsu , MATSUSHIMA, Tomoko
发明人： UENO, Naoto, T. , ISHIHARA, Hideki , SUDO, Tamotsu , MATSUSHIMA, Tomoko
IPC分类号： A61B
CPC分类号： G01N33/5011 , A61K31/337 , C12Q1/485 , G01N2800/52
摘要： The present invention provides a method for determining the chemosensitivity of a cancer cell to a taxane comprising assessing the effect of the taxane on the expression level or activity of one or more cell cylce molecules in a cancer cell. Such a method makes use of an automated analyzer system wherein cell cycle paramteres (molecules) such as CDKI kinase activity, CDK1 expression, CDK2 kinase activity, CDK2 expression, MAD2 expression, Cyclin Bl, Cyclin E expression, p2l expression, and CDK6 expression; are assessed. The present invention further provides a method of obtaining a cell cycle profile of a cancer cell that is sensitive to a taxane.
摘要翻译：本发明提供了确定癌细胞对紫杉烷的化学敏感性的方法，包括评估紫杉烷对癌细胞中一种或多种细胞胞质分子的表达水平或活性的影响。这种方法利用自动分析系统，其中诸如CDKI激酶活性，CDK1表达，CDK2激酶活性，CDK2表达，MAD2表达，细胞周期蛋白B1，细胞周期蛋白E表达，p2表达和CDK6表达的细胞周期参数（分子）被评估。本发明还提供了获得对紫杉烷敏感的癌细胞的细胞周期特征的方法。

5. 发明专利

TW200525034A 膽固醇脫氫之安定化方法、含膽固醇脫氫之組成物及膽固醇測定試劑 METHOD FOR STABILIZING CHOLESTEROL DEHYDROGENASE, CHOLESTEROL DEHYDROGENASE-CONTAINING COMPOSITION AND CHOLESTEROL MEASURING REAGENT 审中-公开
简体标题：胆固醇脱氢之安定化方法、含胆固醇脱氢之组成物及胆固醇测定试剂 METHOD FOR STABILIZING CHOLESTEROL DEHYDROGENASE, CHOLESTEROL DEHYDROGENASE-CONTAINING COMPOSITION AND CHOLESTEROL MEASURING REAGENT
公开(公告)号：TW200525034A
公开(公告)日：2005-08-01
申请号：TW093131770
申请日：2004-10-20
申请人：西斯美股份有限公司 SYSMEX CORPORATION
发明人：酒井康裕 SAKAI, YASUHIRO , 一色健二 ISSHIKI, KENJI , 岸浩司 KISHI, KOUJI
IPC分类号： C12N , C12Q
CPC分类号： C12N9/96 , C12Q1/60
摘要：本發明之目的為提供與以往之膽固醇脫氫安定化方法不同之新穎膽固醇脫氫安定化方法。又，本發明亦以提供新穎之含膽固醇脫氫組成物以及膽固醇測定試劑為目的。本發明係藉由添加下述化學式(1)所示之甘胺酸系化合物而達成目的：093131770-p01.bmp(式中R表示氫、可有取代基之烷基、可有取代基之苯基或可有取代基之羰基，n表示0至2之整數)。
简体摘要：本发明之目的为提供与以往之胆固醇脱氢安定化方法不同之新颖胆固醇脱氢安定化方法。又，本发明亦以提供新颖之含胆固醇脱氢组成物以及胆固醇测定试剂为目的。本发明系借由添加下述化学式(1)所示之甘胺酸系化合物而达成目的：093131770-p01.bmp(式中R表示氢、可有取代基之烷基、可有取代基之苯基或可有取代基之羰基，n表示0至2之整数)。

6. 外观设计

TWD120763S 測試用小管 CUVETTE 有权
简体标题：测试用小管 CUVETTE
公开(公告)号：TWD120763S
公开(公告)日：2008-01-01
申请号：TW096300785
申请日：2007-02-07
申请人：西斯美股份有限公司 SYSMEX CORPORATION
设计人：山本典正 YAMAMOTO, NORIMASA , 喜多川信宏 KITAGAWA, NOBUHIRO , 山登隆司 YAMATO, TAKASHI , 川口修司 KAWAGUCHI, SHUJI
摘要：【物品用途】本創作係用於保存樣本之檢測容器之一種「測試用小管」【創作特點】本創作係有關於一種「測試用小管」之外形設計，係供檢驗工作人員檢驗樣本之用。本創作之本體大致呈現圓筒狀體；於本體腹部以下係形成內縮徑部，該內縮徑部上端與本體上方之下端相連端係形成傾斜端，且該內縮徑部係由上往下形成微內傾狀。於本體頂端形成具有上下邊緣為倒角邊緣之凸緣。而本體底部則形成倒弧角，同時在該底部具有環列之複數扇形小槽口環繞其中心內陷圓部之形態。於本體頂面管口呈現四角為弧角之方形口，且四邊各具向內凸之弧形邊，中央則呈現圓形之形態。如立體圖(非代表圖)所示，係顯示本創作之另一角度之(前仰視)立體狀態。由上述構成本創作整體造形精巧別緻，具新穎獨特之視覺效果及創作性。
简体摘要：【物品用途】本创作系用于保存样本之检测容器之一种“测试用小管”【创作特点】本创作系有关于一种“测试用小管”之外形设计，系供检验工作人员检验样本之用。本创作之本体大致呈现圆筒状体；于本体腹部以下系形成内缩径部，该内缩径部上端与本体上方之下端相连端系形成倾斜端，且该内缩径部系由上往下形成微内倾状。于本体顶端形成具有上下边缘为倒角边缘之凸缘。而本体底部则形成倒弧角，同时在该底部具有环列之复数扇形小槽口环绕其中心内陷圆部之形态。于本体顶面管口呈现四角为弧角之方形口，且四边各具向内凸之弧形边，中央则呈现圆形之形态。如三維图(非代表图)所示，系显示本创作之另一角度之(前仰视)三維状态。由上述构成本创作整体造形精巧别致，具新颖独特之视觉效果及创作性。

7. 发明授权

US12056869B2 Image analysis method, image analysis apparatus, and image analysis program for analyzing cell with deep learning algorithm 有权
公开(公告)号：US12056869B2
公开(公告)日：2024-08-06
申请号：US17197123
申请日：2021-03-10
申请人： SYSMEX CORPORATION
发明人： Yoshinori Sasagawa , Yoshiaki Miyamoto , Kazumi Hakamada , Kengo Gotoh , Yosuke Sekiguchi
IPC分类号： G06T7/00 , G06N3/08 , G06T7/11 , G06T7/187 , G06V20/69
CPC分类号： G06T7/0012 , G06N3/08 , G06T7/11 , G06T7/187 , G06V20/695 , G06T2207/10064 , G06T2207/20081 , G06T2207/30024
摘要： An image analysis method according one or more embodiments may analyze a form of a cell using a deep learning algorithm with a structure of a neural network. The image analysis method may include: generating data for analysis from an image for analysis in which an analysis target cell is captured; inputting the data for analysis into the deep learning algorithm; and generating data indicating a form of the analysis target cell using the deep learning algorithm.

8. 发明授权

US12020492B2 Cell analysis method, cell analysis device, and cell analysis system 有权
公开(公告)号：US12020492B2
公开(公告)日：2024-06-25
申请号：US17105047
申请日：2020-11-25
申请人： SYSMEX CORPORATION
发明人： Momoko Imakubo , Jianyin Lu , Kentaro Shirai , Eri Katsumata , Yuji Okamoto
IPC分类号： G06V20/69 , G01N15/1429 , G01N15/1433 , G01N15/1434 , G06T7/00 , G06V10/70 , G01N15/00 , G01N15/10 , G01N15/14
CPC分类号： G06V20/69 , G01N15/1431 , G01N15/1433 , G01N15/1436 , G06T7/0012 , G06V10/87 , G01N2015/0019 , G01N2015/1028 , G01N2015/1495 , G06T2207/10056 , G06T2207/10064 , G06T2207/20084 , G06T2207/30024
摘要： The present invention is to facilitate analysis of a plurality of analysis items. A cell analysis method for analyzing cells is provided in which data for analysis of cells contained in a sample are generated, and an artificial intelligence algorithm to be the input destination of the generated analysis data is selected from among a plurality of artificial intelligence algorithms, data indicating the properties of the cells are generated based on the analysis data via the artificial intelligence algorithm.

9. 发明公开

US20240142789A1 OPTICAL SYSTEM AND SPECIMEN ANALYZER 审中-公开
公开(公告)号：US20240142789A1
公开(公告)日：2024-05-02
申请号：US18495946
申请日：2023-10-27
申请人： SYSMEX CORPORATION
发明人： Takuya KUWANA , Takeshi SUGIYAMA , Kazuhiro YAMADA , Ayato TAGAWA
IPC分类号： G02B27/42 , G01N15/14
CPC分类号： G02B27/4205 , G01N15/1436 , G01N15/1459 , G01N2015/0065
摘要： Disclosed is an optical system including: a light source configured to emit light; an irradiation optical system including a diffractive optical element on which the light is incident, the irradiation optical system being configured to apply illumination light in which a plurality of diffracted lights generated by the diffractive optical element are distributed; a flow cell in which a sample containing cells is caused to flow to a position at which the illumination light is applied by the irradiation optical system; and a light receiver configured to receive light generated from each cell flowing in the flow cell, upon application of the illumination light by the irradiation optical system. The illumination light includes zero-order diffracted light whose relative intensity relative to another diffracted light is not greater than 10 times. The irradiation optical system applies the illumination light to a position through which the cell in the flow cell passes.

10. 发明公开

US20240118272A1 METHOD FOR MEASURING ACTIVITY OF ALKALINE PHOSPHATEASE CONTAINED IN EXTRACELLULAR VESICLE, CALIBRATOR, AND CONJUGATE 审中-公开
公开(公告)号：US20240118272A1
公开(公告)日：2024-04-11
申请号：US18469093
申请日：2023-09-18
申请人： SYSMEX CORPORATION
发明人： Eiya TAMADA , Masatoshi Yanagida , Kazuto Yamashita , Elnaz Nakhael , Mami Onishi , Maria Kiriyama
IPC分类号： G01N33/543 , C07K14/705 , C07K16/28
CPC分类号： G01N33/54333 , C07K14/70596 , C07K16/2803 , C07K16/2896 , G01N2333/916 , G01N2496/00
摘要： Disclosed is a method for measuring an activity of alkaline phosphatase contained in an extracellular vesicle in a sample, including acquiring an activity value of alkaline phosphatase contained in an extracellular vesicle in a sample using a calibrator, in which the calibrator contains a conjugate in which a polypeptide having alkaline phosphatase activity and a polypeptide including an amino acid sequence of a membrane protein present on a surface of the extracellular vesicle are covalently bound.

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