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1. 发明申请

WO2006110214A2 ANTIBODIES AGAINST MAMMALIAN METAPNEUMOVIRUS 审中-公开
标题翻译：抗马虫亚硫酸氢杆菌抗体
公开(公告)号：WO2006110214A2
公开(公告)日：2006-10-19
申请号：PCT/US2006005692
申请日：2006-02-15
申请人： MEDIMMUNE INC , ULBRANDT NANCY , SUZICH JOANN , COELINGH KATHLEEN L
发明人： ULBRANDT NANCY , SUZICH JOANN , COELINGH KATHLEEN L
IPC分类号： A61K39/42 , C12Q1/70
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies that immunospecifÊcally bind to a polypeptide of a mammalian metapneumovirus, compositions comprising said antibodies, and methods for producing such antibodies. In particular, the invention provides monoclonal antibodies that immunospecifically bind to the F protein of human metapneumovirus and that neutralize human metapneumovirus. The invention also provides antibodies that cross-react with both the F protein of a mammalian metapneumovirus and the F protein of a mammalian respiratory syncytial virus and that neutralize both viruses. Further, the invention provides recombinant antibodies, such as humanized antibodies, against mammalian metapneumovirus, and methods for producing such recombinant antibodies. The invention further provides methods for treating, managing, ameliorating symptoms of and/or preventing infections with mammalian metapneumovirus, such as human metapneumovirus. The invention also provides antibodies that immunospecifically bind the F protein of avian pneumovirus. Antibodies that immunospecifically bind the F protein of avian pneumovirus are useful in the diagnosis and treatment of infections with avian pneumovirus.
摘要翻译：本发明提供了免疫特异性结合哺乳动物偏肺病毒多肽的抗体，包含所述抗体的组合物和用于产生此类抗体的方法。特别地，本发明提供免疫特异性结合人类偏肺病毒的F蛋白并中和人间质肺病毒的单克隆抗体。本发明还提供与哺乳动物偏肺病毒的F蛋白和哺乳动物呼吸道合胞病毒的F蛋白质交叉反应并且中和两种病毒的抗体。此外，本发明提供针对哺乳动物偏肺病毒的重组抗体，例如人源化抗体，以及用于产生此类重组抗体的方法。本发明还提供了用于治疗，控制，改善用哺乳动物偏肺病毒如人类偏肺病毒感染的症状和/或预防感染的方法。本发明还提供免疫特异性结合禽肺病毒F蛋白的抗体。免疫特异性结合禽肺炎病毒F蛋白的抗体可用于禽流感病毒感染的诊断和治疗。

2. 发明申请

WO2009003019A1 METHODS OF TREATING RSV INFECTIONS AND RELATED CONDITIONS 审中-公开
标题翻译：治疗RSV感染的方法和相关条件
公开(公告)号：WO2009003019A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/068155
申请日：2008-06-25
申请人： MEDLMMUNE, LLC , KRISHNAN, Subramaniam , SUZICH, JoAnn , KIENER, Peter , LOSONKSY, Genevieve , WU, Herren , DALL'ACQUA, William , RICHTER, Bettina
发明人： KRISHNAN, Subramaniam , SUZICH, JoAnn , KIENER, Peter , LOSONKSY, Genevieve , WU, Herren , DALL'ACQUA, William , RICHTER, Bettina
IPC分类号： C07K16/00 , A61K39/00 , A61K39/42
CPC分类号： C07K16/1027 , A61K2039/505 , A61K2039/545 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/77
摘要： The present invention provides methods for managing, treating and/or ameliorating a respiratory syncytial virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), and/or a symptom or a long-term respiratory condition relating thereto (e.g., asthma, wheezing, reactive airway disease (RAD), or chronic obstructive pulmonary disease (COPD)) in a subject, comprising administering to said human an effective amount of one or more antibodies that immunospecifically bind to one or more RSV antigens with a high affinity and/or high avidity and further comprise a modified IgG constant domain, or FcRn-binding fragment thereof, to not only decrease RSV infection, but also decrease the pro-inflammatory epithelial cell immune responses in order to mitigate the later development of asthma and/or wheezing and/or COPD in said patient.
摘要翻译：本发明提供了用于管理，治疗和/或改善呼吸道合胞病毒（RSV）感染（例如急性RSV疾病或RSV上呼吸道感染（URI）和/或下呼吸道感染（LRI））的方法，和/或与受试者相关的症状或长期呼吸道状况（例如，哮喘，喘鸣，反应性气道疾病（RAD）或慢性阻塞性肺疾病（COPD））），包括向所述人施用有效量的一种或多种以高亲和性和/或高亲合力免疫特异性结合一种或多种RSV抗原的抗体，并且还包含经修饰的IgG恒定结构域或其FcRn结合片段，以不仅降低RSV感染，而且减少pro - 炎症性上皮细胞免疫应答，以减轻所述患者中哮喘和/或喘息和/或COPD的后期发展。

3. 发明申请

WO2010087927A2 ANTIBODIES AGAINST AND METHODS FOR PRODUCING VACCINES FOR RESPIRATORY SYNCYTIAL VIRUS 审中-公开
标题翻译：抗生素抗生素和生产呼吸道感染病毒疫苗的方法
公开(公告)号：WO2010087927A2
公开(公告)日：2010-08-05
申请号：PCT/US2009/069406
申请日：2009-12-23
申请人： MEDIMMUNE, LLC , MCAULIFFE, Josephine , PALMER-HILL, Frances , ZHU, Qing , SUZICH, Joann
发明人： MCAULIFFE, Josephine , PALMER-HILL, Frances , ZHU, Qing , SUZICH, Joann
IPC分类号： A61K39/155
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , C12N7/00 , C12N2760/18522 , C12N2760/18534 , C12N2760/18551 , G01N33/6854

4. 发明申请

WO2011056697A1 TOPICAL METHODS OF TREATING RSV INFECTIONS AND RELATED CONDITIONS 审中-公开
标题翻译：治疗RSV感染的主要方法和相关条件
公开(公告)号：WO2011056697A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/054411
申请日：2010-10-28
申请人： MEDIMMUNE, LLC , RICHTER, Bettina , SUZICH, Joann
发明人： RICHTER, Bettina , SUZICH, Joann
IPC分类号： A61K39/155
CPC分类号： C07K16/1027 , A61K2039/505 , A61K2039/543 , C07K2317/24 , C07K2317/76 , C12N2760/18511
摘要： The present invention provides methods for preventing, managing, treating and/or ameliorating a respiratory syncytial virus (RSV) infection {e g.. acute RS V disease, or a RSV upper respiratory tract infection (URIj and/or lower respiratory tract infection (LRIj), and/or a symptom or a long-term respiratory condition relating thereto (e.g.. asthma, wheezing, reactive airway disease (RAD). or chronic obstructive pulmonary disease (COPD)) in a human subject, comprising topically administering to said human an effective amount of one or more antibodies that immunospεcifically bind to one or more RSV antigens with a high affinity and/or high avidity and further comprise a modified IgG constant domain, or FcRn-binding fragment thereof, to not only decrease RSV infection, but also decrease the pro-inflammatory epithelial cell immune responses in order to mitigate the later development of asthma and/or wheezing and/or COPD in said patient.
摘要翻译：本发明提供了预防，治疗和/或改善呼吸道合胞病毒（RSV）感染（例如急性RSV疾病或RSV上呼吸道感染（URIj和/或下呼吸道感染（ LRIj），和/或与人有关的症状或长期呼吸道状况（例如哮喘，喘鸣，反应性气道疾病（RAD）或慢性阻塞性肺病（COPD）），包括局部施用于所述人有效量的一种或多种抗体，其以高亲和力和/或高亲合力免疫特异性结合一种或多种RSV抗原，并且还包含经修饰的IgG恒定结构域或其FcRn结合片段，不仅降低RSV感染，而且还减少促炎症上皮细胞免疫应答，以减轻所述患者中哮喘和/或喘息和/或COPD的后期发展。

5. 发明申请

WO2006110214A3 ANTIBODIES AGAINST MAMMALIAN METAPNEUMOVIRUS 审中-公开
公开(公告)号：WO2006110214A3
公开(公告)日：2006-10-19
申请号：PCT/US2006/005692
申请日：2006-02-15
申请人： MEDIMMUNE, INC. , ULBRANDT, Nancy , SUZICH, JoAnn , COELINGH, Kathleen, L.
发明人： ULBRANDT, Nancy , SUZICH, JoAnn , COELINGH, Kathleen, L.
IPC分类号： A61K39/44 , A61K39/00
摘要： The present invention provides antibodies that immunospecifÊcally bind to a polypeptide of a mammalian metapneumovirus, compositions comprising said antibodies, and methods for producing such antibodies. In particular, the invention provides monoclonal antibodies that immunospecifically bind to the F protein of human metapneumovirus and that neutralize human metapneumovirus. The invention also provides antibodies that cross-react with both the F protein of a mammalian metapneumovirus and the F protein of a mammalian respiratory syncytial virus and that neutralize both viruses. Further, the invention provides recombinant antibodies, such as humanized antibodies, against mammalian metapneumovirus, and methods for producing such recombinant antibodies. The invention further provides methods for treating, managing, ameliorating symptoms of and/or preventing infections with mammalian metapneumovirus, such as human metapneumovirus. The invention also provides antibodies that immunospecifically bind the F protein of avian pneumovirus. Antibodies that immunospecifically bind the F protein of avian pneumovirus are useful in the diagnosis and treatment of infections with avian pneumovirus.

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