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1. 发明申请

WO2012073257A2 VACCINE FORMULATION FOR PROPHYLAXIS AND TREATMENT OF CHANDIPURA VIRUS INFECTIONS IN MAMMALS 审中-公开
标题翻译：野生动物疫苗制剂和治疗肉鸡病原菌感染
公开(公告)号：WO2012073257A2
公开(公告)日：2012-06-07
申请号：PCT/IN2011/000817
申请日：2011-11-29
申请人： BHARAT BIOTECH INTERNATIONAL LIMITED , ELLA, Krishna Murthy , SUMATHY, K.
发明人： ELLA, Krishna Murthy , SUMATHY, K.
CPC分类号： A61K39/205 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55583 , C12N2760/20034 , Y02A50/39
摘要： The present invention is related to pharmaceutical formulations capable of eliciting protective immune response against Chandipura virus infection in humans and other mammalian hosts. The immunogenic formulation comprises Chandipura virus glycoprotein (G protein) and/or nucleoprotein expressed as recombinant proteins and purified from host cells. Vaccine compositions comprising the recombinant proteins elicit neutralizing antibodies similar to the vaccine compositions of purified inactivated Chandipura virus in a stable formulation. Methods of inactivating Chandipura virus for use as a candidate vaccine are disclosed. The vaccine compositions have been formulated with adjuvants to potentiate the immune response. The vaccine compositions disclosed in the invention are highly immunogenic and elicit protective immune response in mammalian host. The immunogenic compositions are formulated for in vivo administration to humans. The immunogenic preparation will also find use in diagnosing for the presence of the virus
摘要翻译：本发明涉及能够在人类和其他哺乳动物宿主中引发对钱氏杜氏病毒感染的保护性免疫应答的药物制剂。免疫原性制剂包含由重组蛋白质表达并从宿主细胞纯化的Chandipura病毒糖蛋白（G蛋白）和/或核蛋白。包含重组蛋白的疫苗组合物引起与稳定制剂中纯化的灭活的Chandipura病毒的疫苗组合物类似的中和抗体。公开了将Chandipura病毒灭活用作候选疫苗的方法。疫苗组合物已经用佐剂配制以增强免疫应答。本发明公开的疫苗组合物是高度免疫原性的并且在哺乳动物宿主中引发保护性免疫应答。配制免疫原性组合物用于体内给予人。免疫原性制剂也可用于诊断病毒的存在

2. 发明申请

WO2009014665A3 TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS 审中-公开
标题翻译：具有增强农业条件的转基因植物
公开(公告)号：WO2009014665A3
公开(公告)日：2009-04-30
申请号：PCT/US2008008833
申请日：2008-07-18
申请人： MONSANTO TECHNOLOGY LLC , ABAD MARK , ALIBHAI MURTAZA , AUGUSTINE ALICE CLARA , BASRA AMARJIT , BELL ERIN , BRADSHAW TERRY L , CASTIGLIONI PAOLO , CHITTOOR-VIJAYANATH JAISHREE , DEIKMAN JILL , DENG MOLIAN , EDGERTON MICHAEL , GABBERT KAREN , GOLDMAN BARRY , KARUNANANDAA BALASULOJINI , LELAND TIMOTHY J , KJEMTRUP-LOVELACE SUSANNE , LUND ADRIAN , LUTFIYYA LINDA , MCNABNAY MARCUS , NELSON DONALD , RUFF THOMAS , SAVIDGE BETH , SCHAFFER PAUL , SUDARSHANA PADMINI , SUMATHY K , THAI CAROLYN , THOMPSON-MIZE REBECCA , URWIN CARL P , VEENA H G , VENKATESH T V , VOSS STEVEN , XIE ZHIDONG
发明人： ABAD MARK , ALIBHAI MURTAZA , AUGUSTINE ALICE CLARA , BASRA AMARJIT , BELL ERIN , BRADSHAW TERRY L , CASTIGLIONI PAOLO , CHITTOOR-VIJAYANATH JAISHREE , DEIKMAN JILL , DENG MOLIAN , EDGERTON MICHAEL , GABBERT KAREN , GOLDMAN BARRY , KARUNANANDAA BALASULOJINI , LELAND TIMOTHY J , KJEMTRUP-LOVELACE SUSANNE , LUND ADRIAN , LUTFIYYA LINDA , MCNABNAY MARCUS , NELSON DONALD , RUFF THOMAS , SAVIDGE BETH , SCHAFFER PAUL , SUDARSHANA PADMINI , SUMATHY K , THAI CAROLYN , THOMPSON-MIZE REBECCA , URWIN CARL P , VEENA H G , VENKATESH T V , VOSS STEVEN , XIE ZHIDONG
IPC分类号： C12N15/82 , A01H5/00 , C12N9/16
CPC分类号： C12N15/8261 , Y02A40/146
摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced trait.
摘要翻译：本发明提供具有用于表达蛋白质的重组DNA的转基因植物细胞，其可用于赋予转基因作物植物增强的农艺性状。本发明还提供包含转基因植物细胞的转基因植物和后代种子，其中植物被选择用于具有增强的性状，所述性状选自由增强的水利用效率，增强的耐寒性，增加的产量，增强的氮利用效率，增强的氮利用效率，种子蛋白和增强种子油。还公开了用于制备具有增强特征的转基因种子和植物的方法。

3. 发明申请

WO2012073257A3 VACCINE FORMULATION FOR PROPHYLAXIS AND TREATMENT OF CHANDIPURA VIRUS INFECTIONS IN MAMMALS 审中-公开
标题翻译：用于预防和治疗哺乳动物CHANDIPURA病毒感染的疫苗制剂
公开(公告)号：WO2012073257A3
公开(公告)日：2012-10-11
申请号：PCT/IN2011000817
申请日：2011-11-29
申请人： BHARAT BIOTECH INT LTD , ELLA KRISHNA MURTHY , SUMATHY K
发明人： ELLA KRISHNA MURTHY , SUMATHY K
IPC分类号： A61K39/12 , A61K39/205
CPC分类号： A61K39/205 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55583 , C12N2760/20034
摘要： The present invention is related to pharmaceutical formulations capable of eliciting protective immune response against Chandipura virus infection in humans and other mammalian hosts. The immunogenic formulation comprises Chandipura virus glycoprotein (G protein) and/or nucleoprotein expressed as recombinant proteins and purified from host cells. Vaccine compositions comprising the recombinant proteins elicit neutralizing antibodies similar to the vaccine compositions of purified inactivated Chandipura virus in a stable formulation. Methods of inactivating Chandipura virus for use as a candidate vaccine are disclosed. The vaccine compositions have been formulated with adjuvants to potentiate the immune response. The vaccine compositions disclosed in the invention are highly immunogenic and elicit protective immune response in mammalian host. The immunogenic compositions are formulated for in vivo administration to humans. The immunogenic preparation will also find use in diagnosing for the presence of the virus
摘要翻译：本发明涉及能够在人和其他哺乳动物宿主中引发针对金迪普拉病毒感染的保护性免疫应答的药物制剂。免疫原性制剂包含表达为重组蛋白并从宿主细胞纯化的金迪普拉病毒糖蛋白（G蛋白）和/或核蛋白。包含重组蛋白的疫苗组合物在稳定制剂中引发与纯化的灭活金迪普拉病毒的疫苗组合物相似的中和抗体。公开了灭活金迪普拉病毒以用作候选疫苗的方法。已经用佐剂配制疫苗组合物以增强免疫应答。本发明公开的疫苗组合物具有高度免疫原性并在哺乳动物宿主中引起保护性免疫应答。配制免疫原性组合物用于体内施用给人。免疫原性制剂也可用于诊断病毒的存在

4. 发明申请

WO2009014665A2 TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS 审中-公开
标题翻译：具有增强的农艺性状的转基因植物
公开(公告)号：WO2009014665A2
公开(公告)日：2009-01-29
申请号：PCT/US2008/008833
申请日：2008-07-18
申请人： MONSANTO TECHNOLOGY, LLC , ABAD, Mark , ALIBHAI, Murtaza , AUGUSTINE, Alice, Clara , BASRA, Amarjit , BELL, Erin , BRADSHAW, Terry, L. , CASTIGLIONI, Paolo , CHITTOOR-VIJAYANATH, Jaishree , DEIKMAN, Jill , DENG, Molian , EDGERTON, Michael , GABBERT, Karen , GOLDMAN, Barry , KARUNANANDAA, Balasulojini , LELAND, Timothy, J. , KJEMTRUP-LOVELACE, Susanne , LUND, Adrian , LUTFIYYA, Linda , MCNABNAY, Marcus , NELSON, Donald , RUFF, Thomas , SAVIDGE, Beth , SCHAFFER, Paul , SUDARSHANA, Padmini , SUMATHY, K. , THAI, Carolyn , THOMPSON-MIZE, Rebecca , URWIN, Carl, P. , VEENA, H.G. , VENKATESH, T.V. , VOSS, Steven , XIE, Zhidong
发明人： ABAD, Mark , ALIBHAI, Murtaza , AUGUSTINE, Alice, Clara , BASRA, Amarjit , BELL, Erin , BRADSHAW, Terry, L. , CASTIGLIONI, Paolo , CHITTOOR-VIJAYANATH, Jaishree , DEIKMAN, Jill , DENG, Molian , EDGERTON, Michael , GABBERT, Karen , GOLDMAN, Barry , KARUNANANDAA, Balasulojini , LELAND, Timothy, J. , KJEMTRUP-LOVELACE, Susanne , LUND, Adrian , LUTFIYYA, Linda , MCNABNAY, Marcus , NELSON, Donald , RUFF, Thomas , SAVIDGE, Beth , SCHAFFER, Paul , SUDARSHANA, Padmini , SUMATHY, K. , THAI, Carolyn , THOMPSON-MIZE, Rebecca , URWIN, Carl, P. , VEENA, H.G. , VENKATESH, T.V. , VOSS, Steven , XIE, Zhidong
IPC分类号： C12N15/82 , C12N9/16 , A01H5/00
CPC分类号： C12N15/8261 , Y02A40/146
摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced trait.
摘要翻译：本发明提供了具有重组DNA的转基因植物细胞，用于表达可用于赋予转基因作物植物增强的农学性状的蛋白质。本发明还提供了包含转基因植物细胞的转基因植物和子代种子，其中选择植物具有选自增强的水分利用效率，增强的冷耐受性，提高的产量，提高的氮利用效率，增强的增强性状种子蛋白质和增强的种子油。还公开了用于制造具有增强的性状的转基因种子和植物的方法。

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