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    • 2. 发明申请
    • PROCESSES FOR PRODUCING THIOARYL COMPOUND
    • 生产硫酸化合物的方法
    • WO1995025089A1
    • 1995-09-21
    • PCT/JP1995000455
    • 1995-03-17
    • IHARA CHEMICAL INDUSTRY CO., LTD.SUGIYAMA, TatsuoNAKAYAMA, Tadashi
    • IHARA CHEMICAL INDUSTRY CO., LTD.
    • C07C319/06
    • C07C319/14C07C319/06C07C323/52C07C323/34
    • A process for producing an alkali metal salt of an arylmercaptan compound represented by general formula (3), by the reaction of a disulfide compound represented by general formula (1) with a hydroxide of an alkali metal M in the presence of a sulfur compound represented by the general formula (2): H(2-i)S(M )i, another process for producing an alkoxycarbonylalkylthioaryl compound represented by general formula (5) by the reaction of the alkali metal salt of an arylmercaptan compound obtained above with a halogenated fatty acid ester represented by the general formula (4): X -R -COOR at a pH of 7 to 10; and still another process for producing the alkoxycarbonylalkylthioaryl compound by the reaction of the disulfide compound with the hydroxide of an alkali metal M in the presence of the sulfur compound, followed by the reaction of the obtained alkali metal salt of an arylmercaptan compound, without being isolated, with the halogenated fatty acid ester under the same condition.
    • 一种通式(3)表示的芳基硫醇化合物的碱金属盐的制备方法,通过在通式(1)表示的二硫化物与碱金属M 1的氢氧化物的反应中, 由通式(2)表示的硫化合物:H(2-i)S(M 1)i,另外通过通式(5)表示的烷氧基羰基烷基硫代芳基化合物的制备方法, 在通式(4)表示的卤代脂肪酸酯:X 1 -R 2 -COOR 3,pH7〜10的条件下,得到上述得到的芳基硫醇化合物; 还有在硫化合物存在下,通过二硫化物与碱金属M 1的氢氧化物的反应制备烷氧基羰基烷基硫代芳基化合物的另一种方法,然后将所得到的芳基硫醇化合物的碱金属盐, 在不同的条件下与卤代脂肪酸酯分离。
    • 3. 发明申请
    • PROCESS FOR PRODUCING HEXAHYDROPYRIDAZINE AND HEXAHYDROPYRIDAZINE-1,2-DICARBOXYLATE DERIVATIVE
    • 六氢呋喃并嘧啶衍生物的制造方法和二氢吡啶-2-基二甲氧基硅烷衍生物
    • WO1995021828A1
    • 1995-08-17
    • PCT/JP1995000184
    • 1995-02-10
    • IHARA CHEMICAL INDUSTRY CO., LTD.SUGIYAMA, Tatsuo
    • IHARA CHEMICAL INDUSTRY CO., LTD.
    • C07D237/04
    • C07D237/04
    • A process for producing a hexahydropyridazine-1,2-dicarboxylate derivative represented by general formula (3) (wherein R and R represent each independently alkyl) by reacting a hydrazinedicarboxylate derivative represented by the general formula (1): R OOC-NH-NH-COOR (wherein R and R are each as defined above) with a dihalogenobutane represented by the general formula (2): X -CH2CH2CH2CH2-X (wherein X and X represent each independently halogen) in the presence of an alkali metal hydroxide, characterized by conducting the reaction in an aprotic polar solvent; and a process for producing hexahydropyridazine by decarboxylating the obtained hexahydropyridazine-1,2-dicarboxylate derivative (3), without being isolated, in the presence of an alkali metal hydroxide and a hydrogen donor compound.
    • 由通式(3)表示的肼基二羧酸酯衍生物(1)表示的通式(3)表示的六氢哒嗪-1,2-二羧酸酯衍生物的制造方法(其中R 1和R 2各自独立地为烷基) R 2 OOC-NH-NH-COOR 2(其中R 1和R 2各自如上所定义)与通式(2)表示的二卤代丁烷:X 1 -CH 2 CH 2 CH 2 CH 2 - X 2(其中X 1和X 2各自独立地为卤素)在碱金属氢氧化物的存在下反应,其特征在于在非质子极性溶剂中进行反应; 以及通过在碱金属氢氧化物和氢供体化合物的存在下将所得六氢哒嗪-1,2-二羧酸酯衍生物(3)脱羧而不分离来制备六氢哒嗪的方法。