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1. 发明专利

CA2077695A1 HYDROPYRIDINE DERIVATIVES HAVING ANTITHROMBOTIC ACTIVITY 未知
公开(公告)号：CA2077695A1
公开(公告)日：1993-03-10
申请号：CA2077695
申请日：1992-09-08
申请人： KOIKE HIROYUKI , ASAI FUMITOSHI , SUGIDACHI ATSUHIRO , KIMURA TOMIO , INOUE TERUHIKO , NISHINO SHIGEYOSHI , TSUZAKI YASUNORI
发明人： KOIKE HIROYUKI , ASAI FUMITOSHI , SUGIDACHI ATSUHIRO , KIMURA TOMIO , INOUE TERUHIKO , NISHINO SHIGEYOSHI , TSUZAKI YASUNORI
IPC分类号： A61K31/435 , A61K31/135 , A61K31/365 , A61K31/4365 , A61P7/02 , C07D221/00 , C07D333/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要： The present invention relates to a series of new tetrahydrothieno[3,2-c]pyridine derivatives and furo and pyrrolo analogs of these derivatives, and provides processes for preparing these derivatives as well as methods and compositions using them for inhibiting blood platelet aggregation. More specifically, disclosed is a compound of formula (I): (See formula I) wherein, preferably: R1 represents a hydrogen atom, a methyl group, an ethyl group, a halogen atom, a methyl group substituted by at least one fluorine atom, a hydroxy group, a methoxy group, an ethoxy group, a methoxy group substituted by at least one fluorine atom, a methylthio group, a methylthio group substituted by at least one fluorine atom, a formyl group, an acetyl group, an acetyl group substituted by at least one fluorine atom, an alkoxycarbonyl group having from 2 to 4 carbon atoms, a carbamoyl group, a cyano group, a nitro group, a methanesulfonyl group, an ethanesulfonyl group, a methanesulfonyl group substituted by at least one fluorine atom, or a sulfamoyl group; R2 represents an alkanoyl group having from 2 to 6 carbon atoms, a substituted alkanoyl group which has from 2 to 6 carbon atoms and which is substituted by at least one fluorine atom, a cycloalkylcarbonyl group having from 4 to 7 carbon atoms, or a substituted cycloalkylcarbonyl group which is substituted by at least one fluorine atom; R3 represents a hydrogen atom, a hydroxy group, a methoxy group, an ethoxy group, a t-butoxy group, a methoxymethoxy group, an alkanoyloxymethoxy group in which the alkanoyl part has from 1 to 5 carbon atoms, a benzyloxy group, an alkanoyloxy group having from 1 to 12 carbon atoms, an alkenoyloxy group having 3 or 4 carbon atoms, a cycloalkylcarbonyloxy group having from 4 to 7 carbon atoms, a benzoyloxy group, an alkoxycarbonyloxy group having from 2 to 5 carbon atoms, a benzyloxycarbonyloxy group, a phthalidyloxy group, a (5-methyl-2-oxo-1,3- dioxolen-4-yl)methoxy group, a (5-phenyl-2-oxo-1,3- dioxolen-9-yl)methoxy group, an amino group or a t- butoxycarbonylamino group; Y represents an oxygen or sulfur atom; and n is 1 to 3.

2. 发明专利

CA2077695C HYDROPYRIDINE DERIVATIVES HAVING ANTITHROMBOTIC ACTIVITY 未知
公开(公告)号：CA2077695C
公开(公告)日：2002-08-20
申请号：CA2077695
申请日：1992-09-08
申请人： KOIKE HIROYUKI , ASAI FUMITOSHI , SUGIDACHI ATSUHIRO , KIMURA TOMIO , INOUE TERUHIKO , NISHINO SHIGEYOSHI , TSUZAKI YASUNORI
发明人： KOIKE HIROYUKI , ASAI FUMITOSHI , SUGIDACHI ATSUHIRO , KIMURA TOMIO , INOUE TERUHIKO , NISHINO SHIGEYOSHI , TSUZAKI YASUNORI
IPC分类号： A61K31/435 , A61K31/135 , A61K31/365 , A61K31/4365 , A61P7/02 , C07D221/00 , C07D333/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要： The present invention relates to a series of new tetrahydrothieno[3,2-c]pyridine derivatives and furo and pyrrolo analogs of these derivatives, and provides processes for preparing these derivatives as well as methods and compositions using them for inhibiting blood platelet aggregation. More specifically, disclosed is a compound of formula (I): (See formula I) wherein, preferably: R1 represents a hydrogen atom, a methyl group, an ethyl group, a halogen atom, a methyl group substituted by at least one fluorine atom, a hydroxy group, a methoxy group, an ethoxy group, a methoxy group substituted by at least one fluorine atom, a methylthio group, a methylthio group substituted by at least one fluorine atom, a formyl group, an acetyl group, an acetyl group substituted by at least one fluorine atom, an alkoxycarbonyl group having from 2 to 4 carbon atoms, a carbamoyl group, a cyano group, a nitro group, a methanesulfonyl group, an ethanesulfonyl group, a methanesulfonyl group substituted by at least one fluorine atom, or a sulfamoyl group; R2 represents an alkanoyl group having from 2 to 6 carbon atoms, a substituted alkanoyl group which has from 2 to 6 carbon atoms and which is substituted by at least one fluorine atom, a cycloalkylcarbonyl group having from 4 to 7 carbon atoms, or a substituted cycloalkylcarbonyl group which is substituted by at least one fluorine atom; R3 represents a hydrogen atom, a hydroxy group, a methoxy group, an ethoxy group, a t-butoxy group, a methoxymethoxy group, an alkanoyloxymethoxy group in which the alkanoyl part has from 1 to 5 carbon atoms, a benzyloxy group, an alkanoyloxy group having from 1 to 12 carbon atoms, an alkenoyloxy group having 3 or 4 carbon atoms, a cycloalkylcarbonyloxy group having from 4 to 7 carbon atoms, a benzoyloxy group, an alkoxycarbonyloxy group having from 2 to 5 carbon atoms, a benzyloxycarbonyloxy group, a phthalidyloxy group, a (5-methyl-2-oxo-1,3- dioxolen-4-yl)methoxy group, a (5-phenyl-2-oxo-1,3- dioxolen-9-yl)methoxy group, an amino group or a t- butoxycarbonylamino group; Y represents an oxygen or sulfur atom; and n is 1 to 3.

3. 发明申请

WO1998008811A1 CYCLIC AMINE DERIVATIVES 审中-公开
标题翻译：循环胺衍生物
公开(公告)号：WO1998008811A1
公开(公告)日：1998-03-05
申请号：PCT/JP1997002990
申请日：1997-08-28
申请人： SANKYO COMPANY, LIMITED , UBE INDUSTRIES, LTD. , ASAI, Fumitoshi , SUGIDACHI, Atsuhiro , IKEDA, Toshihiko , KOIKE, Hiroyuki , INOUE, Teruhiko , TAKATA, Katsunori , IWAMURA, Ryo , KITA, Jun-ichiro , YONEDA, Kenji
发明人： SANKYO COMPANY, LIMITED , UBE INDUSTRIES, LTD.
IPC分类号： C07D205/04
CPC分类号： C07D213/70 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/20 , C07D211/54 , C07D451/02 , C07D451/04 , Y02P20/55
摘要： Cyclic amine derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, excellent in the effect of inhibiting platelet aggregation and useful as a preventive or remedy for embolism, thrombosis or arteriosclerosis, wherein R represents optionally substituted phenyl; R represents optionally substituted C1-C8 acyl, optionally substituted benzoyl or C1-C4 alkoxycarbonyl; and R represents optionally fused, substituted three- to seven-membered cyclic saturated amino.
摘要翻译：由通式（I）表示的环胺衍生物或其药理学上可接受的盐，其抑制血小板聚集的效果优异，可用作栓塞，血栓形成或动脉硬化的预防或治疗，其中R 1表示任选取代的苯基; R 2表示任选取代的C 1 -C 8酰基，任选取代的苯甲酰基或C 1 -C 4烷氧基羰基; R 3表示任选稠合的取代的三至七元环饱和的氨基。

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