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1. 发明申请

WO1993020228A1 NOVEL, PHYSIOLOGICALLY ACTIVE PROTEIN AND HEMOPOIETIC STEM CELL GROWTH PROMOTER 审中-公开
标题翻译：新生，生理活性蛋白和致突变干细胞生长促进剂
公开(公告)号：WO1993020228A1
公开(公告)日：1993-10-14
申请号：PCT/JP1993000404
申请日：1993-03-31
申请人： TORAY INDUSTRIES, INC. , NAKAHATA, Tatsutoshi , KAWANO, Genji , SUDO, Tetsuo , KOJIMA, Katsuaki
发明人： TORAY INDUSTRIES, INC.
IPC分类号： C12P21/02
CPC分类号： C07K14/475 , A61K38/00
摘要： A novel, physiologically active protein having the activity of promoting undifferentiated hemopoietic stem cell growth, a molecular weight of 18,000 +/- 2,000 and the above N-terminal amino acid sequence; and a hemopoietic stem cell growth promoter containing the above protein as the active ingredient. This protein is useful as a stem cell growth promoter in the treatment of bone marrow suppression and bone marrow dysfunction and in the in vitro growth of peripheral vessel cells and bone marrow stem cells. In addition, it is useful also as a platelet growth promoter and a remedy for leukopenia.
摘要翻译：一种具有促进未分化造血干细胞生长活性，分子量为18,000 +/- 2,000和上述N-末端氨基酸序列的新型生理活性蛋白质; 和含有上述蛋白质作为活性成分的造血干细胞生长促进剂。该蛋白质可用作干细胞生长促进剂，用于治疗骨髓抑制和骨髓功能障碍以及外周血管细胞和骨髓干细胞的体外生长。此外，作为血小板生长促进剂和白细胞减少症的治疗也是有用的。

2. 发明申请

WO1997005893A1 REMEDY FOR OPHTHALMIC DISEASES 审中-公开
标题翻译：补救眼科疾病
公开(公告)号：WO1997005893A1
公开(公告)日：1997-02-20
申请号：PCT/JP1996001973
申请日：1996-07-15
申请人： TORAY INDUSTRIES, INC. , UTSUMI, Jun , SUDO, Tetsuo , TANAKA, Yasuhiko , MATSUI, Mizuo
发明人： TORAY INDUSTRIES, INC.
IPC分类号： A61K38/18
CPC分类号： A61K38/57 , C07K14/475 , C07K14/8114 , Y10S514/912
摘要： A remedy efficacious in curing various retinochroid diseases such as retinal pigment degeneration, retinopathy, macular disease and retinal detachment, which contains a retinal pigment epitheliocyte growth factor as the active ingredient.
摘要翻译：治疗各种视黄醛变性疾病如视网膜色素变性，视网膜病变，黄斑病变和视网膜剥离的补救措施，其含有视网膜色素上皮细胞生长因子作为活性成分。

3. 发明申请

WO1994028160A1 MONOCLONAL ANTIBODY, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF 审中-公开
标题翻译：单克隆抗体，其生产方法及其用途
公开(公告)号：WO1994028160A1
公开(公告)日：1994-12-08
申请号：PCT/JP1994000887
申请日：1994-06-01
申请人： TORAY INDUSTRIES, INC. , NISHIKAWA, Satomi , SUDO, Tetsuo , OKANO, Kiyoshi , IZAWA, Akiko , NAKAMURA, Noriko , AKIYAMA, Naoko
发明人： TORAY INDUSTRIES, INC.
IPC分类号： C12P21/08
CPC分类号： C07K16/2866 , A01K67/027 , A61K38/00
摘要： A monoclonal antibody specific for mouse IL-7 receptors, and an immunoassay method by which the receptors can be detected and determined readily with high sensitivity and accuracy. An artificially induced model prepared by administering the above antibody to an animal can be utilized in elucidating the mechanism of lymphocyte differentiation and proliferation, developing an immunosuppressant, and investigating organ transplantation, arthritis, diabetes, and so forth. Further, an artificially induced model prepared by administering the above antibody in combination with an anti-SCF receptor antibody to an animal can be utilized in elucidating diseases due to an abnormal hematopoietic function such as aplastic anemia exhibiting decreased myelopoiesis and whole blood hematopenia in the peripheral blood and in developing medicines capable of curing these blood cell disorders. A mouse containing the above antibody in combination with an anti-SCF receptor antibody administered thereto has concentrated hematopoietic stem cells, and hence the myeloma or splenic cells thereof can be used to estimate hematopoietic stem cell proliferation factors. Therefore, the invention method of estimation is useful in searching for such factors.
摘要翻译：对小鼠IL-7受体特异性的单克隆抗体，以及以高灵敏度和准确度容易地检测和确定受体的免疫测定方法。通过对动物施用上述抗体制备的人造诱导模型可以用于阐明淋巴细胞分化和增殖的机制，开发免疫抑制剂，以及研究器官移植，关节炎，糖尿病等。此外，通过将上述抗体与抗SCF受体抗体组合施用于动物而制备的人造诱导模型可用于阐明由于造血功能异常引起的疾病，例如显示骨髓细胞减少和全身血细胞减少的再生障碍性贫血血液和开发能够治愈这些血细胞疾病的药物。含有上述抗体与施用于其的抗SCF受体抗体的小鼠具有浓缩的造血干细胞，因此可以使用其骨髓瘤或脾细胞来估计造血干细胞增殖因子。因此，本发明的估计方法在寻找这些因素方面是有用的。

4. 发明申请

WO1993003061A1 HEMATOPOIETIC STEM CELL MULTIPLIER 审中-公开
公开(公告)号：WO1993003061A1
公开(公告)日：1993-02-18
申请号：PCT/JP1992000949
申请日：1992-07-24
申请人： TORAY INDUSTRIES, INCORPORATED , KOMIYAMA, Atsushi , NAKAHATA, Tatsutoshi , KUBO, Tetsuo , TANAKA, Ryuhei , KAWANO, Genji , SUDO, Tetsuo , SANO, Emiko , KOJIMA, Katsuaki
发明人： TORAY INDUSTRIES, INCORPORATED
IPC分类号： C07K15/04
CPC分类号： C07K14/4753
摘要： A hematopoietic stem cell multiplier containing at least one hepatocyte proliferating factor as an active ingredient. Because hepatocyte proliferating factors have an activity of proliferating undifferentiated pluripotent hematopoietic stem cells, they are useful as a hematopoietic stem cell multiplier not only in treating bone marrow inhibition and insufficiency but also in effecting in vitro growth of peripheral blood stem cells and bone marrow stem cells. Further it is possible to derive a hepatocyte proliferating factor from human normal fibroblasts among other hepatocyte proliferating factors by the gene recombination technique, and the obtained proliferating factor is, too, useful as a hematopoietic stem cell multiplier.

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