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1. 发明申请

WO2010051382A1 MOOD CIRCUIT MONITORING TO CONTROL THERAPY DELIVERY 审中-公开
标题翻译： MOOD电路监控以控制治疗
公开(公告)号：WO2010051382A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/062609
申请日：2009-10-29
申请人： MEDTRONIC, INC. , GIFTAKIS, Jonathon, E. , RISE, Mark, T. , CARLSON, David , STYPULKOWSKI, Paul, H. , STANSLASKI, Scott, R. , JENSEN, Randy, M. , DENISON, Timothy, J.
发明人： GIFTAKIS, Jonathon, E. , RISE, Mark, T. , CARLSON, David , STYPULKOWSKI, Paul, H. , STANSLASKI, Scott, R. , JENSEN, Randy, M. , DENISON, Timothy, J.
IPC分类号： A61B5/0476 , A61N1/36 , A61B5/16
CPC分类号： A61B5/0476 , A61B5/0205 , A61B5/024 , A61B5/0488 , A61B5/16 , A61B5/4076 , A61B5/4839 , A61B5/486 , A61M21/00 , A61M2021/0072 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36082
摘要： Brain signals may be monitored at different locations of a mood circuit in order to determine a mood state of the patient. A relationship (e.g., a ratio) between frequency band characteristics of the monitored brain signals may be indicative of a particular mood state. In some examples, therapy parameter values that define the therapy delivered to the patient may be selected to maintain a target relationship (e.g., a target ratio) between the frequency band characteristics of the brain signals monitored within the mood circuit. In addition, in some examples, therapy delivery to the patient may be controlled based on the frequency band characteristics of brain signals sensed at different portions of the mood circuit.
摘要翻译：可以在心情电路的不同位置监测脑信号，以便确定患者的情绪状态。所监视的脑信号的频带特性之间的关系（例如，比率）可以指示特定的情绪状态。在一些示例中，可以选择限定递送给患者的治疗的治疗参数值，以在心情电路内监测的脑信号的频带特性之间维持目标关系（例如，目标比率）。此外，在一些示例中，可以基于在心情电路的不同部分感测到的脑信号的频带特性来控制对患者的治疗递送。

2. 发明申请

WO2009129486A3 TIMING THERAPY EVALUATION TRIALS 审中-公开
公开(公告)号：WO2009129486A3
公开(公告)日：2009-12-17
申请号：PCT/US2009041005
申请日：2009-04-17
申请人： MEDTRONIC INC , GIFTAKIS JONATHON E , RISE MARK T , STYPULKOWSKI PAUL H , DENISON TIMOTHY J
发明人： GIFTAKIS JONATHON E , RISE MARK T , STYPULKOWSKI PAUL H , DENISON TIMOTHY J
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/36135 , A61N1/0534 , A61N1/36082 , A61N1/37211 , A61N1/37247
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy delivery dissipates. Monitoring a washout period may be useful for timing the delivery of therapy according to different therapy programs during a therapy evaluation period. For example, at least one physiological signal of the patient may be monitored to automatically determine when a washout period has ended, e.g., when stimulation and carryover effects of therapy delivery according to a first therapy program have substantially dissipated, in order to determine when therapy delivery according to a second therapy program can be initiated.

3. 发明申请

WO2009129493A1 ANALYZING A WASHOUT PERIOD CHARACTERISTIC FOR PSYCHIATRIC DISORDER THERAPY DELIVERY 审中-公开
标题翻译：分析精神疾病治疗方法的出院期特征
公开(公告)号：WO2009129493A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/041015
申请日：2009-04-17
申请人： MEDTRONIC, INC. , GIFTAKIS, Jonathon, E. , RISE, Mark, T. , STYPULKOWSKI, Paul, H. , DENISON, Timothy, J.
发明人： GIFTAKIS, Jonathon, E. , RISE, Mark, T. , STYPULKOWSKI, Paul, H. , DENISON, Timothy, J.
IPC分类号： G06F19/00
CPC分类号： G16H40/63 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3561 , A61M2205/3592 , A61M2210/0693 , A61N1/08 , A61N1/36025 , A61N1/36082 , A61N1/37211 , G06F19/00 , G16H40/40
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy dissipates. The washout period characteristic may include, for example, a duration of the washout period, an amplitude or a trend in a physiological signal during the washout period or a power level or a ratio of power levels in frequency bands of the physiological signal. In some embodiments, washout period characteristics associated with a plurality of therapy programs may be used to compare the programs. In other embodiments, a washout period characteristic may be used to determine a mood state of the patient and, in some cases, modify a therapy program. Monitoring a washout period may also be useful for timing therapy program trials.
摘要翻译：根据治疗程序向患者输送治疗后的清洗期间的特征可以基于患者的生理参数来确定。清洗期包括治疗所产生的结转效应消散的时间。清洗期间特征可以包括例如清洗期间的持续时间，清洗期间的生理信号的幅度或趋势，或生理信号的频带的功率水平或功率水平的比率。在一些实施例中，可以使用与多个治疗程序相关联的清除期特征来比较程序。在其他实施例中，清洗周期特征可以用于确定患者的情绪状态，并且在一些情况下可以修改治疗程序。监测清洗期也可能对时间治疗方案试验有用。

4. 发明申请

WO2012103224A1 TARGET THERAPY DELIVERY SITE SELECTION 审中-公开
标题翻译：目标治疗交付网站选择
公开(公告)号：WO2012103224A1
公开(公告)日：2012-08-02
申请号：PCT/US2012/022558
申请日：2012-01-25
申请人： MEDTRONIC, INC. , STYPULKOWSKI, Paul H. , GIFTAKIS, Jonathon E.
发明人： STYPULKOWSKI, Paul H. , GIFTAKIS, Jonathon E.
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36064 , A61N1/0534 , A61N1/36135 , A61N1/36171 , A61N1/36185
摘要： In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
摘要翻译：在选择用于治疗患者病症的靶治疗递送部位的一些实例中，相对高频率的电刺激信号被递送到患者脑部的第一区域内的至少两个区域，以及大脑活动的变化（例如，确定响应于递送的刺激的患者脑部的第二区域内由生物电脑信号指示）。可以基于脑活动的变化来选择目标治疗递送部位，电极组合或两者。

5. 发明申请

WO2009129478A3 TIMING THERAPY EVALUATION TRIALS 审中-公开
标题翻译：定时疗法评估试验
公开(公告)号：WO2009129478A3
公开(公告)日：2009-12-17
申请号：PCT/US2009040988
申请日：2009-04-17
申请人： MEDTRONIC INC , GIFTAKIS JONATHON E , RISE MARK T , STYPULKOWSKI PAUL H , DENISON TIMOTHY J
发明人： GIFTAKIS JONATHON E , RISE MARK T , STYPULKOWSKI PAUL H , DENISON TIMOTHY J
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3561 , A61M2205/3592 , A61M2210/0693 , A61N1/08 , A61N1/36025 , A61N1/36082 , A61N1/37211 , G06F19/3481 , G16H40/40 , G16H40/63
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy delivery dissipates. Monitoring a washout period may be useful for timing the delivery of therapy according to different therapy programs during a therapy evaluation period. For example, at least one physiological signal of the patient may be monitored to automatically determine when a washout period has ended, e.g., when stimulation and carryover effects of therapy delivery according to a first therapy program have substantially dissipated, in order to determine when therapy delivery according to a second therapy program can be initiated.
摘要翻译：可以基于患者的生理参数确定根据治疗程序向患者递送治疗之后的清除期的特征。清除期包括治疗输送带来的滞留效应消失的时间段。在治疗评估期间，根据不同的治疗计划，监测清除期可能对于定时递送治疗有用。例如，可以监测患者的至少一个生理信号以自动确定清洗期何时结束，例如，当根据第一治疗程序的治疗递送的刺激和遗留效应已基本消散时，以便确定何时治疗可以启动根据第二疗法程序的输送。

6. 发明申请

WO2009129486A2 TIMING THERAPY EVALUATION TRIALS 审中-公开
标题翻译：定时疗法评估试验
公开(公告)号：WO2009129486A2
公开(公告)日：2009-10-22
申请号：PCT/US2009/041005
申请日：2009-04-17
申请人： MEDTRONIC, INC. , GIFTAKIS, Jonathon, E. , RISE, Mark, T. , STYPULKOWSKI, Paul, H. , DENISON, Timothy, J.
发明人： GIFTAKIS, Jonathon, E. , RISE, Mark, T. , STYPULKOWSKI, Paul, H. , DENISON, Timothy, J.
IPC分类号： A61N1/36
CPC分类号： A61N1/36135 , A61N1/0534 , A61N1/36082 , A61N1/37211 , A61N1/37247
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy delivery dissipates. Monitoring a washout period may be useful for timing the delivery of therapy according to different therapy programs during a therapy evaluation period. For example, at least one physiological signal of the patient may be monitored to automatically determine when a washout period has ended, e.g., when stimulation and carryover effects of therapy delivery according to a first therapy program have substantially dissipated, in order to determine when therapy delivery according to a second therapy program can be initiated.
摘要翻译：根据治疗计划向患者递送治疗之后的清除期的特征可以基于患者的生理参数来确定。清除期包括治疗输送带来的滞留效应消失的时间段。在治疗评估期间，根据不同的治疗计划，监测清除期可能对于定时递送治疗有用。例如，可以监测患者的至少一个生理信号以自动确定清洗期何时结束，例如，当根据第一治疗程序的治疗递送的刺激和遗留效应已基本消散时，以便确定何时治疗根据第二疗法程序的递送可以被启动。

7. 发明申请

WO2009129480A2 PSYCHIATRIC DISORDER THERAPY CONTROL 审中-公开
标题翻译：心理障碍治疗控制
公开(公告)号：WO2009129480A2
公开(公告)日：2009-10-22
申请号：PCT/US2009/040991
申请日：2009-04-17
申请人： MEDTRONIC, INC. , RISE, Mark, T. , GIFTAKIS, Jonathon, E. , STYPULKOWSKI, Paul, H. , DENISON, Timothy, J. , TORGERSON, Nathan, A.
发明人： RISE, Mark, T. , GIFTAKIS, Jonathon, E. , STYPULKOWSKI, Paul, H. , DENISON, Timothy, J. , TORGERSON, Nathan, A.
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61B5/01 , A61B5/0488 , A61B5/08 , A61B5/0816 , A61B5/165 , A61B5/441 , A61B5/4836 , A61B5/7275 , G06F19/00 , G16H20/70 , G16H40/63
摘要： A therapy system for managing a psychiatric disorder of the patient may be controlled based on a patient mood state. Therapy may be delivered to a patient according to a therapy program, and a physiological parameter of the patient may be monitored during or after therapy delivery. The patient mood state may be determined based on the monitored physiological parameter, and the therapy delivery may be controlled based on the determined mood state. In some embodiments, the therapy delivery is stopped prior to determining the patient mood state and the therapy delivery is restarted upon detecting a negative mood state. In other embodiments, therapy delivery is delivered until a positive mood state is detected, at which point the therapy delivery may be stopped.
摘要翻译：可以基于患者情绪状态来控制用于管理患者精神障碍的治疗系统。治疗可以根据治疗程序递送到患者，并且可以在治疗递送期间或之后监测患者的生理参数。可以基于所监测的生理参数来确定患者情绪状态，并且可以基于所确定的情绪状态来控制治疗递送。在一些实施例中，在确定患者情绪状态之前停止治疗递送，并且在检测到负情绪状态时重新开始治疗递送。在其它实施方案中，递送治疗递送直到检测到正状态，此时可以停止治疗递送。

8. 发明申请

WO2011068947A1 SELECTING THERAPY CYCLE PARAMETERS BASED ON MONITORED BRAIN SIGNAL 审中-公开
标题翻译：基于监测的脑信号选择治疗周期参数
公开(公告)号：WO2011068947A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/058688
申请日：2010-12-02
申请人： MEDTRONIC, INC. , GIFTAKIS, Jonathon, E. , STYPULKOWSKI, Paul, H.
发明人： GIFTAKIS, Jonathon, E. , STYPULKOWSKI, Paul, H.
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/0478 , A61B5/4094 , A61N1/37247 , G16H40/63
摘要： Bioelectrical brain signals may be monitored at one more regions of the brain of a patient by a medical device. The monitored bioelectrical signals may be used to select one or more therapy cycle parameters, e.g., on cycle duration and/or off cycle duration, for therapy delivered to treat a patient disorder. In one example, the off cycle duration of a therapy may be selected based on the washout period determined from sensed brain signals of the patient following delivery of therapy during an on cycle. In another example, the on cycle duration and/or off cycle duration of a therapy may be selected to maintain the value of one or more characteristics of a brain signal (e.g., cortical activity) of patient within a threshold range of a target value defined for the characteristic that is associated with effective treatment of the patient disorder.
摘要翻译：可以通过医疗装置在患者的脑的另外一个区域监测生物电脑信号。监测的生物电信号可用于选择一种或多种治疗周期参数，例如循环持续时间和/或关闭循环持续时间，用于治疗递送用于治疗患者病症的治疗。在一个实例中，治疗的关闭周期持续时间可以基于在开启周期期间递送治疗后患者的感测的脑信号所确定的清除时间来选择。在另一个实例中，可以选择治疗的开启周期持续时间和/或关闭周期持续时间以将患者的脑信号的一个或多个特征值（例如，皮层活动）的值保持在定义的目标值的阈值范围内与有效治疗患者障碍有关的特征。

9. 发明申请

WO2009129480A3 PSYCHIATRIC DISORDER THERAPY CONTROL 审中-公开
标题翻译：心理障碍治疗控制
公开(公告)号：WO2009129480A3
公开(公告)日：2010-03-25
申请号：PCT/US2009040991
申请日：2009-04-17
申请人： MEDTRONIC INC , RISE MARK T , GIFTAKIS JONATHON E , STYPULKOWSKI PAUL H , DENISON TIMOTHY J , TORGERSON NATHAN A
发明人： RISE MARK T , GIFTAKIS JONATHON E , STYPULKOWSKI PAUL H , DENISON TIMOTHY J , TORGERSON NATHAN A
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61B5/01 , A61B5/0488 , A61B5/08 , A61B5/0816 , A61B5/165 , A61B5/441 , A61B5/4836 , A61B5/7275
摘要： A therapy system for managing a psychiatric disorder of the patient may be controlled based on a patient mood state. Therapy may be delivered to a patient according to a therapy program, and a physiological parameter of the patient may be monitored during or after therapy delivery. The patient mood state may be determined based on the monitored physiological parameter, and the therapy delivery may be controlled based on the determined mood state. In some embodiments, the therapy delivery is stopped prior to determining the patient mood state and the therapy delivery is restarted upon detecting a negative mood state. In other embodiments, therapy delivery is delivered until a positive mood state is detected, at which point the therapy delivery may be stopped.
摘要翻译：可以基于患者情绪状态来控制用于管理患者精神障碍的治疗系统。治疗可以根据治疗程序递送到患者，并且可以在治疗递送期间或之后监测患者的生理参数。可以基于所监测的生理参数来确定患者情绪状态，并且可以基于所确定的情绪状态来控制治疗递送。在一些实施例中，在确定患者情绪状态之前停止治疗递送，并且在检测到负情绪状态时重新开始治疗递送。在其它实施方案中，递送治疗递送直到检测到正状态，此时可以停止治疗递送。

10. 发明申请

WO2009129478A4 TIMING THERAPY EVALUATION TRIALS 审中-公开
标题翻译：时间治疗评估试验
公开(公告)号：WO2009129478A4
公开(公告)日：2010-02-04
申请号：PCT/US2009040988
申请日：2009-04-17
申请人： MEDTRONIC INC , GIFTAKIS JONATHON E , RISE MARK T , STYPULKOWSKI PAUL H , DENISON TIMOTHY J
发明人： GIFTAKIS JONATHON E , RISE MARK T , STYPULKOWSKI PAUL H , DENISON TIMOTHY J
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3561 , A61M2205/3592 , A61M2210/0693 , A61N1/08 , A61N1/36025 , A61N1/36082 , A61N1/37211 , G06F19/3481 , G16H40/40 , G16H40/63
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy delivery dissipates. Monitoring a washout period may be useful for timing the delivery of therapy according to different therapy programs during a therapy evaluation period. For example, at least one physiological signal of the patient may be monitored to automatically determine when a washout period has ended, e.g., when stimulation and carryover effects of therapy delivery according to a first therapy program have substantially dissipated, in order to determine when therapy delivery according to a second therapy program can be initiated.
摘要翻译：根据治疗程序向患者输送治疗后的清洗期间的特征可以基于患者的生理参数来确定。清洗期包括治疗期间遗留结果消失的时间。在治疗评估期间，根据不同的治疗方案，监测清除期可能有助于按时交付治疗。例如，可以监测患者的至少一个生理信号，以便自动确定何时清除期已经结束，例如，当根据第一治疗程序的治疗递送的刺激和携带效应已经基本消散时，为了确定何时治疗可以启动根据第二疗法程序的递送。

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