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1. 发明专利

GB2131020A Bis(nitro-1-imidazolyl alkylamine) platinum complexes useful in radiotherapy or chemotherapy 未知
公开(公告)号：GB2131020A
公开(公告)日：1984-06-13
申请号：GB8331035
申请日：1983-11-21
申请人： ADAMS GERALD EDWARD , STRATFORD IAN JAMES , AHMED ISRAR
发明人： ADAMS GERALD EDWARD , STRATFORD IAN JAMES , AHMED ISRAR
IPC分类号： C07D233/91 , C07D233/95 , C07D403/06 , C07D405/04 , C07D405/06 , C07F15/00 , A61K31/415
摘要： Compounds of formula (I): in which:- R1 represents a hydrogen or C1-C6 alkyl, R2 and R3 each independently represent hydrogen or C1-C6 alkyl, X represents a pharmaceutically acceptable ligand incapable of co- ordinating to platinum more strongly than does nitrogen of the moiety -NR2R3, a is 1 or 2, b is 0, 1 or 2, c is 1 or 2, d is 0, 1 or 2, e is 0, 1 or 2 provided that b+d is no greater than 2 and when d is greater than 0, e is greater than 0; are useful in increasing the sensitivity of tumor cells to radiation in radiotherapy and also in potentiating or enhancing damage to tumors by chemotherapeutic agents. Intermediates of the formulae in which R2=R3=H, are also claimed.

2. 发明专利

GB2131020B IMPROVEMENTS RELATING TO COMPOUNDS USEFUL IN RADIOTHERAPY OR CHEMOTHERAPY 未知
公开(公告)号：GB2131020B
公开(公告)日：1986-10-01
申请号：GB8331035
申请日：1983-11-21
申请人： ADAMS GERALD EDWARD , STRATFORD IAN JAMES , AHMED ISRAR
发明人： ADAMS GERALD EDWARD , STRATFORD IAN JAMES , AHMED ISRAR
IPC分类号： C07D233/91 , C07D233/95 , C07D403/06 , C07D405/04 , C07D405/06 , C07F15/00 , A61K31/415

3. 发明申请

WO1993000904A1 DIHYDROPYRIMIDO-QUINOXALINES AND DIHYDROPYRIMIDO-PYRIDOPYRAZINES USEFUL FOR TREATING TUMOURS 审中-公开
标题翻译：用于治疗肿瘤的二羟基二咪喹啉和二羟基吡啶二吡咯烷酮
公开(公告)号：WO1993000904A1
公开(公告)日：1993-01-21
申请号：PCT/GB1992001204
申请日：1992-07-03
申请人： BRITISH TECHNOLOGY GROUP LIMITED , ADAMS, Gerald, Edward , FIELDEN, Edward, Martin , NAYLOR, Matthew, Alexander , STRATFORD, Ian, James
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： A61K31/505
CPC分类号： A61K31/505
摘要： Dihydropyrimido-quinoxalines and dihydropyrimido-pyridopyrazines are useful in the treatment of cancer and in particular the treatment of hypoxic tumours.

4. 发明申请

WO9945127A3 ENHANCED PRODRUG ACTIVATION 审中-公开
标题翻译：加强PRODRUG激活
公开(公告)号：WO9945127A3
公开(公告)日：2000-02-24
申请号：PCT/GB9900674
申请日：1999-03-05
申请人： OXFORD BIOMEDICA LTD , STRATFORD IAN JAMES , PATTERSON ADAM VORN , KINGSMAN SUSAN MARY , KAN ON , GRIFFITHS LEIGH , MITROPHANOUS KYRIACOS
发明人： STRATFORD IAN JAMES , PATTERSON ADAM VORN , KINGSMAN SUSAN MARY , KAN ON , GRIFFITHS LEIGH , MITROPHANOUS KYRIACOS
IPC分类号： C12N15/09 , A61K35/12 , A61K35/76 , A61K38/44 , A61K45/00 , A61K47/48 , A61K48/00 , A61P9/10 , A61P29/00 , A61P35/00 , A61P43/00 , C12N5/10 , C12N7/00 , C12N9/02 , C12N15/62 , C12N7/01 , C12N15/86
CPC分类号： B82Y5/00 , A61K35/12 , A61K38/44 , A61K47/62 , A61K47/6899 , A61K48/00 , C07K2319/00 , C12N9/0077 , C12N2799/022 , C12N2799/027 , C12Y114/14001
摘要： A prodrug activating agent comprising: a) a localisation domain and b) a prodrug activation domain for activating a prodrug in a target cell.
摘要翻译：一种前药活化剂，其包含：a）定位结构域和b）用于在靶细胞中活化前药的前体药物活化结构域。

5. 发明申请

WO1997023456A1 INDOLOQUINONE DERIVATIVES AS BIOREDUCTIVE AGENTS 审中-公开
标题翻译：吲哚喹啉衍生物作为生物降解剂
公开(公告)号：WO1997023456A1
公开(公告)日：1997-07-03
申请号：PCT/GB1996003176
申请日：1996-12-20
申请人： BRITISH TECHNOLOGY GROUP LTD. , STRATFORD, Ian, James , NAYLOR, Matthew, Alexander , JAFFAR, Mohammed , ADAMS, Gerald, Edward
发明人： BRITISH TECHNOLOGY GROUP LTD.
IPC分类号： C07D209/42
CPC分类号： C07D209/12 , A61K31/404
摘要： Use of a compound of general formula (I) or salt thereof wherein R and R are independently selected from hydrogen, halogen and C1-6 alkyl or haloalkyl, C2-6 alkenyl or haloalkenyl, C1-6 alkoxy, phenoxy, C1-6 alkylthio, phenylthio, primary and secondary amino or hydroxy groups and R is hydrogen, hydroxy, a C1-6 alkyl or haloalkyl, C2-6 alkenyl or haloalkenyl or C1-6 alkoxy or haloalkoxy group is provided for the manufacture of a medicament for the treatment of neoplasms, particularly solid cancerous tumours characterised in that R is selected from a C1-6 alkyl or haloalkyl group, -CO2R where R is hydrogen or a C1-6 alkyl or haloalkyl group, or a group -CH2-X where X is selected from groups of formula -S-R , -O-R , and (a) where R is a hydrogen or a leaving group, the acid HR6 of which has a pKa of 10 or less and R and R are the same or different and are selected from C1-6 alkyl or haloalkyl or together with the interjacent nitrogen form a heterocyclic ring of 5 to 7 atoms optionally substituted by C1-4 alkyl or haloalkyl and R is selected from hydrogen, C1-4 alkyl and haloalkyl or groups-(CH2)nCHR R of more than four carbon atoms where n is an integer of 0 to 2 and R and R are independently selected from a C1-4 alkyl or haloalkyl group, or R and R together with the interjacent carbon atom form a C3-7 cycloalkyl or cycloalkenyl ring optionally substituted with one or more C1-4 alkyl or haloalkyl, or C2-4 alkenyl or haloalkenyl groups.
摘要翻译：使用通式（I）的化合物或其盐，其中R和R 4独立地选自氢，卤素和C 1-6烷基或卤代烷基，C 2-6烯基或卤代烯基，C 1-6烷氧基，苯氧基，C 1 -6烷硫基，苯硫基，伯和仲氨基或羟基，R 3为氢，羟基，C 1-6烷基或卤代烷基，C 2-6烯基或卤代链烯基或C 1-6烷氧基或卤代烷氧基，用于制备用于治疗肿瘤，特别是固体癌性肿瘤的药物，其特征在于R 1选自C 1-6烷基或卤代烷基，-CO 2 R 5，其中R 5是氢或C 1-6烷基或卤代烷基，或基团-CH 2 -X（其中X选自式-SR 6，-OR 6）和（a）其中R 6为氢或离去基团的基团，该酸 HR6的pKa为10以下，R 7和R 8相同或不同，选自C 1-6烷基或卤代烷基，或与中间的氮一起形成杂环任选被C 1-4烷基或卤代烷基取代的5至7个原子，R 2选自氢，C 1-4烷基和卤代烷基或多于四个碳原子的基团 - （CH 2）n CHR 9 R 10，其中 n为0〜2的整数，R 9和R 10独立地选自C 1-4烷基或卤代烷基，或R 9和R 10与中间碳原子一起形成C 3 -7环烷基或环烯基，任选被一个或多个C 1-4烷基或卤代烷基取代，或C 2-4链烯基或卤代烯基。

6. 发明申请

WO1993000900A1 1,2-DIHYDRO-8-PIPERAZINYL-4-PHENYLIMIDAZOPYRIDOPYRAZINE OXIDES AND 1,2-DIHYDRO-8-PIPERAZINYL-4 PHENYLIMIDAZOQUINOXALINE OXIDES USEFUL FOR TREATING TUMORS 审中-公开
标题翻译： 1,2-二羟基-8-哌嗪基-4-苯甲酰氨基吡啶氧化物和1,2-二羟基-8-哌嗪-4-基苯基氧杂环己烷氧化物有助于治疗肿瘤
公开(公告)号：WO1993000900A1
公开(公告)日：1993-01-21
申请号：PCT/GB1992001203
申请日：1992-07-03
申请人： BRITISH TECHNOLOGY GROUP LIMITED , ADAMS, Gerald, Edward , FIELDEN, Edward, Martin , NAYLOR, Matthew, Alexander , STRATFORD, Ian, James
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： A61K31/495
CPC分类号： A61K31/495
摘要： 1,2-Dihydro-8-piperazinyl-4-phenylimidazopyridopyrazine oxides and 1,2-dihydro-8-piperazinyl-4-phenylimidazo quinoxaline oxides are useful in the treatment of cancer and in particular in the treatment of hypoxic tumours.

7. 发明申请

WO9945126A2 ENHANCED PRODRUG ACTIVATION 审中-公开
标题翻译：加强PRODRUG激活
公开(公告)号：WO9945126A2
公开(公告)日：1999-09-10
申请号：PCT/GB9900672
申请日：1999-03-05
申请人： OXFORD BIOMEDICA LTD , STRATFORD IAN JAMES , PATTERSON ADAM VORN , KINGSMAN SUSAN MARY , KAN ON , GRIFFITHS LEIGH , MITROPHANOUS KYRIACOS
发明人： STRATFORD IAN JAMES , PATTERSON ADAM VORN , KINGSMAN SUSAN MARY , KAN ON , GRIFFITHS LEIGH , MITROPHANOUS KYRIACOS
IPC分类号： C12N15/09 , A61K35/12 , A61K35/76 , A61K38/44 , A61K45/00 , A61K47/48 , A61K48/00 , A61P9/10 , A61P29/00 , A61P35/00 , A61P43/00 , C12N5/10 , C12N7/00 , C12N9/02 , C12N15/62 , C12N7/01 , C12N15/86
CPC分类号： B82Y5/00 , A61K35/12 , A61K38/44 , A61K47/62 , A61K47/6899 , A61K48/00 , C07K2319/00 , C12N9/0077 , C12N2799/022 , C12N2799/027 , C12Y114/14001
摘要： A prodrug activating agent comprising: a) a localisation domain and b) a prodrug activation domain for activating a prodrug in a target cell.
摘要翻译：一种前药活化剂，其包含：a）定位结构域和b）用于在靶细胞中活化前药的前药活化结构域。

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