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1. 发明申请

WO2009092017A1 BIOMARKERS FOR HPV-INDUCED CANCER 审中-公开
标题翻译： HPV感染癌的生物标志物
公开(公告)号：WO2009092017A1
公开(公告)日：2009-07-23
申请号：PCT/US2009/031302
申请日：2009-01-16
申请人： MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. , DYNAN, William , ARNOUK, Hilal , MERKLEY, Mark , LEE, Jeffrey , FERRIS, Daron , STOPPLER, Hubert , PODOLSKY, Robert, H.
发明人： DYNAN, William , ARNOUK, Hilal , MERKLEY, Mark , LEE, Jeffrey , FERRIS, Daron , STOPPLER, Hubert , PODOLSKY, Robert, H.
IPC分类号： C12Q1/00 , G01N33/48
CPC分类号： G01N33/57411
摘要： Biomarkers that correlate with progression to neoplasia in human papillomavirus (HPV) induced cancer, for example cervical cancer have been identified. These biomarkers can be used to diagnosis or assist in the diagnosis of HPV-induced cancer. They can also be used to increase the positive predictive value of current screening modalities. In addition, they can provide insights into the biology of HPV-induced cancer and thus provide leads for the development of nonsurgical therapies. Exemplary biomarkers include cornulin, PA28 β, DJ-l, actin, transthyretin, HSPB1, CV intracellular channel 1, cytokeratin 8, transferrin, Hsρβ6 (HSP20), aflatoxin reductase, α2 type I collagen, creatine kinase B, cytokeratin 13 GST π, PA28 α, Manganese SOD, lamin A/C, serpin B1 (elastase inhibitor), serpin B3 (SCAA1), cytokeratin 10, cytokeratin 6A, and trp-tRNA synthetase. Preferred biomarkers for HPV-induced cancer include cornulin, DJ-l, PA28 α, and PA28 β, trp-tRNA synthetase, HSPβ6, creatine kinase B, aflatoxin reductase, GST π, transthyretin, transferrin, α2-type 1 collagen, and combinations thereof.
摘要翻译：与人乳头状瘤病毒（HPV）诱导的癌症（例如宫颈癌）发展相关的生物标志物已被鉴定。这些生物标志物可用于诊断或协助HPV诱导的癌症的诊断。它们也可用于增加当前筛选模式的阳性预测值。此外，他们可以深入了解HPV诱导的癌症的生物学，从而为非手术疗法的发展提供依据。示例性生物标志物包括cornulin，PA28β，DJ-1，肌动蛋白，转甲状腺素蛋白，HSPB1，CV细胞内通道1，细胞角蛋白8，转铁蛋白，Hsβ6（HSP20），黄曲霉毒素还原酶，a2型I胶原，肌酸激酶B，细胞角蛋白13 GST p，PA28a，锰SOD，lamin A / C，丝氨酸蛋白酶B1（弹性蛋白酶抑制剂），丝氨酸蛋白酶B3（SCAA1），细胞角蛋白10，细胞角蛋白6A和trp-tRNA合成酶。用于HPV诱导的癌症的优选生物标志物包括cornulin，DJ-1，PA28a和PA28β，trp-tRNA合成酶，HSPβ6，肌酸激酶B，黄曲霉毒素还原酶，GST p，转甲状腺素蛋白，转铁蛋白，a2-型1胶原和组合它们。

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