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1. 发明专利

CA3034371A1 METHOD AND APPARATUS FOR MULTIMODAL ELECTRICAL MODULATION OF PAIN USING COMPOSITE ELECTROMAGNETIC FIELDS 未知
公开(公告)号：CA3034371A1
公开(公告)日：2018-02-22
申请号：CA3034371
申请日：2017-08-21
申请人： STIMGENICS LLC
发明人： VALLEJO RICARDO , CEDENO DAVID LEONARDO
IPC分类号： A61N1/36 , A61N1/32 , A61N1/372 , A61N1/378
摘要： Apparatus and methods for managing pain uses a single composite modulation/stimulation signal with variable characteristics to achieve the same results as separate varying electromagnetic signals. The composite signal is utilized for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques.

2. 发明申请

WO2018035521A1 METHOD AND APPARATUS FOR MULTIMODAL ELECTRICAL MODULATION OF PAIN USING COMPOSITE ELECTROMAGNETIC FIELDS 审中-公开
标题翻译：使用复合电磁场对疼痛进行多模式电调制的方法和设备
公开(公告)号：WO2018035521A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/047798
申请日：2017-08-21
申请人： STIMGENICS, LLC
发明人： VALLEJO, Ricardo , CEDENO, David Leonardo
IPC分类号： A61N1/36 , A61N1/378 , A61N1/372 , A61N1/32
摘要： Apparatus and methods for managing pain uses a single composite modulation/stimulation signal with variable characteristics to achieve the same results as separate varying electromagnetic signals. The composite signal is utilized for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques.
摘要翻译：用于管理疼痛的装置和方法使用具有可变特性的单个复合调制/刺激信号来实现与单独变化的电磁信号相同的结果。利用复合信号来调节在脊髓（SC）和背根神经节（DRG）中的各种途径中包括炎性/免疫系统介质，离子通道和神经递质的基因的表达，其中这种表达调节由脊髓使用所公开的装置和技术刺激脊髓刺激或外周神经刺激。

3. 发明申请

US20180028812A1 METHOD AND APPARATUS FOR MULTIMODAL ELECTRICAL MODULATION OF PAIN USING COMPOSITE ELECTROMAGNETIC FIELDS 审中-公开
公开(公告)号：US20180028812A1
公开(公告)日：2018-02-01
申请号：US15681985
申请日：2017-08-21
申请人： Stimgenics, LLC
发明人： Ricardo Vallejo , David Leonardo Cedeno
IPC分类号： A61N1/36 , A61N1/372 , A61N1/05
摘要： Apparatus and methods for managing pain uses a single composite modulation/stimulation signal with variable characteristics to achieve the same results as separate varying electromagnetic signals. The composite signal is utilized for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques.

4. 发明授权

US10478624B2 Method and apparatus for multimodal electrical modulation of pain 有权
公开(公告)号：US10478624B2
公开(公告)日：2019-11-19
申请号：US15966379
申请日：2018-04-30
申请人： StimGenics, LLC
发明人： Ricardo Vallejo , David Leonardo Cedeno , Ramsin M. Benyamin
IPC分类号： A61N1/36 , A61N2/00 , A61N1/05
摘要： Apparatus and methods for managing pain uses separate varying electromagnetic fields, with a variety of temporal and amplitude characteristics, which are applied to a particular neural structure to modulate glial and neuronal interactions as a mechanism for relieving chronic pain. In another embodiment, a single composite modulation/stimulation signal which has rhythmically varying characteristics is used to achieve the same results as separate varying electromagnetic fields. Also, disclosed is an apparatus and method for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques. In one embodiment of multimodal modulation therapy, the prime signal may be monophasic, or biphasic, in which the polarity of the first phase of the biphasic prime signal may be either cathodic or anodic while the tonic signal may be either monophasic, or biphasic, with the polarity of the first phase of the biphasic tonic signal being either cathodic or anodic.

5. 发明申请

US20180250513A1 METHOD AND APPARATUS FOR MULTIMODAL ELECTRICAL MODULATION OF PAIN 审中-公开
公开(公告)号：US20180250513A1
公开(公告)日：2018-09-06
申请号：US15966379
申请日：2018-04-30
申请人： StimGenics, LLC
发明人： Ricardo Vallejo , David Leonardo Cedeno , Ramsin M. Benyamin
IPC分类号： A61N1/36 , A61N2/00 , A61N1/05
摘要： Apparatus and methods for managing pain uses separate varying electromagnetic fields, with a variety of temporal and amplitude characteristics, which are applied to a particular neural structure to modulate glial and neuronal interactions as a mechanism for relieving chronic pain. In another embodiment, a single composite modulation/stimulation signal which has rhythmically varying characteristics is used to achieve the same results as separate varying electromagnetic fields. Also, disclosed is an apparatus and method for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques. In one embodiment of multimodal modulation therapy, the prime signal may be monophasic, or biphasic, in which the polarity of the first phase of the biphasic prime signal may be either cathodic or anodic while the tonic signal may be either monophasic, or biphasic, with the polarity of the first phase of the biphasic tonic signal being either cathodic or anodic.

6. 发明授权

US10507326B2 Method and apparatus for multimodal electrical modulation of pain 有权
公开(公告)号：US10507326B2
公开(公告)日：2019-12-17
申请号：US15966409
申请日：2018-04-30
申请人： StimGenics, LLC
发明人： Ricardo Vallejo , David Leonardo Cedeno , Ramsin M. Benyamin
IPC分类号： A61N1/36 , A61N2/00 , A61N1/05
摘要： Apparatus and methods for managing pain uses separate varying electromagnetic fields, with a variety of temporal and amplitude characteristics, which are applied to a particular neural structure to modulate glial and neuronal interactions as a mechanism for relieving chronic pain. In another embodiment, a single composite modulation/stimulation signal which has rhythmically varying characteristics is used to achieve the same results as separate varying electromagnetic fields. Also, disclosed is an apparatus and method for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques. In one embodiment of multimodal modulation therapy, the prime signal may be monophasic, or biphasic, in which the polarity of the first phase of the biphasic prime signal may be either cathodic or anodic while the tonic signal may be either monophasic, or biphasic, with the polarity of the first phase of the biphasic tonic signal being either cathodic or anodic.

7. 发明授权

US10434311B2 Method and apparatus for multimodal electrical modulation of pain 有权
公开(公告)号：US10434311B2
公开(公告)日：2019-10-08
申请号：US15075582
申请日：2016-03-21
申请人： StimGenics, LLC
发明人： Ricardo Vallejo , David Leonardo Cedeno , Ramsin M. Benyamin
IPC分类号： A61N2/00 , A61N1/36 , A61N1/05
摘要： Apparatus and methods for managing pain uses separate varying electromagnetic fields, with a variety of temporal and amplitude characteristics, which are applied to a particular neural structure to modulate glial and neuronal interactions as a mechanism for relieving chronic pain. In another embodiment, a single composite modulation/stimulation signal which has rhythmically varying characteristics is used to achieve the same results as separate varying electromagnetic fields. Also, disclosed is an apparatus and method for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques. In one embodiment of multimodal modulation therapy, the prime signal may be monophasic, or biphasic, in which the polarity of the first phase of the biphasic prime signal may be either cathodic or anodic while the tonic signal may be either monophasic, or biphasic, with the polarity of the first phase of the biphasic tonic signal being either cathodic or anodic.

8. 发明授权

US10675466B2 Method and apparatus for multimodal electrical modulation of pain using composite electromagnetic fields 有权
公开(公告)号：US10675466B2
公开(公告)日：2020-06-09
申请号：US15681985
申请日：2017-08-21
申请人： Stimgenics, LLC
发明人： Ricardo Vallejo , David Leonardo Cedeno
IPC分类号： A61N1/36 , A61N1/05 , A61N2/00 , A61N1/372
摘要： Apparatus and methods for managing pain uses a single composite modulation/stimulation signal with variable characteristics to achieve the same results as separate varying electromagnetic signals. The composite signal is utilized for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques.

9. 发明申请

US20200171308A1 METHOD AND APPARATUS FOR MULTIMODAL ELECTRICAL MODULATION OF PAIN 审中-公开
公开(公告)号：US20200171308A1
公开(公告)日：2020-06-04
申请号：US16590538
申请日：2019-10-02
申请人： StimGenics, LLC
发明人： Ricardo Vallejo , David Leonardo Cedeno , Ramsin M. Benyamin
IPC分类号： A61N1/36 , A61N2/00 , A61N1/05
摘要： Apparatus and methods for managing pain uses separate varying electromagnetic fields, with a variety of temporal and amplitude characteristics, which are applied to a particular neural structure to modulate glial and neuronal interactions as a mechanism for relieving chronic pain. In another embodiment, a single composite modulation/stimulation signal which has rhythmically varying characteristics is used to achieve the same results as separate varying electromagnetic fields. Also, disclosed is an apparatus and method for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques. In one embodiment of multimodal modulation therapy, the prime signal may be monophasic, or biphasic, in which the polarity of the first phase of the biphasic prime signal may be either cathodic or anodic while the tonic signal may be either monophasic, or biphasic, with the polarity of the first phase of the biphasic tonic signal being either cathodic or anodic.

10. 发明申请

US20180353758A1 METHOD AND APPARATUS FOR MULTIMODAL ELECTRICAL MODULATION OF PAIN 审中-公开
公开(公告)号：US20180353758A1
公开(公告)日：2018-12-13
申请号：US16055787
申请日：2018-08-06
申请人： StimGenics, LLC
发明人： Ricardo Vallejo , David Leonardo Cedeno , Ramsin M. Benyamin
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36192 , A61N1/36196 , A61N2/002 , A61N2/008
摘要： Apparatus and methods for managing pain uses separate varying electromagnetic fields, with a variety of temporal and amplitude characteristics, which are applied to a particular neural structure to modulate glial and neuronal interactions as a mechanism for relieving chronic pain. In another embodiment, a single composite modulation/stimulation signal which has rhythmically varying characteristics is used to achieve the same results as separate varying electromagnetic fields. Also, disclosed is an apparatus and method for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques. In one embodiment of multimodal modulation therapy, the prime signal may be monophasic, or biphasic, in which the polarity of the first phase of the biphasic prime signal may be either cathodic or anodic while the tonic signal may be either monophasic, or biphasic, with the polarity of the first phase of the biphasic tonic signal being either cathodic or anodic.

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