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1. 发明申请

US20150099663A1 BIOMARKERS 审中-公开
标题翻译：生物标志
公开(公告)号：US20150099663A1
公开(公告)日：2015-04-09
申请号：US14570076
申请日：2014-12-15
申请人： Cambridge Enterprise Limited , Stichting VU-VUMC
发明人： Sabine Bahn , Emanuel Schwarz , Brenda Pennix , Nicole Vogelzangs
IPC分类号： G01N33/68 , G01N33/573
CPC分类号： G01N33/6869 , G01N33/573 , G01N33/68 , G01N33/6863 , G01N33/6866 , G01N2333/435 , G01N2333/525 , G01N2333/54 , G01N2333/5403 , G01N2333/5406 , G01N2333/5409 , G01N2333/5412 , G01N2333/5418 , G01N2333/5421 , G01N2333/5428 , G01N2333/55 , G01N2333/555 , G01N2333/57 , G01N2333/96494 , G01N2800/30 , G01N2800/301
摘要： The invention relates to biomarkers and a method of diagnosing or monitoring depression, anxiety disorder or other psychotic disorder.
摘要翻译：本发明涉及生物标志物和诊断或监测抑郁症，焦虑障碍或其它精神病症的方法。

2. 发明授权

US11267694B2 MEMS sensor structure comprising mechanically preloaded suspension springs 有权
公开(公告)号：US11267694B2
公开(公告)日：2022-03-08
申请号：US16928851
申请日：2020-07-14
申请人： Stichting VU-VUMC , FOM-Nikhef
发明人： Eric Hennes , Alessandro Bertolini , Johannes Franciscus Van Den Brand
IPC分类号： B81B3/00 , G01P15/13 , G01P15/08 , G01P15/09 , G01P15/125
摘要： A MEMS sensor comprising preloaded suspension springs and a method for mechanically preloading suspension springs of a MEMS sensor are described. The MEMS sensor comprises a MEMS support structure; a plurality of suspension springs connected to said support structure; and, a proof mass flexibly suspended by said suspension springs; wherein at least one of said suspension springs is mechanically preloaded with a compressive force for reducing the natural frequency of said proof mass.

3. 发明授权

US10660068B2 Position-based broadcast protocol and time slot schedule for a wireless mesh network 有权
公开(公告)号：US10660068B2
公开(公告)日：2020-05-19
申请号：US14896610
申请日：2014-06-06
申请人： Stichting VU-VUMC , FOM-Nikhef
发明人： Henk Jan Bulten , Johannes Franciscus Josephina Van Den Brand
IPC分类号： H04W72/00 , H04W72/04 , H04W52/02 , H04B7/26 , H04W84/18
摘要： A method for managing communication in a wireless mesh network comprising a plurality of wireless nodes and a wireless node for use in such network are described, wherein said method may comprise: providing a time slot schedule (frame), preferably a TDMA time slot schedule (frame), comprising one or more time slots, including a transmission time slot enabling a node to transmit a broadcast message, a reception time slot enabling a node to receive a broadcast message from one or more other nodes; and/or a sleep time slot for configuring said node in an idle state; and, assigning said time slots to nodes in said network on the basis of the position of said nodes in said network.

4. 发明申请

US20170322215A1 A Novel Auto-Active and Intracellular Mutant of MET 审中-公开
公开(公告)号：US20170322215A1
公开(公告)日：2017-11-09
申请号：US15528322
申请日：2015-11-18
申请人： Stichting Katholieke Universiteit , Stichting VU-Vumc
发明人： Anna Catharina Navis , Wilhelmus Petrus Johannes Leenders , Thomas Würdinger
IPC分类号： G01N33/574 , G01N33/74 , C07K14/71 , C12Q1/68
CPC分类号： G01N33/5748 , A61K2039/505 , C07K14/71 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/574 , G01N33/74 , G01N2333/71
摘要： The present invention relates to the fields of medicine and molecular diagnostics. In particular, it relates to a novel method for the treatment, prevention and/or delay of cancer and to a diagnostic method involving detection of a novel auto-active and intracellular mutant of MET.

5. 发明申请

US20160305945A1 Leukemic stem cell markers 审中-公开
标题翻译：白血病干细胞标志物
公开(公告)号：US20160305945A1
公开(公告)日：2016-10-20
申请号：US15102075
申请日：2014-12-02
申请人： Stichting VU-VUmc
发明人： Gerrit Johan OSSENKOPPELE , Gerrit Jan SCHUURHUIS , Wendelien ZEIJLEMAKER
IPC分类号： G01N33/574 , G01N15/14 , G01N33/50
CPC分类号： G01N33/57426 , G01N15/14 , G01N33/5011 , G01N33/5073 , G01N33/57492 , G01N2015/0065 , G01N2015/1006 , G01N2015/149 , G01N2800/52
摘要： The present invention relates to a method for identifying Leukemic stem cells (LSC), based on measurement of the presence of a specific set of markers. The invention further relates to a container for use in performing the method. Also provided is application of the method for predicting response to therapy and/or chance of relapse of Acute Myeloid Leukemia, and application of the method in the context of screening for compounds that specifically eradicate Leukemic cells and not benign cells.
摘要翻译：本发明涉及一种用于鉴别白血病干细胞（LSC）的方法，该方法是基于特定标记物组的存在的测量。本发明还涉及一种用于执行该方法的容器。还提供了预测对急性骨髓性白血病的治疗反应和/或复发机率的方法的应用，以及在筛选特异性根除白血病细胞而不是良性细胞的化合物的上下文中应用该方法。

6. 发明申请

US20150234170A1 Microscopic Imaging Apparatus and Method to Detect a Microscopic Image 审中-公开
标题翻译：显微镜成像设备和检测显微镜图像的方法
公开(公告)号：US20150234170A1
公开(公告)日：2015-08-20
申请号：US14424700
申请日：2013-08-27
申请人： STICHTING VU-VUMC
发明人： Stefan Michiel Witte , Kjeld Sijbrand Eduard Eikema
IPC分类号： G02B21/36 , G02B21/16 , G02B21/06
CPC分类号： G02B21/367 , G02B21/06 , G02B21/16 , G02B21/365 , G03F7/70616
摘要： A microscopic imaging apparatus to provide an image of a sample. The apparatus includes an illumination system to provide an illumination beam with radiation; and a sensor constructed and arranged to receive: a first image of a first diffraction pattern created by diffraction of the illumination beam on the sample; and a second image of a second diffraction pattern created by diffraction of the illumination beam on the sample.
摘要翻译：一种用于提供样品图像的显微成像装置。该装置包括用于向辐射提供照明光束的照明系统; 以及传感器，被构造和布置成接收：通过所述样品上的所述照射光束的衍射而产生的第一衍射图案的第一图像; 以及由样品上的照明光束衍射产生的第二衍射图案的第二图像。

7. 发明申请

US20140316442A1 SUTURE DEVICE 审中-公开
标题翻译： SUTURE设备
公开(公告)号：US20140316442A1
公开(公告)日：2014-10-23
申请号：US14358136
申请日：2012-11-16
申请人： Stichting VU-VUMC
发明人： Rianne Irene Van Loenen , Micha Ilan Paalman , Alexander Arnold Frederik Adriann Veenhof
IPC分类号： A61B17/04
CPC分类号： A61B17/0469 , A61B2017/047 , A61B2017/0472 , F04C2270/0421
摘要： A suture device includes a needle operating device movable longitudinally with respect to a housing between at least an insertion position and a needle transfer position. The needle operating device includes an elongate operating element arranged extending from a distal end of the housing to or near a housing proximal end. A needle holder connected at a distal end of the operating element holds two or more needles, with free ends directed in proximal direction. The holder is movable with respect to a protection device between at least a protecting position shielding the free ends, and a non-protecting position for the same. A needle receive device at a distal end of the housing receives the free ends when the operating device is moved to the transfer position. In at least the insertion position the holder and the protection device are spaced longitudinally from the housing to receive a tissue therebetween.
摘要翻译：缝合装置包括在至少插入位置和针转移位置之间相对于壳体纵向移动的针操作装置。针操作装置包括从壳体的远端延伸到壳体近端或靠近壳体近端的细长操作元件。连接在操作元件的远端处的针保持器保持两个或更多针，其自由端朝向近端方向。保持器在至少保护自由端的保护位置与保护装置的非保护位置之间相对于保护装置可移动。当操作装置移动到转移位置时，在壳体的远端处的针接收装置接收自由端。在至少插入位置中，保持器和保护装置与壳体纵向隔开以在其间接收组织。

8. 发明授权

US10058324B2 Suture device 有权
公开(公告)号：US10058324B2
公开(公告)日：2018-08-28
申请号：US14358136
申请日：2012-11-16
申请人： Stichting VU-VUMC
发明人： Rianne Irene Van Loenen , Micha Ilan Paalman , Alexander Arnold Frederik Adriaan Veenhof
IPC分类号： A61B17/04 , A61B17/12
CPC分类号： A61B17/0469 , A61B2017/047 , A61B2017/0472 , F04C2270/0421
摘要： A suture device includes a needle operating device movable longitudinally with respect to a housing between at least an insertion position and a needle transfer position. The needle operating device includes an elongate operating element arranged extending from a distal end of the housing to or near a housing proximal end. A needle holder connected at a distal end of the operating element holds two or more needles, with free ends directed in proximal direction. The holder is movable with respect to a protection device between at least a protecting position shielding the free ends, and a non-protecting position for the same. A needle receive device at a distal end of the housing receives the free ends when the operating device is moved to the transfer position. In at least the insertion position the holder and the protection device are spaced longitudinally from the housing to receive a tissue therebetween.

9. 发明申请

US20170199196A1 Biomarkers 审中-公开
公开(公告)号：US20170199196A1
公开(公告)日：2017-07-13
申请号：US15444679
申请日：2017-02-28
申请人： STICHTING VU-VUMC
发明人： Linda Janna Willemien Bosch , Meike De Wit , Beatriz Pinto Pinto Morais De Carvalho , Remond Johannes Adriaan Fijneman , Gerrit Albert Meijer , Cornelia Ramona Jimenez , Sander Rogier Piersma , Viet Thang Pham , Gideon Oudgenoeg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N33/6848 , G01N2500/10 , G01N2570/00 , G01N2800/7028
摘要： The invention provides a method for screening for colorectal cancer, the method comprising: screening a biological sample from an individual for one or more biomarkers selected from the group defined in Table 1 and/or Table 6, wherein the presence of or increased expression of the one or more biomarkers relative to a control sample is indicative that the individual is at risk of suffering from or is suffering from colorectal cancer. The invention also provides an array and kit suitable for use in the methods of the invention, methods of treating colorectal cancer and therapeutic agents for use in methods of treating cancer.

10. 发明申请

US20150368230A1 RADIOLABELED QUINAZOLINE DERIVATIVES 审中-公开
标题翻译：放射性喹唑啉衍生物
公开(公告)号：US20150368230A1
公开(公告)日：2015-12-24
申请号：US14765042
申请日：2014-01-28
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , STICHTING VU-VUMC
发明人： Paul SLOBBE , Alex Johannes POOT , Augustinus Antonius Maria Silvester VAN DONGEN , Heiko NIESSEN , Albert Dirk WINDHORST
IPC分类号： C07D405/12 , A61K51/04
CPC分类号： C07D405/12 , A61K51/0459 , C07B2200/05
摘要： Novel radiotracer for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging are described. Specifically, the invention relates to 18F-labeled afatinib suitable as a PET or SPECT tracer for imaging epidermal growth factor receptor (EGFR, erbB1) and human epidermal growth factor receptor 2 (Her2, erbB2), to a precursor compound for use in its synthesis, to methods for the preparation 18F-labeled afatinib, as well as to the use thereof in in vivo diagnosis, tumor imaging or patient stratification on the basis of mutational status of EGFR (erbB1) and Her2 (erbB2).
摘要翻译：描述了用于正电子发射断层扫描（PET）或单光子发射计算机断层摄影（SPECT）成像的新型放射性示踪剂。具体地说，本发明涉及适用于成像表皮生长因子受体（EGFR，erbB1）和人表皮生长因子受体2（Her2，erbB2）的PET或SPECT示踪剂的18F-标记的阿片碱，用于其合成中的前体化合物，用于制备18F标记的阿伐替尼的方法，以及其在体内诊断，肿瘤成像或患者分层中的用途，其基于EGFR（erbB1）和Her2（erbB2）的突变状态。

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