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1. 发明公开

EP1119738A4 SYSTEM AND METHOD FOR THREE-DIMENSIONAL INSPECTION USING PATTERNED LIGHT PROJECTION 审中-公开
标题翻译：装置和方法用于三维用于测试由投影图案光
公开(公告)号：EP1119738A4
公开(公告)日：2002-09-18
申请号：EP99928436
申请日：1999-06-07
申请人： ACUITY IMAGING LLC , HALLERMAN GREGORY R , LUDLOW JONATHAN E , STERN HOWARD K
发明人： HALLERMAN GREGORY R , LUDLOW JONATHAN E , STERN HOWARD K
IPC分类号： G01N21/88 , G01B11/24 , G01B11/25
CPC分类号： G01N21/88 , G01N21/8806
摘要： An inspection system (10) is used to obtain three-dimensional information pertaining to an article (12) having elements with specular surfaces, such as the solder balls on a BGA device. The system includes patterned light projector (20) which projects a pattern at an oblique angle ( alpha ) with respect to the plane of the article (12) and an image detector (24) disposed generally above the article (12). The light projector (20) includes an extended light source (30) and a light patterning member (32) disposed such that the light pattern is in focus in an image plane parallel to the plane of the article (12), satisfying the Scheimpflug condition. The spacing of the lines is preferably greater than a spacing or pitch of the specular elements. An image processor (26) is coupled to the image detector (24) to receive the image and measure the lateral shift of the lines to determine height information using triangulation.

2. 发明公开

EP1119738A2 SYSTEM AND METHOD FOR THREE-DIMENSIONAL INSPECTION USING PATTERNED LIGHT PROJECTION 审中-公开
标题翻译：装置和方法用于三维用于测试由投影图案光
公开(公告)号：EP1119738A2
公开(公告)日：2001-08-01
申请号：EP99928436.7
申请日：1999-06-07
申请人： Acuity Imaging, LLC , Hallerman, Gregory R. , Ludlow, Jonathan E. , Stern, Howard K.
发明人： HALLERMAN, Gregory, R. , LUDLOW, Jonathan, E. , STERN, Howard, K.
IPC分类号： G01B11/24
CPC分类号： G01N21/88 , G01N21/8806
摘要： An inspection system (10) is used to obtain three-dimensional information pertaining to an article (12) having elements with specular surfaces, such as the solder balls on a BGA device. The system includes patterned light projector (20) which projects a pattern at an oblique angle (α) with respect to the plane of the article (12) and an image detector (24) disposed generally above the article (12). The light projector (20) includes an extended light source (30) and a light patterning member (32) disposed such that the light pattern is in focus in an image plane parallel to the plane of the article (12), satisfying the Scheimpflug condition. The spacing of the lines is preferably greater than a spacing or pitch of the specular elements. An image processor (26) is coupled to the image detector (24) to receive the image and measure the lateral shift of the lines to determine height information using triangulation.

3. 发明申请

WO2008154249A3 GENE EXPRESSION MARKERS OF TUMOR RESISTANCE TO HER2 INHIBITOR TREATMENT 审中-公开
公开(公告)号：WO2008154249A3
公开(公告)日：2008-12-18
申请号：PCT/US2008/065766
申请日：2008-06-04
申请人： GENENTECH, INC. , LEE-HOEFLICH, Si Tuen , STERN, Howard
发明人： LEE-HOEFLICH, Si Tuen , STERN, Howard
IPC分类号： C12Q1/68
摘要： The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.

4. 发明申请

WO2003052106A1 METHOD OF SCREENING COMPOUNDS 审中-公开
标题翻译：筛选化合物的方法
公开(公告)号：WO2003052106A1
公开(公告)日：2003-06-26
申请号：PCT/US2002/040262
申请日：2002-12-17
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , ZON, Leonard, I. , STERN, Howard, M. , MURPHEY, Ryan
发明人： ZON, Leonard, I. , STERN, Howard, M. , MURPHEY, Ryan
IPC分类号： C12N15/63
CPC分类号： G01N33/5088 , A01K67/0275 , A01K2217/05 , A01K2227/40 , A01K2267/0306 , A01K2267/0393 , A61K31/10 , A61K31/167 , A61K31/175 , A61K31/196 , A61K31/197 , A61K31/216 , A61K31/255 , A61K31/352 , A61K31/366 , A61K31/44 , C12N15/8509
摘要： The present invention is directed to a novel, target-blind approach to drug discovery. The concept is to model human phenotypes in a teleost, such as a zebrafish, and then screen compounds, e.g., small molecules, for their ability to alter the phenotype. Because the screen is performed with a whole vertebrate organism and uses a phenotype as the output, the need to first identify target genes is eliminated. This approach is powerful because a single screen can theoretically detect drugs affecting any target relevant to the phenotype being observed, even if those targets are not yet characterized.
摘要翻译：本发明涉及一种用于药物发现的新型靶向盲法。该概念是在硬骨鱼（例如斑马鱼）中模拟人类表型，然后筛选化合物，例如小分子，以改变表型的能力。因为屏幕是用整个脊椎动物进行的并且使用表型作为输出，因此消除了首先识别靶基因的需要。这种方法是强大的，因为一个屏幕理论上可以检测到影响与观察到的表型相关的任何目标的药物，即使这些目标尚未得到表征。

5. 发明申请

WO2008154249A9 GENE EXPRESSION MARKERS OF TUMOR RESISTANCE TO HER2 INHIBITOR TREATMENT 审中-公开
公开(公告)号：WO2008154249A9
公开(公告)日：2008-12-18
申请号：PCT/US2008/065766
申请日：2008-06-04
申请人： GENENTECH, INC. , LEE-HOEFLICH, Si Tuen , STERN, Howard
发明人： LEE-HOEFLICH, Si Tuen , STERN, Howard
IPC分类号： G01N33/50 , C12Q1/68
摘要： The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.

6. 发明申请

WO2008133650A2 METHOD AND SYSTEM FOR PROVIDING A HIGH DEFINITION TRIANGULATION SYSTEM 审中-公开
标题翻译：提供高定义三角化系统的方法和系统
公开(公告)号：WO2008133650A2
公开(公告)日：2008-11-06
申请号：PCT/US2007/023536
申请日：2007-11-07
申请人： RVSI INSPECTION LLC , STERN, Howard , KRICHEVER, Mark , LAWRENCE, Murray , DRANNBAUER, James
发明人： STERN, Howard , KRICHEVER, Mark , LAWRENCE, Murray , DRANNBAUER, James
IPC分类号： G01B11/14 , G01N21/55 , G01J4/00
CPC分类号： G01B11/0608
摘要： A triangulation system including a laser beam, optics focusing the laser beam on an object, a light detection unit detecting light reflected from the object due to impingement of the beam on the object, and an arrangement for determining, based on the detected light, object feature dimensions. The wavelength of the laser beam may be shorter than of infrared radiation, which allows for a reduced spot size without significant loss of depth of field. So as to reduce aberrations or a sensitivity to aberrations due to the shortened wavelength, the system may include (i) a polarization dependent coating matching the index of refraction of an element of the light detection unit to that of air for a range of angles, (ii) tilted projection optics, (iii) a prism wavefront corrector, and/or (iv) a positioning assembly, which provides for increased precision in positioning the laser diode with respect to a collimator lens.
摘要翻译：包括激光束的三角测量系统，将激光束聚焦在物体上的光学装置，检测由于射束在物体上的撞击而从物体反射的光的光检测单元，以及用于确定基于检测到的光线，物体特征尺寸。激光束的波长可以比红外辐射的波长短，这允许减小光斑尺寸而没有显着损失景深。为了减少由于缩短的波长引起的像差或对像差的敏感度，该系统可以包括（i）与光检测单元的元件的折射率对于一定角度范围的空气折射率相匹配的偏振相关涂层，（ii）倾斜投影光学器件，（iii）棱镜波前校正器，和/或（iv）定位组件，其提供相对于准直透镜定位激光二极管的更高的精确度。

7. 发明申请

WO0016071A8 SYSTEM AND METHOD FOR THREE-DIMENSIONAL INSPECTION USING PATTERNED LIGHT PROJECTION 审中-公开
标题翻译：用于使用图案化光投影进行三维检测的系统和方法
公开(公告)号：WO0016071A8
公开(公告)日：2000-06-15
申请号：PCT/US9912706
申请日：1999-06-07
申请人： ACUITY IMAGING LLC , HALLERMAN GREGORY R , LUDLOW JONATHAN E , STERN HOWARD K
发明人： HALLERMAN GREGORY R , LUDLOW JONATHAN E , STERN HOWARD K
IPC分类号： G01N21/88 , G01B11/24
CPC分类号： G01N21/88 , G01N21/8806
摘要： An inspection system (10) is used to obtain three-dimensional information pertaining to an article (12) having elements with specular surfaces, such as the solder balls on a BGA device. The system includes patterned light projector (20) which projects a pattern at an oblique angle ( alpha ) with respect to the plane of the article (12) and an image detector (24) disposed generally above the article (12). The light projector (20) includes an extended light source (30) and a light patterning member (32) disposed such that the light pattern is in focus in an image plane parallel to the plane of the article (12), satisfying the Scheimpflug condition. The spacing of the lines is preferably greater than a spacing or pitch of the specular elements. An image processor (26) is coupled to the image detector (24) to receive the image and measure the lateral shift of the lines to determine height information using triangulation.
摘要翻译：使用检查系统（10）来获得与具有镜面的元件（例如BGA装置上的焊球）的物品（12）有关的三维信息。该系统包括图案化的光投射器（20）和图像检测器（24），图案化的光投射器（20）相对于物品（12）的平面以倾斜角度（α）投影图案，图像检测器（24）大致设置在物品（12）上方。光投射器（20）包括延伸光源（30）和光构图构件（32），光构图构件（32）布置成使得光图案在与物品（12）的平面平行的图像平面内聚焦，满足Scheimpflug条件。线的间距优选地大于镜面元件的间距或间距。图像处理器（26）耦合到图像检测器（24）以接收图像并测量线的横向偏移以使用三角测量来确定高度信息。

8. 发明申请

WO1994009463A1 SYSTEM FOR DETECTING ICE ON METAL SURFACE 审中-公开
标题翻译：金属表面检测系统
公开(公告)号：WO1994009463A1
公开(公告)日：1994-04-28
申请号：PCT/US1993010035
申请日：1993-10-20
申请人： ROBOTIC VISION SYSTEMS, INC. , STERN, Howard
发明人： ROBOTIC VISION SYSTEMS, INC.
IPC分类号： G08B19/02
CPC分类号： G08B19/02 , B64D15/20
摘要： For detecting the presence of a substance such as ice or snow on a surface such as the wing of an aircraft, light is emitted from an unpolarized source (13). The unpolarized light passes through a linear polarizer (11) which has a vertical polarization axis. The vertically polarized light passes through a quarter wave retarder plate (12), which changes the linearly polarized light into circularly polarized light. The quarter wave retarder plate (12) has its slow and fast axes both at 45 degrees relative to the vertical axis of the linear polarizer (11). A specular surface (14) reflects the incident circularly polarized light back along path (23). If surface (14) is ice-free, the reflected light will result in an image viewed by the eye (26) alternating between dark and bright, respectively. Any ice or snow covering a portion of surface (14) will cause that portion of the image to maintain the same brightness.
摘要翻译：为了检测在诸如飞机的翼面的表面上存在诸如冰或雪的物质，光从非偏振源（13）发射。非偏振光通过具有垂直偏振轴的线性偏振器（11）。垂直偏振光通过四分之一波长延迟板（12），其将线偏振光改变为圆偏振光。四分之一波长延迟板（12）具有相对于线性偏振器（11）的垂直轴成45度的缓慢而快速的轴。镜面（14）沿着路径（23）反射入射的圆偏振光。如果表面（14）是无冰的，则反射光将分别导致由眼睛（26）观察到的图像在暗和亮之间交替。覆盖表面（14）的一部分的任何冰或雪将导致图像的该部分保持相同的亮度。

9. 发明专利

IL291945A Treatment of cancers using pi3 kinase isoform modulators 未知
公开(公告)号：IL291945A
公开(公告)日：2022-06-01
申请号：IL29194522
申请日：2022-04-04
申请人： INFINITY PHARMACEUTICALS INC , STERN HOWARD M , KUTOK JEFFERY L
发明人： STERN HOWARD M , KUTOK JEFFERY L
摘要： Provided herein are methods, kits, and pharmaceutical compositions that include a P13 kinase inhibitor for treating cancers or hematologic disorders.

10. 发明专利

CA2405953A1 SECURE TRACKING OF ARTICLES 未知
公开(公告)号：CA2405953A1
公开(公告)日：2001-09-20
申请号：CA2405953
申请日：2001-03-13
申请人： ROBOTIC VISION SYSTEMS , STERN HOWARD
发明人： STERN HOWARD
IPC分类号： G06F1/00 , G06F21/00 , G06Q10/00 , G07B17/00 , G06F17/30
摘要： A secure tracking system and method of tracking for articles which are secur e and include authentication and verification of users and user devices for da ta and information access and input (Fig. 1). Each article to be tracked is provided with a unique secure indicia applied to the article and through whi ch chronological histories are generated and maintained from creation of each article until at least the time when article is scrapped or otherwise destroyed. The articles can include manufactured components (24), assemblies , device and equipment for aircraft, automotive, military and other users, as well as jewelry and works of art.

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