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1. 发明申请

WO2012058014A3 METHOD AND SYSTEM FOR IMAGING HIGH DENSITY BIOCHEMICAL ARRAYS WITH SUB-PIXEL ALIGNMENT 审中-公开
标题翻译：用于用子像素对准成像高密度生物化学阵列的方法和系统
公开(公告)号：WO2012058014A3
公开(公告)日：2014-04-03
申请号：PCT/US2011056211
申请日：2011-10-13
申请人： COMPLETE GENOMICS INC , STAKER BRYAN P , UHRICH CRAIG E
发明人： STAKER BRYAN P , UHRICH CRAIG E
IPC分类号： G01N21/03 , G06K9/00
CPC分类号： G02B21/365 , G01B11/272 , G02B21/002 , G02B21/025 , G02B21/361 , H04N5/37206 , H04N7/18
摘要： A system and associated method for imaging high density biochemical arrays comprises one or more imaging channels that share a common objective lens and a corresponding one or more time delay integration-type imaging cameras with optical alignment mechanisms that permit independent inter-channel and intra-channel adjustment of each of four degrees: X, Y, rotation and scale. The imaging channels are configured to independently examine different spectra of the image of the biochemical arrays.
摘要翻译：用于对高密度生物化学阵列进行成像的系统和相关方法包括共享共同物镜的一个或多个成像通道和具有光学对准机构的相应的一个或多个时间延迟积分型成像相机，其允许独立的通道间和通道内四度调整：X，Y，旋转和刻度。成像通道被配置为独立地检查生物化学阵列的图像的不同光谱。

2. 发明申请

WO2014078855A1 DIGITAL ANALYSIS OF MOLECULAR ANALYTES USING SINGLE MOLECULE DETECTION 审中-公开
标题翻译：使用单分子检测分子分析的数字分析
公开(公告)号：WO2014078855A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/070797
申请日：2013-11-19
申请人： APTON BIOSYSTEMS, INC. , STAKER, Bryan, P. , LIU, Nandong , STAKER, Bart, Lee , MCLAUGLIN, Michael, David
发明人： STAKER, Bryan, P. , LIU, Nandong , STAKER, Bart, Lee , MCLAUGLIN, Michael, David
IPC分类号： G06F19/00
CPC分类号： G01N33/536 , C12Q1/6825 , G01N1/30 , G01N21/6486 , G06F19/20 , G06F19/24 , H03M13/1515
摘要： Methods and systems are provided for small molecule analyte detection using digital signals, key encryption, and communications protocols. The methods provide detection of a large numbers of proteins, peptides, RNA molecules, and DNA molecules in a single optical or electrical detection assay within a large dynamic range.
摘要翻译：提供了使用数字信号，密钥加密和通信协议进行小分子分析物检测的方法和系统。该方法在大动态范围内的单个光学或电学检测测定中提供大量蛋白质，肽，RNA分子和DNA分子的检测。

3. 发明申请

WO2012031011A1 HIGH-DENSITY BIOCHEMICAL ARRAY CHIPS 审中-公开
标题翻译：高密度生物化学阵列
公开(公告)号：WO2012031011A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/050047
申请日：2011-08-31
申请人： COMPLETE GENOMICS, INC. , STAKER, Bryan P.
发明人： STAKER, Bryan P.
IPC分类号： C40B20/02 , C40B60/10 , C12Q1/68
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00531 , B01J2219/00659 , B01J2219/00662 , B01J2219/00693 , C40B20/02 , G01N21/6428 , G01N21/6458
摘要： An array chip useful for biochemical assays is provided wherein the chip includes a field region arranged with attachment sites according to a first pitch and at least one track region having a one-dimensional spot pattern arranged according to a second pitch that is less dense and is a non-integer multiple of the first pitch so that one-dimensional Moiré averaging may be applied in the track region, thereby to attain alignment of the chip to the optical instrumentation with a higher density of attachment sites.
摘要翻译：提供了一种可用于生物化学测定的阵列芯片，其中芯片包括根据第一间距布置有附接位置的场区域和至少一个具有根据第二间距排列的一维点图案的轨道区域，该第二间距不太密集，第一节距的非整数倍，使得可以在轨道区域中施加一维莫尔平均，从而以更高密度的附着位置实现芯片与光学仪器的对准。

4. 发明申请

WO2008061101A2 METHOD AND APPARATUS FOR LOCALIZED BONDING 审中-公开
标题翻译：用于局部结合的方法和设备
公开(公告)号：WO2008061101A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/084575
申请日：2007-11-13
申请人： GLIMMERGLASS NETWORKS, INC. , FERNANDEZ, Andres , STAKER, Bryan, P. , KINDWALL, Alexander, P. , OWENS, Windsor, E.
发明人： FERNANDEZ, Andres , STAKER, Bryan, P. , KINDWALL, Alexander, P. , OWENS, Windsor, E.
IPC分类号： B32B7/14 , B32B37/02 , B32B37/14
CPC分类号： B32B37/1292 , B32B7/12 , B32B2309/68 , B32B2457/00 , B81C3/001 , B81C2203/032 , B81C2203/035 , Y10T428/24612 , Y10T428/2462
摘要： One or more cavities are formed in the bonding surfaces of one, all, or some of the elements to be bonded. These cavities serve as receptacles for the bonding material and are where the bonds are localized. The cavities are of sufficient size and shape so that their volume is greater than the volume of bonding material forming the bond. This ensures that when the elements are brought into contact with one another to mate, the bonding material, which can flow prior to solidifying into a bond, will flow into the cavities and will not impede the separation of the parts. This allows the parts to be mated with nominally zero separation. Once solidified, the bonding material forms a localized bond inside each cavity. Different cavity shapes, such as, rectangular, circular, or any other shape that can be injected or filled with adhesive material may be used.
摘要翻译：一个或多个空腔形成在待粘合的一个，全部或一些元件的粘合表面中。这些空腔用作结合材料的容器并且是结合部位的位置。腔体具有足够的尺寸和形状，使得它们的体积大于形成结合的结合材料的体积。这确保了当元件彼此接触以配合时，在凝固成结合之前可以流动的结合材料将流入空腔并且不会阻止部件的分离。这允许零件与名义上的零分离配合。一旦固化，结合材料在每个腔内形成局部结合。可以使用不同的空腔形状，例如矩形，圆形或可以注入或填充有粘合材料的任何其他形状。

5. 发明申请

WO2008061097A2 CHARGING GUARD WITH PASCHEN STACKING 审中-公开
标题翻译：充电警卫与帕斯坦堆叠
公开(公告)号：WO2008061097A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/084568
申请日：2007-11-13
申请人： GLIMMERGLASS NETWORKS, INC. , STAKER, Bryan, P. , FERNANDEZ, Andres , KINDWALL, Alexander, P. , OWENS, Windsor, E.
发明人： STAKER, Bryan, P. , FERNANDEZ, Andres , KINDWALL, Alexander, P. , OWENS, Windsor, E.
IPC分类号： G02B26/00
CPC分类号： G02B26/0841
摘要： A MEMS-based mirror is provided with trenches between adjacent electrodes in order to be able to withstand relatively high applied voltages, and thus has a substantially reduced exposure to uncontrolled surface potentials. The MEMS-based mirror, thus avoids voltage drifts and has an improved mirror position stability. The trench dimensions are selected such that the voltage applied between each adjacent pair of electrodes stays within predefined limits. An insulating layer, such as silicon dioxide, electrically isolates each pair of adjacent electrodes. Each insulting layer extends partially above an associated trench and is characterized by the same height and width dimensions.
摘要翻译：基于MEMS的反射镜在相邻电极之间设置有沟槽，以便能够承受相对较高的施加电压，并且因此显着降低了暴露于不受控制的表面电位。基于MEMS的反射镜可避免电压漂移，并具有改进的反射镜位置稳定性。选择沟槽尺寸，使得在每个相邻电极对之间施加的电压保持在预定限度内。诸如二氧化硅的绝缘层将每对相邻的电极电隔离。每个绝缘层部分地延伸到相关沟槽的上方，并且具有相同的高度和宽度尺寸。

6. 发明申请

WO1996041224A1 DIFFRACTION GRATING LIGHT DOUBLING COLLECTION SYSTEM 审中-公开
标题翻译： DIFFRACTION GRATING LIGHT DOUBLING收藏系统
公开(公告)号：WO1996041224A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008803
申请日：1996-06-05
申请人： ECHELLE, INC. , STAKER, Bryan, P. , BLOOM, David, M. , LOUCKS, Bryan, E.
发明人： ECHELLE, INC.
IPC分类号： G02B19/00
CPC分类号： G02B26/0808 , G02B19/0028 , G02B19/0047 , G02B27/42 , H04N5/7458 , H04N9/31
摘要： A reflective/diffractive light valve system collects light from multiple dimensions around a single light source. From these multiple collection dimensions, the light is directed to impinge on the valve from multiple directions. When the valve is configured to be reflective, the light returns to the source. On the other hand, when the valve is configured to be diffractive, light from a first and third order diffraction are transmitted from the valve for each of the collection dimensions which greatly enhances the efficiency of the system.
摘要翻译：反射/衍射光阀系统围绕单个光源收集来自多个维度的光。从这些多个收集尺寸，光被引导从多个方向撞击在阀上。当阀被配置为反射时，光返回到源。另一方面，当阀构造为衍射时，对于每个收集尺寸，来自第一和第三级衍射的光从阀传递，这大大提高了系统的效率。

7. 发明申请

WO2012058014A2 METHOD AND SYSTEM FOR IMAGING HIGH DENSITY BIOCHEMICAL ARRAYS WITH SUB-PIXEL ALIGNMENT 审中-公开
标题翻译：用于用子像素对准成像高密度生物化学阵列的方法和系统
公开(公告)号：WO2012058014A2
公开(公告)日：2012-05-03
申请号：PCT/US2011/056211
申请日：2011-10-13
申请人： COMPLETE GENOMICS, INC. , STAKER, Bryan P. , UHRICH, Craig E.
发明人： STAKER, Bryan P. , UHRICH, Craig E.
IPC分类号： G02B21/36 , H04N17/00
CPC分类号： G02B21/365 , G01B11/272 , G02B21/002 , G02B21/025 , G02B21/361 , H04N5/37206 , H04N7/18
摘要： A system and associated method for imaging high density biochemical arrays comprises one or more imaging channels that share a common objective lens and a corresponding one or more time delay integration-type imaging cameras with optical alignment mechanisms that permit independent inter-channel and intra-channel adjustment of each of four degrees: X, Y, rotation and scale. The imaging channels are configured to independently examine different spectra of the image of the biochemical arrays.
摘要翻译：用于对高密度生物化学阵列进行成像的系统和相关方法包括共享共同物镜的一个或多个成像通道和具有光学对准机构的对应的一个或多个时间延迟积分型成像相机，其允许独立的通道间和通道内四度调整：X，Y，旋转和刻度。成像通道被配置为独立地检查生物化学阵列的图像的不同光谱。

8. 发明申请

WO2008070764A3 ARRAY OF GRADUATED PRE-TILTED MEMS MIRRORS 审中-公开
标题翻译：研磨抛光MEMS微镜阵列
公开(公告)号：WO2008070764A3
公开(公告)日：2008-09-12
申请号：PCT/US2007086616
申请日：2007-12-06
申请人： GLIMMERGLASS NETWORKS INC , STAKER BRYAN P , FERNANDEZ ANDRES , KINDWALL ALEXANDER P , OWENS WINDSOR E
发明人： STAKER BRYAN P , FERNANDEZ ANDRES , KINDWALL ALEXANDER P , OWENS WINDSOR E
IPC分类号： G02B26/08 , G02B6/35
CPC分类号： G02B6/3556 , G02B6/357 , G02B26/0841
摘要： An array of MEMS devices is formed on a planar substrate having in each of a plurality of annular regions or sectors a plurality of MEMS mirrors of substantially identical structure, wherein the MEMS mirrors in each region have an identical pre-tilt. The pre-tilt is achieved by embedding each dual-axis tiltable mirror within a pre-tilted microplatform or gimbal. In a specific embodiment, one microplatform of a preselected pre-tilt is provided for each micromirror and an underlying electrode is provided having a shape conforming with the pre-tilt. In a specific embodiment, the annular regions are contiguous elliptical or ovoidal regions. By pre-tilt, it is meant that the rest state or nonactuated state of the micro-mirror is such that a reflected beam from a fixed source is directed to the center of a target array.
摘要翻译：在平面基板上形成MEMS器件的阵列，其具有在多个环形区域或扇区中的每一个中具有基本相同结构的多个MEMS反射镜，其中每个区域中的MEMS反射镜具有相同的预倾斜。预倾斜是通过将每个双轴可倾斜镜嵌入预倾斜的微平台或万向节来实现的。在具体实施例中，为每个微反射镜提供预选的预倾角的一个微平台，并且提供具有与预倾斜一致的形状的底层电极。在具体实施例中，环形区域是相邻的椭圆形或椭圆形区域。通过预倾斜，意味着微镜的静止状态或非激活状态使得来自固定源的反射光束被引导到目标阵列的中心。

9. 发明申请

WO2005047954A1 MEMS STRUCTURE WITH RAISED ELECTRODES 审中-公开
标题翻译：具有电极的MEMS结构
公开(公告)号：WO2005047954A1
公开(公告)日：2005-05-26
申请号：PCT/US2004/007192
申请日：2004-03-08
申请人： GLIMMERGLASS NETWORKS INC. , STAKER, Bryan, P. , MURAY, Lawrence, P. , FERNANDEZ, Andres
发明人： STAKER, Bryan, P. , MURAY, Lawrence, P. , FERNANDEZ, Andres
IPC分类号： G02B26/00
CPC分类号： G02B26/0841 , B81B3/0086 , B81B2201/042
摘要： In an electrostatically controlled deflection apparatus, such as a MEMS array having cavities formed around electrodes and which is mounted directly on a dielectric or controllably resistive substrate in which are embedded electrostatic actuation electrodes disposed in alignment with the individual MEMS elements, a mechanism is provided to mitigate the effects of uncontrolled dielectric surface potentials between the MEMS elements and the electrostatic actuation electrodes, the mechanism being raised electrodes relative to the dielectric or controllably resistive surface of the substrate. The aspect ratio of the gaps between elements (element height to element separation ratio) is at least 0.1 and preferably at least 0.5 and preferably between 0.75 and 2.0 with a typical choice of about 1.0, assuming a surface fill factor of 50% or greater. Higher aspect ratios at these fill factors are believed not to provide more than marginal improvement.
摘要翻译：在静电控制的偏转装置中，例如具有围绕电极形成的空腔的MEMS阵列，其直接安装在电介质或可控电阻衬底上，其中嵌入的静电致动电极与各个MEMS元件对准设置，减轻MEMS元件和静电致动电极之间不受控制的电介质表面电位的影响，该机构是相对于衬底的电介质或可控电阻表面升高的电极。假设表面填充因子为50％以上，元件之间的间隙（元件高度与元件分离比）的纵横比为至少0.1，优选为至少0.5，优选为0.75至2.0，典型选择为约1.0。这些填充因子的较高纵横比被认为不能提供更多的边际改进。

10. 发明申请

WO2011137183A1 METHOD AND SYSTEM FOR ACCURATE ALIGNMENT AND REGISTRATION OF ARRAY FOR DNA SEQUENCING 审中-公开
标题翻译：用于DNA序列的精确对准和阵列注册的方法和系统
公开(公告)号：WO2011137183A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/034178
申请日：2011-04-27
申请人： COMPLETE GENOMICS, INC. , STAKER, Bryan P.
发明人： STAKER, Bryan P.
IPC分类号： C40B20/02 , C40B40/06
CPC分类号： C12Q1/6874 , G06K9/32 , G06K9/42 , G06K2209/07 , G06T7/0012 , G06T7/32 , G06T7/337 , G06T7/74 , G06T2207/10056 , G06T2207/30072
摘要： In a genome sequencing system and methodology, a protocol is provided to precisely and accurately align and register an image of a planar array of nanoballs for optical analysis. Minimization techniques and Moire averaging are used to correct or errors In subperiod x-y offset, scale, and rotation. In Moire averaging, magnification is set so that the pixel period of the imaging element is a noninteger multiple of the site period. Accurate registration is achieved by providing for pre-defined pseudo-random sets of sites, where nanoballs are prevented from attachment to the substrate so that the sites of the array can be used in a pattern matching scheme as registration markers for absolute location identification. Information can be extracted with a high degree of confidence that it is correlated to a known location, while at the same time the amount of information that can be packed on a chip is maximized.
摘要翻译：在基因组测序系统和方法学中，提供了一种协议，用于精确和准确地对准和注册用于光学分析的纳米壁的平面阵列的图像。最小化技术和莫尔平均用于校正或误差在次周期x-y偏移，刻度和旋转。在莫尔平均中，设置放大倍率，使得成像元件的像素周期是站点周期的非整数倍。通过提供预定义的伪随机集合的位置来实现准确的注册，其中防止了纳米线附着到基底，使得阵列的位置可以以模式匹配方案用作绝对位置识别的登记标记。可以高信度地提取信息，使其与已知位置相关联，同时可将芯片上打包的信息量最大化。

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