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1. 发明申请

WO2009060191A2 SYSTEMS FOR CLINICAL TRIALS 审中-公开
标题翻译：临床试验系统
公开(公告)号：WO2009060191A2
公开(公告)日：2009-05-14
申请号：PCT/GB2008/003736
申请日：2008-11-05
申请人： WISTA LABORATORIES LTD. , WISCHIK, Claude, Michel, , WISCHIK, Damon, Jude , STAFF, Roger, Todd , MURRAY, Alison, Dorothy
发明人： WISCHIK, Claude, Michel, , WISCHIK, Damon, Jude , STAFF, Roger, Todd , MURRAY, Alison, Dorothy
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： G06Q99/00 , G06F19/00 , G16H10/20 , G16H50/50
摘要： The invention provides methods and systems for assessing the efficacy of a pharmaceutical which is putatively disease modifying of a cognitive disorder, for use in the treatment or prophylaxis of that cognitive disorder, the method comprising the steps of: (1) stratifying a subject group into at least 2 sub-groups according to a baseline indicator of likely disease progression, (2) treating members of each subject group with the pharmaceutical for a treatment time frame, (3) deriving psychometric and optionally physiological outcome measures for each treated patient group, (4) comparing the outcomes at (3) with a comparator arm of said sub-groups which is optionally a placebo or minimal efficacy comparator arm, (5) using the comparison in (4) to derive an efficacy measure for the pharmaceutical. The methods and systems of the invention address problems such as low rate of decline over the treatment time-frame of patients who have mild-disease severity at baseline and biased withdrawal, particularly in the placebo/comparator treatment arm.
摘要翻译：本发明提供了用于评估药物的功效的方法和系统，所述药物是推定的认知障碍的疾病改变，用于治疗或预防该认知障碍，所述方法包括以下步骤：（1）将受试者组分成根据可能的疾病进展的基线指标，至少2个亚组，（2）用药物处理每个受试者群体的治疗时间框架，（3）为每个治疗的患者组导出心理测量和任选的生理学结果测量，（4）比较（3）与所述亚组的比较组比较，其可选地是安慰剂或最小功效比较组，（5）使用（4）中的比较来得出药物的功效测定。本发明的方法和系统解决了诸如在基线时具有轻度疾病严重程度和偏倚戒断的患者的治疗时间范围内的下降率降低的问题，特别是在安慰剂/比较治疗组中。

2. 发明申请

WO2009060191A9 SYSTEMS FOR CLINICAL TRIALS 审中-公开
标题翻译：临床试验系统
公开(公告)号：WO2009060191A9
公开(公告)日：2009-07-23
申请号：PCT/GB2008003736
申请日：2008-11-05
申请人： WISTA LAB LTD , WISCHIK CLAUDE MICHEL , WISCHIK DAMON JUDE , STAFF ROGER TODD , MURRAY ALISON DOROTHY
发明人： WISCHIK CLAUDE MICHEL , WISCHIK DAMON JUDE , STAFF ROGER TODD , MURRAY ALISON DOROTHY
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： G06Q99/00 , G16H10/20 , G16H50/50
摘要： The invention provides methods and systems for assessing the efficacy of a pharmaceutical which is putatively disease modifying of a cognitive disorder, for use in the treatment or prophylaxis of that cognitive disorder, the method comprising the steps of: (1) stratifying a subject group into at least 2 sub-groups according to a baseline indicator of likely disease progression, (2) treating members of each subject group with the pharmaceutical for a treatment time frame, (3) deriving psychometric and optionally physiological outcome measures for each treated patient group, (4) comparing the outcomes at (3) with a comparator arm of said sub-groups which is optionally a placebo or minimal efficacy comparator arm, (5) using the comparison in (4) to derive an efficacy measure for the pharmaceutical. The methods and systems of the invention address problems such as low rate of decline over the treatment time-frame of patients who have mild-disease severity at baseline and biased withdrawal, particularly in the placebo/comparator treatment arm.

3. 发明申请

WO2008155533A3 PHENOTHIAZINE COMPOUNDS FOR TREATING MILD COGNITIVE IMPAIRMENT 审中-公开
公开(公告)号：WO2008155533A3
公开(公告)日：2008-12-24
申请号：PCT/GB2008/002066
申请日：2008-06-17
申请人： WISTA LABORATORIES LTD , WISCHIK, Claude Michel , HARBARAN, Dominic Venay , RIEDEL, Gernot , DEIANA, Serena , GOATMAN, Elizabeth Anne , WISCHIK, Damon Jude , MURRAY, Alison Dorothy , STAFF, Roger Todd
发明人： WISCHIK, Claude Michel , HARBARAN, Dominic Venay , RIEDEL, Gernot , DEIANA, Serena , GOATMAN, Elizabeth Anne , WISCHIK, Damon Jude , MURRAY, Alison Dorothy , STAFF, Roger Todd
IPC分类号： A61K31/5415 , A61P25/28
摘要： The present invention relates generally to methods and materials based on diaminophenothiazines for use in the treatment of Mild Cognitive Impairment (MCI).

4. 发明申请

WO2008155533A2 COMPOUNDS FOR TREATMENT 审中-公开
标题翻译：化合物治疗
公开(公告)号：WO2008155533A2
公开(公告)日：2008-12-24
申请号：PCT/GB2008002066
申请日：2008-06-17
申请人： WISTA LAB LTD , WISCHIK CLAUDE MICHEL , HARBARAN DOMINIC VENAY , RIEDEL GERNOT , DEIANA SERENA , GOATMAN ELIZABETH ANNE , WISCHIK DAMON JUDE , MURRAY ALISON DOROTHY , STAFF ROGER TODD
发明人： WISCHIK CLAUDE MICHEL , HARBARAN DOMINIC VENAY , RIEDEL GERNOT , DEIANA SERENA , GOATMAN ELIZABETH ANNE , WISCHIK DAMON JUDE , MURRAY ALISON DOROTHY , STAFF ROGER TODD
IPC分类号： A61K31/5415 , A61P25/28
CPC分类号： A61K31/5415
摘要： The present invention relates generally to methods and materials based on diaminophenothiazines for use in the treatment of Mild Cognitive Impairment (MCI).
摘要翻译：本发明一般涉及用于治疗轻度认知障碍（MCI）的二氨基吩噻嗪的方法和材料。

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