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1. 发明专利

JP2017519228A 分析種の抽出、誘導体化および定量审中-公开
公开(公告)号：JP2017519228A
公开(公告)日：2017-07-13
申请号：JP2017515041
申请日：2015-05-30
申请人：エスピーイーウェア・コーポレイションSPEware Corporation , エスピーイーウェア・コーポレイションSPEware Corporation
发明人：チー・ホアン , フィリップ・エイ・ディムソン , カーステン・アール・リーグマン
IPC分类号： G01N27/62 , C07C63/00 , C07C63/10 , C07C69/96 , C07C309/86 , G01N30/06 , G01N30/72 , G01N30/88
CPC分类号： G01N30/7233 , B01D15/24 , G01N1/405 , G01N30/72 , G01N30/84 , G01N2030/027 , G01N2030/8435 , H01J49/0031 , Y10T436/142222 , Y10T436/173845 , Y10T436/24
摘要：本願明細書は、試験試料中の1以上の分析種の存在を決定するための方法、開示の方法を実施するのに有用な材料、および開示の方法を実施するのに有用な試薬を含むキットを開示する。

2. 发明专利

JP2017517012A 微細溶出のベッドの設計によるサンプル抽出装置审中-公开
公开(公告)号：JP2017517012A
公开(公告)日：2017-06-22
申请号：JP2017513604
申请日：2015-05-20
申请人：エスピーイーウェア・コーポレイションSPEware Corporation , エスピーイーウェア・コーポレイションSPEware Corporation
发明人：フィリップ・エイ・ディムソン , ブルース・レドモンド
IPC分类号： G01N1/10
CPC分类号： G01N1/10 , B01L3/0275 , B01L2200/0631 , B01L2300/0681 , G01N1/4055 , G01N33/493 , G01N33/74 , G01N2001/4061
摘要：入口、出口、及び介流する検体を含む液体サンプルの通過のためのそれらの間の通路を伴うコンテナを有する液体サンプルから検体を抽出するための装置であり、コンテナは全直径のベッドの領域及び縮小された直径のベッドの領域を有する。コンテナは、通路に亘って伸長するレイヤ状にされた構造を含み、頂部から底部まで、(i)上側の流れ分散体/支持体レイヤ、(ii)上側の加圧体レイヤ、(iii)レイヤ(ii)へ近接する微粒子抽出培地の抽出体レイヤ、及び(iv)抽出体レイヤ(iii)へ近接して配置される下側の加圧体レイヤ、を有する。レイヤの少なくともいくつかは、全直径のベッドの領域内へ配置され、レイヤのいくつかは、縮小された直径のベッドの領域内へ配置される。

3. 发明申请

WO2011005801A1 LUER SEAL FOR SOLID PHASE EXTRACTION COLUMNS 审中-公开
标题翻译：用于固相萃取柱的LU密封
公开(公告)号：WO2011005801A1
公开(公告)日：2011-01-13
申请号：PCT/US2010/041115
申请日：2010-07-06
申请人： SPEWARE CORPORATION , DIMSON, Philip, A. , REDMOND, Bruce
发明人： DIMSON, Philip, A. , REDMOND, Bruce
IPC分类号： F16L37/00
CPC分类号： B01L3/50255 , B01L3/50853 , B01L2300/042 , B01L2300/0829 , B01L2300/0851
摘要： A seal for sealing a plurality of Solid Phase Extraction (SPE) wells or columns in an array, the seal comprising a flexible, substantially flat mat having a top surface and a bottom surface The top surface has multiple female slip connectors spaced for receiving the open tips of the solid phase extraction wells or columns The female slip connectors sealingly fasten onto the open tips to prevent fluid flow through the open tips Also disclosed is a seal extractor for removing the seal from the open tips substantially simultaneously The tips are typically male luer connectors, or pipette tips.
摘要翻译：用于密封阵列中的多个固相萃取（SPE）井或柱的密封件，所述密封件包括具有顶表面和底表面的柔性基本平坦的垫。所述顶表面具有间隔开的用于接收开口固相萃取井或柱的尖端阴滑动连接器密封地固定在开口尖端上以防止流体流过开口尖端。还公开了一种用于从基本上同时从开口尖端移除密封件的密封提取器。顶端通常为雄性鲁尔连接器，或移液器吸头。

4. 发明申请

WO2016186737A1 SAMPLE EXTRACTION APPARATUS WITH MICRO ELUTION BED DESIGN 审中-公开
标题翻译：样品提取设备与微型设计
公开(公告)号：WO2016186737A1
公开(公告)日：2016-11-24
申请号：PCT/US2016/025100
申请日：2016-03-30
申请人： SPEWARE CORPORATION
发明人： DIMSON, Philip
IPC分类号： B01D24/22 , B01D29/085 , B01D39/02 , B01J20/281 , G01N1/40 , G01N33/487
CPC分类号： G01N30/6065 , G01N1/405 , G01N30/6039 , G01N33/487
摘要： An apparatus for extracting an analyte from a liquid sample having a container with an entrance, an exit, and a passage therebetween for passage of a liquid sample containing an analyte, the container having a full diameter bed region and a reduced diameter bed region. The container includes a layered construction extending across the passage, having from top to bottom one or more of: (i) an upper flow distributor/support layer, (ii) an upper compression layer, (iii) an extraction layer of microparticulate extraction medium adjacent to the layer (ii), and (iv) a lower compression layer located adjacent to the extraction layer (iii), optionally including one or more air gap layers. At least some of the layers are located in the full diameter bed region, and some of the layers are located in the reduced diameter bed region. The apparatus may have a plurality of containers arranged in an array and/or in series so as to provide multi-stage filtration or extraction.
摘要翻译：一种用于从具有入口，出口及其间的通道的液体样品提取分析物的装置，用于通过含有分析物的液体样品，所述容器具有全直径床区域和直径减小的床区域。所述容器包括跨越所述通道延伸的分层结构，其具有从顶部到底部的一个或多个：（i）上部流动分配器/支撑层，（ii）上部压缩层，（iii）微粒提取介质的提取层邻近层（ii），和（iv）位于邻近提取层（iii）的下压缩层，任选地包括一个或多个气隙层。至少一些层位于全直径床区域中，并且一些层位于缩径直径床区域中。该装置可以具有排列成阵列和/或串联的多个容器，以提供多级过滤或提取。

5. 发明申请

WO2015179579A1 SAMPLE EXTRACTION APPARATUS WITH MICRO ELUTION BED DESIGN 审中-公开
标题翻译：样品提取设备与微型设计
公开(公告)号：WO2015179579A1
公开(公告)日：2015-11-26
申请号：PCT/US2015/031858
申请日：2015-05-20
申请人： SPEWARE CORPORATION
发明人： DIMSON, Philip, A. , REDMOND, Bruce
IPC分类号： G01N33/487
CPC分类号： G01N1/10 , B01L3/0275 , B01L2200/0631 , B01L2300/0681 , G01N1/4055 , G01N33/493 , G01N33/74 , G01N2001/4061
摘要： An apparatus for extracting an analyte from a liquid sample having a container with an entrance, an exit, and a passage therebetween for passage of a liquid sample containing an analyte, the container having a full diameter bed region and a reduced diameter bed region. The container includes a layered construction extending across the passage, having from top to bottom: (i) an upper flow distributor/support layer, (ii) an upper compression layer, (iii) an extraction layer of microparticulate extraction medium adjacent to the layer (ii), and (iv) a lower compression layer located adjacent to the extraction layer (iii). At least some of the layers are located in the full diameter bed region, and some of the layers are located in the reduced diameter bed region.
摘要翻译：一种用于从具有入口，出口及其间的通道的液体样品提取分析物的装置，用于通过含有分析物的液体样品，所述容器具有全直径床区域和直径减小的床区域。容器包括跨过通道延伸的分层结构，具有从顶部到底部：（i）上部流动分配器/支撑层，（ii）上部压缩层，（iii）与该层相邻的微粒提取介质的提取层（ii），和（iv）位于所述提取层（iii）附近的较低压缩层。至少一些层位于全直径床区域中，并且一些层位于缩径直径床区域中。

6. 发明申请

US20150338317A1 Sample Extraction Apparatus with Micro Elution Bed Design 审中-公开
标题翻译：具有微洗涤床设计的样品提取设备
公开(公告)号：US20150338317A1
公开(公告)日：2015-11-26
申请号：US14718065
申请日：2015-05-20
申请人： SPEware Corporation
发明人： Philip A. Dimson , Bruce Redmond
IPC分类号： G01N1/10
CPC分类号： G01N1/10 , B01L3/0275 , B01L2200/0631 , B01L2300/0681 , G01N1/4055 , G01N33/493 , G01N33/74 , G01N2001/4061
摘要： An apparatus for extracting an analyte from a liquid sample having a container with an entrance, an exit, and a passage therebetween for passage of a liquid sample containing an analyte, the container having a full diameter bed region and a reduced diameter bed region. The container includes a layered construction extending across the passage, having from top to bottom: (i) an upper flow distributor/support layer, (ii) an upper compression layer, (iii) an extraction layer of microparticulate extraction medium adjacent to the layer (ii), and (iv) a lower compression layer located adjacent to the extraction layer (iii). At least some of the layers are located in the full diameter bed region, and some of the layers are located in the reduced diameter bed region.
摘要翻译：一种用于从具有入口，出口及其间的通道的液体样品提取分析物的装置，用于通过含有分析物的液体样品，所述容器具有全直径床区域和直径减小的床区域。容器包括跨过通道延伸的分层结构，具有从顶部到底部：（i）上部流动分配器/支撑层，（ii）上部压缩层，（iii）与该层相邻的微粒提取介质的提取层（ii），和（iv）位于所述提取层（iii）附近的较低压缩层。至少一些层位于全直径床区域中，并且一些层位于缩径直径床区域中。

7. 发明授权

US10094746B2 Sample extraction apparatus with micro elution bed design 有权
公开(公告)号：US10094746B2
公开(公告)日：2018-10-09
申请号：US14718065
申请日：2015-05-20
申请人： SPEware Corporation
发明人： Philip A. Dimson , Bruce Redmond
IPC分类号： G01N1/10 , G01N33/74 , G01N33/493
摘要： An apparatus for extracting an analyte from a liquid sample having a container with an entrance, an exit, and a passage therebetween for passage of a liquid sample containing an analyte, the container having a full diameter bed region and a reduced diameter bed region. The container includes a layered construction extending across the passage, having from top to bottom: (i) an upper flow distributor/support layer, (ii) an upper compression layer, (iii) an extraction layer of microparticulate extraction medium adjacent to the layer (ii), and (iv) a lower compression layer located adjacent to the extraction layer (iii). At least some of the layers are located in the full diameter bed region, and some of the layers are located in the reduced diameter bed region.

8. 发明授权

US09976993B2 Sample extraction apparatus with micro elution bed design 有权
公开(公告)号：US09976993B2
公开(公告)日：2018-05-22
申请号：US15086029
申请日：2016-03-30
申请人： SPEware Corporation
发明人： Philip A. Dimson
IPC分类号： G01N30/60 , G01N33/487 , G01N1/10 , B01D15/20 , B01D15/22 , G01N1/40
CPC分类号： G01N30/6065 , B01D15/206 , B01D15/22 , G01N1/10 , G01N1/405 , G01N30/6039 , G01N30/6069 , G01N30/6095 , G01N33/487 , G01N2001/4061
摘要： An apparatus for extracting an analyte from a liquid sample having a container with an entrance, an exit, and a passage therebetween for passage of a liquid sample containing an analyte, the container having a full diameter bed region and a reduced diameter bed region. The container includes a layered construction extending across the passage, having from top to bottom one or more of: (i) an upper flow distributor/support layer, (ii) an upper compression layer, (iii) an extraction layer of microparticulate extraction medium adjacent to the layer (ii), and (iv) a lower compression layer located adjacent to the extraction layer (iii), optionally including one or more air gap layers. At least some of the layers are located in the full diameter bed region, and some of the layers are located in the reduced diameter bed region. The apparatus may have a plurality of containers arranged in an array and/or in series so as to provide multi-stage filtration or extraction.

9. 发明授权

US10267775B2 Extraction, derivatization, and quantification of analytes 有权
公开(公告)号：US10267775B2
公开(公告)日：2019-04-23
申请号：US14726530
申请日：2015-05-30
申请人： SPEware Corporation
发明人： Qi Huang , Philip A. Dimson , Karsten R. Liegmann
IPC分类号： G01N30/00 , G01N30/72 , G01N30/84 , H01J49/00 , G01N1/40 , G01N30/02 , B01D15/24
摘要： The present specification discloses methods for determining the presence one or more analytes in a test sample, materials useful to perform the disclosed methods, and kits comprising reagents useful to practice the disclosed methods.

10. 发明申请

US20160209393A1 Sample Extraction Apparatus with Micro Elution Bed Design 有权
标题翻译：具有微洗涤床设计的样品提取设备
公开(公告)号：US20160209393A1
公开(公告)日：2016-07-21
申请号：US15086029
申请日：2016-03-30
申请人： SPEware Corporation
发明人： Philip A. Dimson
IPC分类号： G01N33/487 , G01N1/10
CPC分类号： G01N30/6065 , B01D15/206 , B01D15/22 , G01N1/10 , G01N1/405 , G01N30/6039 , G01N30/6069 , G01N30/6095 , G01N33/487 , G01N2001/4061
摘要： An apparatus for extracting an analyte from a liquid sample having a container with an entrance, an exit, and a passage therebetween for passage of a liquid sample containing an analyte, the container having a full diameter bed region and a reduced diameter bed region. The container includes a layered construction extending across the passage, having from top to bottom one or more of: (i) an upper flow distributor/support layer, (ii) an upper compression layer, (iii) an extraction layer of microparticulate extraction medium adjacent to the layer (ii), and (iv) a lower compression layer located adjacent to the extraction layer (iii), optionally including one or more air gap layers. At least some of the layers are located in the full diameter bed region, and some of the layers are located in the reduced diameter bed region. The apparatus may have a plurality of containers arranged in an array and/or in series so as to provide multi-stage filtration or extraction.
摘要翻译：一种用于从具有入口，出口及其间的通道的液体样品提取分析物的装置，用于通过含有分析物的液体样品，所述容器具有全直径床区域和直径减小的床区域。所述容器包括跨越所述通道延伸的分层结构，其具有从顶部到底部的一个或多个：（i）上部流动分配器/支撑层，（ii）上部压缩层，（iii）微粒提取介质的提取层邻近层（ii），和（iv）位于邻近提取层（iii）的下压缩层，任选地包括一个或多个气隙层。至少一些层位于全直径床区域中，并且一些层位于缩径直径床区域中。该装置可以具有排列成阵列和/或串联的多个容器，以提供多级过滤或提取。

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