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1. 发明申请

WO2014011521A1 IMMUNOCONJUGATES COMPRISING ANTI - CD79B ANTIBODIES 审中-公开
标题翻译：包含抗CD79B抗体的免疫球蛋白
公开(公告)号：WO2014011521A1
公开(公告)日：2014-01-16
申请号：PCT/US2013/049519
申请日：2013-07-08
申请人： GENENTECH, INC. , POLAKIS, Paul , POLSON, Andrew , SPENCER, Susan Diane , YU, Shang-Fan , ZHENG, Bing
发明人： POLAKIS, Paul , POLSON, Andrew , SPENCER, Susan Diane , YU, Shang-Fan , ZHENG, Bing
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： A61K47/6809 , A61K31/706 , A61K45/06 , A61K47/6849 , A61K47/6851 , A61K47/6867
摘要： The invention provides immunoconjugates comprising anti-CD79b antibodies covalently attached to a nemorubicin derivative and methods of using the same.
摘要翻译：本发明提供免疫偶联物，其包含共价连接于尼莫星星衍生物的抗CD79b抗体及其使用方法。

2. 发明申请

WO2009059010A4 BEAM-STEERING APPARATUS HAVING FIVE DEGREES OF FREEDOM OF LINE-OF-SIGHT STEERING 审中-公开
标题翻译：具有五度自由度的视线转向的光束转向装置
公开(公告)号：WO2009059010A4
公开(公告)日：2009-07-09
申请号：PCT/US2008081797
申请日：2008-10-30
申请人： RAYTHEON CO , COOK LACY G , LEWANSKI ANDREW J , SPENCER SUSAN B
发明人： COOK LACY G , LEWANSKI ANDREW J , SPENCER SUSAN B
IPC分类号： G02B26/08
CPC分类号： G02B26/0816 , G02B7/1821 , G02B26/105
摘要： A beam-steering apparatus includes a set of planar tiltable mirrors positioned to define a light beam path therebetween. The set of planar tiltable mirrors may incldue from three to five planar tiltable mirrors. Each of the planar tiltable mirrors has a center of rotation lying in a plane of the mirror and each of the planar tiltable mirrors is tiltable about one axis of rotation or two orthogonal axes of rotation that lie in the plane of the mirror. The total number of axes of rotation about which the planar tiltable mirrors of the set of planar tiltable mirrors can tilt is at least five. A mirror drive system tilts each respective planar mirror about its respective axis of rotation or axes of rotation. With this apparatus, an input or output light beam path is steerable over two angular, one rotational, and two lateral-position degrees of freedom.
摘要翻译：波束控制设备包括一组平面可倾斜的镜子，其定位成在其间限定光束路径。这组平面可倾斜的镜子可以包含三至五个平面可倾斜的镜子。每个平面可倾斜反射镜具有位于反射镜平面中的旋转中心，并且每个平面可倾斜反射镜可围绕位于反射镜平面内的一个旋转轴线或两个正交旋转轴线倾斜。该组平面可倾斜镜子的平面可倾斜镜子可以倾斜的旋转轴线总数至少为5。反射镜驱动系统围绕其各自的旋转轴线或旋转轴线倾斜每个相应的平面反射镜。利用该设备，输入或输出光束路径可在两个角度，一个旋转和两个横向位置自由度上操纵。

3. 发明申请

WO1997031863A1 CONCENTRATION OF WATERBORNE PATHOGENIC ORGANISMS 审中-公开
标题翻译：水中致病性有机体的浓度
公开(公告)号：WO1997031863A1
公开(公告)日：1997-09-04
申请号：PCT/US1997003176
申请日：1997-02-27
申请人： MARSHFIELD CLINIC , BORCHARDT, Mark, A. , SPENCER, Susan, K.
发明人： MARSHFIELD CLINIC
IPC分类号： C02F01/38
CPC分类号： C12N1/02 , B04B5/0442 , B04B2005/045 , B04B2005/0457 , C12M47/02
摘要： A method of concentrating waterborne pathogenic organisms from water potentially contaminated by dilute densities of the organisms is described. Potentially contaminated water is directed along an elongated flow path (34) which rests generally within a plane perpendicular to an axis of rotation, and is subjected to centrifugal forces by rotating the flow path about the rotational axis. The method may be executed by use of a conventional continuous flow channel-type blood plasmapheresis centrifuge (30). The method has been tested for its capacity for recovering pathogenic protozoan parasites such as Cryptosporidium and Giarda from contaminated water, and recovery rates of up to 100 % have been observed.
摘要翻译：描述了浓缩水中可能被生物稀释密度污染的水中致病生物的方法。潜在污染的水沿着细长的流动路径（34）引导，该流动通道（34）大致位于垂直于旋转轴线的平面内，并且通过围绕旋转轴线旋转流动路径而受到离心力。该方法可以通过使用常规的连续流动通道型血浆置换离心机（30）来执行。已经测试了该方法从污染水中回收致病原生动物寄生虫如隐孢子虫和贾尔达的能力，并且观察到高达100％的回收率。

4. 发明申请

WO2012087962A3 ANTI-MESOTHELIN ANTIBODIES AND IMMUNOCONJUGATES 审中-公开
公开(公告)号：WO2012087962A3
公开(公告)日：2012-06-28
申请号：PCT/US2011/065895
申请日：2011-12-19
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG , DENNIS, Mark , SCALES, Suzanna J. , SPENCER, Susan D. , ZHANG, Yin
发明人： DENNIS, Mark , SCALES, Suzanna J. , SPENCER, Susan D. , ZHANG, Yin
IPC分类号： C07K16/30 , A61K47/48 , A61K39/395 , A61P35/00
摘要： The disclosure provides anti -mesothelin antibodies and immunoconj ugates and methods of using the same.

5. 发明申请

WO2006029183A2 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR 审中-公开
标题翻译：用于诊断和治疗肿瘤的组合物和方法
公开(公告)号：WO2006029183A2
公开(公告)日：2006-03-16
申请号：PCT/US2005031798
申请日：2005-09-07
申请人： GENENTECH INC , CAIRNS BELINDA , CHEN RUIHUAN , CHUNTHARAPAI ANAN , FRANTZ GRETCHEN , HILLAN KENNETH , KOEPPEN KARTMUT , PHILLIPS HEIDI , POLAKIS PAUL , REED CHAE JANEKA , SAKANAKA CHIE , SMITH VICTORIA , SPENCER SUSAN , WILLIAMS P MICKEY , WU THOMAS , ZHANG ZEMIN
发明人： CAIRNS BELINDA , CHEN RUIHUAN , CHUNTHARAPAI ANAN , FRANTZ GRETCHEN , HILLAN KENNETH , KOEPPEN KARTMUT , PHILLIPS HEIDI , POLAKIS PAUL , REED CHAE JANEKA , SAKANAKA CHIE , SMITH VICTORIA , SPENCER SUSAN , WILLIAMS P MICKEY , WU THOMAS , ZHANG ZEMIN
IPC分类号： C07K16/18
CPC分类号： G01N33/57484 , A61K47/60 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6839 , A61K47/6851 , A61K47/6859 , A61K51/1006 , A61K51/1018 , A61K2039/505 , C07K16/1072 , C07K16/18 , C07K16/30 , C07K16/303 , C07K2317/73 , C07K2317/76 , C07K2317/77
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译：本发明涉及可用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。

6. 发明申请

WO2005081711A3 MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS 审中-公开
公开(公告)号：WO2005081711A3
公开(公告)日：2005-09-09
申请号：PCT/US2004/038392
申请日：2004-11-05
申请人： SEATTLE GENETICS, INC. , DORONINA, Svetlana, O. , SENTER, Peter, D. , TOKI, Brian, E. , EBENS, Allen, J. , KLINE, Toni, Beth , POLAKIS, Paul , SLIWKOWSKI, Mark, X. , SPENCER, Susan, D.
发明人： DORONINA, Svetlana, O. , SENTER, Peter, D. , TOKI, Brian, E. , EBENS, Allen, J. , KLINE, Toni, Beth , POLAKIS, Paul , SLIWKOWSKI, Mark, X. , SPENCER, Susan, D.
IPC分类号： A61K39/395 , A61K38/06 , C07K16/46
摘要： Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.

7. 发明申请

WO2011130598A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF 审中-公开
标题翻译：。。。。。。。。。。。。
公开(公告)号：WO2011130598A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/032632
申请日：2011-04-15
申请人： SPIROGEN LIMITED , HOWARD, Philip, Wilson , MASTERSON, Luke , TIBERGHIEN, Arnaud , FLYGARE, John, A. , GUNZNER, Janet, L. , POLAKIS, Paul , POLSON, Andrew , RAAB, Helga, E. , SPENCER, Susan, D.
发明人： HOWARD, Philip, Wilson , MASTERSON, Luke , TIBERGHIEN, Arnaud , FLYGARE, John, A. , GUNZNER, Janet, L. , POLAKIS, Paul , POLSON, Andrew , RAAB, Helga, E. , SPENCER, Susan, D.
IPC分类号： A61K47/48 , C07D487/04 , A61P35/00
CPC分类号： C07D487/04 , A61K47/6849 , A61K47/6855 , A61K47/6869 , C07D519/00
摘要： Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer.
摘要翻译：公开了用于制备作为通过N10位置连接的PBD分子的缀合物的缀合物和化合物，以及缀合物用于治疗包括癌症在内的增殖性疾病的用途。

8. 发明申请

WO2010009124A3 ANTHRACYCLINE DERIVATIVE CONJUGATES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR COMPOUNDS 审中-公开
标题翻译：蒽醌衍生物偶联物，其制备方法及其作为抗微生物化合物的用途
公开(公告)号：WO2010009124A3
公开(公告)日：2010-12-23
申请号：PCT/US2009050537
申请日：2009-07-14
申请人： GENENTECH INC , NERVIANO MEDICAL SCIENCES SRL , BERIA ITALO , CARUSO MICHELE , FLYGARE JOHN A , LUPI VITTORIA , PEREGO RITA , POLAKIS PAUL , POLSON ANDREW , SALSA MATTEO , SPENCER SUSAN D , VALSASINA BARBARA
发明人： BERIA ITALO , CARUSO MICHELE , FLYGARE JOHN A , LUPI VITTORIA , PEREGO RITA , POLAKIS PAUL , POLSON ANDREW , SALSA MATTEO , SPENCER SUSAN D , VALSASINA BARBARA
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： C07K16/2863 , A61K47/64 , A61K47/6809 , C07K2317/76
摘要： The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.
摘要翻译：本发明涉及治疗有用的蒽环类与载体的缀合物，例如天然或合成来源的多克隆和单克隆抗体，蛋白质或肽; 其制备方法，含有它们的药物组合物及其在治疗某些哺乳动物肿瘤中的用途。

9. 发明申请

WO2006110760A3 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR 审中-公开
公开(公告)号：WO2006110760A3
公开(公告)日：2007-03-08
申请号：PCT/US2006013501
申请日：2006-04-05
申请人： GENENTECH INC , DOWD PATRICK , FRANTZ GRETCHEN , POLAKIS PAUL , SMITH VICTORIA , SPENCER SUSAN , WU THOMAS , ZHANG ZEMIN
发明人： DOWD PATRICK , FRANTZ GRETCHEN , POLAKIS PAUL , SMITH VICTORIA , SPENCER SUSAN , WU THOMAS , ZHANG ZEMIN
IPC分类号： C12N15/52 , A61K39/395 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/30 , C12N1/18 , C12N5/06 , C12N5/10 , C12N9/48 , C12N15/63 , C12P21/06
CPC分类号： C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

10. 发明申请

WO2006110760A2 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR 审中-公开
公开(公告)号：WO2006110760A2
公开(公告)日：2006-10-19
申请号：PCT/US2006/013501
申请日：2006-04-05
申请人： GENENTECH, INC. , DOWD, Patrick , FRANTZ, Gretchen , POLAKIS, Paul , SMITH, Victoria , SPENCER, Susan , WU, Thomas , ZHANG, Zemin
发明人： DOWD, Patrick , FRANTZ, Gretchen , POLAKIS, Paul , SMITH, Victoria , SPENCER, Susan , WU, Thomas , ZHANG, Zemin
IPC分类号： A61K39/395 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/30 , C12N1/18 , C12N5/06 , C12P21/06
CPC分类号： C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

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