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1. 发明申请

WO2010089699A2 CT PERFUSION PHANTOM 审中-公开
公开(公告)号：WO2010089699A2
公开(公告)日：2010-08-12
申请号：PCT/IB2010/050475
申请日：2010-02-03
申请人： HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , SOSNA, Jacob , HIRSCHENBAIN, Aviv
发明人： SOSNA, Jacob , HIRSCHENBAIN, Aviv
IPC分类号： A61B6/00
CPC分类号： A61B6/504 , A61B6/484 , A61B6/507 , A61B6/583 , G01R33/56366
摘要： A physical phantom reference to control for variability of computed tomography measurement results duplicates the density curve of blood perfusion of contrast material in a healthy aorta or large artery to normalize observed changes in healthy arterial blood perfusion when calculating the reduction in tumor blood perfusion between two examination times. In one embodiment, a plurality of compartments with different concentrations of contrast material corresponding to a density curve of blood perfusion of a healthy tissue are positioned-in a screening field of a CT machine so the CT machine images the compartments when it images the healthy tissue. In another embodiemnt, a pipe containing fluid receives an injection of contrast material from the injector when the injector injects the contrast material into the patient, the pipe having sections of varying diameter so the sections together correspond to a blood perfusion curve of the contrast material in a healthy tissue.
摘要翻译：对计算机断层扫描测量结果的变异性进行控制的物理幻影参考重复了健康主动脉或大动脉中对比材料的血液灌注密度曲线，以便在计算两次检查之间的肿瘤血液灌注减少时，使健康动脉血液灌注中观察到的变化正常化倍。在一个实施例中，具有对应于健康组织的血液灌注的密度曲线的对比度材料的不同浓度的多个隔室位于CT机器的筛选区域中，使得CT机器在对隔室进行成像时对其进行成像。在另一个实施例中，当注射器将造影剂注射到患者体内时，含有流体的管道接收来自注射器的造影材料的注入，该管道具有不同直径的部分，使得这些部分在一起对应于造影剂材料的血液灌注曲线健康的组织。

2. 发明申请

WO2010089699A3 CT PERFUSION PHANTOM 审中-公开
公开(公告)号：WO2010089699A3
公开(公告)日：2010-09-30
申请号：PCT/IB2010050475
申请日：2010-02-03
申请人： HADASIT MED RES SERVICE , SOSNA JACOB , HIRSCHENBAIN AVIV
发明人： SOSNA JACOB , HIRSCHENBAIN AVIV
IPC分类号： A61B6/00
CPC分类号： A61B6/504 , A61B6/484 , A61B6/507 , A61B6/583 , G01R33/56366
摘要： A physical phantom reference to control for variability of computed tomography measurement results duplicates the density curve of blood perfusion of contrast material in a healthy aorta or large artery to normalize observed changes in healthy arterial blood perfusion when calculating the reduction in tumor blood perfusion between two examination times. In one embodiment, a plurality of compartments with different concentrations of contrast material corresponding to a density curve of blood perfusion of a healthy tissue are positioned-in a screening field of a CT machine so the CT machine images the compartments when it images the healthy tissue. In another embodiemnt, a pipe containing fluid receives an injection of contrast material from the injector when the injector injects the contrast material into the patient, the pipe having sections of varying diameter so the sections together correspond to a blood perfusion curve of the contrast material in a healthy tissue.
摘要翻译：在计算两次检查之间的肿瘤血液灌注减少时，用于控制计算机断层摄影测量结果的可变性的物理幻像参考复制了健康主动脉或大动脉中造影材料的血液灌注密度曲线以使观察到的健康动脉血液灌注变化正常化倍。在一个实施例中，将具有与健康组织的血液灌注的密度曲线对应的不同浓度的对比材料的多个隔室放置在CT机的筛选区域中，使得CT机器在对健康组织。在另一个实施例中，当注射器将对比剂材料注射到患者体内时，容纳流体的管接收来自注射器的造影剂注射，管具有不同直径的部分，因此这些部分一起对应于造影剂材料的血液灌注曲线一个健康的组织。

3. 发明申请

WO2012120498A1 NON-INVASIVE THERMAL TREATMENT MONITORING 审中-公开
标题翻译：非侵入性热处理监测
公开(公告)号：WO2012120498A1
公开(公告)日：2012-09-13
申请号：PCT/IL2012/000104
申请日：2012-03-04
申请人： TECHNION RESEARCH & DEVELOPMENT , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , WEISS, Noam , AZHARI, Haim , SOSNA, Jacob
发明人： WEISS, Noam , AZHARI, Haim , SOSNA, Jacob
IPC分类号： A61B5/01
CPC分类号： A61B5/01 , A61B6/032 , A61B2017/00057 , A61B2018/00791 , A61B2090/376 , A61N7/02
摘要： A method for thermal monitoring of HIFU and other thermal treatments, utilizing electro-magnetic radiation signal detection or image processing. The images or detectors output signals show the attenuation at the target tissue, and changes in the attenuation level may be correlated to changes in the tissue temperature and condition during treatment and the subsequent cooling down period. Additionally, the point at which denaturation and coagulation of the tissue occurs can be determined. Analysis of the functional change in attenuation with time of treatment enables the accumulated tissue damage to be quantified. The advantage of this method is that it indicates the level of damage in the tissue directly, instead of displaying tissue temperatures only. The method provides a cost effective non-invasive method for thermal monitoring during ablation, as an alternative to MRI monitoring or to CT monitoring based on temperature determination.
摘要翻译：用于利用电磁辐射信号检测或图像处理对HIFU和其他热处理进行热监控的方法。图像或检测器输出信号显示目标组织处的衰减，并且衰减水平的变化可能与治疗期间和随后的冷却期间组织温度和状况的变化相关。另外，可以确定组织发生变性和凝固的点。对治疗时间衰减的功能变化进行分析，可以对累积的组织损伤进行量化。这种方法的优点是它直接显示组织的损伤程度，而不是仅显示组织温度。该方法为消融过程中的热监测提供了具有成本效益的非侵入性方法，作为MRI监测或基于温度测定的CT监测的替代方法。

4. 发明申请

WO2012120498A8 NON-INVASIVE THERMAL TREATMENT MONITORING 审中-公开
标题翻译：非侵入式热处理监测
公开(公告)号：WO2012120498A8
公开(公告)日：2012-11-29
申请号：PCT/IL2012000104
申请日：2012-03-04
申请人： TECHNION RES & DEV , HADASIT MED RES SERVICE , WEISS NOAM , AZHARI HAIM , SOSNA JACOB
发明人： WEISS NOAM , AZHARI HAIM , SOSNA JACOB
IPC分类号： A61B5/01
CPC分类号： A61B5/01 , A61B6/032 , A61B2017/00057 , A61B2018/00791 , A61B2090/376 , A61N7/02
摘要： A method for thermal monitoring of HIFU and other thermal treatments, utilizing electro-magnetic radiation signal detection or image processing. The images or detectors output signals show the attenuation at the target tissue, and changes in the attenuation level may be correlated to changes in the tissue temperature and condition during treatment and the subsequent cooling down period. Additionally, the point at which denaturation and coagulation of the tissue occurs can be determined. Analysis of the functional change in attenuation with time of treatment enables the accumulated tissue damage to be quantified. The advantage of this method is that it indicates the level of damage in the tissue directly, instead of displaying tissue temperatures only. The method provides a cost effective non-invasive method for thermal monitoring during ablation, as an alternative to MRI monitoring or to CT monitoring based on temperature determination.
摘要翻译：一种利用电磁辐射信号检测或图像处理对HIFU和其他热处理进行热监测的方法。图像或检测器输出信号显示目标组织的衰减，并且衰减水平的变化可能与治疗期间和随后的冷却期间的组织温度和状况的变化相关。此外，可以确定发生组织的变性和凝结的点。通过治疗时间分析衰减的功能变化可以量化累积的组织损伤。该方法的优点是它直接指示组织的损伤程度，而不仅仅显示组织温度。该方法提供了用于消融期间的热监测的成本有效的非侵入性方法，作为MRI监测的替代或者基于温度测定的CT监测。

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