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1. 发明申请

WO2006050033A9 SYSTEM AND METHOD FOR ANALYTE SAMPLING AND ANALYSIS 审中-公开
标题翻译：分析采样和分析的系统和方法
公开(公告)号：WO2006050033A9
公开(公告)日：2007-02-01
申请号：PCT/US2005038786
申请日：2005-10-27
申请人： SONTRA MEDICAL CORP , KELLOGG SCOTT C , CHUANG HAN
发明人： KELLOGG SCOTT C , CHUANG HAN
IPC分类号： A61B5/05
CPC分类号： A61B5/681 , A61B5/14514 , A61B5/1486 , A61B5/150022 , A61B5/150083 , A61B5/150358 , A61B5/150969 , A61B5/15134 , A61B5/157 , A61B10/0045 , A61B2010/0003
摘要： The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement an error correction method that corrects for sensor drift.
摘要翻译：本发明涉及一种透皮分析物监测系统，其包括适于与生物膜接合并接收来自生物膜的分析物的介质和包含多个电极的电极组件，其中所述介质适于与分析物连续反应，电信号由电极组件检测，电信号与分析物值相关。分析物值可以是通过生物膜的分析物的通量或受试者的体液中分析物的浓度。介质可以包括例如基于乙酸乙烯酯的水凝胶，基于琼脂糖的水凝胶或基于聚乙二醇二丙烯酸酯（PEG-DA）的水凝胶。电极的表面区域可以包括纯铂。该系统可以包括位于生物膜和电极组件之间的干涉滤波器，用于减少系统中的干扰。系统可以包括被编程为实现校正传感器漂移的纠错方法的处理器。

2. 发明申请

WO2006091719A2 COMPOSITIONS AND METHODS ENHANCING TRANSDERMAL DELIVERY OF DRUGS AND BIOLOGICS 审中-公开
标题翻译：组合物和方法增强药物和生物学的转运
公开(公告)号：WO2006091719A2
公开(公告)日：2006-08-31
申请号：PCT/US2006006385
申请日：2006-02-23
申请人： SONTRA MEDICAL CORP , BARMAN SHIKHA P , FARNHAM HANNAH , ROODE LAUREN K , WAN ANNA
发明人： BARMAN SHIKHA P , FARNHAM HANNAH , ROODE LAUREN K , WAN ANNA
CPC分类号： A61K9/0009 , A61K9/0014 , A61K9/0019
摘要： Improved methods for transdermal transport of drug formulations are described herein. Formulations designed to enhance transport of therapeutic levels of topically applied drugs into the systemic circulation, methods of making the formulations are also described herein. The formulations contain at least one active agent to be delivered and at least one skin permeation enhancer in a polymeric hydrogel, and optional additional excipients. Methods for enhancing transport of formulations into and through the skin include: (a) pretreatment of the skin with a hydrating solution, (b) physical permeation of the stratum corneum by low frequency ultrasound (administered by a sono-permeation device, such as SONOPREP ® , available from Sontra Medical Corporation, Franklin, MA), (c) topical application of a formulation containing the bioactive molecule, and optionally (d) application of an electric potential difference that forces ionized drugs through the skin. Optionally, the formulation contains permeation-enhancing agents. The method may be used with the formulations described herein or with other formulations for topical administration. In a preferred embodiment, the active agent to be delivered is a drug. Preferably the drug is a local anesthetic, such as lidocaine.
摘要翻译：本文描述了用于药物制剂的透皮转运的改进方法。设计用于增强局部应用药物治疗水平进入体循环的制剂，制备制剂的方法也在本文中描述。制剂含有至少一种待递送的活性剂和聚合物水凝胶中至少一种皮肤渗透促进剂，以及任选的另外的赋形剂。用于增强制剂进入皮肤和通过皮肤的运输的方法包括：（a）用水合溶液预处理皮肤，（b）通过低频超声（由超音波渗透装置如SONOPREP施用的角质层的物理渗透（Sontra Medical Corporation，Franklin，MA）），（c）局部施用含有生物活性分子的制剂，以及任选地（d）施加电离差，其强制电离药物通过皮肤。任选地，制剂含有渗透增强剂。该方法可以与本文所述的制剂一起使用或与其它用于局部给药的制剂一起使用。在优选的实施方案中，待递送的活性剂是药物。优选地，药物是局部麻醉剂，例如利多卡因。

3. 发明申请

WO2006050033B1 SYSTEM AND METHOD FOR ANALYTE SAMPLING AND ANALYSIS 审中-公开
公开(公告)号：WO2006050033B1
公开(公告)日：2006-12-14
申请号：PCT/US2005038786
申请日：2005-10-27
申请人： SONTRA MEDICAL CORP , KELLOGG SCOTT C , CHUANG HAN
发明人： KELLOGG SCOTT C , CHUANG HAN
IPC分类号： A61B5/05
CPC分类号： A61B5/681 , A61B5/14514 , A61B5/1486 , A61B5/150022 , A61B5/150083 , A61B5/150358 , A61B5/150969 , A61B5/15134 , A61B5/157 , A61B10/0045 , A61B2010/0003
摘要： The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement an error correction method that corrects for sensor drift.

4. 发明申请

WO2006050033A3 SYSTEM AND METHOD FOR ANALYTE SAMPLING AND ANALYSIS 审中-公开
标题翻译：分析物采样和分析的系统和方法
公开(公告)号：WO2006050033A3
公开(公告)日：2006-11-02
申请号：PCT/US2005038786
申请日：2005-10-27
申请人： SONTRA MEDICAL CORP , KELLOGG SCOTT C , CHUANG HAN
发明人： KELLOGG SCOTT C , CHUANG HAN
IPC分类号： A61B5/05
CPC分类号： A61B5/681 , A61B5/14514 , A61B5/1486 , A61B5/150022 , A61B5/150083 , A61B5/150358 , A61B5/150969 , A61B5/15134 , A61B5/157 , A61B10/0045 , A61B2010/0003
摘要： The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement an error correction method that corrects for sensor drift.
摘要翻译：本发明涉及一种透皮分析物监测系统，该系统包括适于与生物膜界面接触并从生物膜接收分析物的介质和包含多个电极的电极组件，其中该介质适于与分析物连续反应，电信号被电极组件检测到，并且电信号与分析物值相关。分析物值可以是分析物通过生物膜的通量或者受试者体液中分析物的浓度。例如，介质可以包含基于乙酸乙烯酯的水凝胶，基于琼脂糖的水凝胶或基于聚乙二醇二丙烯酸酯（PEG-DA）的水凝胶。电极的表面区域可以包含纯铂。该系统可以包括位于生物膜和电极组件之间的干扰滤波器，用于减少系统中的干扰。该系统可以包括处理器，该处理器被编程为实施纠正传感器漂移的纠错方法。

5. 发明申请

WO2006050032A3 SYSTEM AND METHOD FOR ANALYTE SAMPLING AND ANALYSIS WITH HYDROGEL 审中-公开
标题翻译：用于分析仪采样和分析的系统和方法
公开(公告)号：WO2006050032A3
公开(公告)日：2006-09-08
申请号：PCT/US2005038785
申请日：2005-10-27
申请人： SONTRA MEDICAL CORP , CHUANG HAN , BARMAN SHIKHA P
发明人： CHUANG HAN , BARMAN SHIKHA P
IPC分类号： A61B5/05
CPC分类号： A61B5/681 , A61B5/14514 , A61B5/1486 , A61B5/150022 , A61B5/150083 , A61B5/150358 , A61B5/150969 , A61B5/15134 , A61B5/157 , A61B10/0045 , A61B2010/0003
摘要： The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement an error correction method that corrects for sensor drift.
摘要翻译：本发明涉及一种透皮分析物监测系统，其包括适于与生物膜接合并接收来自生物膜的分析物的介质和包含多个电极的电极组件，其中所述介质适于与分析物连续反应，电信号由电极组件检测，电信号与分析物值相关。分析物值可以是通过生物膜的分析物的通量或受试者的体液中分析物的浓度。介质可以包括例如基于乙酸乙烯酯的水凝胶，基于琼脂糖的水凝胶或基于聚乙二醇二丙烯酸酯（PEG-DA）的水凝胶。电极的表面区域可以包括纯铂。该系统可以包括位于生物膜和电极组件之间的干涉滤波器，用于减少系统中的干扰。系统可以包括被编程为实现校正传感器漂移的纠错方法的处理器。

6. 发明申请

WO2006091877A2 AGENTS AND METHODS FOR ENHANCEMENT OF TRANSDERMAL TRANSPORT 审中-公开
标题翻译：增强运输的代理和方法
公开(公告)号：WO2006091877A2
公开(公告)日：2006-08-31
申请号：PCT/US2006006712
申请日：2006-02-27
申请人： SONTRA MEDICAL CORP
发明人： KELLOG SCOTT C , BARMAN SHIKHA , ROODE LAUREN , FARNHAM HANNAH , MORAN SEAN P , MITRAGOTRI SAMIR S , KOST JOSEPH , WARNER NICHOLAS F
IPC分类号： A61B17/20 , A61B5/00
CPC分类号： A61B5/681 , A61B5/14514 , A61B5/14532 , A61B5/1486 , A61B5/411 , A61B5/415 , A61B5/418 , A61B5/6843 , A61B17/20 , A61K9/0009 , A61K47/10 , A61M37/0092 , A61N1/30
摘要： The invention according to an exemplary embodiment relates to a method for transporting a substance across a biological membrane comprising the steps of applying a delipidation agent to a portion of the biological membrane, applying a hydration agent to the portion of the biological membrane, sonicating the portion of the biological membrane, and transporting the substance across the biological membrane. The step of applying the delipidation agent may be carried out prior to or simultaneously with the step of applying the hydration agent. The hydration agent may be applied before, during, or after the sonication step. The methods according to exemplary embodiments of the invention can provide improved transdermal transport in applications such as continuous analyte extraction and analysis and transdermal delivery of drugs and vaccines.
摘要翻译：根据示例性实施方案的本发明涉及一种用于在物质膜上输送物质的方法，包括以下步骤：将一种脱脂剂施用于该生物膜的一部分，向生物膜的该部分施加水化剂，将该部分的生物膜，并将物质运送到生物膜上。施用脱脂剂的步骤可以在施用水化剂的步骤之前或同时进行。水合剂可以在超声处理步骤之前，期间或之后施用。根据本发明的示例性实施方案的方法可以在诸如连续分析物提取和分析以及药物和疫苗的透皮递送等应用中提供改进的透皮转运。

7. 发明申请

WO2006050031A3 SYSTEM AND METHOD FOR ANALYTE SAMPLING AND ANALYSIS WITH ERROR CORRECTION 审中-公开
标题翻译：用于分析采样的系统和方法以及具有错误校正的分析
公开(公告)号：WO2006050031A3
公开(公告)日：2007-05-18
申请号：PCT/US2005038784
申请日：2005-10-27
申请人： SONTRA MEDICAL CORP , CHUANG HAN
发明人： CHUANG HAN
IPC分类号： A61B5/05
CPC分类号： A61B5/681 , A61B5/14514 , A61B5/1486 , A61B5/150022 , A61B5/150083 , A61B5/150358 , A61B5/150969 , A61B5/15134 , A61B5/157 , A61B10/0045 , A61B2010/0003
摘要： The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement and error correction method that corrects for sensor drift.
摘要翻译：本发明涉及透皮分析物监测系统，其包括适于与生物膜接触并接收来自生物膜的分析物的介质和包括多个电极的电极组件，其中所述介质适于与分析物连续反应，电信号由电极组件检测，并且电信号与分析物值相关。分析物值可以是通过生物膜的分析物的通量或受试者的体液中分析物的浓度。介质可以包括基于乙酸乙烯酯的水凝胶，基于琼脂糖的水凝胶或基于聚乙二醇二丙烯酸酯（PEG-DA）的水凝胶。电极的表面区域可以包括纯铂。该系统可以包括位于生物膜和电极组件之间的干涉滤光器，用于减少系统中的干扰。该系统可以包括编程为实现的处理器和纠正传感器漂移的纠错方法。

8. 发明申请

WO2006050032A9 SYSTEM AND METHOD FOR ANALYTE SAMPLING AND ANALYSIS WITH HYDROGEL 审中-公开
标题翻译：系统和方法分析采样和水凝胶分析
公开(公告)号：WO2006050032A9
公开(公告)日：2006-11-02
申请号：PCT/US2005038785
申请日：2005-10-27
申请人： SONTRA MEDICAL CORP , CHUANG HAN , BARMAN SHIKHA P
发明人： CHUANG HAN , BARMAN SHIKHA P
IPC分类号： A61B5/05
CPC分类号： A61B5/681 , A61B5/14514 , A61B5/1486 , A61B5/150022 , A61B5/150083 , A61B5/150358 , A61B5/150969 , A61B5/15134 , A61B5/157 , A61B10/0045 , A61B2010/0003
摘要： The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement an error correction method that corrects for sensor drift.
摘要翻译：本发明涉及一种透皮分析物监测系统，该系统包括适于与生物膜界面接触并从生物膜接收分析物的介质和包含多个电极的电极组件，其中该介质适于与分析物连续反应，电信号被电极组件检测到，并且电信号与分析物值相关。分析物值可以是分析物通过生物膜的通量或者受试者体液中分析物的浓度。例如，介质可以包含基于乙酸乙烯酯的水凝胶，基于琼脂糖的水凝胶或基于聚乙二醇二丙烯酸酯（PEG-DA）的水凝胶。电极的表面区域可以包含纯铂。该系统可以包括位于生物膜和电极组件之间的干扰滤波器，用于减少系统中的干扰。该系统可以包括处理器，该处理器被编程为实施纠正传感器漂移的纠错方法。

9. 发明申请

WO2006050031A9 SYSTEM AND METHOD FOR ANALYTE SAMPLING AND ANALYSIS WITH ERROR CORRECTION 审中-公开
标题翻译：具有误差校正的分析采样和分析的系统和方法
公开(公告)号：WO2006050031A9
公开(公告)日：2006-06-15
申请号：PCT/US2005038784
申请日：2005-10-27
申请人： SONTRA MEDICAL CORP , CHUANG HAN
发明人： CHUANG HAN
IPC分类号： A61B17/20
CPC分类号： A61B5/681 , A61B5/14514 , A61B5/1486 , A61B5/150022 , A61B5/150083 , A61B5/150358 , A61B5/150969 , A61B5/15134 , A61B5/157 , A61B10/0045 , A61B2010/0003
摘要： The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement and error correction method that corrects for sensor drift.
摘要翻译：本发明涉及一种透皮分析物监测系统，该系统包括适于与生物膜界面接触并从生物膜接收分析物的介质和包含多个电极的电极组件，其中该介质适于与分析物连续反应，电信号被电极组件检测到，并且电信号与分析物值相关。分析物值可以是分析物通过生物膜的通量或者受试者体液中分析物的浓度。例如，介质可以包含基于乙酸乙烯酯的水凝胶，基于琼脂糖的水凝胶或基于聚乙二醇二丙烯酸酯（PEG-DA）的水凝胶。电极的表面区域可以包含纯铂。该系统可以包括位于生物膜和电极组件之间的干扰滤波器，用于减少系统中的干扰。该系统可以包括处理器，该处理器被编程为执行校正传感器漂移的纠错方法。

10. 发明专利

BRPI0517255A 未知
公开(公告)号：BRPI0517255A
公开(公告)日：2008-10-07
申请号：BRPI0517255
申请日：2005-10-27
申请人： SONTRA MEDICAL CORP
发明人： CHUANG HAN , BARMAN SHIKHA P
IPC分类号： A61B5/296
摘要： An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.

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