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1. 发明申请

WO9924421A8 IMIDAZOYLALKYL SUBSTITUTED WITH A FIVE, SIX OR SEVEN MEMBERED HETEROCYCLIC RING CONTAINING ONE NITROGEN ATOM 审中-公开
标题翻译：用五分之一取代的咪唑啉酮，六种或七种含有一个氮原子的成员杂环
公开(公告)号：WO9924421A8
公开(公告)日：1999-08-26
申请号：PCT/US9823224
申请日：1998-11-05
申请人： SCHERING CORP , VACCARO WAYNE D , WOLIN RONALD L , SOLOMON DANIEL M , ASLANIAN ROBERT G , PIWINSKI JOHN J , ROSENBLUM STUART B
发明人： VACCARO WAYNE D , WOLIN RONALD L , SOLOMON DANIEL M , ASLANIAN ROBERT G , PIWINSKI JOHN J , ROSENBLUM STUART B
IPC分类号： A61K31/4178 , A61K31/4427 , A61K31/445 , A61K31/454 , A61K31/495 , A61P1/00 , A61P3/04 , A61P9/00 , A61P9/02 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/28 , A61P27/06 , A61P37/08 , C07D401/06 , C07D403/06 , A61K31/415
CPC分类号： C07D401/06 , A61K31/445 , A61K31/495 , C07D403/06 , A61K31/415 , A61K2300/00
摘要： Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof. Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and an effective amount of a Compound of Formula (I). Further disclosed is a method of treating allergy (for example asthma), inflammation, hypotension, raised intraocular pressure (such as glaucoma) i.e., a method of lowering intraocular pressure, sleeping disorders, states of hyper and hypo motility and acidic secretion of the gastrointestinal tract, hypo and hyperactivity of the central nervous system (for example, agitation and depression) and other CNS disorders (such as Alzheimer's, Schizophrenia, obesity and migraine) comprising administering an effective amount of a compound of Formula (I) to a patient in need of such treatment. Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of Formula (I) in combination or admixture with a histamine H1 receptor antagonist.
摘要翻译：公开了式（I）的化合物或其药学上可接受的盐或溶剂化物。还公开了包含药学上可接受的载体和有效量的式（I）的化合物的药物组合物。进一步公开的是治疗过敏（例如哮喘），炎症，低血压，升高的眼内压（例如青光眼）的方法，即降低眼内压，睡眠障碍，超低运动性状态和胃肠酸性分泌的方法中枢神经系统（例如，激动和抑郁）和其它CNS疾病（例如阿尔茨海默病，精神分裂症，肥胖症和偏头痛）的多发，低血压和多动症（包括向患者施用有效量的式（I）化合物）需要这样的治疗。还公开了治疗上呼吸道过敏反应的方法，包括与组胺H1受体拮抗剂组合或混合施用式（I）的化合物或其盐或溶剂合物。

2. 发明申请

WO2009085880A3 C-21 THIOETHERS AS GLUCOCORTICOID RECEPTOR AGONISTS 审中-公开
标题翻译：作为糖皮质激素受体激动剂的C-21硫酯
公开(公告)号：WO2009085880A3
公开(公告)日：2009-09-17
申请号：PCT/US2008087301
申请日：2008-12-18
申请人： SCHERING CORP , ANTHES JOHN C , MCCORMICK KEVIN D , HEY JOHN A , ASLANIAN ROBERT G , BIJU PURAKKATTLE J , BERLIN MICHAEL Y , SOLOMON DANIEL M , WANG HONGWU , LIM YEON HEE , LEE YOON JON , BITAR REMA DANIELLE
发明人： ANTHES JOHN C , MCCORMICK KEVIN D , HEY JOHN A , ASLANIAN ROBERT G , BIJU PURAKKATTLE J , BERLIN MICHAEL Y , SOLOMON DANIEL M
IPC分类号： C07J43/00 , A61K31/573 , A61K31/58 , A61P5/44 , C07J31/00 , C07J71/00
CPC分类号： C07J43/003 , C07J31/006 , C07J71/0031
摘要： The present invention provides compounds of Formula (VII) and 11-keto analogs thereof, and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, and isomers of said compounds and said 11-keto analogs, having the general structure formula (VII): wherein L, R1, R2, R3, R4, and R5 are selected independently of each other and as defined herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions. The novel compounds of the present invention possess useful pharmacological activity while having unexpectedly low systemic activiy. Thus, the compounds of the invention represent a safer alternative to those known glucocorticoids which have poor side-effect profiles.
摘要翻译：本发明提供具有通式结构式（VII）的所述化合物和所述11-酮基类似物的式（VII）化合物及其11-酮基类似物及其药学上可接受的盐，溶剂化物，酯，前药，互变异构体和异构体，：其中L，R 1，R 2，R 3，R 4和R 5彼此独立地选择和如本文所定义。还提供了药物组合物，制备方法以及使用这些化合物治疗和预防各种免疫，自身免疫和炎性疾病和病症的方法。本发明的新化合物具有有用的药理学活性，同时具有意想不到的低全身活性。因此，本发明的化合物代表了那些副作用较差的已知糖皮质激素的安全替代品。

4. 发明申请

WO2007075688A3 SUBSTITUTED ANILINE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS 审中-公开
标题翻译：取代的苯胺衍生物有用于组胺H3拮抗剂
公开(公告)号：WO2007075688A3
公开(公告)日：2007-09-07
申请号：PCT/US2006048440
申请日：2006-12-19
申请人： SCHERING CORP , SOLOMON DANIEL M , ASLANIAN ROBERT G , BERLIN MICHAEL Y , DE LERA RUIZ MANUEL , MCCORMICK KEVIN D , MUTAHI MWANGI W , TOM WING C
发明人： SOLOMON DANIEL M , ASLANIAN ROBERT G , BERLIN MICHAEL Y , DE LERA RUIZ MANUEL , MCCORMICK KEVIN D , MUTAHI MWANGI W , TOM WING C
IPC分类号： C07D213/74 , A61K31/44 , A61P29/00 , C07D401/12 , C07D401/14
CPC分类号： C07D401/12 , C07D213/73 , C07D213/74 , C07D401/14 , C07D471/04
摘要： Disclosed are compounds of the formula Chemical formula (I) or a pharmaceutically acceptable salt thereof, wherein M 2 is N; X is a bond, optionally substituted alkylene, alkenylene, -O-, -CH 2 N(R 12 )-, -N(R 12 )CH 2 -, -N(R 12 )-, -NHC(O)-, -OCH 2 -, -CH 2 O-, or -S(O) 0-2 -; and Y is -(CH 2 ) 1-2 -, -C(=O)-, -C(=NOR 13 )- or -SO0-2-; or M 1 is N; M 2 is N or CH; X is a bond, alkylene, alkenylene, -C(O)-, -NHC(O)-, -OC(O)- or -S(O) 1-2 -; Y is -(CH 2 ) 1-2 -, -C(=O)- or -SO 0-2 -; and when M 2 is CH, Y is also Y is -O- or -C(=NOR 13 )-; Z is a bond or optionally substituted alkylene or alkenylene; U and W are CH, or one is CH and one is N; R 1 is optionally substituted alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl; R 2 is optionally substituted alkyl, alkenyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl or heterocycloalkyl; and the remaining variables are as defined in the specification; and compositions and methods of treating obesity, metabolic syndrome and a cognition deficit disorder, alone or in combination with other agents.
摘要翻译：公开了下式的化合物：化学式（I）或其药学上可接受的盐，其中M 2是N; X是一个键，任选取代的亚烷基，亚烯基，-O - ， - CH 2 N（R 12） - ， - N（R 12） CH 2 - ， - N（R 12） - ， - NHC（O） - ， - OCH 2 - ， - O - 或-S（O）0-2 - ; - 并且Y是 - （CH 2）2 - ， - C（= O） - ， - C（= NOR 13） - 或-SOO 2 - ; 或M 1是N; N 2是N或CH; X是一个键，亚烷基，亚烯基，-C（O） - ， - NHC（O） - ， - OC（O） - 或-S（O） Y是 - （CH 2）2 - ， - C - （= O） - 或-SO 0-2 - 。当M 2是CH时，Y也是Y是-O-或-C（= NOR 13） - ; Z是键或任选取代的亚烷基或亚烯基; U和W是CH，或一个是CH，一个是N; R 1是任选取代的烷基，环烷基，芳基，芳基烷基，杂芳基，杂环烷基; R 2是任选取代的烷基，烯基，芳基，芳基烷基，杂芳基，杂芳基烷基，环烷基或杂环烷基; 剩余的变量如规范中所定义; 以及单独或与其他药物组合治疗肥胖症，代谢综合征和认知缺陷障碍的组合物和方法。

5. 发明申请

WO2009085880A8 C-21 THIOETHERS AS GLUCOCORTICOID RECEPTOR AGONISTS 审中-公开
公开(公告)号：WO2009085880A8
公开(公告)日：2009-07-09
申请号：PCT/US2008/087301
申请日：2008-12-18
申请人： SCHERING CORPORATION , ANTHES, John, C. , MCCORMICK, Kevin, D. , HEY, John, A. , ASLANIAN, Robert, G. , BIJU, Purakkattle, J. , BERLIN, Michael, Y. , SOLOMON, Daniel, M. , WANG, Hongwu , LIM, Yeon-hee , LEE, Yoon Joo , BITAR, Rema, Danielle
发明人： ANTHES, John, C. , MCCORMICK, Kevin, D. , HEY, John, A. , ASLANIAN, Robert, G. , BIJU, Purakkattle, J. , BERLIN, Michael, Y. , SOLOMON, Daniel, M. , WANG, Hongwu , LIM, Yeon-hee , LEE, Yoon Joo , BITAR, Rema, Danielle
IPC分类号： C07J43/00 , C07J31/00 , C07J71/00 , A61P5/44 , A61K31/573 , A61K31/58
摘要： The present invention provides compounds of Formula (VII) and 11-keto analogs thereof, and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, and isomers of said compounds and said 11-keto analogs, having the general structure formula (VII): wherein L, R 1 , R 2 , R 3 , R 4 , and R 5 are selected independently of each other and as defined herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions. The novel compounds of the present invention possess useful pharmacological activity while having unexpectedly low systemic activiy. Thus, the compounds of the invention represent a safer alternative to those known glucocorticoids which have poor side-effect profiles.

6. 发明申请

WO2007001975A8 PIPERIDINE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS 审中-公开
标题翻译：哌嗪衍生物作为组胺H3拮抗剂有用
公开(公告)号：WO2007001975A8
公开(公告)日：2008-01-24
申请号：PCT/US2006023800
申请日：2006-06-19
申请人： SCHERING CORP , ASLANIAN ROBERT G , BERLIN MICHAEL Y , BOYCE CHRISTOPHER W , CHAO JIANHUA , DE LERA RUIZ MANUEL , MANGIARACINA PIETRO , MCCORMICK KEVIN D , MUTAHI MWANGI W , ROSENBLUM STUART B , SHIH NENG-YANG , SOLOMON DANIEL M , TOM WING C , VACCARO HENRY A , ZHENG JUNYING , ZHU XIAOHONG
发明人： ASLANIAN ROBERT G , BERLIN MICHAEL Y , BOYCE CHRISTOPHER W , CHAO JIANHUA , DE LERA RUIZ MANUEL , MANGIARACINA PIETRO , MCCORMICK KEVIN D , MUTAHI MWANGI W , ROSENBLUM STUART B , SHIH NENG-YANG , SOLOMON DANIEL M , TOM WING C , VACCARO HENRY A , ZHENG JUNYING , ZHU XIAOHONG
IPC分类号： C07D401/12 , A61P3/04 , A61P29/00 , A61P37/00 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04
CPC分类号： C07D295/185 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要： Disclosed are novel compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: M 1 and M 3 are CH or N; M 2 is CH, CF or N; Y is -C(=O)-, -C(=S)-, -(CH 2 ) q -, -C(=NOR 7 )- or -SO 1-2 -; Z is a bond or optionally substituted alkylene or alkenylene; R 1 is H, or alkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, all optionally substituted, or a group of the formula (II) where ring A is a heteroaryl ring; R 2 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R 3 is H, -C(O)NH 2 , or alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl, all optionally substituted; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome, alcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma and cognition deficit disorders using said compounds, alone or in combination with other agents.
摘要翻译：公开了式（I）的新化合物或其药学上可接受的盐，其中：M 1和M 3是CH或N; M 2是CH，CF或N; Y是-C（= O） - ， - C（= S） - ， - （CH 2 CH 2）q - ， - / SO 2 - ） - 或-SO 2 1-2。 Z是键或任选取代的亚烷基或亚烯基; R 1是H或烷基，环烷基，芳基，杂芳基，杂环烷基，全部任意取代，或其中环A是杂芳基环的式（II）基团; R 2是任选取代的烷基，烯基，芳基，杂芳基，环烷基或杂环烷基; R 3是H，-C（O）NH 2或烷基，芳基，环烷基，杂环烷基或杂芳基，全部任选被取代; 剩余的变量如规范中所定义; 使用所述化合物单独或与其它试剂组合治疗过敏引起的气道反应，充血，肥胖，代谢综合征，酒精性脂肪肝疾病，肝脂肪变性，非酒精性脂肪性肝炎，肝硬化，肝细胞癌和认知缺陷障碍的组合物和方法。

7. 发明申请

WO2007075688A2 SUBSTITUTED ANILINE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS 审中-公开
标题翻译：取代的苯胺衍生物可用作组胺H3拮抗剂
公开(公告)号：WO2007075688A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/048440
申请日：2006-12-19
申请人： SCHERING CORPORATION , SOLOMON, Daniel, M. , ASLANIAN, Robert, G. , BERLIN, Michael, Y. , DE LERA RUIZ, Manuel , MCCORMICK, Kevin, D. , MUTAHI, Mwangi, W. , TOM, Wing, C.
发明人： SOLOMON, Daniel, M. , ASLANIAN, Robert, G. , BERLIN, Michael, Y. , DE LERA RUIZ, Manuel , MCCORMICK, Kevin, D. , MUTAHI, Mwangi, W. , TOM, Wing, C.
IPC分类号： C07D213/74 , C07D401/12 , C07D401/14 , A61K31/44 , A61P29/00
CPC分类号： C07D401/12 , C07D213/73 , C07D213/74 , C07D401/14 , C07D471/04
摘要： Disclosed are compounds of the formula Chemical formula (I) or a pharmaceutically acceptable salt thereof, wherein M 2 is N; X is a bond, optionally substituted alkylene, alkenylene, -O-, -CH 2 N(R 12 )-, -N(R 12 )CH 2 -, -N(R 12 )-, -NHC(O)-, -OCH 2 -, -CH 2 O-, or -S(O) 0-2 -; and Y is -(CH 2 ) 1-2 -, -C(=O)-, -C(=NOR 13 )- or -SO0-2-; or M 1 is N; M 2 is N or CH; X is a bond, alkylene, alkenylene, -C(O)-, -NHC(O)-, -OC(O)- or -S(O) 1-2 -; Y is -(CH 2 ) 1-2 -, -C(=O)- or -SO 0-2 -; and when M 2 is CH, Y is also Y is -O- or -C(=NOR 13 )-; Z is a bond or optionally substituted alkylene or alkenylene; U and W are CH, or one is CH and one is N; R 1 is optionally substituted alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl; R 2 is optionally substituted alkyl, alkenyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl or heterocycloalkyl; and the remaining variables are as defined in the specification; and compositions and methods of treating obesity, metabolic syndrome and a cognition deficit disorder, alone or in combination with other agents.
摘要翻译：公开了化学式（I）的化合物或其药学上可接受的盐，其中M 2是N; X是键，任选取代的亚烷基，亚烯基，-O - ， - CH 2 N（R 12） - ， - N（R 12）（CH 2）2，-NHC（O） - ， - OCH 2 - ， - CH 2 CH 2 - （O）0-2 - ;或者-S（O）0-2 - 。和Y是 - （CH 2）1-2 - ，-C（= O） - ， - C（= NOR 13）或-SO0-2-; 或M <1>是N; M 2是N或CH; （O） - ， - OC（O） - 或-S（O）1-2 - ; - Y是 - （CH 2）2 1-2 - ， - C（= O） - 或-SO 2 0-2 - ; - 当M 2是CH时，Y也是Y是-O-或-C（= NOR 13） - ; Z是键或任选取代的亚烷基或亚烯基; U和W是CH，或者一个是CH，一个是N; R 1是任选取代的烷基，环烷基，芳基，芳基烷基，杂芳基，杂环烷基; R 2是任选取代的烷基，烯基，芳基，芳基烷基，杂芳基，杂芳基烷基，环烷基或杂环烷基; 其余变量如说明书中所定义; 以及单独或与其他药物联合治疗肥胖症，代谢综合征和认知缺陷障碍的组合物和方法。

8. 发明申请

WO1989007100A1 2,2-DISUBSTITUTED GLYCEROL AND GLYCEROL-LIKE COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： 2,2-取代的甘油和甘油样化合物，组合物和使用方法
公开(公告)号：WO1989007100A1
公开(公告)日：1989-08-10
申请号：PCT/US1989000336
申请日：1989-02-02
申请人： SCHERING CORPORATION , SOLOMON, Daniel, M. , KAMINSKI, James, J. , WHITE, Steven, K. , LEHMAN, Laura, S. , GANGULY, Ashit, K.
发明人： SCHERING CORPORATION
IPC分类号： C07D277/22
CPC分类号： C07D213/20 , C07D213/65 , C07D213/74 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/88 , C07D249/08 , C07D249/14 , C07D277/04 , C07D277/06 , C07D277/18 , C07D277/22 , C07D277/40 , C07D277/42 , C07D277/82 , C07D285/135 , C07D295/088 , C07F9/10 , C07F9/58 , C07F9/6506 , C07F9/6539
摘要： Novel 2,2-disubstituted glycerol compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor (''PAF''). Also disclosed are methods of synthesizing and using the compounds of the invention as well as pharmaceutical compositions thereof. The compounds have formula (I), wherein R , R , R , and R are as defined in the specification.
摘要翻译：公开了新的2,2-二取代的甘油化合物用作抗过敏和抗炎化合物。这些化合物是血小板激活因子（“PAF”）的拮抗剂。还公开了合成和使用本发明化合物的方法及其药物组合物。化合物具有式（I），其中R 1，R 2，R 3和R 4如说明书中所定义。

9. 发明申请

WO2007001975A1 PIPERIDINE DERIVATIVES USEFUL AS?HISTAMINE H3 ANTAGONISTS 审中-公开
标题翻译：哌嗪衍生物有用作为组胺H3拮抗剂
公开(公告)号：WO2007001975A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/023800
申请日：2006-06-19
申请人： SCHERING CORPORATION , ASLANIAN, Robert, G. , BERLIN, Michael, Y. , BOYCE, Christopher, W. , CHAO, Jianhua , DE LERA RUIZ, Manuel , MANGIARACINA, Pietro , MCCORMICK, Kevin, D. , MUTAHI, Mwangi, W. , ROSENBLUM, Stuart, B. , SHIH, Neng-Yang , SOLOMON, Daniel, M. , TOM, Wing, C. , VACCARO, Henry, A. , ZHENG, Junying , ZHU, Xiaohong
发明人： ASLANIAN, Robert, G. , BERLIN, Michael, Y. , BOYCE, Christopher, W. , CHAO, Jianhua , DE LERA RUIZ, Manuel , MANGIARACINA, Pietro , MCCORMICK, Kevin, D. , MUTAHI, Mwangi, W. , ROSENBLUM, Stuart, B. , SHIH, Neng-Yang , SOLOMON, Daniel, M. , TOM, Wing, C. , VACCARO, Henry, A. , ZHENG, Junying , ZHU, Xiaohong
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , A61P3/04 , A61P29/00 , A61P37/00 , C07D409/14 , C07D471/04
CPC分类号： C07D295/185 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要： Disclosed are novel compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: M 1 and M 3 are CH or N; M 2 is CH, CF or N; Y is -C(=O)-, -C(=S)-, -(CH 2 ) q -, -C(=NOR 7 )- or -SO 1-2 -; Z is a bond or optionally substituted alkylene or alkenylene; R 1 is H, or alkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, all optionally substituted, or a group of the formula (II) where ring A is a heteroaryl ring; R 2 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R 3 is H, -C(O)NH 2 , or alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl, all optionally substituted; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome, alcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma and cognition deficit disorders using said compounds, alone or in combination with other agents.
摘要翻译：公开了式（I）的新化合物或其药学上可接受的盐，其中：M 1和M 3是CH或N; M 2是CH，CF或N; Y是-C（= O） - ， - C（= S） - ， - （CH 2 CH 2）q - ， - / SO 2 - ） - 或-SO 2 1-2。 Z是键或任选取代的亚烷基或亚烯基; R 1是H或烷基，环烷基，芳基，杂芳基，杂环烷基，全部任选取代的，或其中环A是杂芳基环的式（II）的基团; R 2是任选取代的烷基，烯基，芳基，杂芳基，环烷基或杂环烷基; R 3是H，-C（O）NH 2或烷基，芳基，环烷基，杂环烷基或杂芳基，全部被取代; 其余变量如规范中所定义; 使用所述化合物单独或与其它试剂组合治疗过敏引起的气道反应，充血，肥胖，代谢综合征，酒精性脂肪肝疾病，肝脂肪变性，非酒精性脂肪性肝炎，肝硬化，肝细胞癌和认知缺陷障碍的组合物和方法。

10. 发明申请

WO1989007099A1 2,2-DISUBSTITUTED GLYCEROL AND GLYCEROL-LIKE COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： 2,2-取代的甘油和甘油样化合物，组合物和使用方法
公开(公告)号：WO1989007099A1
公开(公告)日：1989-08-10
申请号：PCT/US1988000315
申请日：1988-02-05
申请人： SCHERING CORPORATION , SOLOMON, Daniel, M. , KAMINSKI, James, J. , WHITE, Steven, K. , LEHMAN, Laura, S. , GANGULY, Ashit, K.
发明人： SCHERING CORPORATION
IPC分类号： C07D277/22
CPC分类号： C07D213/20 , C07D213/65 , C07D213/74 , C07D233/64 , C07D233/88 , C07D249/14 , C07D277/04 , C07D277/06 , C07D277/18 , C07D277/22 , C07D277/40 , C07D277/42 , C07D277/82 , C07D285/135 , C07D295/088 , C07F9/10 , C07F9/58 , C07F9/6506 , C07F9/6539
摘要： Novel 2,2-disubstituted glycerol compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor ("PAF). Also disclosed are methods of synthesizing and using the compounds of the invention as well as pharmaceutical compositions thereof. The compounds have the formula wherein R , R , R , and R are as defined in the specification.

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