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1. 发明申请

WO2012166665A3 BROAD SPECTRUM ANTIBIOTICS 审中-公开
标题翻译： BROAD SPECTRUM抗生素
公开(公告)号：WO2012166665A3
公开(公告)日：2013-03-07
申请号：PCT/US2012039727
申请日：2012-05-25
申请人： RQX PHARMACEUTICALS INC , ROBERTS TUCKER CURRAN , SMITH PETER ANDREW , CAMPBELL DAVID , DURON SERGIO G , HIGUCHI ROBERT I
发明人： ROBERTS TUCKER CURRAN , SMITH PETER ANDREW , CAMPBELL DAVID , DURON SERGIO G , HIGUCHI ROBERT I
IPC分类号： C07C271/10 , A61K31/16 , A61P31/00 , C07D207/10
CPC分类号： C07K7/06 , A61K38/00 , A61K45/06 , C07D207/10
摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broader spectrum of antibiotic bioactivity compared to the natural product. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
摘要翻译：本文提供的是抗菌化合物，其中在一些实施方案中的化合物具有广谱生物活性。本文提供的化合物可以在其它实施方案中克服在细菌信号肽酶（SPase）的限定位置由单个氨基酸突变赋予的抗性，并且在其它实施方案中，与天然产物相比，提供更广谱的抗生素生物活性。还提供了使用本文所述的化合物进行治疗的药物组合物和方法。

2. 发明申请

WO1997036983A1 RINSING COMPOSITIONS 审中-公开
标题翻译：冲洗组合物
公开(公告)号：WO1997036983A1
公开(公告)日：1997-10-09
申请号：PCT/US1997004831
申请日：1997-03-25
申请人： THE PROCTER & GAMBLE COMPANY , CRUICKSHANK, Graeme, Duncan , SMITH, Peter, Andrew
发明人： THE PROCTER & GAMBLE COMPANY
IPC分类号： C11D03/33
CPC分类号： C11D3/33
摘要： There is provided a rinse aid composition containing an amino tricarboxylic acid or its salts or complexes. The pH of said composition as a 1 % solution in distilled water at 20 DEG C is preferably less than 7.
摘要翻译：提供了含有氨基三羧酸或其盐或络合物的漂洗助剂组合物。所述组合物在20℃下在蒸馏水中的1％溶液的pH优选小于7。

3. 发明申请

WO2021236050A1 ASSAY DEVICE, SYSTEM, METHOD, AND KIT 审中-公开
公开(公告)号：WO2021236050A1
公开(公告)日：2021-11-25
申请号：PCT/US2020/033365
申请日：2020-05-18
申请人： BASELINE GLOBAL, INC. , SMITH, Peter, Andrew , KRISTAL, Leonard , O'DONNELL, Michael, Eugene , ZIGNEGO, Jay, Colton , KWOK, Mark, Kin Ming , MCALLISTER, Jeffery, Floyd , RAI, Balwant
发明人： SMITH, Peter, Andrew , KRISTAL, Leonard , O'DONNELL, Michael, Eugene , ZIGNEGO, Jay, Colton , KWOK, Mark, Kin Ming , MCALLISTER, Jeffery, Floyd , RAI, Balwant
IPC分类号： G01N33/53
摘要： Assay devices, systems, methods, and kits useful for detection of analytes in a bodily fluid sample 11, such as saliva, are disclosed herein. Assay devices 10 may include a fluid sample collector 13 and an assessment unit 15 to which the fluid sample collector 13 couples. The fluid sample collector 13 may include a cap 17 with a plunger 19 and absorbent member 21 that collects a bodily fluid sample 11. Insertion of the plunger 19 into the assessment unit 15 during coupling provides pressure-driven fluid flow through a filter 75 rapidly delivering bodily fluid filtrate 11a to one or more test panels 101, 103 which provide the assay result. In embodiments, an on-board light source 81 enables a user to readily detect changes in a test panel 101, 103 indicative of the presence of an analyte thus providing an opportunity for obtaining rapid results with improved confidence.

4. 发明申请

WO2015023898A1 LINEAR PEPTIDE ANTIBIOTCS 审中-公开
标题翻译：线性抗原抗体
公开(公告)号：WO2015023898A1
公开(公告)日：2015-02-19
申请号：PCT/US2014/051151
申请日：2014-08-14
申请人： RQX PHARMACEUTICALS, INC. , SMITH, Peter, Andrew , ROBERTS, Tucker, Curran , HIGUCHI, Robert, I. , PARASELLI, Prasuna , KOEHLER, Michael, F., T. , CRAWFORD, James, John
发明人： SMITH, Peter, Andrew , ROBERTS, Tucker, Curran , HIGUCHI, Robert, I. , PARASELLI, Prasuna , KOEHLER, Michael, F., T. , CRAWFORD, James, John
IPC分类号： C07K7/08 , A01N37/44 , A01N63/00 , A61K38/10 , A61P31/00
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , Y02A50/401 , Y02A50/406 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
摘要翻译：本文提供的是抗菌化合物，其中在一些实施方案中的化合物具有广谱生物活性。本文提供的化合物在其它实施方案中可以克服在细菌信号肽酶（SPases）的限定位置由单个氨基酸突变所赋予的抗性，并且在其它实施方案中提供广谱抗生素生物活性。还提供了使用本文所述的化合物进行治疗的药物组合物和方法。

5. 发明申请

WO2012142672A1 A PLANT AND METHOD FOR RECOVERING SULPHUR HEXAFLUORIDE FOR REUSE 审中-公开
标题翻译：一种用于回收硫化氢的工厂和方法用于再利用
公开(公告)号：WO2012142672A1
公开(公告)日：2012-10-26
申请号：PCT/AU2012/000417
申请日：2012-04-20
申请人： ABB TECHNOLOGY LTD , ABB AUSTRALIA PTY LIMITED , SMITH, Peter, Andrew , ROBY, David, Alan , ROBBIE, Duncan Gwai Yee , ALEXANDER, Brett , DAVIES, Wayne, Alexander
发明人： SMITH, Peter, Andrew , ROBY, David, Alan , ROBBIE, Duncan Gwai Yee , ALEXANDER, Brett , DAVIES, Wayne, Alexander
IPC分类号： F25J3/00 , B01D53/48 , C01B17/45
CPC分类号： B01D53/002 , B01D2257/204 , B01D2257/30 , C01B17/453 , Y02P20/151
摘要： Recovery of re-useable grade sulphur hexafluoride from a contaminated source comprises first evacuating a stream of contaminated sulphur hexafluoride from a transport or storage vessel (10) into a separation via an intermediary and optional clean-up stage, involving scrubbing and filtering. Sulphur hexafluoride in the partially clean-up stream is directly solidified within the separation vessel (30), preferably onto a large surface area tube heat exchanger (4) arranged within the separation vessel (30). Uncondensed contaminant gases are vented to atmosphere, and the solidified sulphur hexafluoride within the separator vessel is melted and transferred to a collection vessel (5) for subsequent reuse. The recovery process re-introduces sulphur hexafluoride obtained from the collection vessel (50) back into the separation vessel (30) for effecting heat transfer to the solidified sulphur hexafluoride thereby to assist in said melting. A valve assembly (53) is provided between the collection vessel (50) and separator vessel (30), which is controlled to allow warm, substantially uncontaminated and previously cleaned sulphur hexafluoride gas to be transferred from the collection vessel (50) to the separator vessel (30) to melt the solidified sulphur hexafluoride. The valve assembly (53) allows the melted sulphur hexafluoride to be transferred to the collection vessel (50) in liquid or gas phase.
摘要翻译：从污染源回收可再利用级六硫化硫包括先将污染的六氟化硫流从运输或储存容器（10）排出到通过中间和任选的清理阶段进行分离，包括洗涤和过滤。部分净化物流中的六氟化硫在分离容器（30）内直接固化，优选在布置在分离容器（30）内的大表面积管热交换器（4）上固化。将未冷凝的污染气体排放到大气中，并且分离器容器内的固化的六氟化硫被熔化并转移到收集容器（5）中以供后续再利用。回收过程将从收集容器（50）获得的六氟化硫重新引入分离容器（30）中，以进行固化的六氟化硫的热传递，从而有助于所述熔融。阀组件（53）设置在收集容器（50）和分离器容器（30）之间，其被控制以允许温暖，基本上未被污染并预先清洁的六氟化硫气体从收集容器（50）转移到分离器容器（30）熔化固化的六氟化硫。阀组件（53）允许熔融的六氟化硫以液相或气相转移到收集容器（50）。

6. 发明申请

WO2012166665A2 BROAD SPECTRUM ANTIBIOTICS 审中-公开
标题翻译： BROAD SPECTRUM抗生素
公开(公告)号：WO2012166665A2
公开(公告)日：2012-12-06
申请号：PCT/US2012/039727
申请日：2012-05-25
申请人： RQX PHARMACEUTICALS, INC. , ROBERTS, Tucker, Curran , SMITH, Peter, Andrew , CAMPBELL, David , DURON, Sergio, G. , HIGUCHI, Robert, I.
发明人： ROBERTS, Tucker, Curran , SMITH, Peter, Andrew , CAMPBELL, David , DURON, Sergio, G. , HIGUCHI, Robert, I.
IPC分类号： C07C271/10 , C07D207/10 , A61K31/16 , A61P31/00
CPC分类号： C07K7/06 , A61K38/00 , A61K45/06 , C07D207/10 , Y02A50/47
摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broader spectrum of antibiotic bioactivity compared to the natural product. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
摘要翻译：本文提供的是抗菌化合物，其中在一些实施方案中的化合物具有广谱生物活性。本文提供的化合物可以在其它实施方案中克服在细菌信号肽酶（SPase）的限定位置由单个氨基酸突变赋予的抗性，并且在其它实施方案中，与天然产物相比，提供更广谱的抗生素生物活性。还提供了使用本文所述的化合物进行治疗的药物组合物和方法。

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