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1. 发明专利

GB0704032D0 Balance board 未知
公开(公告)号：GB0704032D0
公开(公告)日：2007-04-11
申请号：GB0704032
申请日：2007-03-02
申请人： SMITH NICHOLAS D

2. 发明专利

GB0612018D0 Balance board 未知
公开(公告)号：GB0612018D0
公开(公告)日：2006-07-26
申请号：GB0612018
申请日：2006-06-16
申请人： SMITH NICHOLAS D

3. 发明专利

GB0130155D0 Rainproof rotary washing line 未知
公开(公告)号：GB0130155D0
公开(公告)日：2002-02-06
申请号：GB0130155
申请日：2001-12-18
申请人： SMITH NICHOLAS D

4. 发明专利

GB201110592D0 Exercise apparatus 未知
公开(公告)号：GB201110592D0
公开(公告)日：2011-08-03
申请号：GB201110592
申请日：2007-06-15
申请人： SMITH NICHOLAS D
摘要： A balance board has a top side and an under side. The under side is arranged to be mounted on top of a ball with a user balancing on the top side. The board is shaped to define a generally longitudinal direction and a direction generally transverse to the longitudinal direction. The board is formed from a first top portion defining the topside and having a substantially flat region on its under side and a second lower portion joined to the first top portion and defining a wall at least substantially bounding a portion of the flat region. The distance across the bounded portion in the longitudinal direction of the board is greater than in the transverse direction. With the bounded portion balanced on a ball with a diameter less than the distance across the bounded portion in the transverse direction, the board is enabled to move relative to the ball with at least a degree of spherical rotational freedom and also a degree of translational freedom in directions other than the vertical.

5. 发明专利

GB0711760D0 Balance board 未知
公开(公告)号：GB0711760D0
公开(公告)日：2007-07-25
申请号：GB0711760
申请日：2007-06-15
申请人： SMITH NICHOLAS D
摘要： A balance board has a top side and an under side. The under side is arranged to be mounted on top of a ball with a user balancing on the top side. The board is shaped to define a generally longitudinal direction and a direction generally transverse to the longitudinal direction. The board is formed from a first top portion defining the topside and having a substantially flat region on its under side and a second lower portion joined to the first top portion and defining a wall at least substantially bounding a portion of the flat region. The distance across the bounded portion in the longitudinal direction of the board is greater than in the transverse direction. With the bounded portion balanced on a ball with a diameter less than the distance across the bounded portion in the transverse direction, the board is enabled to move relative to the ball with at least a degree of spherical rotational freedom and also a degree of translational freedom in directions other than the vertical.

6. 发明申请

WO2011159769A3 INDANE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF 审中-公开
标题翻译： INDANE ESTROGEN受体调节剂及其用途
公开(公告)号：WO2011159769A3
公开(公告)日：2012-08-09
申请号：PCT/US2011040466
申请日：2011-06-15
申请人： ARAGON PHARMACEUTICALS INC , GOVEK STEVEN P , SMITH NICHOLAS D
发明人： GOVEK STEVEN P , SMITH NICHOLAS D
IPC分类号： C07D207/04 , A61K31/40 , A61P35/00 , C07D207/08
CPC分类号： C07D295/096 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/2054 , A61K9/2095 , A61K9/4866 , A61K47/10 , A61K47/14 , A61K47/38 , C07D207/06 , C07D207/08 , C07D295/088
摘要： Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
摘要翻译：本文描述的是雌激素受体调节剂的化合物。还描述了包括本文所述化合物的药物组合物和药物，以及使用这种雌激素受体调节剂单独使用并与其它化合物联合用于治疗介导或依赖于雌激素受体的疾病或病症的方法。

7. 发明申请

WO2011156518A2 ESTROGEN RECEPTOR MODULATORS AND USES THEREOF 审中-公开
标题翻译：雌激素受体调节剂及其用途
公开(公告)号：WO2011156518A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/039669
申请日：2011-06-08
申请人： ARAGON PHARMACEUTICALS, INC. , KAHRAMAN, Mehmet , GOVEK, Steven, P. , NAGASAWA, Johnny, Y. , SMITH, Nicholas, D.
发明人： KAHRAMAN, Mehmet , GOVEK, Steven, P. , NAGASAWA, Johnny, Y. , SMITH, Nicholas, D.
IPC分类号： C07D405/12 , C07D405/10 , C07D311/04 , A61K31/453 , A61K31/352 , A61P35/00 , A61P25/28
CPC分类号： A61K31/352 , A61K31/4025 , A61K31/403 , A61K31/4178 , A61K31/439 , A61K31/453 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D311/60 , C07D405/12 , C07D407/14 , C07D471/08 , C07D487/08
摘要： Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
摘要翻译：本文描述的是雌激素受体调节剂的化合物。还描述了包括本文所述化合物的药物组合物和药物，以及使用这种雌激素受体调节剂单独使用并与其它化合物联合用于治疗介导或依赖于雌激素受体的疾病或病症的方法。

8. 发明申请

WO2009029617A1 DIARYLAMINE-SUBSTITUTED QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开
标题翻译：二胺选择性喹诺酮作为可诱导的氧化亚氮合酶抑制剂有用
公开(公告)号：WO2009029617A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/074316
申请日：2008-08-26
申请人： KALYPSYS, INC. , SMITH, Nicholas, D. , BONNEFOUS, Celine , ZHUANG, Hui , CHEN, Xiaohong , DURON, Sergio , LINDSTROM, Andrew
发明人： SMITH, Nicholas, D. , BONNEFOUS, Celine , ZHUANG, Hui , CHEN, Xiaohong , DURON, Sergio , LINDSTROM, Andrew
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D487/04 , C07D493/04 , C07D495/04 , C07D215/227 , A61K31/4704 , A61P29/00
CPC分类号： C07D401/12 , C07D215/227 , C07D401/14 , C07D403/12 , C07D413/12 , C07D487/04 , C07D493/04 , C07D495/04
摘要： Novel diarylamine-substituted quinolone compounds and pharmaceutical compositions, certain of which have been found to inhibit inducible NOS synthase have been discovered, together with methods of synthesizing and using the compounds including methods for the treatment of iNOS-mediated diseases in a patient by administering the compounds.
摘要翻译：已经发现了新的二芳基胺取代的喹诺酮化合物和药物组合物，其中某些已被发现抑制诱导型NOS合成酶，以及合成和使用化合物的方法，包括通过施用患者来治疗iNOS介导的疾病的方法化合物。

9. 发明申请

WO2009029592A1 HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开
标题翻译：用作氮氧化物合成酶抑制剂的异环取代的喹诺酮
公开(公告)号：WO2009029592A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/074251
申请日：2008-08-25
申请人： KALYPSYS, INC. , SMITH, Nicholas, D. , PAYNE, Joseph, E. , BONNEFOUS, Celine , DURON, Sergio , ZHUANG, Hui , CHEN, Xiaohong , GOVEK, Steven , LINDSTROM, Andrew, K.
发明人： SMITH, Nicholas, D. , PAYNE, Joseph, E. , BONNEFOUS, Celine , DURON, Sergio , ZHUANG, Hui , CHEN, Xiaohong , GOVEK, Steven , LINDSTROM, Andrew, K.
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4985
CPC分类号： C07D487/04 , C07D471/04
摘要： Novel Quinolone derivatives and pharmaceutical compositions, certain of which have been found to inhibit inducible NOS synthase have been discovered, together with methods of synthesizing and using the compounds including methods for the treatment of iNOS-mediated diseases in a patient by administering the compounds.
摘要翻译：已经发现了新的喹诺酮衍生物和药物组合物，其中某些已被发现抑制诱导型NOS合成酶，以及合成和使用包括通过施用化合物在患者中治疗iNOS介导的疾病的方法的化合物的方法。

10. 发明申请

WO2007117778A3 QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开
标题翻译：喹诺酮作为可诱导的氧化氮合酶抑制剂有用
公开(公告)号：WO2007117778A3
公开(公告)日：2008-02-07
申请号：PCT/US2007062769
申请日：2007-02-23
申请人： KALYPSYS INC , ROPPE JEFFREY R , BONNEFOUS CELINE , SMITH NICHOLAS D , LINDSTROM ANDREW K , NOBLE STEWART A , HASSIG CHRISTIAN A , PAYNE JOSEPH E , ZHUANG HUI , CHEN XIAOHONG , DURON SERGIO G
发明人： ROPPE JEFFREY R , BONNEFOUS CELINE , SMITH NICHOLAS D , LINDSTROM ANDREW K , NOBLE STEWART A , HASSIG CHRISTIAN A , PAYNE JOSEPH E , ZHUANG HUI , CHEN XIAOHONG , DURON SERGIO G
IPC分类号： A61P29/00 , A61K31/4704 , A61K31/4709 , C07D215/227 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： C07D405/12 , A61K31/4704 , A61K31/4709 , C07D215/227 , C07D401/06 , C07D401/12 , C07D409/12
摘要： The present invention relates to novel quinolones of Formula (I) that inhibit inducible NOS synthase together with methods of synthesizing and using the compounds including methods for inhibiting or modulating nitric oxide synthesis and/or lowering nitric oxide levels in a patient by administering the compounds for the treatment of disease.
摘要翻译：本发明涉及抑制诱导型NOS合成的新型喹诺酮，以及合成和使用化合物的方法，包括用于抑制或调节一氧化氮合成和/或降低患者一氧化氮水平的方法，所述方法包括给予治疗疾病。

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