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1. 发明申请

WO2008136852A3 METHODS AND COMPOSITIONS RELATED TO THE STRUCTURE AND FUNCTION OF APOBEC3G 审中-公开
标题翻译：与APOBEC3G的结构和功能相关的方法和组合
公开(公告)号：WO2008136852A3
公开(公告)日：2009-04-23
申请号：PCT/US2007083348
申请日：2007-11-01
申请人： UNIV ROCHESTER , SMITH HAROLD C , WEDEKIND JOSEPH E , BENNETT RYAN PATRICK
发明人： SMITH HAROLD C , WEDEKIND JOSEPH E , BENNETT RYAN PATRICK
IPC分类号： C12Q1/68 , C12N7/00
CPC分类号： C12N9/78 , A61L2/0082 , A61L2/16 , C07K2299/00 , C12N2740/16011 , C12Q1/10 , C12Y305/04005 , G01N33/50 , G01N33/56983 , G01N2333/16 , G01N2333/978 , G01N2500/02
摘要： Disclosed are methods and compositions related to the structure and function of APOBEC3G.
摘要翻译：公开了与APOBEC3G的结构和功能相关的方法和组合。

2. 发明申请

WO2008070049A2 PEPTIDE AND TREATMENT FOR HIV-1 INFECTION 审中-公开
标题翻译：艾滋病毒1感染的肽和治疗
公开(公告)号：WO2008070049A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/024790
申请日：2007-12-04
申请人： THOMAS JEFFERSON UNIVERSITY , OYAGEN INC. , ZHANG, Hui , SMITH, Harold, C.
发明人： ZHANG, Hui , SMITH, Harold, C.
IPC分类号： A61K38/10
CPC分类号： C07K14/00 , A61K38/162 , A61K45/06 , A61K2300/00
摘要： A compound of the formula X1 -M-SEQ ID NO.l, or a derivative thereof, is provided, wherein X1 -M- represents an optional group comprising a protein transduction domain conjugated to the N-terminus of the amino acid sequence SEQ ID NO:1. Pharmaceutical compositions comprising and therapeutic methods using the compound are also provided.
摘要翻译：提供式X1-M-SEQ ID NO.1或其衍生物的化合物，其中X1-M-表示任选的基团，其包含与氨基酸序列SEQ ID NO的N末端缀合的蛋白质转导结构域 NO：1。还提供了包含使用该化合物的药物组合物和治疗方法。

3. 发明申请

WO2008027899A3 METHODS AND COMPOSITIONS RELATED TO APOBEC-1 EXPRESSION 审中-公开
公开(公告)号：WO2008027899A3
公开(公告)日：2008-03-06
申请号：PCT/US2007/077009
申请日：2007-08-28
申请人： UNIVERSITY OF ROCHESTER , SMITH, Harold, C.
发明人： SMITH, Harold, C.
IPC分类号： A01K67/00 , A61K31/713 , A61K38/43 , C07H21/04 , C12N9/00 , C12N15/00 , C12N15/12
摘要： Disclosed are methods and compositions related to a chimeric fusion protein comprising a secretion signal sequence, a protein transduction sequence, and an APOBEC- 1 sequence.

4. 发明申请

WO2004013160A3 PROTEIN TRANSDUCING DOMAIN/DEAMINASE CHIMERIC PROTEINS, RELATED COMPOUNDS, AND USES THEREOF 审中-公开
标题翻译：蛋白质转移域/脱氨酶重组蛋白，相关化合物及其用途
公开(公告)号：WO2004013160A3
公开(公告)日：2006-01-26
申请号：PCT/US0324458
申请日：2003-08-05
申请人： UNIV ROCHESTER , SMITH HAROLD C , SOWDEN MARK P , DEWHURST STEPHEN , KIM BAEK , WEDEKIND JOSEPH
发明人： SMITH HAROLD C , SOWDEN MARK P , DEWHURST STEPHEN , KIM BAEK , WEDEKIND JOSEPH
IPC分类号： A61K38/50 , C07K20060101 , C07K1/00 , C07K14/00 , C07K17/00 , C07K19/00 , C12N9/12 , C12N9/74 , C12N9/78 , C12N15/00 , C12N15/62 , C12P19/34 , C12P21/08 , C12Q1/34 , C12Q1/68 , C12Q1/70 , A61K39/00
CPC分类号： C12N9/1205 , C07K2319/10 , C12N9/6429 , C12N9/78 , C12N15/62 , C12Y304/21005
摘要： Disclosed are compositions for chimeric proteins comprising a protein transduction domain and a deaminase domain, mimetics or analog thereof, and uses of same.
摘要翻译：公开了包含蛋白转导结构域和脱氨酶结构域，模拟物或其类似物的嵌合蛋白的组合物及其用途。

5. 发明申请

WO2011143553A1 COMPOSITIONS AND METHODS FOR TARGETING A3G:RNA COMPLEXES 审中-公开
标题翻译：用于靶向A3G的组合物和方法：RNA复合物
公开(公告)号：WO2011143553A1
公开(公告)日：2011-11-17
申请号：PCT/US2011/036430
申请日：2011-05-13
申请人： UNIVERSITY OF ROCHESTER , SMITH, Harold, C. , PROHASKA, Kimberly , MCDOUGALL, William, M.
发明人： SMITH, Harold, C. , PROHASKA, Kimberly , MCDOUGALL, William, M.
IPC分类号： C12Q1/68 , C40B30/04 , C40B40/06
CPC分类号： G01N33/5008 , A61K31/407 , A61K31/517 , C12Q1/18 , G01N2333/978 , Y02A50/463
摘要： The present invention provides an assay for screening any agent that modulates the ability of A3G to bind with RNA. The invention provides an agent identified by high throughput screening methods and methods of treatment using the identified agent as a means of inhibiting HIV infection and reducing the emergence of viral drug-resistance.
摘要翻译：本发明提供了用于筛选调节A3G与RNA结合的能力的任何试剂的测定法。本发明提供了一种通过高通量筛选方法和使用所鉴定的试剂作为抑制HIV感染并减少病毒耐药性出现的手段的方法鉴定的药剂。

6. 发明申请

WO2007126402A2 METHODS AND COMPOSITIONS RELATED TO HEIGHTENED APOBEC-1 RELATED PROTEIN (ARP) EXPRESSION 审中-公开
标题翻译：与APOBEC-1相关蛋白（ARP）表达相关的方法和组合
公开(公告)号：WO2007126402A2
公开(公告)日：2007-11-08
申请号：PCT/US2006/004920
申请日：2006-02-13
申请人： UNIVERSITY OF ROCHESTER , SMITH, Harold, C. , JIN, Xia , BROOKS, Andrew
发明人： SMITH, Harold, C. , JIN, Xia , BROOKS, Andrew
IPC分类号： C12Q1/68
CPC分类号： C12Q1/703
摘要： Disclosed are methods and compositions related to determining the status and mechanisms underlying long-term nonprogression of viral infections.
摘要翻译：公开了与确定病毒感染的长期非进展的状态和机制相关的方法和组合物。

7. 发明申请

WO2014210082A2 CAMPTOTHECIN DERIVATIVES AS ANTI-HIV AGENTS AND METHODS OF IDENTIFYING AGENTS THAT DISRUPT VIF SELF-ASSOCIATION 审中-公开
标题翻译：作为抗HIV药物的CAMPTOTHECIN衍生物和识别VIF自身协会的药剂的方法
公开(公告)号：WO2014210082A2
公开(公告)日：2014-12-31
申请号：PCT/US2014/043974
申请日：2014-06-24
申请人： OYAGEN, INC. , SMITH, Harold C. , BENNETT, Ryan P.
发明人： SMITH, Harold C. , BENNETT, Ryan P.
IPC分类号： A61K31/4745 , A61K31/4738 , A61K31/44 , A61P31/18 , A61P31/12
CPC分类号： A61K31/4745 , A61K45/06 , G01N33/6845 , G01N2333/15 , G01N2333/163 , G01N2500/02 , G01N2500/10
摘要： The present invention relates to the use of camptothecin derivatives as anti HIV agents that disrupt self-association of the viral infectivity factor (Vif) found in HIV and other retroviruses. The present invention also relates to methods of identifying agents that disrupt Vif self-association and methods of using these agents, including methods of treating or preventing HIV infection.
摘要翻译：本发明涉及喜树碱衍生物作为抗HIV药物的用途，其破坏HIV和其他逆转录病毒中发现的病毒感染因子（Vif）的自身结合。本发明还涉及鉴定破坏Vif自身结合的药剂的方法以及使用这些药物的方法，包括治疗或预防HIV感染的方法。

8. 发明申请

WO2014186423A1 COMBINATION THERAPY FOR TREATING HIV AND AIDS 审中-公开
标题翻译：治疗艾滋病毒和艾滋病的组合治疗
公开(公告)号：WO2014186423A1
公开(公告)日：2014-11-20
申请号：PCT/US2014/037935
申请日：2014-05-13
申请人： OYAGEN, INC. , SMITH, Harold C. , BENNETT, Ryan P. , PROHASKA, Kimberly
发明人： SMITH, Harold C. , BENNETT, Ryan P. , PROHASKA, Kimberly
IPC分类号： A61K31/4745 , A61K31/437 , A61P31/18 , A61P31/12
CPC分类号： A61K31/4745 , A61K31/427 , A61K31/517 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of a Vif inhibitor and an APOBEC3G (A3G) activator in combination to inhibit HIV infectivity in a host cell and to treat or prevent HIV infection or AIDS in a patient. In one embodiment, the present invention relates to a method for inhibiting infectivity of HIV in a host cell, which method comprises contacting a host cell comprising A3G host defense factor with a combination of antiviral-effective amounts of a Vif inhibitor and an A3G activator, thereby inhibiting infectivity of HIV in the host cell by simultaneously inhibiting Vif-dependent degradation of A3G and activating A3G deaminase activity in the host cell, where the Vif inhibitor inhibits Vif-dependent degradation of A3G by disrupting or inhibiting dimerization of Vif in the host cell, and where the A3G activator activates A3G deaminase activity by disrupting or inhibiting A3G:nucleic acid molecule interaction in the host cell.
摘要翻译：本发明涉及组合的Vif抑制剂和APOBEC3G（A3G）激活剂在宿主细胞中抑制HIV感染性并在患者中治疗或预防HIV感染或AIDS的用途。在一个实施方案中，本发明涉及一种抑制宿主细胞中HIV感染性的方法，该方法包括将包含A3G宿主防御因子的宿主细胞与抗病毒有效量的Vif抑制剂和A3G活化剂的组合物接触，从而通过同时抑制宿主细胞中的A3G的Vif依赖性降解和激活A3G脱氨酶活性来抑制HIV宿主细胞的感染性，其中Vif抑制剂通过破坏或抑制宿主细胞中Vif的二聚化来抑制A3G的Vif依赖性降解，并且其中A3G活化剂通过破坏或抑制宿主细胞中的A3G：核酸分子相互作用来激活A3G脱氨酶活性。

9. 发明申请

WO2008136852A9 METHODS AND COMPOSITIONS RELATED TO THE STRUCTURE AND FUNCTION OF APOBEC3G 审中-公开
公开(公告)号：WO2008136852A9
公开(公告)日：2008-11-13
申请号：PCT/US2007/083348
申请日：2007-11-01
申请人： UNIVERSITY OF ROCHESTER , SMITH, Harold, C. , WEDEKIND, Joseph, E. , BENNETT, Ryan, Patrick
发明人： SMITH, Harold, C. , WEDEKIND, Joseph, E. , BENNETT, Ryan, Patrick
IPC分类号： A61K48/00
摘要： Disclosed are methods and compositions related to the structure and function of APOBEC3G.

10. 发明申请

WO2008070049A8 PEPTIDE AND TREATMENT FOR HIV-1 INFECTION 审中-公开
标题翻译：艾滋病毒1感染的肽和治疗
公开(公告)号：WO2008070049A8
公开(公告)日：2008-10-30
申请号：PCT/US2007024790
申请日：2007-12-04
申请人： UNIV JEFFERSON , OYAGEN INC , ZHANG HUI , SMITH HAROLD C
发明人： ZHANG HUI , SMITH HAROLD C
IPC分类号： C07K4/00 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/16 , C07K5/00 , C07K7/00
CPC分类号： C07K14/00 , A61K38/162 , A61K45/06 , A61K2300/00
摘要： A compound of the formula X1 -M-SEQ ID NO.l, or a derivative thereof, is provided, wherein X1 -M- represents an optional group comprising a protein transduction domain conjugated to the N-terminus of the amino acid sequence SEQ ID NO:1. Pharmaceutical compositions comprising and therapeutic methods using the compound are also provided.

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