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1. 发明申请

WO2021242788A1 METHODS AND COMPOSITIONS FOR TREATING RETINAL DISEASES AND CONDITIONS 审中-公开
公开(公告)号：WO2021242788A1
公开(公告)日：2021-12-02
申请号：PCT/US2021/034114
申请日：2021-05-25
申请人： LINEAGE CELL THERAPEUTICS, INC. , BINETTE, Francois , HOGGE, Gary , SKALITER, Rami , SHABAT, Avi Ben , MONÉS, Jordi , BANIN, Eyal , QIU, Tina Guanting
发明人： BINETTE, Francois , HOGGE, Gary , SKALITER, Rami , SHABAT, Avi Ben , MONÉS, Jordi , BANIN, Eyal , QIU, Tina Guanting
IPC分类号： A61K9/00 , A61K35/12 , A61K35/30 , A61L27/38 , A61P9/10 , A61P27/02
摘要： Provided herein are methods, compositions of matter, and devices for treating diseases and illnesses of the eye, including retinal conditions such as macular degeneration.

2. 发明申请

WO2008132723A2 THERAPEUTIC DELIVERY OF INHIBITORY NUCLEIC ACID MOLECULES TO THE RESPIRATORY SYSTEM 审中-公开
标题翻译：将抑制性核酸分子的治疗药物输送到呼吸系统
公开(公告)号：WO2008132723A2
公开(公告)日：2008-11-06
申请号：PCT/IL2008/000522
申请日：2008-04-27
申请人： QUARK PHARMACEUTICALS, INC. , SKALITER, Rami
发明人： SKALITER, Rami
IPC分类号： A61K48/00
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/32
摘要： The present invention relates to methods of treating respiratory disorders of all types, including pulmonary disorders, by delivering inhibitory nucleic acid molecules directly to the respiratory system. siRNAs or other nucleic acids are delivered to the lung / respiratory system for the treatment of disease.
摘要翻译：本发明涉及通过将抑制性核酸分子直接递送到呼吸系统来治疗所有类型的呼吸系统疾病（包括肺部疾病）的方法。 siRNA或其他核酸被递送到肺/呼吸系统用于治疗疾病。

3. 发明申请

WO2004047978A2 MICROARRAYS AND PRODUCTION THEREOF 审中-公开
标题翻译： 1MICROARRAYS和生产
公开(公告)号：WO2004047978A2
公开(公告)日：2004-06-10
申请号：PCT/IL2003/001012
申请日：2003-11-27
申请人： QUARK BIOTECH, INC. , GARZON, Aaron , JOHNSTON, Rick , SKALITER, Rami
发明人： GARZON, Aaron , JOHNSTON, Rick , SKALITER, Rami
IPC分类号： B01J19/00
CPC分类号： C40B60/14 , B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00497 , B01J2219/00511 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00603 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , C07B2200/11 , C12Q1/6837 , C40B30/04 , C40B40/04 , C40B40/06 , C40B40/10 , C40B50/14 , G01N33/54353
摘要： The present invention relates to a novel microarray, which may be used to present chemical molecules, and methods of preparing said microarray and screening said microarray. The microarrays of the present invention may be used in various applications, such as, inter alia, drug discovery.
摘要翻译：一种多功能微阵列，其包含以下元件：a）固体支持物; b）固体支持物上包含的一系列井; c）连接到每个井的多个连接器; d）由多个接头中的一部分接头存在的第一功能; 以及e）由所述多个接头中的所述接头的不同部分存在的第二不同功能。

4. 发明申请

WO2002086089A3 THE 76A11 POLYPEPTIDE AND USES THEREOF 审中-公开
公开(公告)号：WO2002086089A3
公开(公告)日：2002-10-31
申请号：PCT/US2002/013138
申请日：2002-04-23
申请人： QUARK BIOTECH, INC. , CHAJUT, Ayelet , LEVINSON, Matat , SKALITER, Rami
发明人： CHAJUT, Ayelet , LEVINSON, Matat , SKALITER, Rami
IPC分类号： A01N61/00
摘要： This invention provides a method for treating a subject suffering from a disease, wherein the disease is characterized by aberrant cellular proliferation or aberrant cellular differentiation, comprising administering to the subject an antagonist of a polypeptide, wherein the polypeptide has an amino acid sequence as presented in SEQ ID NO:2. This invention also provides the use of a polynucleotide as a probe for identifying undifferentiated embryonic stem cells, wherein the polynucleotide comprises a nucleotide sequence as presented in SEQ ID NO:1. This invention further provides the use of the 76A11 polypeptide in vivo or ex vivo for expansion of adult somatic stem cell. This invention further provides the use of an antibody directed to an epitope presented by the polypeptide comprising the amino acid sequence as presented in SEQ ID NO:2 for detection of cancerous cells or of undifferentiated stem cells. This invention further provides the use of a polynucleotide comprising the nucleotide sequences as presented in SEQ ID NO:1 or fragments thereof for identifying cancerous cells. This invention further provides a method for identifying a chemical compound that modulates proliferation of differentiation of cells which comprises: (a) contacting a cell expressing a gene comprising the sequence as presented in SEQ ID NO:1 with the chemical compound, under conditions permitting expression of the gene; and (b) determining whether the proliferation of differentiation of the cell is stimulated or inhibited in the presence of the compound, as compared to a control and this invention further provides a method for identifying a test chemical compound that modulates proliferation or differentiation of cells which comprises the steps of (a) providing a mixture comprising polypeptide 76A11, (b) contacting said mixture with a test substance under conditions which normally lead to 76A11 activity, and (c) determining whether the activity of said polypeptide is affected by said compound.

5. 发明申请

WO2009116037A3 NOVEL siRNA COMPOUNDS FOR INHIBITING RTP801 审中-公开
标题翻译：用于抑制RTP801的新型siRNA化合物
公开(公告)号：WO2009116037A3
公开(公告)日：2010-03-11
申请号：PCT/IL2009000302
申请日：2009-03-17
申请人： QUARK PHARMACEUTICALS INC , FEINSTEIN ELENA , SKALITER RAMI , KALINSKI HAGAR , METT IGOR
发明人： FEINSTEIN ELENA , SKALITER RAMI , KALINSKI HAGAR , METT IGOR
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , C12N2310/14 , C12N2320/31
摘要： The present invention provides chemically modified siRNA compounds that target RTP801 and pharmaceutical compositions comprising same useful for treating microvascular disorders, eye diseases, hearing impairment, neurodegenerative diseases and disorders, spinal cord injury and respiratory conditions.
摘要翻译：本发明提供了靶向RTP801的化学修饰的siRNA化合物和包含用于治疗微血管病症，眼睛疾病，听觉障碍，神经变性疾病和病症，脊髓损伤和呼吸病症的药物组合物。

6. 发明申请

WO2004047978A3 1MICROARRAYS AND PRODUCTION THEREOF 审中-公开
标题翻译： 1MICROARRAYS及其生产
公开(公告)号：WO2004047978A3
公开(公告)日：2004-07-15
申请号：PCT/IL0301012
申请日：2003-11-27
申请人： QUARK BIOTECH INC , GARZON AARON , JOHNSTON RICK , SKALITER RAMI
发明人： GARZON AARON , JOHNSTON RICK , SKALITER RAMI
IPC分类号： B01J19/00 , C12M1/34 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/53 , G01N33/543 , C07B61/00
CPC分类号： C40B60/14 , B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00497 , B01J2219/00511 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00603 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , C07B2200/11 , C12Q1/6837 , C40B30/04 , C40B40/04 , C40B40/06 , C40B40/10 , C40B50/14 , G01N33/54353
摘要： A multi-functional microarray comprising the following elements: a) a solid support; b) a series of wells contained on the solid support; c) a plurality of linkers attached to each well; d) a first functionality present by a portion of the linkers within the plurality of linkers; and e) a second different functionality present by a different portion of the linkers within the plurality of linkers.
摘要翻译：包含以下元件的多功能微阵列：a）固体支持物; b）固体支持物上的一系列井; c）连接到每个孔上的多个连接子; d）由所述多个接头内的一部分接头存在的第一功能性; 和e）由所述多个接头内的不同部分的接头存在的第二种不同功能。

7. 发明申请

WO0246364A8 GENES ASSOCIATED WITH MECHANICAL STRESS, EXPRESSION PRODUCTS THEREFROM, AND USES THEREOF 审中-公开
标题翻译：与机械应力相关的基因，其表达产物及其用途
公开(公告)号：WO0246364A8
公开(公告)日：2004-01-15
申请号：PCT/US0146400
申请日：2001-12-04
申请人： QUARK BIOTECH INC , EINAT PAZ , SEGEV ORIT , SKALITER RAMI , FEINSTEIN ELENA , FAERMAN ALEXANDER , SAMACH AVIVA
发明人： EINAT PAZ , SEGEV ORIT , SKALITER RAMI , FEINSTEIN ELENA , FAERMAN ALEXANDER , SAMACH AVIVA
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/02 , A61P19/08 , A61P19/10 , C07K14/47 , C07K14/51 , C07K14/705 , C07K16/18 , C12N15/12 , C12P21/02 , C12Q1/68 , C07H21/02 , A01N37/18 , A01N43/40 , A61K31/70 , C07H21/04 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/47 , A61K48/00 , C07K14/51 , C12Q1/6883 , C12Q2600/158

8. 发明申请

WO2002086089A2 THE 76A11 POLYPEPTIDE AND USES THEREOF 审中-公开
标题翻译： 76A11多肽及其用途
公开(公告)号：WO2002086089A2
公开(公告)日：2002-10-31
申请号：PCT/US2002/013138
申请日：2002-04-23
申请人： QUARK BIOTECH, INC. , CHAJUT, Ayelet , LEVINSON, Matat , SKALITER, Rami
发明人： CHAJUT, Ayelet , LEVINSON, Matat , SKALITER, Rami
IPC分类号： C12N
CPC分类号： C07K14/4748
摘要： This invention provides a method for treating a subject suffering from a disease, wherein the disease is characterized by aberrant cellular proliferation or aberrant cellular differentiation, comprising administering to the subject an antagonist of a polypeptide, wherein the polypeptide has an amino acid sequence as presented in SEQ ID NO:2. This invention also provides the use of a polynucleotide as a probe for identifying undifferentiated embryonic stem cells, wherein the polynucleotide comprises a nucleotide sequence as presented in SEQ ID NO:1. This invention further provides the use of the 76A11 polypeptide in vivo or ex vivo for expansion of adult somatic stem cell. This invention further provides the use of an antibody directed to an epitope presented by the polypeptide comprising the amino acid sequence as presented in SEQ ID NO:2 for detection of cancerous cells or of undifferentiated stem cells. This invention further provides the use of a polynucleotide comprising the nucleotide sequences as presented in SEQ ID NO:1 or fragments thereof for identifying cancerous cells. This invention further provides a method for identifying a chemical compound that modulates proliferation of differentiation of cells which comprises: (a) contacting a cell expressing a gene comprising the sequence as presented in SEQ ID NO:1 with the chemical compound, under conditions permitting expression of the gene; and (b) determining whether the proliferation of differentiation of the cell is stimulated or inhibited in the presence of the compound, as compared to a control and this invention further provides a method for identifying a test chemical compound that modulates proliferation or differentiation of cells which comprises the steps of (a) providing a mixture comprising polypeptide 76A11, (b) contacting said mixture with a test substance under conditions which normally lead to 76A11 activity, and (c) determining whether the activity of said polypeptide is affected by said compound.
摘要翻译：本发明提供了一种治疗患有疾病的受试者的方法，其中所述疾病的特征在于异常细胞增殖或异常细胞分化，其包括向所述受试者施用多肽的拮抗剂，其中所述多肽具有如 SEQ ID NO：2。本发明还提供多核苷酸作为鉴定未分化胚胎干细胞的探针的用途，其中所述多核苷酸包含如SEQ ID NO：1所示的核苷酸序列。本发明进一步提供76A11多肽体内或体外用于成体体细胞干细胞扩增的用途。本发明还提供了针对由包含SEQ ID NO：2所示的氨基酸序列的多肽呈递的表位的抗体用于检测癌细胞或未分化干细胞的用途的用途。本发明还提供了包含SEQ ID NO：1所示的核苷酸序列或其片段的多核苷酸用于鉴定癌细胞的用途。本发明还提供了一种鉴定调节细胞分化增殖的化合物的方法，其包括：（a）在允许表达的条件下，将表达包含SEQ ID NO：1所示序列的基因的细胞与化学化合物接触的基因; 和（b）与对照相比，确定在化合物存在下细胞分化的增殖是否被刺激或抑制，本发明还提供了鉴定调节细胞增殖或分化的测试化合物的方法，包括以下步骤：（a）提供包含多肽76A11的混合物，（b）在通常导致76A11活性的条件下将所述混合物与测试物质接触，和（c）确定所述多肽的活性是否受所述化合物的影响。

9. 发明申请

WO2022035895A1 COMPOSITIONS AND METHODS FOR EMBRYONIC STEM CELL EXPANSION 审中-公开
公开(公告)号：WO2022035895A1
公开(公告)日：2022-02-17
申请号：PCT/US2021/045437
申请日：2021-08-10
申请人： LINEAGE CELL THERAPEUTICS, INC. , ALON, Lilach , SKALITER, Rami , TIKOTZKI, Ravid , HAYOUN NEEMAN, Dana , WISER, Ofer
发明人： ALON, Lilach , SKALITER, Rami , TIKOTZKI, Ravid , HAYOUN NEEMAN, Dana , WISER, Ofer
IPC分类号： C12N5/06 , C12N11/02 , A61P43/00
摘要： Provided herein are methods and compositions for expansion of human embryonic stem with suspendable expansion complexes including microcarriers.

10. 发明申请

WO2021203042A1 A UNIVERSAL ADOPTIVE IMMUNOTHERAPY APPROACH TO TREAT COVID-19 AND FUTURE EMERGING INFECTIOUS DISEASES 审中-公开
公开(公告)号：WO2021203042A1
公开(公告)日：2021-10-07
申请号：PCT/US2021/025638
申请日：2021-04-02
申请人： LINEAGE CELL THERAPEUTICS, INC. , BINETTE, Francois , CULLEY, Brian M. , SKALITER, Rami
发明人： BINETTE, Francois , CULLEY, Brian M. , SKALITER, Rami
IPC分类号： A61K48/00 , A61P31/12 , A61P31/14 , A61P31/16 , A61K39/12 , A61K39/215
摘要： Provided herein are methods and compositions for engineering antigen-presenting cells (APCs), such as dendritic cells (DCs), macrophages, and B-Cells, that are modified to express viral antigens. With this approach, large cell banks can be created that can be rapidly modified and deployed to fight various types of infectious diseases such as those associated with coronaviruses and other viral infections.

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