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1. 发明申请

WO2006027701A2 FAS ASSOCIATED FACTOR 1 审中-公开
标题翻译： FAS相关因素1
公开(公告)号：WO2006027701A2
公开(公告)日：2006-03-16
申请号：PCT/IB2005/003393
申请日：2005-04-29
申请人： SK CORP. , EWHA WOMANS UNIVERSITY , LEE, Kong-Joo , KIM, Hee-Jung , CHO, Jeong, Woo , KIM, Eunhee , SONG, Eun, Joo , MAENG, Cheol, Young
发明人： LEE, Kong-Joo , KIM, Hee-Jung , CHO, Jeong, Woo , KIM, Eunhee , SONG, Eun, Joo , MAENG, Cheol, Young
IPC分类号： A61K38/00 , A61K38/18 , C07K14/47 , C07K14/475
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4747
摘要： The present application describes a Fas associated Factor 1 protein and fragment thereof that bind Hsc70/Hsp70, ubiquitinated protein and valosin containing protein.
摘要翻译：本申请描述了结合Hsc70 / Hsp70，泛素化蛋白质和含有valosin的蛋白质的Fas相关因子1蛋白及其片段。

2. 发明申请

WO2004047722A2 METHOD OF PREPARING 10H-DIBENZO[b,f]]1,4]THIAZEPIN-11-ONE 审中-公开
标题翻译：制备10H-二苯并[b，f]] 1,4]噻吩并-11-酮的方法
公开(公告)号：WO2004047722A2
公开(公告)日：2004-06-10
申请号：PCT/KR0302579
申请日：2003-11-26
申请人： SK CORP , KWAK BYONG-SUNG , CHUNG KI-NAM , KOH KI-HO , HWANG HEE-JUN
发明人： KWAK BYONG-SUNG , CHUNG KI-NAM , KOH KI-HO , HWANG HEE-JUN
IPC分类号： C07D281/16 , A61K
CPC分类号： C07D281/16
摘要： Disclosed is a method of preparing 10H-dibenzo[b,f][1,4]thiazepin-11-one, including reacting dithiosalicylic acid with 1-chloro-2-nitrobenzene in a basic aqueous solution in the presence of absence of a reducing agent, to prepare 2-(2-nitrophenylsulfuryl)benzoic acid; subjecting the 2-(2-nitrophenylsulfuryl)benzoic acid to nitro group reduction in the presence of hydrogen, a solvent and a heterogeneous metal catalyst, to prepare 2-(2-aminophenylsulfuryl)benzoic acid; and directly cyclizing the 2-(2-aminophenylsulfuryl)benzoic acid in an organic solvent in the presence or absence of an acid catalyst. The method according to the present invention is economical due to the use of the inexpensive starting material, and also environmentally friendly and efficient by minimizing the use of the organic solvent and performing direct cyclization without the activation of carboxylic acid.
摘要翻译：公开了一种制备10H-二苯并[b，f] [1,4]硫杂吖庚因-11-酮的方法，包括在碱性水溶液中，在不存在还原剂的情况下，将二硫代水杨酸与1-氯-2-硝基苯反应制备2-（2-硝基苯基硫基）苯甲酸; 在氢气，溶剂和非均相金属催化剂的存在下使2-（2-硝基苯基亚磺酰基）苯甲酸进行硝基还原，制备2-（2-氨基苯基硫基）苯甲酸; 并在酸催化剂存在或不存在下，在有机溶剂中直接环化2-（2-氨基苯基硫基）苯甲酸。根据本发明的方法由于使用廉价的起始材料而是经济的，并且通过最小化有机溶剂的使用并且在没有羧酸活化的情况下进行直接环化，也是环境友好和有效的。

3. 发明申请

WO0053567A8 METHOD FOR THE PRODUCTION OF SERINOL 审中-公开
标题翻译：生产SERINOL的方法
公开(公告)号：WO0053567A8
公开(公告)日：2001-04-12
申请号：PCT/KR0000192
申请日：2000-03-09
申请人： SK CORP , KWAK BYONG SUNG , CHUNG KI NAM , KIM CHOON GIL , KOH KI HO
发明人： KWAK BYONG-SUNG , CHUNG KI-NAM , KIM CHOON-GIL , KOH KI-HO
IPC分类号： B01J23/44 , B01J23/46 , C07B61/00 , C07C205/15 , C07C213/02 , C07C215/10 , C07C205/14
CPC分类号： C07C213/02 , C07C201/12 , C07C215/10 , C07C205/15
摘要： Disclosed is a method for preparing serinol (2-amino-1,3-proanediol). From nitromethane, para-formaldehyde and sodium hydroxide, 1-nitro-1,3-propanediol sodium salt is prepared as a medical intermediate. In a fixed bed, this intermediate is allowed to undergo the continuous hydrogenation of 2-nitro-1,3-propanediol sodium salt and methanol as shown in reaction (I). In addition to being simple, the method is economically favorable and affords the high yield and high purity of serinol.
摘要翻译：公开了一种制备丝氨醇（2-氨基-1,3-丙二醇）的方法。由硝基甲烷，对甲醛和氢氧化钠制备1-硝基-1,3-丙二醇钠盐作为医疗中间体。在固定床中，如反应（I）所示，使该中间体进行2-硝基-1,3-丙二醇钠盐和甲醇的连续氢化。除了简单之外，该方法在经济上是有利的，并且提供了高产率和高纯度的丝氨醇。

4. 发明申请

WO2004047722A8 METHOD OF PREPARING 10H-DIBENZO[b,f][1,4]THIAZEPIN-11-ONE 审中-公开
标题翻译：制备10H-二苯并[b，f] [1,4]噻吩并-11-酮的方法
公开(公告)号：WO2004047722A8
公开(公告)日：2005-07-21
申请号：PCT/KR0302579
申请日：2003-11-26
申请人： SK CORP , KWAK BYONG-SUNG , CHUNG KI-NAM , KOH KI-HO , HWANG HEE-JUN
发明人： KWAK BYONG-SUNG , CHUNG KI-NAM , KOH KI-HO , HWANG HEE-JUN
IPC分类号： C07D281/16
CPC分类号： C07D281/16
摘要： Disclosed is a method of preparing 10H-dibenzo[b,f][1,4]thiazepin-11-one, including reacting dithiosalicylic acid with 1-chloro-2-nitrobenzene in a basic aqueous solution in the presence of absence of a reducing agent, to prepare 2-(2-nitrophenylsulfuryl)benzoic acid; subjecting the 2-(2-nitrophenylsulfuryl)benzoic acid to nitro group reduction in the presence of hydrogen, a solvent and a heterogeneous metal catalyst, to prepare 2-(2-aminophenylsulfuryl)benzoic acid; and directly cyclizing the 2-(2-aminophenylsulfuryl)benzoic acid in an organic solvent in the presence or absence of an acid catalyst. The method according to the present invention is economical due to the use of the inexpensive starting material, and also environmentally friendly and efficient by minimizing the use of the organic solvent and performing direct cyclization without the activation of carboxylic acid.
摘要翻译：公开了一种制备10H-二苯并[b，f] [1,4]硫杂吖庚因-11-酮的方法，包括在碱性水溶液中，在不存在还原剂的情况下，将二硫代水杨酸与1-氯-2-硝基苯反应制备2-（2-硝基苯基硫基）苯甲酸; 在氢气，溶剂和非均相金属催化剂的存在下使2-（2-硝基苯基亚磺酰基）苯甲酸进行硝基还原，制备2-（2-氨基苯基硫基）苯甲酸; 并在酸催化剂存在或不存在下，在有机溶剂中直接环化2-（2-氨基苯基硫基）苯甲酸。根据本发明的方法由于使用廉价的起始材料而是经济的，并且通过最小化有机溶剂的使用并且在没有羧酸活化的情况下进行直接环化，也是环境友好和有效的。

5. 发明申请

WO0106987A2 TRANSNASAL ANTICONVULSIVE COMPOSITIONS AND MODULATED PROCESS 审中-公开
标题翻译：传导性静电组合物和调节过程
公开(公告)号：WO0106987A2
公开(公告)日：2001-02-01
申请号：PCT/US0020119
申请日：2000-07-24
申请人： SK CORP
发明人： CHOI YONG WONG , LI LIANLI , KIM KWON H
IPC分类号： A61K9/72 , A61K9/00 , A61K9/08 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/197 , A61K31/4015 , A61K31/4166 , A61K31/513 , A61K31/55 , A61K31/5513 , A61K45/00 , A61K47/06 , A61K47/10 , A61K47/24 , A61K47/28 , A61P25/08 , A61K
CPC分类号： A61K9/0043 , A61K47/10 , A61K47/24 , A61K47/28 , Y10S514/975
摘要： A novel method of vehicle modulated administration of an anticonvulsive agent to the mucous membranes of humans and animals is disclosed. The vehicle system is an aqueous pharmaceutical carrier comprising an aliphatic alcohol (10-80 %) or a glycol (10-80 %), and their combinations with a biological surfactant such as a bile salt or a lecithin. The pharmaceutical composition provides a means to control and promote the rate and extent of transmucosal permeation and absorption of the medicaments via a single and multiple administration. Nasal administration of the pharmaceutical preparation produces a high plasma concentration of the anticonvulsant nearly as fast as intravenous administration. Such compositions are particularly suitable for a prompt and timely medication of patients in the acute and/or emergency treatment of status epilepticus and other fever-induced seizures.
摘要翻译：公开了一种抗人惊厥剂对人和动物粘膜的车辆调节施用的新方法。载体系统是包含脂族醇（10-80％）或二醇（10-80％））及其与生物表面活性剂如胆汁盐或卵磷脂的组合的水性药物载体。药物组合物通过单次和多次施用提供控制和促进药物经粘膜渗透和吸收的速率和程度的手段。药物制剂的鼻内给药几乎与静脉内施用一样快地产生抗惊厥药的高血浆浓度。这种组合物特别适用于急性和/或紧急治疗癫痫持续状态和其他发热引起的发作的患者的及时和及时的药物。

6. 发明申请

WO2006104367A3 LAYERED CORE-SHELL CATHODE ACTIVE MATERIALS FOR LITHIUM SECONDARY BATTERIES, METHOD FOR PREPARING THEREOF AND LITHIUM SECONDARY BATTERIES USING THE SAME 审中-公开
标题翻译：用于锂二次电池的层状核壳阴极活性材料，其制备方法和使用该锂二次电池的锂二次电池
公开(公告)号：WO2006104367A3
公开(公告)日：2007-04-26
申请号：PCT/KR2006001201
申请日：2006-03-31
申请人： SK CORP , SUN YANG KOOK , LEE DOO KYUN , PARK SANG HO
发明人： SUN YANG KOOK , LEE DOO KYUN , PARK SANG HO
IPC分类号： H01M4/58
CPC分类号： H01M4/485 , C01G45/1242 , C01G51/54 , C01G53/54 , C01P2002/32 , C01P2002/52 , C01P2002/72 , C01P2004/03 , C01P2004/32 , C01P2004/61 , C01P2006/40 , H01M4/505 , H01M4/525
摘要： Disclosed herein is a layered core-shell cathode active material for secondary lithium batteries, in which the core layer has a structural formula of Li 1+a [M x Mn 1-x ] 2 O 4 (M is selected from a group consisting of Ni, Co, Mg, Zn, Ca, Sr, Cu, Zr, P, Fe, Al, Ga, In, Cr, Ge, Sn and combinations thereof, 0.01=x=0.25, O=a=O.l) and the shell layer has a structural formula of Li 1+a [M' y Mn 1-y ] 2 O 4 (M' is selected from a group consisting of Ni, Mg, Cu, Zn and combinations thereof, 0.01=y=0.5, O=a=O.l). hi the layered cathode active material, the core layer, corresponding to a 4V spinel-type manganese cathode, functions to increase the capacity of the active material while the shell layer, corresponding to a 5 V spinel-type transition metal mix-based cathode, is electrochemically stable enough to prevent the reaction of the components with electrolytes and the dissolution of transition metals in electrolytes, thereby improving thermal and lifetime characteristics of the active material.
摘要翻译：本文公开了一种用于二次锂电池的分层芯壳阴极活性材料，其中芯层具有结构式为Li 1 + a M M （1）选自Ni，Co，Mg，Zn，Ca，Sr，Cu，Zr中的1种以上，P，Fe，Al，Ga，In，Cr，Ge，Sn及其组合，0.01 = x = 0.25，O = a = 0，壳层的结构式为Li 1 + （M'选自一个或多个），其中M'选自基团由Ni，Mg，Cu，Zn及其组合组成，0.01 = y = 0.5，O = a = O 1）。在层状阴极活性材料中，对应于4V尖晶石型锰阴极的芯层起到增加活性材料的容量的作用，而壳层对应于5V尖晶石型过渡金属混合物阴极，在电化学上足够稳定以防止组分与电解质的反应和过渡金属在电解质中的溶解，从而改善活性材料的热寿命和寿命特性。

7. 发明申请

WO2006027701A3 FAS ASSOCIATED FACTOR 1 审中-公开
公开(公告)号：WO2006027701A3
公开(公告)日：2006-06-22
申请号：PCT/IB2005003393
申请日：2005-04-29
申请人： SK CORP , EWHA WOMANS UNIVERSITY , LEE KONG-JOO , KIM HEE-JUNG , CHO JEONG WOO , KIM EUNHEE , SONG EUN JOO , MAENG CHEOL YOUNG
发明人： LEE KONG-JOO , KIM HEE-JUNG , CHO JEONG WOO , KIM EUNHEE , SONG EUN JOO , MAENG CHEOL YOUNG
IPC分类号： C07K14/47 , A61K38/00 , A61K38/17 , A61K38/18 , A61P35/00 , A61P43/00 , C07K14/475 , G01N33/574
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4747
摘要： The present application describes a Fas associated Factor 1 protein and fragment thereof that bind Hsc70/Hsp70, ubiquitinated protein and valosin containing protein.
摘要翻译：本申请描述了结合Hsc70 / Hsp70，泛素化蛋白和含缬氨酸蛋白的Fas相关因子1蛋白及其片段。

8. 发明申请

WO9967345A3 METHOD FOR MANUFACTURING CLEANER FUELS 审中-公开
标题翻译：制造清洁燃料的方法
公开(公告)号：WO9967345A3
公开(公告)日：2000-05-04
申请号：PCT/KR9900338
申请日：1999-06-25
申请人： SK CORP
发明人： MIN WHA SIK , CHOI KYUNG I , KHANG SIN YOUNG , MIN DONG SOON , RYU JAE WOOK , YOO KWAN SIK , KIM JYU HWAN
IPC分类号： C10G25/02 , C10G25/03 , C10G25/06 , C10G67/04 , C10G67/06 , C10M159/04
CPC分类号： C10G67/06 , C10G67/04
摘要： A method is provided for manufacturing cleaner fuels, in which NPC (Natural Polar Compounds), naturally existing in small quantities within various petrolic hydrocarbon fractions, are removed from the petrolic hydrocarbon fractions ranging, in boiling point, from 110 to 560 DEG C and preferably from 200 to 400 DEG C, in advance of catalytic hydroprocessing. The removal of NPC improves the efficiency of the catalytic process and produces environment-friendly products, such as diesel fuel with a sulfur content of 50 ppm (wt) or lower. Also the NPC can be used to improve fuel lubricity.
摘要翻译：提供了一种用于制造清洁燃料的方法，其中天然存在少量的各种石油烃馏分中的NPC（天然极性化合物）从石油烃馏分中除去，沸点为110-560℃，优选从200至400℃，提前进行催化加氢处理。 NPC的去除提高了催化过程的效率，并且生产了环境友好的产品，例如硫含量为50ppm（wt）或更低的柴油。此外，NPC也可用于提高燃油润滑性。

9. 发明申请

WO2006028333A9 SOLID ACID CATALYST FOR PRODUCING LIGHT OLEFINS AND PROCESS USING THE SAME 审中-公开
标题翻译：用于生产光油的固体酸催化剂和使用它的方法
公开(公告)号：WO2006028333A9
公开(公告)日：2007-09-07
申请号：PCT/KR2005002866
申请日：2005-08-30
申请人： SK CORP , KOREA RES INST CHEM TECH , CHOI SUN , PARK DEUK SOO , KIM SUK JOON , CHOI AHN SEOP , KIM HEE YOUNG , PARK YONG KI , LEE CHUL WEE , CHOI WON CHOON , HAN SANG YUN , KIM JEONG RI
发明人： CHOI SUN , PARK DEUK SOO , KIM SUK JOON , CHOI AHN SEOP , KIM HEE YOUNG , PARK YONG KI , LEE CHUL WEE , CHOI WON CHOON , HAN SANG YUN , KIM JEONG RI
IPC分类号： B01J35/10
CPC分类号： C07C4/06 , B01J21/02 , B01J21/04 , B01J21/08 , B01J21/16 , B01J27/14 , B01J27/16 , B01J29/049 , B01J29/40 , B01J35/0006 , B01J35/023 , B01J35/1014 , B01J35/1019 , B01J37/0045 , B01J37/04 , B01J37/08 , B01J37/14 , C10G2300/1044 , C10G2300/4018 , C10G2300/4081 , C10G2400/20 , Y02P20/52 , C07C11/06 , C07C11/04
摘要： Disclosed is a porous solid acid catalyst for producing light olefins. The catalyst is prepared through pillaring and a solid state reaction of a raw material mixture, and is made of a porous material having a crystalline structure that is different from that of the raw material mixture. The catalyst exhibits an excellent catalytic activity (i.e., conversion and selectivity) in the production of light olefins from hydrocarbon feeds such as full range naphthas.
摘要翻译：公开了一种用于生产轻质烯烃的多孔固体酸催化剂。催化剂通过原料混合物的柱状和固态反应制备，并且由具有不同于原料混合物的结晶结构的多孔材料制成。该催化剂在从烃进料如全程石脑油生产轻质烯烃时表现出优异的催化活性（即转化率和选择性）。

10. 发明申请

WO2004026223A3 CONTINUOUS PROCESS FOR THE PRODUCTION OF OPTICALLY PURE (S)-beta HYDROXY-gamma-BUTYROLACTONE 审中-公开
标题翻译：用于生产光学纯度（S）-beta羟基-γ-丁酮的连续方法
公开(公告)号：WO2004026223A3
公开(公告)日：2005-06-09
申请号：PCT/KR0201775
申请日：2002-09-18
申请人： SK CORP , KWAK BYONG-SUNG , CHUNG KI-NAM , KIM TAE-YUN , KOH KI-HO , KIM JIN-WOONG , LEE SANG-IL
发明人： KWAK BYONG-SUNG , CHUNG KI-NAM , KIM TAE-YUN , KOH KI-HO , KIM JIN-WOONG , LEE SANG-IL
IPC分类号： C07D307/33 , A61K20060101 , C07B61/00 , C07D307/20 , C07D307/32
CPC分类号： C07D307/33 , C07D307/32
摘要： Disclosed is a continuous process for the production of optically pure (S)-beta-hydroxy-gamma-butyrolactone having constantly maintained optical activity, consisting of hydrogenating 2-50 wt% of a substituted carboxylic acid derivative in a solvent using a fixed bed reactor filled with a precious metal catalyst-impregnated inorganic oxide carrier at 50-500 °C under pressure of 15-5,500 psig at weight-space-velocity of 0.1-10 h , in which a molar ratio of hydrogen to carboxylic acid derivative ranges from 2 to 10. The desired material can be produced in higher optical purity and at higher yield by the current process which is relatively simpler and environmentally safer than conventional processes. Additionally, increased production efficiency leads to production of the desired material on a large scale.
摘要翻译：公开了一种用于生产具有持续保持光学活性的光学纯（S）-β-羟基-γ-丁内酯的连续方法，其包括使用固定床反应器在溶剂中2-50重量％的取代的羧酸衍生物在50-500℃，15-5,500psig的压力下填充贵重金属催化剂浸渍的无机氧化物载体，重量 - 空间速度为0.1-10h -1，其中氢与羧酸的摩尔比衍生物的范围为2至10.所需材料可以通过当前方法以更高的光学纯度和更高的收率生产，其比常规方法相对更简单且环境更安全。此外，提高的生产效率导致所需材料的大规模生产。

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