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1. 发明申请

WO2008024677A1 BIOMARKERS FOR ALZHEIMER'S DISEASE PROGRESSION 审中-公开
标题翻译：阿尔茨海默病的生物标志物
公开(公告)号：WO2008024677A1
公开(公告)日：2008-02-28
申请号：PCT/US2007/076159
申请日：2007-08-17
申请人： NOVARTIS AG , NOVARTIS PHARMA GmbH , SINGER, Jonathan Bejamin
发明人： SINGER, Jonathan Bejamin
IPC分类号： A61K45/00 , A61P25/28
CPC分类号： A61K31/222 , Y10T436/143333
摘要： This invention relates generally to the analytical testing of tissue samples in vitro , and more particularly to aspects of genetic polymorphisms associated with the conversion from Mile Cognitive Impairment to dementia, e.g. , Alzheimer's Disease (AD). The invention provides AD-associated mutations which are useful in the diagnosis, prognosis or therapeutic treatment of dementia, e.g. , Alzheimer's Disease.
摘要翻译：本发明一般涉及体外组织样品的分析测试，更具体地涉及与从Mile认知障碍转化为痴呆（例如阿尔茨海默氏病（AD））相关的遗传多态性的方面。本发明提供了可用于痴呆症例如阿尔茨海默氏病的诊断，预后或治疗性治疗的AD相关突变。

2. 发明申请

WO1998020796A1 DENTAL RADIOGRAPHY USING AN INTRA-ORAL LINEAR ARRAY SENSOR 审中-公开
标题翻译：使用内部线性阵列传感器进行牙齿放射学检查
公开(公告)号：WO1998020796A1
公开(公告)日：1998-05-22
申请号：PCT/US1997020411
申请日：1997-11-12
申请人： SCHICK TECHNOLOGIES, INC. , SCHICK, David, B. , NEUGROSCHL, Daniel, A. , PLASS, David, B. , SINGER, Jonathan
发明人： SCHICK TECHNOLOGIES, INC.
IPC分类号： A61B06/14
CPC分类号： A61B6/145 , A61C9/0073
摘要： A method and apparatus for producing X-ray image of a patient's teeth (21) by placing an intra-oral sensor (23) having a plurality of pixels (25) disposed in a linear array inside the patient's mouth, and moving a radiation source (11) around outside of the patient's mouth. The intra-oral sensor (23) detects the radiation that has passed through the patient's teeth (21) and generates corresponding output signals that depend on the amount of radiation arriving at each pixel (25). The information contained in the output signals is stored and can be used to create an X-ray image of the patient's teeth. The intra-oral sensor can be moved about inside the patient's mouth in coordination with the movement of the radiation source in order to improve the resulting image quality. This method and apparatus can be used to obtain an X-ray image of any number of teeth, including a panoramic image of all of the patient's teeth (21), in a single, quick, uninterrupted operation.
摘要翻译：一种用于通过将具有以线性阵列布置在患者口内的多个像素（25）的口内传感器（23）放置在患者口腔内来产生X射线图像的方法和装置，以及移动辐射源（11）围绕患者口腔外。口内传感器（23）检测穿过患者牙齿（21）的辐射并产生取决于到达每个像素（25）的辐射量的相应输出信号。包含在输出信号中的信息被存储并且可以用于创建患者牙齿的X射线图像。口腔内传感器可以与辐射源的运动协调地围绕患者口腔内部移动，以便改善所得到的图像质量。该方法和装置可以用于以单个，快速，不间断的操作获得任何数量的牙齿的X射线图像，包括所有患者牙齿（21）的全景图像。

3. 发明申请

WO2014144307A2 PROBE ASSEMBLY AND DISPOSABLE COVER PARTICULARLY FOR USE IN ENDOSCOPE APPLICATIONS OF LOW COHERENCE INTERFEROMETRY 审中-公开
标题翻译：探针组件和可替换的封盖，特别适用于低相干干涉仪的内窥镜应用
公开(公告)号：WO2014144307A2
公开(公告)日：2014-09-18
申请号：PCT/US2014028654
申请日：2014-03-14
申请人： GEBHART STEVEN C , AKENS NORMAN R , BLACK ANDREW , CORSON ANDREW , DRAPER CHRISTOPHER , GENOVA PERRY A , HALL ROBERT CHRISTOPHER , HARGENS TANNER , KOPP VICTOR , PENNY MATT , SINGER JONATHAN , WALSH BRIAN
发明人： GEBHART STEVEN C , AKENS NORMAN R , BLACK ANDREW , CORSON ANDREW , DRAPER CHRISTOPHER , GENOVA PERRY A , HALL ROBERT CHRISTOPHER , HARGENS TANNER , KOPP VICTOR , PENNY MATT , SINGER JONATHAN , WALSH BRIAN
IPC分类号： G01J3/02
CPC分类号： A61B1/00059 , A61B1/00142 , A61B1/07 , A61B2560/028 , A61B2562/08 , A61B2562/247 , G01B9/02043 , G01B9/02044 , G01B9/0205 , G01B9/0209 , G01J3/0218 , G01J3/2823 , G01J3/453 , G02B23/26
摘要： A fiber optic probe assembly comprises an optical engine and a fiber optic probe. A proximal end connector comprises a self-aligning connector for connecting optical fibers of the fiber optic probe to the optical engine and an integrated fiber optic-based polarizer. A disposable cover is provided for enclosing at least a portion of a fiber optic probe assembly. The disposable cover comprises an elongated tubular housing and a sheath portion adapted to receive at least a portion of the fiber optic probe between ends of the housing. A handle is disposed on a proximal end of the housing, the handle comprising a self-tensioning device. An optical window is disposed on a distal end of the housing, the optical window adapted to provide for alignment with optical elements of the fiber optic probe.
摘要翻译：光纤探针组件包括光学引擎和光纤探针。近端连接器包括用于将光纤探针的光纤连接到光学引擎的自对准连接器和集成的基于光纤的偏振器。提供一次性盖以封闭光纤探针组件的至少一部分。一次性罩包括细长的管状外壳和护套部分，其适于在外壳的端部之间容纳光纤探针的至少一部分。手柄设置在壳体的近端上，手柄包括自张紧装置。光学窗口设置在壳体的远端上，该光学窗口适于提供与光纤探针的光学元件对准。

4. 发明申请

WO2010022211A1 USE OF A COX-2 INHIBITOR FOR THE TREATMENT OF A COX-2 DEPENDENT DISORDER IN A PATIENT NOT CARRYING HLA ALLELES ASSOCIATED WITH HEPATOTOXICITY 审中-公开
标题翻译：使用COX-2抑制剂治疗患有COX-2依赖性疾病的患者，不携带与肝细胞毒性相关的HLA ALLELE
公开(公告)号：WO2010022211A1
公开(公告)日：2010-02-25
申请号：PCT/US2009/054415
申请日：2009-08-20
申请人： NOVARTIS AG , LEWITZKY, Steven , MEYER, Joanne , PAULDING, Charles , SINGER, Jonathan, Benjamin
发明人： LEWITZKY, Steven , MEYER, Joanne , PAULDING, Charles , SINGER, Jonathan, Benjamin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/142 , C12Q2600/156 , Y10T436/143333
摘要： This disclosure relates to a method of determining the presence of at least one HLA allele, preferably selected from the group consisting of DQA1*0102, DRB1*1501, DQB1*0602 and DRB5*0101 to assess whether a patient is at risk for developing hepatotoxicity upon administration of the COX-2 inhibitor lumiracoxib. Also disclosed is the use of a kit for carrying out this method. The disclosure also relates to a method of treating cyclooxygenase-2 dependent disorders with lumiracoxib in a subject that is not a carrier of one or more HLA alleles, preferably selected from the group consisting of DQA1*0102, DRB1*1501, DQB1*0602 and DRB5*0101.
摘要翻译：本公开涉及确定至少一种HLA等位基因的存在的方法，优选选自DQA1 * 0102，DRB1 * 1501，DQB1 * 0602和DRB5 * 0101，以评估患者是否存在发生肝毒性的风险在给予COX-2抑制剂lumiracoxib后。还公开了用于实施该方法的试剂盒的用途。本公开还涉及在不是一种或多种HLA等位基因的载体的情况下用罗西考布治疗环氧合酶-2依赖性疾病的方法，优选选自DQA1 * 0102，DRB1 * 1501，DQB1 * 0602和 DRB5 * 0101。

5. 发明申请

WO2014186362A1 BARRIER FILM APPLICATIONS AND BARRIER FILM DISPENSERS FOR A STETHOSCOPE, AND METHODS THEREOF 审中-公开
标题翻译：阻塞膜应用和障碍胶囊分配器及其方法
公开(公告)号：WO2014186362A1
公开(公告)日：2014-11-20
申请号：PCT/US2014/037852
申请日：2014-05-13
申请人： SINGER, Jonathan , BRATSKEIR, Stan
发明人： SINGER, Jonathan , BRATSKEIR, Stan
IPC分类号： A61B7/02
CPC分类号： A61B7/02 , A61B46/10 , A61B50/30
摘要： The invention generally relates to barrier film applications that cover the diaphragm (head) of a stethoscope and/or barrier film dispensers for dispensing the barrier film applications. The barrier film applications and/or barrier film dispenser can be used to prevent the spread of infection which may otherwise result from the same stethoscope being used from patient to patient in a hospital and/or clinical environment. Further, the barrier film dispenser and/or a barrier film cartridge housed in the barrier film dispenser can contain multiple barrier film applications sufficiently or substantially preventing them from contamination and/or making application fast and easy. By way of example, prior to each patient exam, a health care worker can apply a new sheet of barrier film application to the diaphragm of a stethoscope, thereby substantially reducing the chance of passing on an infection or other sources of disease from one patient to another.
摘要翻译：本发明一般涉及覆盖用于分配阻挡膜应用的听诊器和/或阻隔膜分配器的隔膜（头部）的阻挡膜应用。阻挡膜应用和/或阻挡膜分配器可以用于防止在医院和/或临床环境中从患者到患者使用相同听诊器的感染传播。此外，容纳在阻挡膜分配器中的阻挡膜分配器和/或阻挡膜盒可以充分或基本上防止它们被污染和/或使应用变得快速和容易的多个阻挡膜应用。举例来说，在每次患者检查之前，医护人员可以将新的阻隔膜应用片施加到听诊器的隔膜上，从而大大减少将感染或其他疾病来源从一个患者传递到另一个。

6. 发明申请

WO02072488A3 APPARATUS AND METHOD FOR FABRICATING CHIRAL FIBER GRATINGS 审中-公开
标题翻译：用于制造手性光纤光栅的装置和方法
公开(公告)号：WO02072488A3
公开(公告)日：2002-11-14
申请号：PCT/US0207770
申请日：2002-03-14
申请人： CHIRAL PHOTONICS INC , SINGER JONATHAN , CHAO NORMAN , KOPP VICTOR IL ICH , NEUGROSCHL DANIEL
发明人： SINGER JONATHAN , CHAO NORMAN , KOPP VICTOR IL ICH , NEUGROSCHL DANIEL
IPC分类号： G02B6/02 , G02B6/024 , G02B6/10 , G02B6/34 , C03B37/00
CPC分类号： G02B6/024 , G02B6/02085 , G02B6/02123 , G02B6/02152 , G02B6/02185 , G02B6/105 , G02B2006/0209
摘要： An apparatus(100) and method for fabricating fiber gratings from optical fibers(114) by imposing constant or variable chiral refractive index modulation along an optical fiber. The refractive index modulation may be of single helix symmetry or of double helix symmetry. In several embodiments of the present invention the refractive index modulation is imposed by twisting and moving a specially prepared optical fiber through a heater(116) that heats a small region of the fiber to a temperature sufficient to allow the fiber to twist in that region as it moves through the heater. Alternately, a normal optical fiber may specially prepared for u se with the apparatus of the present invention at a pre-process stage prior to twisting and heating. In other embodiments of the inventive apparatus, the refractive index modulation is imposed by cutting one or more helical groove patterns into a normal optical fiber, or wrapping a normal fiber with one or more elongated dielectric fibers of a smaller diameter than the optical fiber in one or more helical patterns. Advantageously, the fabrication of the chiral fiber grating may be monitored and the fabrication parameters automatically adjusted to ensure that the chiral fiber grating meets desired requirements.
摘要翻译：一种用于通过沿着光纤施加恒定或可变的手性折射率调制来由光纤（114）制造光纤光栅的设备（100）和方法。折射率调制可以是单螺旋对称或双螺旋对称。在本发明的几个实施例中，折射率调制是通过加捻和移动特制的光纤通过加热器（116）来实现的，该加热器将光纤的小区域加热到足以允许光纤在那个区域中扭曲的温度，它移动通过加热器。可选地，普通光纤可以在扭曲和加热之前的预处理阶段为本发明的设备专门制备。在本发明设备的其他实施例中，折射率调制是通过将一个或多个螺旋凹槽图案切割成普通光纤，或者将具有比光纤更小直径的一个或多个细长介电纤维的普通光纤卷绕成一个或更多的螺旋模式。有利的是，可以监测手性光纤光栅的制造并自动调整制造参数以确保手性光纤光栅满足所需要求。

7. 发明申请

WO2002072488A2 APPARATUS AND METHOD FOR FABRICATING CHIRAL FIBER GRATINGS 审中-公开
标题翻译：用于制造纤维光栅的装置和方法
公开(公告)号：WO2002072488A2
公开(公告)日：2002-09-19
申请号：PCT/US2002/007770
申请日：2002-03-14
申请人： CHIRAL PHOTONICS, INC. , SINGER, Jonathan , CHAO, Norman , KOPP, Victor, Il'ich , NEUGROSCHL, Daniel
发明人： SINGER, Jonathan , CHAO, Norman , KOPP, Victor, Il'ich , NEUGROSCHL, Daniel
IPC分类号： C03B37/00
CPC分类号： G02B6/024 , G02B6/02085 , G02B6/02123 , G02B6/02152 , G02B6/02185 , G02B6/105 , G02B2006/0209
摘要： An apparatus and method for fabricating fiber gratings from optical fibers by imposing constant or variable chiral refractive index modulation along an optical fiber. The refractive index modulation may be of single helix symmetry or of double helix symmetry. In several embodiments of the present invention the refractive index modulation is imposed by twisting and moving a specially prepared optical fiber through a heater that heats a small region of the fiber to a temperature sufficient to allow the fiber to twist in that region as it moves through the heater. Alternately, a normal optical fiber may be specially prepared for use with the apparatus of the present invention at a pre-process stage prior to twisting and heating. In other embodiments of the inventive apparatus, the refractive index modulation is imposed by cutting one or more helical groove patterns into a normal optical fiber, or by wrapping a normal fiber with one or more elongated dielectric fibers of a smaller diameter than the optical fiber in one or more helical patterns. Advantageously, the fabrication of the chiral fiber grating may be monitored and the fabrication parameters automatically adjusted to ensure that the chiral fiber grating meets desired requirements.
摘要翻译：一种用于通过沿着光纤施加恒定或可变的手性折射率调制从光纤（114）制造光纤光栅的装置（100）和方法。折射率调制可以是单螺旋对称性或双螺旋对称性。在本发明的几个实施例中，折射率调制是通过将特制的光纤通过加热器（116）进行扭转和移动来实现的，加热器（116）将纤维的小区域加热至足以允许纤维在该区域内扭曲的温度，如它通过加热器移动。或者，普通光纤可以在扭转和加热之前的预处理阶段与本发明的设备一起专门准备。在本发明装置的其它实施例中，折射率调制是通过将一个或多个螺旋槽图案切割成普通光纤或者用一个或多个细长的电介质纤维缠绕普通光纤而实现的，该介电纤维的直径比光纤的直径小或更多的螺旋图案。有利地，可以监测手性光纤光栅的制造，并且自动调节制造参数，以确保手性光纤光栅满足期望的要求。

8. 发明专利

CA2352654A1 PROCESS FOR PROVIDING LOWER-COST PHARMACEUTICAL PRODUCTS TO UNITED STATES CONSUMERS WITH REGULATORY COMPLIANCE 未知
公开(公告)号：CA2352654A1
公开(公告)日：2002-01-06
申请号：CA2352654
申请日：2001-07-06
申请人： SINGER JONATHAN
发明人： SINGER JONATHAN
IPC分类号： G06F17/60
摘要： There is disclosed a process for distributing lower-cost prescription-bas ed pharmaceutical or medical device products for United States resident consume rs or patients while complying with governmental pharmaceutical and device regulatory requirements. More specifically, there is disclosed a process for locating a United States regulated pharmacy physically outside of the United States in a free trade zone type environment such as a Canadian economic development corporation (e.g., Province of British Columbia), physical free trade zone (e.g., Mirabel airport outside of Montreal) of nati ve peoples reservation (e.g., Indian reservation). The inventive pharmacy fulfillment center will fill prescriptions for U.S. citizens and residents with valid prescription- regulated medical products (e.g., pharmaceutical products, biological products and medical devices) obtained from non-U.S. distributors but sourced from the same manufacturers who distribute to U.S. distributors. The products will add U.S. approved labeling information or a derivative of such information and the pharmacy will fill prescriptions with a maximum allowable supply (where appropriate and according to prescription information) to U.S. residents according to the prescription information, all without running afoul of U.S. laws andregu lations of the Food and Drug Administration and respective state pharmacy boards.

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