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1. 发明公开

EP3618827A1 MANUFACTURE OF TRANS-[TETRACHLOROBIS(1H-INDAZOLE)RUTHENATE (III)]AND COMPOSITIONS THEREOF 有权转让
公开(公告)号：EP3618827A1
公开(公告)日：2020-03-11
申请号：EP18794220.6
申请日：2018-05-07
申请人： Intezyne Technologies Inc. , Vojkovsky, Tomas , Sill, Kevin , Carie, Adam
发明人： VOJKOVSKY, Tomas , SILL, Kevin , CARIE, Adam
IPC分类号： A61K31/416 , A61K31/555 , A61K33/24

2. 发明专利

AU2018263965A1 Manufacture of trans-(tetrachlorobis(1H-indazole)ruthenate (III)) and compositions thereof 未知
公开(公告)号：AU2018263965A1
公开(公告)日：2019-11-21
申请号：AU2018263965
申请日：2018-05-07
申请人： CARIE ADAM , INTEZYNE TECHNOLOGIES INC , SILL KEVIN , VOJKOVSKY TOMAS
发明人： VOJKOVSKY TOMAS , SILL KEVIN , CARIE ADAM
IPC分类号： A61K31/416 , A61K31/555 , A61K33/24
摘要： The present invention relates to the preparation of compositions comprising sodium

3. 发明专利

CA3062369A1 MANUFACTURE OF TRANS-[TETRACHLOROBIS(1H-INDAZOLE)RUTHENATE (III)] AND COMPOSITIONS THEREOF 未知
公开(公告)号：CA3062369A1
公开(公告)日：2018-11-08
申请号：CA3062369
申请日：2018-05-07
申请人： INTEZYNE TECH INC , VOJKOVSKY TOMAS , SILL KEVIN , CARIE ADAM
发明人： VOJKOVSKY TOMAS , SILL KEVIN , CARIE ADAM
IPC分类号： A61K31/416 , A61K31/555 , A61K33/24
摘要： The present invention relates to the preparation of compositions comprising sodium trans-[tetrachlorobis(1H-indazole)ruthenate (III)]. Synthesis and formulation preparation is detailed. Impurity profiles are also discussed. Compositions herein are useful for anti-cancer applications.

4. 发明专利

SG11201910043PA MANUFACTURE OF TRANS-[TETRACHLOROBIS(1H-INDAZOLE)RUTHENATE (III)] AND COMPOSITIONS THEREOF 未知
公开(公告)号：SG11201910043PA
公开(公告)日：2019-11-28
申请号：SG11201910043P
申请日：2018-05-07
申请人： INTEZYNE TECHNOLOGIES INC , VOJKOVSKY TOMAS , SILL KEVIN , CARIE ADAM
发明人： VOJKOVSKY TOMAS , SILL KEVIN , CARIE ADAM
IPC分类号： A61K31/555 , A61K31/416 , A61K33/24
摘要： INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIPO I PCT Iiiimmoimiolollmonolooloviimiflinomovom (10) International Publication Number WO 2018/204930 Al (51) International Patent Classification: A61K 31/416 (2006.01) A61K 33/24 (2006.01) A61K 31/555 (2006.01) (21) International Application Number: PCT/US2018/031436 (22) International Filing Date: 07 May 2018 (07.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/501,984 05 May 2017 (05.05.2017) US (71) Applicant: INTEZYNE TECHNOLOGIES, INC. [US/US]; 3720 Spectrum Blvd., Suite 104, Tampa, Florida 33612 (US). (72) Inventors; and (71) Applicants: VOJKOVSKY, Tomas [ /US]; 23 Shelby Lane, Palm Beach Gardens, Florida 33418 (US). SILL, Kevin [ /US]; 16308 Royal Park Ct., Tampa, Florida 33647 (US). CARIE, Adam [ /US]; 4206 Knob Lake Ct., Tampa, FL 33619 (US). (74) Agent: REID, Andrea L.C. et al.; One International Place, 100 Oliver Street, 40th Floor, Boston, Massachusetts 02110-2605 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: MANUFACTURE OF TRANS-[TETRACHLOROBIS(1H-INDAZOLE)RUTHENATE (III)] AND COMPOSITIONS = THEREOF 120 100 IT- 139 Drug Su b O cr O 1 \ \ 80 1 \ 1 \ \ 60 7 1 \\ \ \ \ 40d \ , 1 20 1 \\ \ 1 01 1 0 10 20 IT-139 2-8°C - -0- - IT-13918-22°C 30 40 50 60 Time (h) Figure 1 1-1 (57) : The present invention relates to the preparation of compositions comprising sodium trans-[tetrachlorobis(1H- ei • mdazole)ruthenate (III)]. Synthesis and formulation preparation is detailed. Impurity profiles are also discussed. Compositions herein C are useful for anti-cancer applications. [Continued on next page] WO 2018/204930 Al MIDEDIMOMMIDIRE10100101011fifilIMIHMEMOIS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))

5. 发明申请

WO2012058552A1 IRON STABILIZED POLYMER MICELLES FOR DRUG DELIVERY APPLICATIONS 审中-公开
标题翻译：用于药物递送应用的铁稳定聚合物微粒
公开(公告)号：WO2012058552A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/058308
申请日：2011-10-28
申请人： INTEZYNE TECHNOLOGIES, INCORPORATED , SILL, Kevin, N. , RIOS-DORIA, Jonathan , SKAFF, Habib , CARIE, Adam
发明人： SILL, Kevin, N. , RIOS-DORIA, Jonathan , SKAFF, Habib , CARIE, Adam
IPC分类号： C08G73/10
CPC分类号： C08G69/10 , A61K9/0019 , A61K9/107 , A61K31/704 , A61K47/02 , A61K47/34 , C08G69/40 , C08L77/04
摘要： The present invention provides polymer micelles for drug delivery applications.
摘要翻译：本发明提供用于药物递送应用的聚合物胶束。

6. 发明申请

WO2011088405A1 PLASMA MODIFICATION OF METAL SURFACES 审中-公开
标题翻译：金属表面等离子体改性
公开(公告)号：WO2011088405A1
公开(公告)日：2011-07-21
申请号：PCT/US2011/021411
申请日：2011-01-14
申请人： INTEZYNE TECHNOLOGIES, INCORPORATED , SILL, Kevin, N. , SKAFF, Habib , BREITENKAMP, Kurt
发明人： SILL, Kevin, N. , SKAFF, Habib , BREITENKAMP, Kurt
IPC分类号： C23C8/00
CPC分类号： B05D7/14 , A61L27/04 , A61L27/50 , A61L29/02 , A61L29/14 , A61L31/022 , A61L31/14 , A61L2400/18 , B05D3/002 , B05D3/102 , B05D3/142 , Y10T428/31678
摘要： The present invention provides modified metal surfaces, methods of preparing the same, and intermediates thereto. These materials are useful in a variety of applications including biomaterials.
摘要翻译：本发明提供改性金属表面，其制备方法及其中间体。这些材料可用于各种应用，包括生物材料。

7. 发明申请

WO2010127271A1 POLYMER MICELLES CONTAINING ANTHRACYLINES FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：含有治疗癌症的抗坏血酸的聚合物细胞
公开(公告)号：WO2010127271A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/033205
申请日：2010-04-30
申请人： INTEZYNE TECHNOLOGIES, INCORPORATED , SILL, Kevin, N. , SKAFF, Habib , RIOS-DORIA, Jonathan , CARDOEN, Gregoire
发明人： SILL, Kevin, N. , SKAFF, Habib , RIOS-DORIA, Jonathan , CARDOEN, Gregoire
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： A61K9/1075 , A61K31/704
摘要： The present invention provides micelles having an anthracycline encapsulated therein, the micelles comprising a multiblock copolymer. The invention further provides methods of preparing and using said micelles, and compositions thereof.
摘要翻译：本发明提供了胶囊中包含蒽环类胶束，胶束包含多嵌段共聚物。本发明还提供了制备和使用所述胶束的方法及其组合物。

8. 发明申请

WO2008134734A3 ENCAPSULATED CONTRAST AGENTS 审中-公开
标题翻译：包埋对比剂
公开(公告)号：WO2008134734A3
公开(公告)日：2009-06-04
申请号：PCT/US2008062038
申请日：2008-04-30
申请人： INTEZYNE TECHNOLOGIES INC , SKAFF HABIB , BREITENKAMP KURT , SILL KEVIN N
发明人： SKAFF HABIB , BREITENKAMP KURT , SILL KEVIN N
IPC分类号： A61K49/18 , A61K9/107
CPC分类号： A61K49/1806 , A61K9/1075 , A61K49/1887 , B82Y5/00
摘要： The present invention relates to the field of polymer chemistry and more particularly to encapsulated contrast agents and methods for using the same. One embodiment of the present invention provides a micelle having a contrast agent encapsulated therein, comprising a multiblock copolymer which comprises a polymeric hydrophilic block, optionally a poly(amino acid block) that is optionally crosslinkable or crosslinked, and another poly(amino acid) block, characterized in that said micelle has an inner core, optionally a crosslinkable or crosslinked outer core, and a hydrophilic shell.
摘要翻译：本发明涉及聚合物化学领域，更具体地涉及封装造影剂及其使用方法。本发明的一个实施方案提供了包含其中的造影剂的胶束，其包含多嵌段共聚物，其包含聚合物亲水嵌段，任选地可任选地可交联或交联的聚（氨基酸嵌段）和另一个聚（氨基酸）嵌段其特征在于，所述胶束具有内芯，任选的可交联或交联的外核和亲水壳。

9. 发明申请

WO2006135387A3 QUANTUM DOTS TAILORED WITH ELECTRONICALLY-ACTIVE POLYMERS 审中-公开
标题翻译：量子素与电子活性聚合物配制
公开(公告)号：WO2006135387A3
公开(公告)日：2009-04-16
申请号：PCT/US2005028034
申请日：2005-08-08
申请人： UNIV MASSACHUSETTS , SKAFF HABIB , EMRICK TODD S , SILL KEVIN
发明人： SKAFF HABIB , EMRICK TODD S , SILL KEVIN
IPC分类号： C09K11/02 , C07F9/02
CPC分类号： C08K5/0091 , B82Y10/00 , B82Y30/00 , C08K5/5397 , C08L47/00
摘要： Cadmium selenide, and other quantum dot materials, can be integrated into thin films of poly(para-phenylene vinylene) (PPV) or other polymer compounds without aggregation of the nanocrystals. Solid-state photoluminescence spectra of composite materials prepared by these novel techniques reveal the effect of this greatly enhanced quantum dot-polymer interface relative to cases where the nanoparticles are aggregated, such that electronic communication and energy transfer between the nanoparticle and polymer components is made more efficient.
摘要翻译：硒化镉和其他量子点材料可以整合到聚（对亚苯基亚乙烯基）（PPV）或其它聚合物化合物的薄膜中，而不会聚集纳米晶体。通过这些新技术制备的复合材料的固态光致发光光谱显示了相对于纳米颗粒聚集的情况，这种大大增强的量子点聚合物界面的效果，使得纳米颗粒和聚合物组分之间的电子通信和能量转移更多高效。

10. 发明申请

WO2007127440A3 HETEROFUNCTIONAL POLY(ETHYLENE GLYCOL) CONTAINING ACID-LABILE AMINO PROTECTING GROUPS AND USES THEREOF 审中-公开
标题翻译：含有酸可溶性氨基保护基的异戊二烯（乙二醇）及其用途
公开(公告)号：WO2007127440A3
公开(公告)日：2008-12-04
申请号：PCT/US2007010358
申请日：2007-04-27
申请人： INTEZYNE TECHNOLOGIES INC , BREITENKAMP KURT , SILL KEVIN N , SKAFF HABIB
发明人： BREITENKAMP KURT , SILL KEVIN N , SKAFF HABIB
IPC分类号： C08F283/00 , C07C61/12 , C07D207/00 , C07D323/00 , C07D417/00 , C07F7/04
CPC分类号： C07F9/36 , C07D273/01 , C07F9/46 , C07F9/5721 , C07F9/6561 , C08G65/2612 , C08G65/2624 , C08G65/263 , C08G65/325 , C08G65/329 , C08G65/3344 , C08G65/337 , Y02P20/55
摘要： The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.
摘要翻译：本发明提供双官能聚合物，其制备方法及其中间体。这些化合物可用于各种应用，包括生物活性分子的PEG化。本发明还提供了使用所述化合物及其组合物的方法。

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