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1. 发明申请

WO2005075081A1 INTEGRATED SYSTEM WITH MODULAR MICROFLUIDI COMPONENTS 审中-公开
标题翻译：具有模块化微流控组件的集成系统
公开(公告)号：WO2005075081A1
公开(公告)日：2005-08-18
申请号：PCT/US2005/003579
申请日：2005-02-02
申请人： SILICON VALLEY SCIENTIFIC, INC. , JOVANOVICH, Stevan, B. , BLAGA, Luliu , MCINTOSH, Roger
发明人： JOVANOVICH, Stevan, B. , BLAGA, Luliu , MCINTOSH, Roger
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2300/087 , B01L2400/0644 , B01L2400/065 , G01N21/645 , G01N2021/0346
摘要： Modular fluidic microchips, systems integrating such microchips, and associated preparative and analytical methods are presented.
摘要翻译：提出了模块化流体微芯片，集成这种微芯片的系统，以及相关的制备和分析方法。

2. 发明申请

WO2017075293A1 METHOD AND APPARATUS FOR ENCODING CELLULAR SPATIAL POSITION INFORMATION 审中-公开
标题翻译：用于编码细胞空间位置信息的方法和设备
公开(公告)号：WO2017075293A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/059232
申请日：2016-10-27
申请人： SILICON VALLEY SCIENTIFIC, INC.
发明人： JOVANOVICH, Stevan, B. , WAGNER, Peter
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1003 , C12Q1/6806 , C12Q2525/191 , C12Q2535/122 , C12Q2563/179 , C12Q2525/161 , C12Q2525/173 , C12Q2563/149 , C12Q2563/159 , C12Q2565/514 , C12Q2521/507
摘要： A system, methods, and apparatus are described to collect and prepare single cells and groups of cells from microsamples of specimens and encode spatial information of the physical position of the cells in the specimen. In some embodiment, beads or surfaces with oligonucleotides containing spatial barcodes are used to analyze DNA or RNA. The spatial barcodes allow the position of the cell to be defined and the nucleic acid sequencing information, such as target sequencing, whole genome, gene expression, used to analyze the cells in a microsample for cell type, expression pattern, DNA sequence, and other information, in the context of the cell's physical position in the specimen. In other embodiment, markers such as isotopes are added to a microsample to encode spatial position with mass spectoscopy or other analysis. The spatial encoded information is then readout by analysis such as DNA sequencing, mass spectrometry, fluorescence, or other methods.
摘要翻译：描述了一种系统，方法和装置，用于从样本的微样本收集和制备单细胞和细胞组，并且编码样本中细胞的物理位置的空间信息。在一些实施方案中，使用含有空间条形码的寡核苷酸的珠或表面来分析DNA或RNA。空间条形码允许定义细胞的位置，并且用于分析细胞类型，表达模式，DNA序列等的微型样品中的细胞的核酸测序信息（例如靶测序，全基因组，基因表达）信息，在细胞在标本中的物理位置的上下文中。在其他实施方案中，诸如同位素的标记物通过质谱或其他分析添加到微型样品以编码空间位置。然后通过分析如DNA测序，质谱，荧光或其他方法读出空间编码的信息。

3. 发明申请

US20210046482A1 METHOD AND APPARATUS FOR PROCESSING TISSUE AND OTHER SAMPLES ENCODING CELLULAR SPATIAL POSITION INFORMATION 有权
公开(公告)号：US20210046482A1
公开(公告)日：2021-02-18
申请号：US16980358
申请日：2019-03-12
申请人： SILICON VALLEY SCIENTIFIC, INC.
发明人： Stevan Bogdan JOVANOVICH
IPC分类号： B01L3/00 , G01N1/28 , G01N35/08 , G01N35/00 , C12N15/10 , G16B5/00
摘要： Provided herein is a system comprising: a) spatial sampler system configured to collect and transmit one or a plurality of cells or nuclei from a tissue specimen, the system comprising: i) a lower carrier having an array of conduits passing therethrough, each conduit comprising an opening on a first side and communicating with an opening on a second side, wherein the opening on the second side either (1) terminates in a capillary or (2) opens onto a well of a multiwell plate; ii) positioned, above the lower carrier, a perforated specimen holder configured to support a frozen tissue specimen, wherein the specimen holder comprises a plurality of perforations having a size sufficient to permit the passage of single cells or nuclei; and iii) positioned, above the specimen holder, a multifunctional head comprising an upper array of upper conduits, optionally, each aligned with a conduit opening of the lower carrier.

4. 发明授权

US12103004B2 Method and apparatus for processing tissue and other samples encoding cellular spatial position information 有权
公开(公告)号：US12103004B2
公开(公告)日：2024-10-01
申请号：US16980358
申请日：2019-03-12
申请人： SILICON VALLEY SCIENTIFIC, INC.
发明人： Stevan Bogdan Jovanovich
IPC分类号： B01L3/00 , C12N15/10 , G01N1/28 , G01N35/00 , G01N35/08 , G16B5/00
CPC分类号： B01L3/502784 , B01L3/502761 , B01L3/50857 , C12N15/1013 , G01N1/286 , G01N35/0099 , G01N35/08 , G16B5/00 , B01L2200/025 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/0867 , B01L2300/0893 , B01L2300/0896 , B01L2300/18
摘要： Provided herein is a system comprising: a) spatial sampler system configured to collect and transmit one or a plurality of cells or nuclei from a tissue specimen, the system comprising: i) a lower carrier having an array of conduits passing therethrough, each conduit comprising an opening on a first side and communicating with an opening on a second side, wherein the opening on the second side either (1) terminates in a capillary or (2) opens onto a well of a multiwell plate; ii) positioned, above the lower carrier, a perforated specimen holder configured to support a frozen tissue specimen, wherein the specimen holder comprises a plurality of perforations having a size sufficient to permit the passage of single cells or nuclei; and iii) positioned, above the specimen holder, a multifunctional head comprising an upper array of upper conduits, optionally, each aligned with a conduit opening of the lower carrier.

5. 发明授权

US11667907B2 Method and apparatus for encoding cellular spatial position information 有权
公开(公告)号：US11667907B2
公开(公告)日：2023-06-06
申请号：US17381796
申请日：2021-07-21
申请人： SILICON VALLEY SCIENTIFIC, INC.
发明人： Stevan Bogdan Jovanovich , Peter Wagner
IPC分类号： C12N15/10 , C12Q1/6806
CPC分类号： C12N15/1003 , C12N15/1017 , C12N15/1093 , C12Q1/6806 , C12N15/1003 , C12Q2525/191 , C12Q2535/122 , C12Q2563/179 , C12Q1/6806 , C12Q2525/161 , C12Q2525/173 , C12Q2535/122 , C12Q2563/149 , C12Q2563/159 , C12Q2563/179 , C12Q2565/514 , C12Q1/6806 , C12Q2521/507 , C12Q2525/161 , C12Q2525/191 , C12Q2535/122 , C12Q2563/149 , C12Q2563/159 , C12Q2563/179 , C12Q2565/514
摘要： A system, methods, and apparatus are described to collect and prepare single cells and groups of cells from microsamples of specimens and encode spatial information of the physical position of the cells in the specimen. In some embodiment, beads or surfaces with oligonucleotides containing spatial barcodes are used to analyze DNA or RNA. The spatial barcodes allow the position of the cell to be defined and the nucleic acid sequencing information, such as target sequencing, whole genome, gene expression, used to analyze the cells in a microsample for cell type, expression pattern, DNA sequence, and other information, in the context of the cell's physical position in the specimen. In other embodiment, markers such as isotopes are added to a microsample to encode spatial position with mass spectoscopy or other analysis. The spatial encoded information is then readout by analysis such as DNA sequencing, mass spectrometry, fluorescence, or other methods.

6. 发明授权

US11111487B2 Method and apparatus for encoding cellular spatial position information 有权
公开(公告)号：US11111487B2
公开(公告)日：2021-09-07
申请号：US15771607
申请日：2016-10-27
申请人： SILICON VALLEY SCIENTIFIC, INC.
发明人： Stevan B. Jovanovich , Peter Wagner
IPC分类号： C12N15/10 , C12Q1/6806
摘要： A system, methods, and apparatus are described to collect and prepare single cells and groups of cells from microsamples of specimens and encode spatial information of the physical position of the cells in the specimen. In some embodiment, beads or surfaces with oligonucleotides containing spatial barcodes are used to analyze DNA or RNA. The spatial barcodes allow the position of the cell to be defined and the nucleic acid sequencing information, such as target sequencing, whole genome, gene expression, used to analyze the cells in a microsample for cell type, expression pattern, DNA sequence, and other information, in the context of the cell's physical position in the specimen. In other embodiment, markers such as isotopes are added to a microsample to encode spatial position with mass spectoscopy or other analysis. The spatial encoded information is then readout by analysis such as DNA sequencing, mass spectrometry, fluorescence, or other methods.

7. 发明公开

US20240026338A1 METHOD AND APPARATUS FOR ENCODING CELLULAR SPATIAL POSITION INFORMATION 审中-公开
公开(公告)号：US20240026338A1
公开(公告)日：2024-01-25
申请号：US18200569
申请日：2023-05-22
申请人： SILICON VALLEY SCIENTIFIC, INC.
发明人： Stevan Bogdan Jovanovich , Peter Wagner
IPC分类号： C12N15/10 , C12Q1/6806
CPC分类号： C12N15/1003 , C12Q1/6806 , C12N15/1017 , C12N15/1093
摘要： A system, methods, and apparatus are described to collect and prepare single cells and groups of cells from microsamples of specimens and encode spatial information of the physical position of the cells in the specimen. In some embodiment, beads or surfaces with oligonucleotides containing spatial barcodes are used to analyze DNA or RNA. The spatial barcodes allow the position of the cell to be defined and the nucleic acid sequencing information, such as target sequencing, whole genome, gene expression, used to analyze the cells in a microsample for cell type, expression pattern, DNA sequence, and other information, in the context of the cell's physical position in the specimen. In other embodiment, markers such as isotopes are added to a microsample to encode spatial position with mass spectoscopy or other analysis. The spatial encoded information is then readout by analysis such as DNA sequencing, mass spectrometry, fluorescence, or other methods.

8. 发明申请

US20220033802A1 METHOD AND APPARATUS FOR ENCODING CELLULAR SPATIAL POSITION INFORMATION 有权
公开(公告)号：US20220033802A1
公开(公告)日：2022-02-03
申请号：US17381796
申请日：2021-07-21
申请人： SILICON VALLEY SCIENTIFIC, INC.
发明人： Stevan Bogdan Jovanovich , Peter Wagner
IPC分类号： C12N15/10 , C12Q1/6806
摘要： A system, methods, and apparatus are described to collect and prepare single cells and groups of cells from microsamples of specimens and encode spatial information of the physical position of the cells in the specimen. In some embodiment, beads or surfaces with oligonucleotides containing spatial barcodes are used to analyze DNA or RNA. The spatial barcodes allow the position of the cell to be defined and the nucleic acid sequencing information, such as target sequencing, whole genome, gene expression, used to analyze the cells in a microsample for cell type, expression pattern, DNA sequence, and other information, in the context of the cell's physical position in the specimen. In other embodiment, markers such as isotopes are added to a microsample to encode spatial position with mass spectoscopy or other analysis. The spatial encoded information is then readout by analysis such as DNA sequencing, mass spectrometry, fluorescence, or other methods.

9. 发明申请

US20180305681A1 METHOD AND APPARATUS FOR ENCODING CELLULAR SPATIAL POSITION INFORMATION 审中-公开
公开(公告)号：US20180305681A1
公开(公告)日：2018-10-25
申请号：US15771607
申请日：2016-10-27
申请人： SILICON VALLEY SCIENTIFIC, INC.
发明人： Stevan B. JOVANOVICH , Peter WAGNER
IPC分类号： C12N15/10 , C12Q1/6806
CPC分类号： C12N15/1003 , C12N15/1017 , C12N15/1093 , C12Q1/6806 , C12Q2525/191 , C12Q2535/122 , C12Q2563/179 , C12Q2525/161 , C12Q2525/173 , C12Q2563/149 , C12Q2563/159 , C12Q2565/514 , C12Q2521/507
摘要： A system, methods, and apparatus are described to collect and prepare single cells and groups of cells from microsamples of specimens and encode spatial information of the physical position of the cells in the specimen. In some embodiment, beads or surfaces with oligonucleotides containing spatial barcodes are used to analyze DNA or RNA. The spatial barcodes allow the position of the cell to be defined and the nucleic acid sequencing information, such as target sequencing, whole genome, gene expression, used to analyze the cells in a microsample for cell type, expression pattern, DNA sequence, and other information, in the context of the cell's physical position in the specimen. In other embodiment, markers such as isotopes are added to a microsample to encode spatial position with mass spectoscopy or other analysis. The spatial encoded information is then readout by analysis such as DNA sequencing, mass spectrometry, fluorescence, or other methods.

10. 发明公开

EP1711264A1 INTEGRATED SYSTEM WITH MODULAR MICROFLUIDI COMPONENTS 有权转让
标题翻译：与模块化微流体元件集成系统
公开(公告)号：EP1711264A1
公开(公告)日：2006-10-18
申请号：EP05722738.1
申请日：2005-02-02
申请人： Silicon Valley Scientific, Inc.
发明人： JOVANOVICH, Stevan, B. , BLAGA, Luliu , MCINTOSH, Roger
IPC分类号： B01L3/00 , B01L9/00 , G01N27/447
CPC分类号： B01L3/502738 , B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2300/087 , B01L2400/0644 , B01L2400/065 , G01N21/645 , G01N2021/0346
摘要： Modular fluidic microchips, systems integrating such microchips, and associated preparative and analytical methods are presented.

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