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1. 发明申请

WO2007028602A1 NOVEL GENE SMS 37 审中-公开
标题翻译：新基因短信37
公开(公告)号：WO2007028602A1
公开(公告)日：2007-03-15
申请号：PCT/EP2006/008706
申请日：2006-09-07
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , HAUK, Corina , MOUNCEY, Nigel , MUFFLER, Andrea , SHINJOH, Masako
发明人： CHEVREUX, Bastien , HAUK, Corina , MOUNCEY, Nigel , MUFFLER, Andrea , SHINJOH, Masako
IPC分类号： C12N15/09 , C12P17/04 , C07K14/195
CPC分类号： C07K14/195 , C12P17/04
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

2. 发明申请

WO2007028601A1 NADP-DEPENDENT GLUCOSE DEHYDROGENASE FROM GLUCONOBACTER OXYDANS 审中-公开
标题翻译：来自GLUCONOBACTER OXYDANS的NADP依赖性葡萄糖脱氢酶
公开(公告)号：WO2007028601A1
公开(公告)日：2007-03-15
申请号：PCT/EP2006/008705
申请日：2006-09-07
申请人： DSM IP ASSETS B.V. , SHINJOH, Masako
发明人： SHINJOH, Masako
IPC分类号： C12N9/04 , C12N1/20
CPC分类号： C12N1/20 , C12N9/0006 , C12N15/52 , C12P1/04
摘要： The present invention relates to microorganisms genetically engineered to increase yield and/or efficiency of biomass production from a carbon source, such as e.g. glucose. Processes for generating such microorganisms are also provided by the present invention. The invention also relates to polynucleotide sequences comprising genes that encode proteins that are involved in the bioconversion of a carbon source such as e.g. glucose into biomass. The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. Also included are processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms leading to a microorganism with reduced carbon source diversion, i.e. higher yield and/or efficiency of biomass production from a carbon source such as e.g. glucose.
摘要翻译：本发明涉及基因工程改造以增加来自碳源的生物质生产的产量和/或效率的微生物，例如，葡萄糖。产生这种微生物的方法也由本发明提供。本发明还涉及包含编码参与碳源的生物转化的蛋白质的基因的多核苷酸序列，例如碳源。葡萄糖转化为生物量。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。还包括使用多核苷酸和修饰的多核苷酸序列来转化宿主微生物的方法，所述宿主微生物导致具有降低的碳源转移的微生物，即来自碳源的生物质产量的较高产量和/或效率，例如。葡萄糖。

3. 发明申请

WO2006084713A3 NOVEL GENE VCS 03 审中-公开
标题翻译：新基因VCS 03
公开(公告)号：WO2006084713A3
公开(公告)日：2007-01-25
申请号：PCT/EP2006001208
申请日：2006-02-10
申请人： DSM IP ASSETS BV , CHEVREUX BASTIEN , GELDER VAN MARINA , HAUK CORINA , KOEKMAN BERTUS PIETER , MEURY ANJA , MOUNCEY NIGEL JOHN , SCHIPPER DICK , SHINJOH MASAKO , VOLLEBREGT ADRIANUS WILHELMUS
发明人： CHEVREUX BASTIEN , GELDER VAN MARINA , HAUK CORINA , KOEKMAN BERTUS PIETER , MEURY ANJA , MOUNCEY NIGEL JOHN , SCHIPPER DICK , SHINJOH MASAKO , VOLLEBREGT ADRIANUS WILHELMUS
IPC分类号： C12N9/02
CPC分类号： C12P17/04 , C12N9/0034 , C12Y105/03001
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽作为生物技术工具在从微生物生产维生素C中的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

4. 发明申请

WO2006084722A3 GENE STS 15 审中-公开
标题翻译：基因STS 15
公开(公告)号：WO2006084722A3
公开(公告)日：2006-09-28
申请号：PCT/EP2006001217
申请日：2006-02-10
申请人： DSM IP ASSETS BV , CHEVREUX BASTIEN , MAYER ANNE FRANCOISE , MEURY ANJA , MOUNCEY NIGEL JOHN , SHINJOH MASAKO
发明人： CHEVREUX BASTIEN , MAYER ANNE FRANCOISE , MEURY ANJA , MOUNCEY NIGEL JOHN , SHINJOH MASAKO
IPC分类号： C12N9/14 , C12P17/04
CPC分类号： C12P7/60 , C12N9/14 , C12P17/04
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

5. 发明申请

WO2006084646A3 SMS 22 GENE AND GENE PRODUCT THAT PLAYS A ROLE IN THE SYNTHESIS OF VITAMIN C 审中-公开
标题翻译： SMS 22基因组和基因产物在维生素C的合成中发挥作用
公开(公告)号：WO2006084646A3
公开(公告)日：2006-09-28
申请号：PCT/EP2006001012
申请日：2006-02-06
申请人： DSM IP ASSETS BV , SHINJOH MASAKO
发明人： SHINJOH MASAKO
IPC分类号： C07K14/195 , C12P17/04
CPC分类号： C12P17/04 , C07K14/195 , C12N15/52
摘要： The present invention relates to newly identified microorganisms capable of direct production of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Vitamin C. The invention also features polynucleotides comprising the full length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及能够直接生产L-抗坏血酸（以下也称为维生素C）的新鉴定的微生物。本发明还涉及包含参与维生素C合成的蛋白质的基因的多核苷酸序列。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸和片段编码的新多肽以及它们的功能等同物。本发明还涉及所述多核苷酸和多肽作为生物技术工具在从微生物生产维生素C中的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

6. 发明申请

WO2006084735A1 GENE FOR COENZYME PQQ SYNTHESIS PROTEIN B FROM GLUCONOBACTER OXYDANS 审中-公开
标题翻译：来自葡萄球菌OXYDANS的COENZYME PQQ合成蛋白B的基因
公开(公告)号：WO2006084735A1
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001230
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne Francoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne Francoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C07K14/195 , C12P17/04
CPC分类号： C12P7/60 , C07K14/195 , C12P17/04
摘要： The present invention relates to a newly identified gene that encodes a protein that is involved in the synthesis of L-ascorbic acid (hereinafter also referred to a Vitamin C). The protein is coenzyme PQQ synthesis protein B. The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及新鉴定的参与L-抗坏血酸合成的蛋白质的基因（以下也称为维生素C）。蛋白质是辅酶PQQ合成蛋白B.本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽作为生物技术工具在从微生物生产维生素C中的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

7. 发明申请

WO2006084732A2 NOVEL GENE RCS 07 审中-公开
标题翻译：新基因RCS 07
公开(公告)号：WO2006084732A2
公开(公告)日：2006-08-17
申请号：PCT/EP2006001227
申请日：2006-02-10
申请人： DSM IP ASSETS BV , CHEVREUX BASTIEN , MAYER ANNE FRANCOISE , MEURY ANJA , MOUNCEY NIGEL JOHN , SHINJOH MASAKO
发明人： CHEVREUX BASTIEN , MAYER ANNE FRANCOISE , MEURY ANJA , MOUNCEY NIGEL JOHN , SHINJOH MASAKO
IPC分类号： C12N9/02
CPC分类号： C12P17/04 , C12N9/0004
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

8. 发明申请

WO2006084726A1 GENE RCS 08 审中-公开
公开(公告)号：WO2006084726A1
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001221
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne, Françoise , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne, Françoise , SHINJOH, Masako
IPC分类号： C12N9/04 , C12P17/04
CPC分类号： C12P17/04 , C12N9/0006
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

9. 发明申请

WO2006084721A1 ALCOHOL DEHYDROGENASE GENE FROM GLUCONOBACTER OXYDANS 审中-公开
标题翻译：来自葡萄糖酸氧化酶的酒精脱氢酶基因
公开(公告)号：WO2006084721A1
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001216
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C12N9/04 , C12P17/04
CPC分类号： C12P17/04 , C12N9/0006
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽作为生物技术工具在从微生物生产维生素C中的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

10. 发明申请

WO2006084708A1 GENE SMS 05 审中-公开
标题翻译：基因SMS 05
公开(公告)号：WO2006084708A1
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001203
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , HOSHINO, Tatsuo , SHINJOH, Masako , TOEPFER, Christine , TOMIYAMA, Noribumi
发明人： HOSHINO, Tatsuo , SHINJOH, Masako , TOEPFER, Christine , TOMIYAMA, Noribumi
IPC分类号： C12N9/02 , C12P17/04
CPC分类号： C12P17/04 , C12N9/0008 , C12P1/04
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

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