专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2003026659A1 LOW HYGROSCOPIC ARIPIPRAZOLE DRUG SUBSTANCE AND PROCESSES FOR THE PREPARATION THEREOF 审中-公开
标题翻译：低剂量阿维替唑药物及其制备方法
公开(公告)号：WO2003026659A1
公开(公告)日：2003-04-03
申请号：PCT/JP2002/009858
申请日：2002-09-25
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , BANDO, Takuji , AOKI, Satoshi , KAWASAKI, Junichi , ISHIGAMI, Makoto , TANIGUCHI, Youichi , YABUUCHI, Tsuyoshi , FUJIMOTO, Kiyoshi , NISHIOKA, Yoshihiro , KOBAYASHI, Noriyuki , FUJIMURA, Tsutomu , TAKAHASHI, Masanori , ABE, Kaoru , NAKAGAWA, Tomonori , SHINHAMA, Koichi , UTSUMI, Naoto , TOMINAGA, Michiaki , OI, Yoshihiro , YAMADA, Shohei , TOMIKAWA, Kenji
发明人： BANDO, Takuji , AOKI, Satoshi , KAWASAKI, Junichi , ISHIGAMI, Makoto , TANIGUCHI, Youichi , YABUUCHI, Tsuyoshi , FUJIMOTO, Kiyoshi , NISHIOKA, Yoshihiro , KOBAYASHI, Noriyuki , FUJIMURA, Tsutomu , TAKAHASHI, Masanori , ABE, Kaoru , NAKAGAWA, Tomonori , SHINHAMA, Koichi , UTSUMI, Naoto , TOMINAGA, Michiaki , OI, Yoshihiro , YAMADA, Shohei , TOMIKAWA, Kenji
IPC分类号： A61K31/496
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
摘要翻译：本发明提供低吸湿形式的阿立哌唑及其制备方法，即使当含有阿立哌唑酐晶体的药物制剂长时间储存时，其也不会转化为水合物或丧失其原始溶解度。

2. 发明申请

WO2006035960A3 PROCESS FOR PRODUCTION OF 2-CHLORO-4-NITROIMIDAZOLE 审中-公开
标题翻译：生产2-氯-4-硝基咪唑的方法
公开(公告)号：WO2006035960A3
公开(公告)日：2006-05-11
申请号：PCT/JP2005018230
申请日：2005-09-27
申请人： OTSUKA PHARMA CO LTD , SHINHAMA KOICHI
发明人： SHINHAMA KOICHI
IPC分类号： C07D233/92 , A61K31/4164 , C07D233/94
CPC分类号： C07D233/92 , C07D233/94
摘要： The present invention provides a process for production of 2-chloro-4-nitroimidazole in a high yield and at a high purity by a simple operation in a safer manner involving a low risk of explosion or the like. The present invention provides a process for production of 2-chloro-4-nitroimidazole represented by the formula (1): comprising a reaction of a 1-alkoxyalkyl-2-bromo-4-nitroimidazole compound represented by the general formula (7): wherein R1 represents a lower alkyl group, and n represents an integer of 1 to 3, with hydrogen chloride.
摘要翻译：本发明提供了一种通过简单的操作以较安全的方式以较低的爆炸风险等生产高收率和高纯度的2-氯-4-硝基咪唑的方法。本发明提供了由通式（1）表示的2-氯-4-硝基咪唑的制备方法：该方法包括由通式（7）表示的1-烷氧基烷基-2-溴-4-硝基咪唑化合物与通式其中R 1表示低级烷基，并且n表示1至3的整数。

3. 发明申请

WO2013015456A1 METHOD FOR PRODUCING BENZO[B]THIOPHENE COMPOUND 审中-公开
标题翻译：生产苯并[B]噻吩化合物的方法
公开(公告)号：WO2013015456A1
公开(公告)日：2013-01-31
申请号：PCT/JP2012/069784
申请日：2012-07-27
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , SHINHAMA, Koichi , UTSUMI, Naoto , SOTA, Masahiro , FUJIEDA, Shigeo , OGASAWARA, Shin
发明人： SHINHAMA, Koichi , UTSUMI, Naoto , SOTA, Masahiro , FUJIEDA, Shigeo , OGASAWARA, Shin
IPC分类号： C07D333/54 , C07D409/12 , C07B61/00
CPC分类号： C07D409/12 , C07D333/54 , Y02P20/55
摘要： The present invention provides a method for producing a compound of Formula (4): wherein R 1 is a hydrogen atom etc. by reacting a compound of Formula (2): wherein X 1 is a leaving group, with a compound of Formula (3): wherein R 1 is as defined above, in the presence of (a) a palladium compound and a tertiary phosphine or (b) a palladium carbene complex, in an inert solvent or without a solvent. The present invention can produce the compound of Formula (4), with high purity and high yield, and by a simple operation.
摘要翻译：本发明提供式（4）的化合物的制备方法：其中，R 1为氢原子等，式（2）的化合物：其中X1为离去基团与式（3）的化合物反应：其中R 1如上定义，在（a）钯化合物和叔膦或（b）钯卡宾络合物的存在下，在惰性溶剂中或不用溶剂存在下进行。本发明可以通过简单的操作制备高纯度和高收率的式（4）化合物。

4. 发明申请

WO2011093529A1 SYNTHETIC INTERMEDIATE OF OXAZOLE COMPOUND AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：奥扎唑化合物的合成中间体及其制备方法
公开(公告)号：WO2011093529A1
公开(公告)日：2011-08-04
申请号：PCT/JP2011/052307
申请日：2011-01-28
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , YAMAMOTO, Akihiro , SHINHAMA, Koichi , FUJITA, Nobuhisa , AKI, Shinji , OGASAWARA, Shin , UTSUMI, Naoto
发明人： YAMAMOTO, Akihiro , SHINHAMA, Koichi , FUJITA, Nobuhisa , AKI, Shinji , OGASAWARA, Shin , UTSUMI, Naoto
IPC分类号： C07D211/46 , C07D405/12 , C07D498/04
CPC分类号： C07D211/46 , C07D405/12 , C07D498/04
摘要： An object of the present invention is to provide a method for producing an oxazole compound in a high yield. The object can be achieved by a compound represented by Formula (11): wherein R 1 is a hydrogen atom or lower-alkyl group; R 2 is a 1-piperidyl group substituted at the 4-position with a substituent selected from (A1a) a phenoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1b) a phenoxy-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkyl groups, (A1c) a phenyl-substituted lower-alkoxy lower-alkyl group substituted on the phenyl moiety with halogen, (A1d) a phenyl-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1e) an amino group substituted with a phenyl group substituted with one or more halogen-substituted lower-alkoxy groups, and a lower-alkyl group, and (A1f) a phenyl-substituted lower-alkoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups; n is an integer from 1 to 6; and X 3 is an organic sulfonyloxy group.
摘要翻译：本发明的目的是提供以高产率制备恶唑化合物的方法。该目的可以通过式（11）表示的化合物来实现：其中R1是氢原子或低级烷基; R2是在4-位被取代基取代的1-哌啶基，其具有选自（A1a）在苯基部分被一个或多个卤素取代的低级烷氧基取代的苯氧基的取代基，（A1b）苯氧基取代的低级烷氧基，在苯基部分被一个或多个卤素取代的低级烷基取代的烷基（A1c）在苯基部分被卤素取代的苯基取代的低级烷氧基低级烷基，（A1d）苯基取代的低级烷基，在苯基部分被一个或多个卤素取代的低级烷氧基取代的烷基，（A1e）被被一个或多个卤素取代的低级烷氧基取代的苯基取代的氨基和低级烷基，和（A1f）在苯基部分上被一个或多个卤素取代的低级烷氧基取代的苯基取代的低级烷氧基; n是1至6的整数; X3是有机磺酰氧基。

5. 发明申请

WO2008140090A1 EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME 审中-公开
标题翻译：环氧化合物及其制造方法
公开(公告)号：WO2008140090A1
公开(公告)日：2008-11-20
申请号：PCT/JP2008/058798
申请日：2008-05-07
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , TSUBOUCHI, Hidetsugu , HARAGUCHI, Yoshikazu , HAYAKAWA, Satoshi , UTSUMI, Naoto , TAIRA, Shinichi , TANADA, Yoshihisa , FUJITA, Nobuhisa , SHINHAMA, Koichi , ANNAKA, Kimiyoshi , FURUTA, Takuya
发明人： TSUBOUCHI, Hidetsugu , HARAGUCHI, Yoshikazu , HAYAKAWA, Satoshi , UTSUMI, Naoto , TAIRA, Shinichi , TANADA, Yoshihisa , FUJITA, Nobuhisa , SHINHAMA, Koichi , ANNAKA, Kimiyoshi , FURUTA, Takuya
IPC分类号： C07D407/12 , C07D498/04
CPC分类号： C07D405/12 , C07D303/18 , C07D498/04
摘要： The present invention provides a novel intermediate for manufacturing a 2,3-dihydroimidazo[2,1-b]oxazole compound with a high yield and a high purity, and a manufacturing method of the intermediate. The present invention provides an epoxy compound represented by the general formula (2): wherein, R1 represents hydrogen or a lower alkyl group; and R2 represents a piperidyl group represented by the general formula (A1): (wherein, R3 represents a phenoxy group having a halogen-substituted lower alkoxy group substituted on a phenyl group, and the like) and the like; and n represents an integer of 1 to 6, a manufacturing method of the epoxy compound, and a manufacturing method of an oxazole compound using the epoxy compound.
摘要翻译：本发明提供了一种制备具有高产率和高纯度的2,3-二氢咪唑并[2,1-b]恶唑化合物的新型中间体及其制备方法。本发明提供由通式（2）表示的环氧化合物：其中，R1表示氢或低级烷基; R 2表示由通式（A1）表示的哌啶基：（其中，R3表示在苯基取代的卤素取代的低级烷氧基的苯氧基等）等。 n表示1〜6的整数，环氧化合物的制造方法和使用该环氧化合物的恶唑化合物的制造方法。

6. 发明申请

WO2006035960A2 PROCESS FOR PRODUCTION OF 2-CHLORO-4-NITROIMIDAZOLE 审中-公开
标题翻译： 2-氯-4-硝基吡唑的制备方法
公开(公告)号：WO2006035960A2
公开(公告)日：2006-04-06
申请号：PCT/JP2005/018230
申请日：2005-09-27
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , SHINHAMA, Koichi
发明人： SHINHAMA, Koichi
IPC分类号： C07D233/92 , C07D233/94 , A61K31/4164
CPC分类号： C07D233/92 , C07D233/94
摘要： The present invention provides a process for production of 2-chloro-4-nitroimidazole in a high yield and at a high purity by a simple operation in a safer manner involving a low risk of explosion or the like. The present invention provides a process for production of 2-chloro-4-nitroimidazole represented by the formula (1): comprising a reaction of a 1-alkoxyalkyl-2-bromo-4-nitroimidazole compound represented by the general formula (7): wherein R1 represents a lower alkyl group, and n represents an integer of 1 to 3, with hydrogen chloride.
摘要翻译：本发明通过简单的操作提供以高产率和高纯度生产2-氯-4-硝基咪唑的方法，以更安全的方式涉及低的爆炸风险等。本发明提供由式（1）表示的2-氯-4-硝基咪唑的制备方法：包括由通式（7）表示的1-烷氧基烷基-2-溴-4-硝基咪唑化合物：其中R1表示低级烷基，n表示1〜3的整数，与氯化氢反应。

7. 发明申请

WO2005077913A1 METHOD FOR PRODUCING 4-NITROIMIDAZOLE COMPOUND 审中-公开
标题翻译：生产4-硝基咪唑化合物的方法
公开(公告)号：WO2005077913A1
公开(公告)日：2005-08-25
申请号：PCT/JP2005/002668
申请日：2005-02-15
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , SHINHAMA, Koichi
发明人： SHINHAMA, Koichi
IPC分类号： C07D233/92
CPC分类号： C07D233/92
摘要： The present invention provides a method for producing a 4-nitroimidazole compound represented by general formula (1) at high yield and at high purity by a safe method causing few dangers such as explosion. The production method of the present invention comprises iodinating a 4-nitroimidazole compound represented by general formula (2): wherein each of X 1 and X 2 represents a chlorine atom or bromine atom, and then reducing the obtained 5-iodo-4-nitroimidazole compound represented by general formula (3): wherein X 2 is the same as defined above.
摘要翻译：本发明提供了一种以高产率和高纯度制备由通式（1）表示的4-硝基咪唑化合物的方法，该方法是通过安全的方法产生很少的危险例如爆炸。本发明的制造方法包括对由通式（2）表示的4-硝基咪唑化合物进行碘化：其中X 1和X 2各自表示氯原子或溴原子，然后将得到的5-碘 -4-硝基咪唑化合物，其中X 2与上述定义相同。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式