专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007137072A3 ASSAYS FOR DIAGNOSING AND EVALUATING TREATMENT OPTIONS FOR FABRY DISEASE 审中-公开
标题翻译：用于诊断和评估治疗疾病的治疗方案的测定
公开(公告)号：WO2007137072A3
公开(公告)日：2008-10-16
申请号：PCT/US2007069046
申请日：2007-05-16
申请人： AMICUS THERAPEUTICS INC , NAT INST HEALTH , KANESKI CHRISTINE , SHIN SANG-HOON , MURRAY GARY , LUDWIG KARIN , LOCKHART DAVID , CASTELLI JEFF
发明人： KANESKI CHRISTINE , SHIN SANG-HOON , MURRAY GARY , LUDWIG KARIN , LOCKHART DAVID , CASTELLI JEFF
IPC分类号： G01N33/53 , G01N33/567 , G01N33/573
CPC分类号： A61K31/445 , A61K9/0053 , A61K9/48 , A61K31/45 , A61K45/06 , C07D211/46 , G01N33/5094 , G01N2333/924 , G01N2333/94 , G01N2800/04 , G01N2800/52 , A61K2300/00
摘要： Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.
摘要翻译：提供了用于确定法布里病患者是否将以特定药物伴侣的治疗反应的体外和体内方法。

2. 发明申请

WO2007142400A1 EXTENDED SPHERICAL LNG STORAGE TANK AND METHOD FOR MANUFACTURING THE SAME 审中-公开
标题翻译：扩展的球形液化天然气贮存罐及其制造方法
公开(公告)号：WO2007142400A1
公开(公告)日：2007-12-13
申请号：PCT/KR2007/000890
申请日：2007-02-21
申请人： HYUNDAI HEAVY INDUSTRIES CO., LTD. , MIN, Keh-Sik , KIM, Oi-Hyun , PARK, Jin-Soo , CHOE, Ick-Hung , SHIN, Sang-Hoon , KWON, Bong-Jae , KWON, Il-Keun
发明人： MIN, Keh-Sik , KIM, Oi-Hyun , PARK, Jin-Soo , CHOE, Ick-Hung , SHIN, Sang-Hoon , KWON, Bong-Jae , KWON, Il-Keun
IPC分类号： F17C1/00
CPC分类号： F17C3/025 , F17C13/082 , F17C2201/0128 , F17C2201/0147 , F17C2201/032 , F17C2201/052 , F17C2203/0619 , F17C2205/013 , F17C2205/0161 , F17C2209/221 , F17C2221/033 , F17C2223/0161 , F17C2223/033 , F17C2260/011 , F17C2270/0105
摘要： The present invention provides an extended spherical LNG storage tank, installed on an LNG tanker, and a method for manufacturing the same, in which the junctions between a connection tank part and upper and lower tank parts are configured as smooth parts, thus increasing the LNG storage capacity of the tank and mitigating stress concentration on the junctions, and the connection tank part is constructed by integrating a plurality of plates into a single structure, thus increasing work efficiency while fabricating the connection tank part and thereby enabling quick and easy production of the LNG storage tanks. In the extended spherical LNG storage tank, which includes the upper and lower tank parts, each having a predetermined radius of curvature R, and the connection tank part provided between the upper and lower tank parts so as to increase the LNG storage capacity of the tank, the connection tank part is defined by a circular arc or a parabola C3, which is circumscribed with two circles Cl and C2, which define the upper tank part and the lower tank part, respectively, outside the two circles Cl and C2.
摘要翻译：本发明提供一种安装在LNG罐车上的扩展球形LNG储罐及其制造方法，其中连接罐部分与上部和下部罐部分之间的接合部构造为平滑部分，从而增加LNG 罐的储存容量和减轻接头处的应力集中，连接箱部分通过将多个板整合成单个结构而构成，从而在制造连接罐部分的同时提高工作效率，从而能够快速和容易地生产 LNG储罐。在包括上部和下部箱体部分的扩展球形LNG储罐中，每个具有预定的曲率半径R，以及设置在上部和下部箱体之间的连接罐部分，以便增加罐的LNG储存容量连接箱部分由圆弧或抛物线C3限定，该圆弧或抛物线C3分别限定两个圆C1和C2，它们分别在两个圆C1和C2的外面限定上部罐部分和下部罐部分。

3. 发明申请

WO2004110343A2 2-AMINO-9-(2-SUBSTITUTED ETHYL)PURINES AND PREPARING METHODS FOR 9-[4-ACETOXY-3-(ACETOXYMETHYL)BUT-1-YL]- 2- AMINOPURINE USING THE SAME 审中-公开
标题翻译： 2-氨基-9-（2-取代的乙醇）和9- [4-乙酰氧基-3-（乙酰氧基甲基）丁-1-炔基] -2-氨基嘌呤的制备方法
公开(公告)号：WO2004110343A2
公开(公告)日：2004-12-23
申请号：PCT/KR2004/001405
申请日：2004-06-12
申请人： KYUNGDONG PHARM. CO., LTD. , LEE, Byoung-Suk , SHIN, Sang-Hoon , PARK, Jong-Sik
发明人： LEE, Byoung-Suk , SHIN, Sang-Hoon , PARK, Jong-Sik
IPC分类号： A61K
CPC分类号： C07D473/32
摘要： The present invention relates to a new compound of 2-amino-9-(2-substituted ethyl)purine and an effective method for preparing 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurin (famciclovir) using the same. The 2-amino-9-(2-substituted ethyl)purine according to the invention is represented by the following formula (II'): (Formula II') wherein R is a hydroxy, halogen, mesyloxy or tosyloxy group. The inventive method for the preparation of famciclovir comprises the steps of halogenating 2-amino-9-(2-substituted ethyl)purine to give 2-amino-9-(2-halogenoethyl)purine, and reacting the halogenated compound with diethylmalonate. The inventive preparation method allows famciclovir, a purine derivative drug with effective antiviral activity, to be prepared in a high selectivity of 100% in a pure form by using the inventive new compound of 2-amino-9-(2-substituted ethyl)purine. In addition, the inventive method allows the utilization of relatively mild reaction conditions, and thus, has high industrial process efficiency.
摘要翻译：本发明涉及2-氨基-9-（2-取代乙基）嘌呤的新化合物和制备9- [4-乙酰氧基-3-（乙酰氧基甲基）丁-1-基] -2-氨基嘌呤的有效方法（泛昔洛韦）使用相同。根据本发明的2-氨基-9-（2-取代的乙基）嘌呤由下式（II'）表示：（式II'）其中R是羟基，卤素，甲磺酰氧基或甲苯磺酰氧基。用于制备泛昔洛韦的本发明方法包括以下步骤：将2-氨基-9-（2-取代的乙基）嘌呤卤化得到2-氨基-9-（2-卤代乙基）嘌呤，并使该卤代化合物与丙二酸二乙酯反应。本发明的制备方法允许泛昔洛韦（一种具有有效抗病毒活性的嘌呤衍生物）通过使用本发明新的2-氨基-9-（2-取代的乙基）嘌呤化合物以高纯度的100％选择性制备。此外，本发明的方法允许利用相对温和的反应条件，因此具有高工业过程效率。

4. 发明申请

WO2008115026A1 DEVICE AND METHOD FOR RECORDING AND RECONSTRUCTING DIGITAL HOLOGRAM WITHOUT VIRTUAL IMAGE 审中-公开
标题翻译：没有虚拟图像记录和重新编码数字HOLOGRAM的设备和方法
公开(公告)号：WO2008115026A1
公开(公告)日：2008-09-25
申请号：PCT/KR2008/001601
申请日：2008-03-21
申请人： APNTECH CO., LTD , SHIN, Sang-Hoon , CHOI, Seung-Kil
发明人： SHIN, Sang-Hoon , CHOI, Seung-Kil
IPC分类号： G11B7/0065
CPC分类号： G03H1/0866 , G03H1/0443 , G03H2001/005
摘要： The present invention relates to a device and method for digital hologram recording and reconstructing that solves the problem of overlapping real and virtual images when reconstructing a hologram with a digital hologram device such as a digital hologram microscope. The device comprises a hologram reconstructing module for dividing the hologram area recorded on the CCD, recording in the interim each divided area whereby for each of the areas the pixel values of the rest of the areas except for that divided area is set to zero, outputting a reconstructed image with the virtual image removed by integrating each of the reconstructed hologram images recorded in the interim, and a control unit for controlling the hologram recording on the CCD, including dividing, mid-recording, and integration operations of the hologram reconstructing module, thus leading to perfect holographic information of the object.
摘要翻译：本发明涉及一种用于数字全息图记录和重构的装置和方法，该装置和方法解决了使用诸如数字全息显微镜的数字全息图装置重建全息图时重叠实像和虚像的问题。该装置包括全息图重建模块，用于分割记录在CCD上的全息图区域，在每个划分区域的中间记录，由此对于每个区域，除了该分割区域之外的其余区域的像素值被设置为零，输出通过对在中间记录的每个重建全息图像进行积分而去除虚像的重建图像，以及控制单元，用于控制CCD上的全息图记录，包括全息图重建模块的分割，中间记录和积分操作，从而导致物体的完美全息信息。

5. 发明申请

WO2007137072A2 ASSAYS FOR DIAGNOSING AND EVALUATING TREATMENT OPTIONS FOR FABRY DISEASE 审中-公开
标题翻译：用于诊断和评估治疗疾病的治疗方案的测定
公开(公告)号：WO2007137072A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/069046
申请日：2007-05-16
申请人： AMICUS THERAPEUTICS, INC. , NATIONAL INSTITUTES OF HEALTH , KANESKI, Christine , SHIN, Sang-hoon , MURRAY, Gary , LUDWIG, Karin , LOCKHART, David , CASTELLI, Jeff
发明人： KANESKI, Christine , SHIN, Sang-hoon , MURRAY, Gary , LUDWIG, Karin , LOCKHART, David , CASTELLI, Jeff
IPC分类号： G01N33/53
CPC分类号： A61K31/445 , A61K9/0053 , A61K9/48 , A61K31/45 , A61K45/06 , C07D211/46 , G01N33/5094 , G01N2333/924 , G01N2333/94 , G01N2800/04 , G01N2800/52 , A61K2300/00
摘要： Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.
摘要翻译：提供了用于确定法布里病患者是否将以特定药物伴侣的治疗反应的体外和体内方法。

6. 发明申请

WO2004110343A3 2-AMINO-9-(2-SUBSTITUTED ETHYL)PURINES AND PREPARING METHODS FOR 9-[4-ACETOXY-3-(ACETOXYMETHYL)BUT-1-YL]- 2- AMINOPURINE USING THE SAME 审中-公开
标题翻译： 2-氨基-9-（2-取代的乙醇）和9- [4-乙酰氧基-3-（乙酰氧基甲基）丁-1-炔基] -2-氨基嘌呤的制备方法
公开(公告)号：WO2004110343A3
公开(公告)日：2005-09-01
申请号：PCT/KR2004001405
申请日：2004-06-12
申请人： KYUNGDONG PHARM CO LTD , LEE BYOUNG-SUK , SHIN SANG-HOON , PARK JONG-SIK
发明人： LEE BYOUNG-SUK , SHIN SANG-HOON , PARK JONG-SIK
IPC分类号： A61K20060101 , C07D473/32
CPC分类号： C07D473/32
摘要： The present invention relates to a new compound of 2-amino-9-(2-substituted ethyl)purine and an effective method for preparing 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurin (famciclovir) using the same. The 2-amino-9-(2-substituted ethyl)purine according to the invention is represented by the following formula (II'): (Formula II') wherein R is a hydroxy, halogen, mesyloxy or tosyloxy group. The inventive method for the preparation of famciclovir comprises the steps of halogenating 2-amino-9-(2-substituted ethyl)purine to give 2-amino-9-(2-halogenoethyl)purine, and reacting the halogenated compound with diethylmalonate. The inventive preparation method allows famciclovir, a purine derivative drug with effective antiviral activity, to be prepared in a high selectivity of 100% in a pure form by using the inventive new compound of 2-amino-9-(2-substituted ethyl)purine. In addition, the inventive method allows the utilization of relatively mild reaction conditions, and thus, has high industrial process efficiency.
摘要翻译：本发明涉及2-氨基-9-（2-取代乙基）嘌呤的新化合物和制备9- [4-乙酰氧基-3-（乙酰氧基甲基）丁-1-基] -2-氨基嘌呤的有效方法（泛昔洛韦）使用相同。根据本发明的2-氨基-9-（2-取代的乙基）嘌呤由下式（II'）表示：（式II'）其中R是羟基，卤素，甲磺酰氧基或甲苯磺酰氧基。用于制备泛昔洛韦的本发明方法包括以下步骤：将2-氨基-9-（2-取代的乙基）嘌呤卤化得到2-氨基-9-（2-卤代乙基）嘌呤，并使该卤代化合物与丙二酸二乙酯反应。本发明的制备方法允许泛昔洛韦（一种具有有效抗病毒活性的嘌呤衍生物）通过使用本发明新的2-氨基-9-（2-取代的乙基）嘌呤化合物以高纯度的100％选择性制备。此外，本发明的方法允许利用相对温和的反应条件，因此具有高工业过程效率。

7. 发明申请

WO2004007497A1 PROCESS FOR PREPARING 9-[4-ACETOXY-3-(ACETOXYMETHYL)BUT-1-YL]-2-AMINOPURINE 审中-公开
标题翻译：制备9- [4-乙酰氧基-3-（乙酰氧基甲基）丁-1-基] -2-氨基嘌呤的方法
公开(公告)号：WO2004007497A1
公开(公告)日：2004-01-22
申请号：PCT/KR2003/001396
申请日：2003-07-15
申请人： KYUNGDONG PHARM. CO., LTD. , LEE, Byoung-Suk , SHIN, Sang-Hoon
发明人： LEE, Byoung-Suk , SHIN, Sang-Hoon
IPC分类号： C07D473/32
CPC分类号： C07D473/00
摘要： Disclosed is a process for preparing 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine (called Famciclovir), a drug of purine derivatives having antiviral activity. This process comprises reacting 2-aminopurine with 2-acetoxymethyl-4-bromobut-1-yl-acetate in the presence of thallium (I) ethoxide to give the desired compound. According to this process, the desired compound can be prepared in very high selectivity and purity under mild reaction conditions.
摘要翻译：公开了一种制备具有抗病毒活性的嘌呤衍生物的9- [4-乙酰氧基-3-（乙酰氧基甲基）丁-1-基] -2-氨基嘌呤（称为泛昔洛韦）的方法。该方法包括在乙酸铊（I）存在下使2-氨基嘌呤与2-乙酰氧基甲基-4-溴丁-1-基 - 乙酸酯反应，得到所需化合物。根据该方法，可以在温和的反应条件下以非常高的选择性和纯度制备所需化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式